Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Zhenghui Gordon Jiang, M.D.

Title
Institution
Department
Address
Phone
Fax
Profile Picture

Biography
education and training
Boston University, BostonMD2011Medicine
Boston University, BostonPh.D.2005Physiology and Biophysics

Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. Novel Therapeutic Delivery Award (Jiang, Zhenghui Gordon) Aug 1, 2022 - Jul 31, 2025
    Massachusetts Life Sciences Center
    Role Description: Liver failure is a rising cause of death in the US with no cure other than liver transplant. We will establish hepatocyte-specific therapeutics using small activating RNA (saRNA), a double-stranded RNA with the ability to enhance target gene expression. This project aims to develop a viable therapy for liver failure and define therapeutic efficacy and safety.
    Role: Principal Investigator
  2. K08DK115883 (JIANG, ZHENGHUI GORDON) Sep 1, 2018 - Jul 31, 2023
    NIH
    Adenosine deaminase 2 regulates macrophage phenotype and liver fibrosis in nonalcoholic fatty liver disease
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG. Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis. Hepatology. 2022 04; 75(4):968-982. PMID: 34662439; PMCID: PMC9299888.
    Citations: 2     Fields:    Translation:Humans
  2. Hakim A, Moll M, Brancale J, Liu J, Lasky-Su JA, Silverman EK, Vilarinho S, Jiang ZG, Pita-Juárez YH, Vlachos IS, Zhang X, Åberg F, Afdhal NH, Hobbs BD, Cho MH. Genetic Variation in the Mitochondrial Glycerol-3-Phosphate Acyltransferase Is Associated With Liver Injury. Hepatology. 2021 12; 74(6):3394-3408. PMID: 34216018; PMCID: PMC8639615.
    Citations: 1     Fields:    Translation:HumansCells
  3. Tiwari-Heckler S, Yee EU, Yalcin Y, Park J, Nguyen DT, Gao W, Csizmadia E, Afdhal N, Mukamal KJ, Robson SC, Lai M, Schwartz RE, Jiang ZG. Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease. Cell Rep. 2021 10 26; 37(4):109897. PMID: 34706243; PMCID: PMC8606247.
    Citations:    Fields:    Translation:HumansCells
  4. Niezen S, Tapper EB, Trivedi H, Lai M, Curry MP, Mukamal KJ, Jiang ZG. Prevalence of High Liver Stiffness and a Screening Strategy Using the SODA-2B Score Among US Adults. Hepatol Commun. 2022 04; 6(4):898-909. PMID: 34697916; PMCID: PMC8948660.
    Citations: 1     Fields:    Translation:Humans
  5. Mathur K, Vilar-Gomez E, Connelly MA, He H, Sanyal AJ, Chalasani N, Jiang ZG. Circulating high density lipoprotein distinguishes alcoholic hepatitis from heavy drinkers and predicts 90-day outcome: lipoproteins in alcoholic hepatitis. J Clin Lipidol. 2021 Nov-Dec; 15(6):805-813. PMID: 34756674; PMCID: PMC8688310.
    Citations: 1     Fields:    Translation:Humans
  6. Niezen S, Mehta M, Jiang ZG, Tapper EB. Coffee Consumption Is Associated With Lower Liver Stiffness: A Nationally Representative Study. Clin Gastroenterol Hepatol. 2022 09; 20(9):2032-2040.e6. PMID: 34626832; PMCID: PMC8983790.
    Citations: 3     Fields:    Translation:Humans
  7. Trivedi HD, Niezen S, Jiang ZG, Tapper EB. Severe Hepatic Steatosis by Controlled Attenuation Parameter Predicts Quality of Life Independent of Fibrosis. Dig Dis Sci. 2022 08; 67(8):4215-4222. PMID: 34417922.
    Citations: 1     Fields:    Translation:Humans
  8. Niezen S, Trivedi HD, Mukamal KJ, Jiang ZG. Associations between alcohol consumption and hepatic steatosis in the USA. Liver Int. 2021 09; 41(9):2020-2023. PMID: 34297882; PMCID: PMC9330542.
    Citations: 3     Fields:    Translation:Humans
  9. Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe Å, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Biermann J, Bloom-Ackermann Z, Barkas N, Ganna A, Gomez J, Melms JC, Katsyv I, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Wang Y, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jané-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hibshoosh H, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Ellinor PT, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Jiang ZG, Juric D, Babadi M, Farhi SL, Izar B, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev A. COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature. 2021 07; 595(7865):107-113. PMID: 33915569; PMCID: PMC8919505.
    Citations: 203     Fields:    Translation:HumansCells
  10. Hakim A, Moll M, Qiao D, Liu J, Lasky-Su JA, Silverman EK, Vilarinho S, Jiang ZG, Hobbs BD, Cho MH. Heterozygosity of the Alpha 1-Antitrypsin Pi*Z Allele and Risk of Liver Disease. Hepatol Commun. 2021 Aug; 5(8):1348-1361. PMID: 34430780; PMCID: PMC8369947.
    Citations: 5     Fields:    
  11. Åberg F, Danford CJ, Thiele M, Talbäck M, Rasmussen DN, Jiang ZG, Hammar N, Nasr P, Ekstedt M, But A, Puukka P, Krag A, Sundvall J, Erlund I, Salomaa V, Stål P, Kechagias S, Hultcrantz R, Lai M, Afdhal N, Jula A, Männistö S, Lundqvist A, Perola M, Färkkilä M, Hagström H. A Dynamic Aspartate-to-Alanine Aminotransferase Ratio Provides Valid Predictions of Incident Severe Liver Disease. Hepatol Commun. 2021 Jun; 5(6):1021-1035. PMID: 34141987; PMCID: PMC8183175.
    Citations: 7     Fields:    
  12. Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe A, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Bloom-Ackerman Z, Barkas N, Ganna A, Gomez J, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jane-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Gordon Jiang Z, Juric D, Babadi M, Farhi SL, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev A. A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2. bioRxiv. 2021 Feb 25. PMID: 33655247.
    Citations: 12     
  13. Sandhu B, Perez-Matos MC, Tran S, Singhal G, Syed I, Feldbrügge L, Mitsuhashi S, Pelletier J, Huang J, Yalcin Y, Csizmadia E, Tiwari-Heckler S, Enjyoji K, Sévigny J, Maratos-Flier E, Robson SC, Jiang ZG. Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism. Metabolism. 2021 05; 118:154731. PMID: 33631144; PMCID: PMC8052311.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Bedi S, Garcia E, Jeyarajah EJ, Shalaurova I, Perez-Matos MC, Jiang ZG, Dullaart RPF, Matyus SP, Kirk WJ, Otvos JD, Davidson WS, Connelly MA. Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay. J Clin Med. 2020 Sep 10; 9(9). PMID: 32927635.
    Citations: 7     
  15. Ezaz G, Trivedi HD, Connelly MA, Filozof C, Howard K, L Parrish M, Kim M, Herman MA, Nasser I, Afdhal NH, Jiang ZG, Lai M. Differential Associations of Circulating MicroRNAs With Pathogenic Factors in NAFLD. Hepatol Commun. 2020 May; 4(5):670-680. PMID: 32363318.
    Citations: 9     Fields:    
  16. Libman H, Jiang ZG, Tapper EB, Reynolds EE. How Would You Manage This Patient With Nonalcoholic Fatty Liver Disease? Ann Intern Med. 2019 12 03; 171(11):862. PMID: 31791052.
    Citations: 1     Fields:    Translation:Humans
  17. Tiwari-Heckler S, Jiang ZG, Popov Y, J Mukamal K. Daily high-dose aspirin does not lower APRI in the Aspirin-Myocardial Infarction Study. J Biomed Res. 2019 Oct 24; 34(2):139-142. PMID: 32305968; PMCID: PMC7183302.
    Citations:    
  18. Danford CJ, Jiang ZG, Salomaa V, Färkkilä M, Jula A, Männistö S, Lundqvist A, Valsta L, Perola M, Åberg F. Insulin Resistance and Genetic Risk Predict Liver-Related Outcomes and Death in Nonalcoholic Fatty Liver Disease. Hepatol Commun. 2019 Dec; 3(12):1704-1705. PMID: 31832576; PMCID: PMC6887916.
    Citations:    Fields:    
  19. Jiang ZG, Tapper EB. Cost Saving or Cost Effective? Unanswered Questions in the Screening of Patients With Nonalcoholic Fatty Liver Disease. Hepatol Commun. 2019 Oct; 3(10):1293-1295. PMID: 31592491; PMCID: PMC6771157.
    Citations: 2     Fields:    
  20. Grunwald D, Landau A, Jiang ZG, Liu JJ, Najarian R, Sheth SG. Further Defining the 2012 Multi-Society Task Force Guidelines for Surveillance of High-risk Adenomas: Is a 3-Year Interval Needed for All Patients? J Clin Gastroenterol. 2019 10; 53(9):673-679. PMID: 30036239.
    Citations: 1     Fields:    Translation:Humans
  21. Libman H, Jiang ZG, Tapper EB, Reynolds EE. How Would You Manage This Patient With Nonalcoholic Fatty Liver Disease?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. Ann Intern Med. 2019 08 06; 171(3):199-207. PMID: 31382287.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  22. Tiwari-Heckler S, Jiang ZG. Adenosinergic Signaling in Liver Fibrosis. Clin Liver Dis (Hoboken). 2019 Jul; 14(1):1-4. PMID: 31391927; PMCID: PMC6677012.
    Citations: 1     
  23. Rich NE, Yang JD, Perumalswami PV, Alkhouri N, Jackson W, Parikh ND, Mehta N, Salgia R, Duarte-Rojo A, Kulik L, Rakoski M, Said A, Oloruntoba O, Ioannou GN, Hoteit MA, Moon AM, Rangnekar AS, Eswaran SL, Zheng E, Jou JH, Hanje J, Pillai A, Hernaez R, Wong R, Scaglione S, Samant H, Kapuria D, Chandna S, Rosenblatt R, Ajmera V, Frenette CT, Satapathy SK, Mantry P, Jalal P, John BV, Fix OK, Leise M, Lindenmeyer CC, Flores A, Patel N, Jiang ZG, Latt N, Dhanasekaran R, Odewole M, Kagan S, Marrero JA, Singal AG. Provider Attitudes and Practice Patterns for Direct-Acting Antiviral Therapy for Patients With Hepatocellular Carcinoma. Clin Gastroenterol Hepatol. 2020 04; 18(4):974-983. PMID: 31357028.
    Citations: 9     Fields:    Translation:Humans
  24. Rothweiler S, Feldbrügge L, Jiang ZG, Csizmadia E, Longhi MS, Vaid K, Enjyoji K, Popov YV, Robson SC. Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis. Purinergic Signal. 2019 09; 15(3):375-385. PMID: 31243614.
    Citations: 12     Fields:    Translation:AnimalsCells
  25. Sandhu B, Perez Matos MC, Tran S, Zhong A, Csizmadia E, Kim M, Herman MA, Nasser I, Lai M, Jiang ZG. Quantitative digital pathology reveals association of cell-specific PNPLA3 transcription with NAFLD disease activity. JHEP Rep. 2019 Sep; 1(3):199-202. PMID: 32039370; PMCID: PMC7001539.
    Citations: 3     
  26. Perez-Matos MC, Sandhu B, Bonder A, Jiang ZG. Lipoprotein metabolism in liver diseases. Curr Opin Lipidol. 2019 02; 30(1):30-36. PMID: 30550414.
    Citations: 9     Fields:    Translation:HumansAnimals
  27. Wah-Suarez MI, Danford CJ, Patwardhan VR, Jiang ZG, Bonder A. Hyperlipidaemia in primary biliary cholangitis: treatment, safety and efficacy. Frontline Gastroenterol. 2019 Oct; 10(4):401-408. PMID: 31656566; PMCID: PMC6788128.
    Citations: 6     
  28. Danford CJ, Yao ZM, Jiang ZG. Non-alcoholic fatty liver disease: a narrative review of genetics. J Biomed Res. 2018 Nov 20; 32(5):389-400. PMID: 30355853; PMCID: PMC6283828.
    Citations: 19     
  29. Danford CJ, Connelly MA, Shalaurova I, Kim M, Herman MA, Nasser I, Otvos JD, Afdhal NH, Jiang ZG, Lai M. A Pathophysiologic Approach Combining Genetics and Insulin Resistance to Predict the Severity of Nonalcoholic Fatty Liver Disease. Hepatol Commun. 2018 Dec; 2(12):1467-1478. PMID: 30556036; PMCID: PMC6287585.
    Citations: 7     Fields:    
  30. Jiang ZG, Tapper EB, Kim M, Connelly MA, Krawczyk SA, Yee EU, Herman MA, Mukamal KJ, Lai M. Genetic Determinants of Circulating Lipoproteins in Nonalcoholic Fatty Liver Disease. J Clin Gastroenterol. 2018 May/Jun; 52(5):444-451. PMID: 28362682; PMCID: PMC5623166.
    Citations: 5     Fields:    Translation:Humans
  31. Pérez-Matos MC, Jiang ZG, Tapper EB. Factors That Affect Results of Psychometric Tests to Identify Patients With Minimal Hepatic Encephalopathy. Clin Gastroenterol Hepatol. 2018 11; 16(11):1836-1838. PMID: 29551739; PMCID: PMC6139070.
    Citations: 7     Fields:    Translation:Humans
  32. El-Sherif O, Jiang ZG, Tapper EB, Huang KC, Zhong A, Osinusi A, Charlton M, Manns M, Afdhal NH, Mukamal K, McHutchison J, Brainard DM, Terrault N, Curry MP. Baseline Factors Associated With Improvements in Decompensated Cirrhosis After Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection. Gastroenterology. 2018 06; 154(8):2111-2121.e8. PMID: 29535028.
    Citations: 35     Fields:    Translation:HumansCells
  33. Jiang ZG, Vardeh H, Evenson A. A Case of Cryptogenic Liver Failure. Gastroenterology. 2018 07; 155(1):23-24.e1. PMID: 29408637.
    Citations:    Fields:    Translation:Humans
  34. Ghaziani TT, Liu JJ, Jiang ZG, Nasser I, Khwaja K, Fisher RA, Nahas M, Curry MP. Posttransplant Lymphoproliferative Disorder Isolated to the Adrenal Gland in a Liver Transplant Patient. ACG Case Rep J. 2018; 5:e10. PMID: 29430469; PMCID: PMC5797803.
    Citations:    
  35. Jiang ZG, Sandhu B, Feldbrügge L, Yee EU, Csizmadia E, Mitsuhashi S, Huang J, Afdhal NH, Robson SC, Lai M. Serum Activity of Macrophage-Derived Adenosine Deaminase 2 Is Associated With Liver Fibrosis in Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2018 07; 16(7):1170-1172. PMID: 29170098; PMCID: PMC5962372.
    Citations: 6     Fields:    Translation:HumansCells
  36. Feldbrügge L, Jiang ZG, Csizmadia E, Mitsuhashi S, Tran S, Yee EU, Rothweiler S, Vaid KA, Sévigny J, Schmelzle M, Popov YV, Robson SC. Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis. Purinergic Signal. 2018 03; 14(1):37-46. PMID: 29134411.
    Citations: 9     Fields:    Translation:Animals
  37. Zhong AH, Gordon Jiang Z, Cummings RD, Robson SC. Various N-glycoforms differentially upregulate E-NTPDase activity of the NTPDase3/CD39L3 ecto-enzymatic domain. Purinergic Signal. 2017 Dec; 13(4):601-609. PMID: 28956227; PMCID: PMC5714850.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  38. Feldbrügge L, Moss AC, Yee EU, Csizmadia E, Mitsuhashi S, Longhi MS, Sandhu B, Stephan H, Wu Y, Cheifetz AS, Müller CE, Sévigny J, Robson SC, Jiang ZG. Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease. J Crohns Colitis. 2017 Sep 01; 11(9):1113-1123. PMID: 28472257; PMCID: PMC5881706.
    Citations: 11     Fields:    Translation:HumansAnimals
  39. Mitsuhashi S, Ballou S, Jiang ZG, Hirsch W, Nee J, Iturrino J, Cheng V, Lembo A. Characterizing Normal Bowel Frequency and Consistency in a Representative Sample of Adults in the United States (NHANES). Am J Gastroenterol. 2018 01; 113(1):115-123. PMID: 28762379.
    Citations: 20     Fields:    Translation:Humans
  40. Longhi MS, Moss A, Jiang ZG, Robson SC. Purinergic signaling during intestinal inflammation. J Mol Med (Berl). 2017 Sep; 95(9):915-925. PMID: 28547076; PMCID: PMC5702590.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  41. De Giorgi M, Enjyoji K, Jiang G, Csizmadia E, Mitsuhashi S, Gumina RJ, Smolenski RT, Robson SC. Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice. J Lipid Res. 2017 07; 58(7):1292-1305. PMID: 28487312.
    Citations: 8     Fields:    Translation:AnimalsCells
  42. Koch M, Furtado JD, Jiang GZ, Gray BE, Cai T, Sacks F, Tjønneland A, Overvad K, Jensen MK. Associations of anthropometry and lifestyle factors with HDL subspecies according to apolipoprotein C-III. J Lipid Res. 2017 06; 58(6):1196-1203. PMID: 28365588.
    Citations: 12     Fields:    Translation:Humans
  43. Jiang ZG, Matthew M, Yee EU, Horst D. Elastofibromatous Change in Association With Pneumatosis Intestinalis. Am J Gastroenterol. 2017 03; 112(3):1514. PMID: 28270672.
    Citations:    Fields:    Translation:Humans
  44. Jiang ZG, Feldbrügge L, Tapper EB, Popov Y, Ghaziani T, Afdhal N, Robson SC, Mukamal KJ. Letter: would aspirin alleviate fibrosis in alcoholic liver disease? Authors' reply. Aliment Pharmacol Ther. 2016 07; 44(2):209-10. PMID: 27296690.
    Citations:    Fields:    Translation:Humans
  45. Liberal R, Grant CR, Ma Y, Csizmadia E, Jiang ZG, Heneghan MA, Yee EU, Mieli-Vergani G, Vergani D, Robson SC, Longhi MS. CD39 mediated regulation of Th17-cell effector function is impaired in juvenile autoimmune liver disease. J Autoimmun. 2016 08; 72:102-12. PMID: 27210814; PMCID: PMC6348153.
    Citations: 17     Fields:    Translation:HumansCells
  46. Jiang ZG, Tapper EB, Connelly MA, Pimentel CF, Feldbrügge L, Kim M, Krawczyk S, Afdhal N, Robson SC, Herman MA, Otvos JD, Mukamal KJ, Lai M. Steatohepatitis and liver fibrosis are predicted by the characteristics of very low density lipoprotein in nonalcoholic fatty liver disease. Liver Int. 2016 08; 36(8):1213-20. PMID: 26815314; PMCID: PMC4942367.
    Citations: 15     Fields:    Translation:Humans
  47. Jiang ZG, Feldbrügge L, Tapper EB, Popov Y, Ghaziani T, Afdhal N, Robson SC, Mukamal KJ. Aspirin use is associated with lower indices of liver fibrosis among adults in the United States. Aliment Pharmacol Ther. 2016 Mar; 43(6):734-43. PMID: 26749582.
    Citations: 36     Fields:    Translation:Humans
  48. Grunwald D, Tapper EB, Jiang ZG, Ahmed M, Malik R. A Standardized Assessment of Functional Disability Predicts 1-year Mortality in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt for Refractory Ascites. J Clin Gastroenterol. 2016 Jan; 50(1):75-9. PMID: 25984975.
    Citations: 5     Fields:    Translation:Humans
  49. Jiang ZG, de Boer IH, Mackey RH, Jensen MK, Lai M, Robson SC, Tracy R, Kuller LH, Mukamal KJ. Associations of insulin resistance, inflammation and liver synthetic function with very low-density lipoprotein: The Cardiovascular Health Study. Metabolism. 2016 Mar; 65(3):92-9. PMID: 26892520; PMCID: PMC4761104.
    Citations: 9     Fields:    Translation:Humans
  50. Pimentel CF, Jiang ZG, Otsubo T, Feldbrügge L, Challies TL, Nasser I, Robson S, Afdhal N, Lai M. Poor Inter-test Reliability Between CK18 Kits as a Biomarker of NASH. Dig Dis Sci. 2016 Mar; 61(3):905-12. PMID: 26462489; PMCID: PMC4761280.
    Citations: 8     Fields:    Translation:Humans
  51. Feuerstein JD, Jiang ZG, Belkin E, Lewandowski JJ, Martinez-Vazquez M, Singla A, Cataldo T, Poylin V, Cheifetz AS. Surgery for Ulcerative Colitis Is Associated with a High Rate of Readmissions at 30 Days. Inflamm Bowel Dis. 2015 Sep; 21(9):2130-6. PMID: 26020605.
    Citations: 7     Fields:    Translation:Humans
  52. Jiang ZG, Tsugawa Y, Tapper EB, Lai M, Afdhal N, Robson SC, Mukamal KJ. Low-fasting triglyceride levels are associated with non-invasive markers of advanced liver fibrosis among adults in the United States. Aliment Pharmacol Ther. 2015 Jul; 42(1):106-16. PMID: 25913437.
    Citations: 9     Fields:    Translation:Humans
  53. Tapper EB, Jiang ZG, Patwardhan VR. Refining the ammonia hypothesis: a physiology-driven approach to the treatment of hepatic encephalopathy. Mayo Clin Proc. 2015 May; 90(5):646-58. PMID: 25865476.
    Citations: 47     Fields:    Translation:Humans
  54. Jiang ZG, Wu Y, Csizmadia E, Feldbrügge L, Enjyoji K, Tigges J, Toxavidis V, Stephan H, Müller CE, Müller CE, McKnight CJ, Moss A, Robson SC. Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma. Purinergic Signal. 2014 Dec; 10(4):611-8. PMID: 25165006.
    Citations: 15     Fields:    Translation:HumansCells
  55. Mitsche MA, Packer LE, Brown JW, Jiang ZG, Small DM, McKnight CJ. Surface tensiometry of apolipoprotein B domains at lipid interfaces suggests a new model for the initial steps in triglyceride-rich lipoprotein assembly. J Biol Chem. 2014 Mar 28; 289(13):9000-12. PMID: 24515109.
    Citations: 5     Fields:    Translation:HumansCells
  56. Jiang ZG, Mukamal K, Tapper E, Robson SC, Tsugawa Y. Low LDL-C and high HDL-C levels are associated with elevated serum transaminases amongst adults in the United States: a cross-sectional study. PLoS One. 2014; 9(1):e85366. PMID: 24454851.
    Citations: 7     Fields:    Translation:Humans
  57. Jiang ZG, Robson SC, Yao Z. Lipoprotein metabolism in nonalcoholic fatty liver disease. J Biomed Res. 2013 Jan; 27(1):1-13. PMID: 23554788.
    Citations: 30     
  58. Qin W, Sundaram M, Wang Y, Zhou H, Zhong S, Chang CC, Manhas S, Yao EF, Parks RJ, McFie PJ, Stone SJ, Jiang ZG, Wang C, Figeys D, Jia W, Yao Z. Missense mutation in APOC3 within the C-terminal lipid binding domain of human ApoC-III results in impaired assembly and secretion of triacylglycerol-rich very low density lipoproteins: evidence that ApoC-III plays a major role in the formation of lipid precursors within the microsomal lumen. J Biol Chem. 2011 Aug 05; 286(31):27769-80. PMID: 21676879.
    Citations: 42     Fields:    Translation:HumansCells
  59. Wang L, Jiang ZG, McKnight CJ, Small DM. Interfacial properties of apolipoprotein B292-593 (B6.4-13) and B611-782 (B13-17). Insights into the structure of the lipovitellin homology region in apolipoprotein B. Biochemistry. 2010 May 11; 49(18):3898-907. PMID: 20353182.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  60. Sundaram M, Zhong S, Bou Khalil M, Zhou H, Jiang ZG, Zhao Y, Iqbal J, Hussain MM, Figeys D, Wang Y, Yao Z. Functional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemia. J Lipid Res. 2010 Jun; 51(6):1524-34. PMID: 20097930.
    Citations: 25     Fields:    Translation:HumansCells
  61. Chen L, Jiang ZG, Khan AA, Chishti AH, McKnight CJ. Dematin exhibits a natively unfolded core domain and an independently folded headpiece domain. Protein Sci. 2009 Mar; 18(3):629-36. PMID: 19241372.
    Citations: 11     Fields:    Translation:HumansCells
  62. Mitsche MA, Wang L, Jiang ZG, McKnight CJ, Small DM. Interfacial properties of a complex multi-domain 490 amino acid peptide derived from apolipoprotein B (residues 292-782). Langmuir. 2009 Feb 17; 25(4):2322-30. PMID: 19146422.
    Citations: 9     Fields:    Translation:Cells
  63. Jiang ZG, Liu Y, Hussain MM, Atkinson D, McKnight CJ. Reconstituting initial events during the assembly of apolipoprotein B-containing lipoproteins in a cell-free system. J Mol Biol. 2008 Nov 28; 383(5):1181-94. PMID: 18804479; PMCID: PMC2637522.
    Citations: 21     Fields:    Translation:Cells
  64. Burnett JR, Zhong S, Jiang ZG, Hooper AJ, Fisher EA, McLeod RS, Zhao Y, Barrett PH, Hegele RA, van Bockxmeer FM, Zhang H, Vance DE, McKnight CJ, Yao Z. Missense mutations in APOB within the betaalpha1 domain of human APOB-100 result in impaired secretion of ApoB and ApoB-containing lipoproteins in familial hypobetalipoproteinemia. J Biol Chem. 2007 Aug 17; 282(33):24270-83. PMID: 17588943.
    Citations: 21     Fields:    Translation:HumansCells
  65. Smirnov SL, Isern NG, Jiang ZG, Hoyt DW, McKnight CJ. The isolated sixth gelsolin repeat and headpiece domain of villin bundle F-actin in the presence of calcium and are linked by a 40-residue unstructured sequence. Biochemistry. 2007 Jun 26; 46(25):7488-96. PMID: 17547371.
    Citations: 8     Fields:    Translation:Cells
  66. Jiang ZG, Simon MN, Wall JS, McKnight CJ. Structural analysis of reconstituted lipoproteins containing the N-terminal domain of apolipoprotein B. Biophys J. 2007 Jun 01; 92(11):4097-108. PMID: 17369413; PMCID: PMC1868998.
    Citations: 8     Fields:    Translation:Cells
  67. Jiang ZG, Gantz D, Bullitt E, McKnight CJ. Defining lipid-interacting domains in the N-terminal region of apolipoprotein B. Biochemistry. 2006 Oct 03; 45(39):11799-808. PMID: 17002280.
    Citations: 15     Fields:    Translation:HumansCells
  68. Jiang ZG, McKnight CJ. A phosphorylation-induced conformation change in dematin headpiece. Structure. 2006 Feb; 14(2):379-87. PMID: 16472756.
    Citations: 15     Fields:    Translation:HumansCells
  69. Jiang ZG, Carraway M, McKnight CJ. Limited proteolysis and biophysical characterization of the lipovitellin homology region in apolipoprotein B. Biochemistry. 2005 Feb 01; 44(4):1163-73. PMID: 15667210.
    Citations: 12     Fields:    Translation:AnimalsCells
  70. Mu XQ, Jiang ZG, Bullitt E. Localization of a critical interface for helical rod formation of bacterial adhesion P-pili. J Mol Biol. 2005 Feb 11; 346(1):13-20. PMID: 15663923.
    Citations: 10     Fields:    Translation:Cells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Jiang's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (315)
Explore
_
Co-Authors (70)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
© 2023 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.