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Zhenghui Gordon Jiang, M.D.

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  1. K08DK115883 (JIANG, ZHENGHUI GORDON) Sep 1, 2018 - Jul 31, 2023
    Adenosine deaminase 2 regulates macrophage phenotype and liver fibrosis in nonalcoholic fatty liver disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Libman H, Jiang ZG, Tapper EB, Reynolds EE. How Would You Manage This Patient With Nonalcoholic Fatty Liver Disease? Ann Intern Med. 2019 12 03; 171(11):862. PMID: 31791052.
  2. Danford CJ, Jiang ZG, Salomaa V, Färkkilä M, Jula A, Männistö S, Lundqvist A, Valsta L, Perola M, Åberg F. Insulin Resistance and Genetic Risk Predict Liver-Related Outcomes and Death in Nonalcoholic Fatty Liver Disease. Hepatol Commun. 2019 Dec; 3(12):1704-1705. PMID: 31832576.
  3. Jiang ZG, Tapper EB. Cost Saving or Cost Effective? Unanswered Questions in the Screening of Patients With Nonalcoholic Fatty Liver Disease. Hepatol Commun. 2019 Oct; 3(10):1293-1295. PMID: 31592491.
  4. Grunwald D, Landau A, Jiang ZG, Liu JJ, Najarian R, Sheth SG. Further Defining the 2012 Multi-Society Task Force Guidelines for Surveillance of High-risk Adenomas: Is a 3-Year Interval Needed for All Patients? J Clin Gastroenterol. 2019 10; 53(9):673-679. PMID: 30036239.
    Citations:    Fields:    
  5. Libman H, Jiang ZG, Tapper EB, Reynolds EE. How Would You Manage This Patient With Nonalcoholic Fatty Liver Disease?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. Ann Intern Med. 2019 08 06; 171(3):199-207. PMID: 31382287.
  6. Tiwari-Heckler S, Jiang ZG. Adenosinergic Signaling in Liver Fibrosis. Clin Liver Dis (Hoboken). 2019 Jul; 14(1):1-4. PMID: 31391927.
  7. Rich NE, Yang JD, Perumalswami PV, Alkhouri N, Jackson W, Parikh ND, Mehta N, Salgia R, Duarte-Rojo A, Kulik L, Rakoski M, Said A, Oloruntoba O, Ioannou GN, Hoteit MA, Moon AM, Rangnekar AS, Eswaran SL, Zheng E, Jou JH, Hanje J, Pillai A, Hernaez R, Wong R, Scaglione S, Samant H, Kapuria D, Chandna S, Rosenblatt R, Ajmera V, Frenette CT, Satapathy SK, Mantry P, Jalal P, John BV, Fix OK, Leise M, Lindenmeyer CC, Flores A, Patel N, Jiang ZG, Latt N, Dhanasekaran R, Odewole M, Kagan S, Marrero JA, Singal AG. Provider Attitudes and Practice Patterns for Direct-Acting Antiviral Therapy for Patients With Hepatocellular Carcinoma. Clin Gastroenterol Hepatol. 2020 Apr; 18(4):974-983. PMID: 31357028.
  8. Rothweiler S, Feldbrügge L, Jiang ZG, Csizmadia E, Longhi MS, Vaid K, Enjyoji K, Popov YV, Robson SC. Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis. Purinergic Signal. 2019 09; 15(3):375-385. PMID: 31243614.
  9. Perez-Matos MC, Sandhu B, Bonder A, Jiang ZG. Lipoprotein metabolism in liver diseases. Curr Opin Lipidol. 2019 02; 30(1):30-36. PMID: 30550414.
    Citations:    Fields:    
  10. Wah-Suarez MI, Danford CJ, Patwardhan VR, Jiang ZG, Bonder A. Hyperlipidaemia in primary biliary cholangitis: treatment, safety and efficacy. Frontline Gastroenterol. 2019 Oct; 10(4):401-408. PMID: 31656566.
  11. Danford CJ, Yao ZM, Jiang ZG. Non-alcoholic fatty liver disease: a narrative review of genetics. J Biomed Res. 2018 Nov 20; 32(5):389-400. PMID: 30355853.
  12. Danford CJ, Connelly MA, Shalaurova I, Kim M, Herman MA, Nasser I, Otvos JD, Afdhal NH, Jiang ZG, Lai M. A Pathophysiologic Approach Combining Genetics and Insulin Resistance to Predict the Severity of Nonalcoholic Fatty Liver Disease. Hepatol Commun. 2018 Dec; 2(12):1467-1478. PMID: 30556036.
  13. Jiang ZG, Tapper EB, Kim M, Connelly MA, Krawczyk SA, Yee EU, Herman MA, Mukamal KJ, Lai M. Genetic Determinants of Circulating Lipoproteins in Nonalcoholic Fatty Liver Disease. J Clin Gastroenterol. 2018 May/Jun; 52(5):444-451. PMID: 28362682.
    Citations:    Fields:    
  14. Pérez-Matos MC, Jiang ZG, Tapper EB. Factors That Affect Results of Psychometric Tests to Identify Patients With Minimal Hepatic Encephalopathy. Clin Gastroenterol Hepatol. 2018 11; 16(11):1836-1838. PMID: 29551739.
  15. El-Sherif O, Jiang ZG, Tapper EB, Huang KC, Zhong A, Osinusi A, Charlton M, Manns M, Afdhal NH, Mukamal K, McHutchison J, Brainard DM, Terrault N, Curry MP. Baseline Factors Associated With Improvements in Decompensated Cirrhosis After Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection. Gastroenterology. 2018 06; 154(8):2111-2121.e8. PMID: 29535028.
    Citations: 1     Fields:    Translation:HumansCells
  16. Jiang ZG, Vardeh H, Evenson A. A Case of Cryptogenic Liver Failure. Gastroenterology. 2018 07; 155(1):23-24.e1. PMID: 29408637.
    Citations:    Fields:    Translation:Humans
  17. Ghaziani TT, Liu JJ, Jiang ZG, Nasser I, Khwaja K, Fisher RA, Nahas M, Curry MP. Posttransplant Lymphoproliferative Disorder Isolated to the Adrenal Gland in a Liver Transplant Patient. ACG Case Rep J. 2018; 5:e10. PMID: 29430469.
  18. Jiang ZG, Sandhu B, Feldbrügge L, Yee EU, Csizmadia E, Mitsuhashi S, Huang J, Afdhal NH, Robson SC, Lai M. Serum Activity of Macrophage-Derived Adenosine Deaminase 2 Is Associated With Liver Fibrosis in Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2018 07; 16(7):1170-1172. PMID: 29170098.
    Citations:    Fields:    
  19. Feldbrügge L, Jiang ZG, Csizmadia E, Mitsuhashi S, Tran S, Yee EU, Rothweiler S, Vaid KA, Sévigny J, Schmelzle M, Popov YV, Robson SC. Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis. Purinergic Signal. 2018 03; 14(1):37-46. PMID: 29134411.
    Citations:    Fields:    Translation:Animals
  20. Feldbrügge L, Moss AC, Yee EU, Csizmadia E, Mitsuhashi S, Longhi MS, Sandhu B, Stephan H, Wu Y, Cheifetz AS, Müller CE, Sévigny J, Robson SC, Jiang ZG. Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease. J Crohns Colitis. 2017 Sep 01; 11(9):1113-1123. PMID: 28472257.
    Citations: 1     Fields:    Translation:HumansAnimals
  21. Mitsuhashi S, Ballou S, Jiang ZG, Hirsch W, Nee J, Iturrino J, Cheng V, Lembo A. Characterizing Normal Bowel Frequency and Consistency in a Representative Sample of Adults in the United States (NHANES). Am J Gastroenterol. 2018 01; 113(1):115-123. PMID: 28762379.
    Citations: 3     Fields:    
  22. Longhi MS, Moss A, Jiang ZG, Robson SC. Purinergic signaling during intestinal inflammation. J Mol Med (Berl). 2017 Sep; 95(9):915-925. PMID: 28547076.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  23. De Giorgi M, Enjyoji K, Jiang G, Csizmadia E, Mitsuhashi S, Gumina RJ, Smolenski RT, Robson SC. Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice. J Lipid Res. 2017 07; 58(7):1292-1305. PMID: 28487312.
    Citations:    Fields:    Translation:AnimalsCells
  24. Koch M, Furtado JD, Jiang GZ, Gray BE, Cai T, Sacks F, Tjønneland A, Overvad K, Jensen MK. Associations of anthropometry and lifestyle factors with HDL subspecies according to apolipoprotein C-III. J Lipid Res. 2017 06; 58(6):1196-1203. PMID: 28365588.
    Citations:    Fields:    Translation:Humans
  25. Jiang ZG, Matthew M, Yee EU, Horst D. Elastofibromatous Change in Association With Pneumatosis Intestinalis. Am J Gastroenterol. 2017 03; 112(3):1514. PMID: 28270672.
    Citations:    Fields:    Translation:Humans
  26. Jiang ZG, Feldbrügge L, Tapper EB, Popov Y, Ghaziani T, Afdhal N, Robson SC, Mukamal KJ. Letter: would aspirin alleviate fibrosis in alcoholic liver disease? Authors' reply. Aliment Pharmacol Ther. 2016 07; 44(2):209-10. PMID: 27296690.
    Citations:    Fields:    Translation:Humans
  27. Liberal R, Grant CR, Ma Y, Csizmadia E, Jiang ZG, Heneghan MA, Yee EU, Mieli-Vergani G, Vergani D, Robson SC, Longhi MS. CD39 mediated regulation of Th17-cell effector function is impaired in juvenile autoimmune liver disease. J Autoimmun. 2016 08; 72:102-12. PMID: 27210814.
    Citations: 7     Fields:    Translation:HumansCells
  28. Jiang ZG, Tapper EB, Connelly MA, Pimentel CF, Feldbrügge L, Kim M, Krawczyk S, Afdhal N, Robson SC, Herman MA, Otvos JD, Mukamal KJ, Lai M. Steatohepatitis and liver fibrosis are predicted by the characteristics of very low density lipoprotein in nonalcoholic fatty liver disease. Liver Int. 2016 08; 36(8):1213-20. PMID: 26815314.
    Citations: 3     Fields:    Translation:Humans
  29. Jiang ZG, Feldbrügge L, Tapper EB, Popov Y, Ghaziani T, Afdhal N, Robson SC, Mukamal KJ. Aspirin use is associated with lower indices of liver fibrosis among adults in the United States. Aliment Pharmacol Ther. 2016 Mar; 43(6):734-43. PMID: 26749582.
    Citations: 3     Fields:    Translation:Humans
  30. Grunwald D, Tapper EB, Jiang ZG, Ahmed M, Malik R. A Standardized Assessment of Functional Disability Predicts 1-year Mortality in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt for Refractory Ascites. J Clin Gastroenterol. 2016 Jan; 50(1):75-9. PMID: 25984975.
    Citations: 1     Fields:    Translation:Humans
  31. Jiang ZG, de Boer IH, Mackey RH, Jensen MK, Lai M, Robson SC, Tracy R, Kuller LH, Mukamal KJ. Associations of insulin resistance, inflammation and liver synthetic function with very low-density lipoprotein: The Cardiovascular Health Study. Metabolism. 2016 Mar; 65(3):92-9. PMID: 26892520.
    Citations: 3     Fields:    Translation:Humans
  32. Pimentel CF, Jiang ZG, Otsubo T, Feldbrügge L, Challies TL, Nasser I, Robson S, Afdhal N, Lai M. Poor Inter-test Reliability Between CK18 Kits as a Biomarker of NASH. Dig Dis Sci. 2016 Mar; 61(3):905-12. PMID: 26462489.
    Citations: 3     Fields:    Translation:Humans
  33. Feuerstein JD, Jiang ZG, Belkin E, Lewandowski JJ, Martinez-Vazquez M, Singla A, Cataldo T, Poylin V, Cheifetz AS. Surgery for Ulcerative Colitis Is Associated with a High Rate of Readmissions at 30 Days. Inflamm Bowel Dis. 2015 Sep; 21(9):2130-6. PMID: 26020605.
    Citations: 5     Fields:    Translation:Humans
  34. Jiang ZG, Tsugawa Y, Tapper EB, Lai M, Afdhal N, Robson SC, Mukamal KJ. Low-fasting triglyceride levels are associated with non-invasive markers of advanced liver fibrosis among adults in the United States. Aliment Pharmacol Ther. 2015 Jul; 42(1):106-16. PMID: 25913437.
    Citations: 3     Fields:    Translation:Humans
  35. Tapper EB, Jiang ZG, Patwardhan VR. Refining the ammonia hypothesis: a physiology-driven approach to the treatment of hepatic encephalopathy. Mayo Clin Proc. 2015 May; 90(5):646-58. PMID: 25865476.
    Citations: 13     Fields:    Translation:Humans
  36. Jiang ZG, Wu Y, Csizmadia E, Feldbrügge L, Enjyoji K, Tigges J, Toxavidis V, Stephan H, Müller CE, Müller CE, McKnight CJ, Moss A, Robson SC. Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma. Purinergic Signal. 2014 Dec; 10(4):611-8. PMID: 25165006.
    Citations: 5     Fields:    Translation:HumansCells
  37. Mitsche MA, Packer LE, Brown JW, Jiang ZG, Small DM, McKnight CJ. Surface tensiometry of apolipoprotein B domains at lipid interfaces suggests a new model for the initial steps in triglyceride-rich lipoprotein assembly. J Biol Chem. 2014 Mar 28; 289(13):9000-12. PMID: 24515109.
    Citations: 3     Fields:    Translation:HumansCells
  38. Jiang ZG, Mukamal K, Tapper E, Robson SC, Tsugawa Y. Low LDL-C and high HDL-C levels are associated with elevated serum transaminases amongst adults in the United States: a cross-sectional study. PLoS One. 2014; 9(1):e85366. PMID: 24454851.
    Citations: 3     Fields:    Translation:Humans
  39. Jiang ZG, Robson SC, Yao Z. Lipoprotein metabolism in nonalcoholic fatty liver disease. J Biomed Res. 2013 Jan; 27(1):1-13. PMID: 23554788.
    Citations: 13     
  40. Qin W, Sundaram M, Wang Y, Zhou H, Zhong S, Chang CC, Manhas S, Yao EF, Parks RJ, McFie PJ, Stone SJ, Jiang ZG, Wang C, Figeys D, Jia W, Yao Z. Missense mutation in APOC3 within the C-terminal lipid binding domain of human ApoC-III results in impaired assembly and secretion of triacylglycerol-rich very low density lipoproteins: evidence that ApoC-III plays a major role in the formation of lipid precursors within the microsomal lumen. J Biol Chem. 2011 Aug 05; 286(31):27769-80. PMID: 21676879.
    Citations: 23     Fields:    Translation:HumansCells
  41. Wang L, Jiang ZG, McKnight CJ, Small DM. Interfacial properties of apolipoprotein B292-593 (B6.4-13) and B611-782 (B13-17). Insights into the structure of the lipovitellin homology region in apolipoprotein B. Biochemistry. 2010 May 11; 49(18):3898-907. PMID: 20353182.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  42. Sundaram M, Zhong S, Bou Khalil M, Zhou H, Jiang ZG, Zhao Y, Iqbal J, Hussain MM, Figeys D, Wang Y, Yao Z. Functional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemia. J Lipid Res. 2010 Jun; 51(6):1524-34. PMID: 20097930.
    Citations: 22     Fields:    Translation:HumansCells
  43. Chen L, Jiang ZG, Khan AA, Chishti AH, McKnight CJ. Dematin exhibits a natively unfolded core domain and an independently folded headpiece domain. Protein Sci. 2009 Mar; 18(3):629-36. PMID: 19241372.
    Citations: 7     Fields:    Translation:HumansCells
  44. Mitsche MA, Wang L, Jiang ZG, McKnight CJ, Small DM. Interfacial properties of a complex multi-domain 490 amino acid peptide derived from apolipoprotein B (residues 292-782). Langmuir. 2009 Feb 17; 25(4):2322-30. PMID: 19146422.
    Citations: 9     Fields:    Translation:Cells
  45. Jiang ZG, Liu Y, Hussain MM, Atkinson D, McKnight CJ. Reconstituting initial events during the assembly of apolipoprotein B-containing lipoproteins in a cell-free system. J Mol Biol. 2008 Nov 28; 383(5):1181-94. PMID: 18804479.
    Citations: 15     Fields:    Translation:Cells
  46. Burnett JR, Zhong S, Jiang ZG, Hooper AJ, Fisher EA, McLeod RS, Zhao Y, Barrett PH, Hegele RA, van Bockxmeer FM, Zhang H, Vance DE, McKnight CJ, Yao Z. Missense mutations in APOB within the betaalpha1 domain of human APOB-100 result in impaired secretion of ApoB and ApoB-containing lipoproteins in familial hypobetalipoproteinemia. J Biol Chem. 2007 Aug 17; 282(33):24270-83. PMID: 17588943.
    Citations: 18     Fields:    Translation:HumansCells
  47. Smirnov SL, Isern NG, Jiang ZG, Hoyt DW, McKnight CJ. The isolated sixth gelsolin repeat and headpiece domain of villin bundle F-actin in the presence of calcium and are linked by a 40-residue unstructured sequence. Biochemistry. 2007 Jun 26; 46(25):7488-96. PMID: 17547371.
    Citations: 6     Fields:    Translation:Cells
  48. Jiang ZG, Simon MN, Wall JS, McKnight CJ. Structural analysis of reconstituted lipoproteins containing the N-terminal domain of apolipoprotein B. Biophys J. 2007 Jun 01; 92(11):4097-108. PMID: 17369413.
    Citations: 8     Fields:    Translation:Cells
  49. Jiang ZG, Gantz D, Bullitt E, McKnight CJ. Defining lipid-interacting domains in the N-terminal region of apolipoprotein B. Biochemistry. 2006 Oct 03; 45(39):11799-808. PMID: 17002280.
    Citations: 14     Fields:    Translation:HumansCells
  50. Jiang ZG, McKnight CJ. A phosphorylation-induced conformation change in dematin headpiece. Structure. 2006 Feb; 14(2):379-87. PMID: 16472756.
    Citations: 12     Fields:    Translation:HumansCells
  51. Jiang ZG, Carraway M, McKnight CJ. Limited proteolysis and biophysical characterization of the lipovitellin homology region in apolipoprotein B. Biochemistry. 2005 Feb 01; 44(4):1163-73. PMID: 15667210.
    Citations: 12     Fields:    Translation:AnimalsCells
  52. Mu XQ, Jiang ZG, Bullitt E. Localization of a critical interface for helical rod formation of bacterial adhesion P-pili. J Mol Biol. 2005 Feb 11; 346(1):13-20. PMID: 15663923.
    Citations: 9     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.