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profileEbru Oral, Ph.D.

TitleAssistant Professor of Orthopedic Surgery
InstitutionMassachusetts General Hospital
DepartmentOrthopedic Surgery
AddressMassachusetts General Hospital
Grj 1206
55 Fruit St
Boston MA 02114
Phone617/726-0657
Fax617/643-2521
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Collapse Biography 
Collapse awards and honors
1999 - 2003Fellowship, IGERT Program on Therapeutic and Diagnostic Devices
2002Outstanding Graduate Research
2006HAP Paul Award
2007Young Investigator
2011Claflin Distinguished Scholar

Collapse Mentoring 
Collapse completed student projects
Radioprotection of Bone Allograft using Vitamin E Derivatives
Summer, 06/01/13 - 08/31/13

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gul RM, Fung K, Doshi BN, Oral E, Muratoglu OK. Surface cross-linked UHMWPE using peroxides. J Orthop Res. 2017 Apr 04. PMID: 28374917.
    View in: PubMed
  2. Oral E, O'Brien C, Doshi B, Muratoglu OK. High temperature homogenization improves impact toughness of vitamin E-diffused, irradiated UHMWPE. J Orthop Res. 2017 Jun; 35(6):1343-1347. PMID: 27487014.
    View in: PubMed
  3. Oral E, Doshi BN, Gul RM, Neils AL, Kayandan S, Muratoglu OK. Peroxide cross-linked UHMWPE blended with vitamin E. J Biomed Mater Res B Appl Biomater. 2017 Aug; 105(6):1379-1389. PMID: 27080171.
    View in: PubMed
  4. Doshi B, Ward JS, Oral E, Muratoglu OK. Fatigue toughness of irradiated vitamin E/UHMWPE blends. J Orthop Res. 2016 Sep; 34(9):1514-20. PMID: 26773556.
    View in: PubMed
  5. Oral E, Neils AL, Doshi BN, Fu J, Muratoglu OK. Effects of simulated oxidation on the in vitro wear and mechanical properties of irradiated and melted highly crosslinked UHMWPE. J Biomed Mater Res B Appl Biomater. 2016 Feb; 104(2):316-22. PMID: 25766106.
    View in: PubMed
  6. Oral E, Neils A, Muratoglu OK. High vitamin E content, impact resistant UHMWPE blend without loss of wear resistance. J Biomed Mater Res B Appl Biomater. 2015 May; 103(4):790-7. PMID: 25115567.
    View in: PubMed
  7. Oral E, Neils A, Yabannavar P, Muratoglu OK. The effect of an additional phosphite stabilizer on the properties of radiation cross-linked vitamin E blends of UHMWPE. J Orthop Res. 2014 Jun; 32(6):757-61. PMID: 24536024.
    View in: PubMed
  8. Oral E, Neils AL, Rowell SL, Lozynsky AJ, Muratoglu OK. Increasing irradiation temperature maximizes vitamin E grafting and wear resistance of ultrahigh molecular weight polyethylene. J Biomed Mater Res B Appl Biomater. 2013 Apr; 101(3):436-40. PMID: 23115033.
    View in: PubMed
  9. Oral E, Neils AL, Lyons C, Fung M, Doshi B, Muratoglu OK. Surface cross-linked UHMWPE can enable the use of larger femoral heads in total joints. J Orthop Res. 2013 Jan; 31(1):59-66. PMID: 22847503.
    View in: PubMed
  10. Oral E, Ghali BW, Neils A, Muratoglu OK. A new mechanism of oxidation in ultrahigh molecular weight polyethylene caused by squalene absorption. J Biomed Mater Res B Appl Biomater. 2012 Apr; 100(3):742-51. PMID: 22190411.
    View in: PubMed
  11. Bracco P, Oral E. Vitamin E-stabilized UHMWPE for total joint implants: a review. Clin Orthop Relat Res. 2011 Aug; 469(8):2286-93. PMID: 21132413; PMCID: PMC3126938.
  12. Oral E, Ghali BW, Muratoglu OK. The elimination of free radicals in irradiated UHMWPEs with and without vitamin E stabilization by annealing under pressure. J Biomed Mater Res B Appl Biomater. 2011 Apr; 97(1):167-74. PMID: 21381192; PMCID: PMC3747829.
  13. Rowell SL, Oral E, Muratoglu OK. Comparative oxidative stability of a-tocopherol blended and diffused UHMWPEs at 3 years of real-time aging. J Orthop Res. 2011 May; 29(5):773-80. PMID: 21437958.
    View in: PubMed
  14. Oral E, Muratoglu OK. Vitamin E diffused, highly crosslinked UHMWPE: a review. Int Orthop. 2011 Feb; 35(2):215-23. PMID: 21120476; PMCID: PMC3032101.
  15. Jarrett BT, Cofske J, Rosenberg AE, Oral E, Muratoglu O, Malchau H. In vivo biological response to vitamin E and vitamin-E-doped polyethylene. J Bone Joint Surg Am. 2010 Nov 17; 92(16):2672-81. PMID: 21084577.
    View in: PubMed
  16. Bichara DA, Zhao X, Bodugoz-Senturk H, Ballyns FP, Oral E, Randolph MA, Bonassar LJ, Gill TJ, Muratoglu OK. Porous poly(vinyl alcohol)-hydrogel matrix-engineered biosynthetic cartilage. Tissue Eng Part A. 2011 Feb; 17(3-4):301-9. PMID: 20799889.
    View in: PubMed
  17. Oral E, Ghali BW, Rowell SL, Micheli BR, Lozynsky AJ, Muratoglu OK. A surface crosslinked UHMWPE stabilized by vitamin E with low wear and high fatigue strength. Biomaterials. 2010 Sep; 31(27):7051-60. PMID: 20579730.
    View in: PubMed
  18. Oral E, Godleski-Beckos C, Ghali BW, Lozynsky AJ, Muratoglu OK. Effect of cross-link density on the high pressure crystallization of UHMWPE. J Biomed Mater Res B Appl Biomater. 2009 Aug; 90(2):720-9. PMID: 19213055; PMCID: PMC3065948.
  19. Oral E, Godleski Beckos CA, Lozynsky AJ, Malhi AS, Muratoglu OK. Improved resistance to wear and fatigue fracture in high pressure crystallized vitamin E-containing ultra-high molecular weight polyethylene. Biomaterials. 2009 Apr; 30(10):1870-80. PMID: 19135247; PMCID: PMC3747844.
  20. Oral E, Beckos CG, Muratoglu OK. FREE RADICAL ELIMINATION IN IRRADIATED UHMWPE THROUGH CRYSTAL MOBILITY IN PHASE TRANSITION TO THE HEXAGONAL PHASE. Polymer (Guildf). 2008 Oct 06; 49(21):4733-4739. PMID: 18985170.
    View in: PubMed
  21. Oral E, Malhi AS, Wannomae KK, Muratoglu OK. Highly cross-linked ultrahigh molecular weight polyethylene with improved fatigue resistance for total joint arthroplasty: recipient of the 2006 Hap Paul Award. J Arthroplasty. 2008 Oct; 23(7):1037-44. PMID: 18547783; PMCID: PMC2614333.
  22. Oral E, Godleski Beckos C, Malhi AS, Muratoglu OK. The effects of high dose irradiation on the cross-linking of vitamin E-blended ultrahigh molecular weight polyethylene. Biomaterials. 2008 Sep; 29(26):3557-60. PMID: 18514813; PMCID: PMC2516939.
  23. Oral E, Muratoglu OK. Radiation cross-linking in ultra-high molecular weight polyethylene for orthopaedic applications. Nucl Instrum Methods Phys Res B. 2007 Dec; 265(1):18-22. PMID: 19050735.
    View in: PubMed
  24. Bodugoz-Senturk H, Choi J, Oral E, Kung JH, Macias CE, Braithwaite G, Muratoglu OK. The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing. Biomaterials. 2008 Jan; 29(2):141-9. PMID: 17950839.
    View in: PubMed
  25. Oral E, Muratoglu OK. Radiation cross-linking in ultrahigh molecular weight polyethylene for orthopaedic applications. Nuclear Instruments and Methods B. 2007; 265:18-22.
  26. Oral E, Wannomae KK, Huang A, Rowell SL, Muratoglu OK. Diffusion of vitamin E in UHMWPE. Biomaterials. 2007; 28:5525-5237.
  27. Oral E, Bodugoz-Senturk H, Macias CE, Muratoglu OK. Vitamin E prevents radiation cross-linking in aqueous poly(vinyl alcohol) solutions. Nuclear Instruments and Methods in Physics Research B. 2007; 265:92-97.
  28. Oral E, Rowell SL, Muratoglu OK. The effect of alpha-tocopherol on the oxidation and free radical decay in irradiated UHMWPE. Biomaterials. 2006 Nov; 27(32):5580-7. PMID: 16887182; PMCID: PMC2570163.
  29. Oral E, Peppas NA. Hydrophilic molecularly imprinted poly(hydroxyethyl-methacrylate) polymers. J Biomed Mater Res A. 2006 Jul; 78(1):205-10. PMID: 16602126.
    View in: PubMed
  30. Oral E, Christensen SD, Malhi AS, Wannomae KK and Muratoglu OK. Wear resistance and mechanical properties of highly crosslinked UHMWPE doped with vitamin E. Journal of Arthroplasty. 2006; 21(4):580-591.
  31. Oral E, Wannomae KK,Christensen SD, Muratoglu OK. Migration stability of vitamin E in doped, irradiated UHMWPE. Biomaterials. 2006; 27:2434-2439.
  32. Oral E, Greenbaum ES, Malhi AS, Harris WH, Muratoglu OK. Characterization of irradiated blends of alpha-tocopherol and UHMWPE. Biomaterials. 2005 Nov; 26(33):6657-63. PMID: 15993487; PMCID: PMC1463566.
  33. Oral E, Malhi AS, Muratoglu OK. Mechanisms of decrease in fatigue crack propagation resistance in irradiated and melted UHMWPE. Biomaterials. 2006 Feb; 27(6):917-25. PMID: 16105682; PMCID: PMC1463251.
  34. Oral E, Wannomae KK, Hawkins N, Harris WH, Muratoglu OK. Alpha-tocopherol-doped irradiated UHMWPE for high fatigue resistance and low wear. Biomaterials. 2004 Nov; 25(24):5515-22. PMID: 15142733.
    View in: PubMed
  35. Oral E, Peppas NA. Responsive and recognitive hydrogels using star polymers. J Biomed Mater Res A. 2004 Mar 01; 68(3):439-47. PMID: 14762923.
    View in: PubMed
  36. Oral E, Wannomae, KK, Harris WH and Muratoglu OK. Alpha-tocopherol doped crosslinked UHMWPE for high fatigue resistance and low wear. Biomaterials. 2004; 25:5515-5522.
  37. Oral E and Peppas NA. Dynamic polymerization kinetics of molecularly imprinted polymers. Polymer. 2004; 45:6163-6173.
  38. Oral E. Recognitive Polymer Networks for Therapeutic and Diagnostic Devices. 2003.
  39. Byrne, ME, Hilt, JZ, Oral, E and Peppas, NA. UV Free-radical polymerizations for micropatterning and microimprinting of poly(ethylene glycol)-containing films. Polym. Advan. Technol.,. 2002; 13(10-12):798-816.
  40. Bures, P, Huang, Y, Oral, E, and Peppas, NA. Surface modification and molecular imprinting of polymers in medical and pharmaceutical applications. J. Controlled Release. 2001; 72:25-33.
  41. • Oral E. and Peppas NA. Molecular Imprinting in Biological Applications. STP Pharma Sciences. 2000; 10(4):261-267.
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