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Ebru Oral, Ph.D.

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Bogaziçi University, Istanbul, TurkeyBS07/1997Chemical Engineering
Purdue University, West Lafayette, INPhD12/2002Chemical Engineering
Massachusetts General Hospital/Harvard Medical School, Boston, MA04/2005Orthopaedic Surgery
Fellow of the National Academy of Inventors
Fellow of the American Institute of Medical and Biological Engineers
Innovation Discovery Award - Partners Healthcare
Innovation Discovery Award - Partners Healthcare
Lifetime Honorary Member of the ISTA
HAP Paul Award for Outstanding Research in Arthroplasty
Claflin Distinguished Scholar
Young Investigator
HAP Paul Award for Outstanding Research in Arthroplasty
1999 - 2003
Fellowship, IGERT Program on Therapeutic and Diagnostic Devices

Radioprotection of Bone Allograft using Vitamin E Derivatives
Summer, 06/01/13 - 08/31/13

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gil D, Atici AE, Connolly RL, Hugard S, Shuvaev S, Wannomae KK, Oral E, Muratoglu OK. Addressing prosthetic joint infections via gentamicin-eluting UHMWPE spacer. Bone Joint J. 2020 Jun; 102-B(6_Supple_A):151-157. PMID: 32475290.
  2. Suhardi JV, Morgan DFA, Muratoglu OK, Oral E. Radioprotection and cross-linking of allograft bone in the presence of vitamin E. J Biomed Mater Res B Appl Biomater. 2020 Jul; 108(5):2354-2367. PMID: 31975566.
  3. Gil D, Daffinee K, Friedman R, Bhushan B, Muratoglu OK, LaPlante K, Oral E. Synergistic antibacterial effects of analgesics and antibiotics against Staphylococcus aureus. Diagn Microbiol Infect Dis. 2020 Apr; 96(4):114967. PMID: 32057521.
  4. Fan Y, Xiao Y, Sabuhi WA, Leape CP, Gil D, Grindy S, Muratoglu OK, Bedair H, Collins JE, Randolph M, Oral E. Longitudinal Model of Periprosthetic Joint Infection in the Rat. J Orthop Res. 2020 05; 38(5):1101-1112. PMID: 31808572.
  5. Oral E, Doshi BN, Fung K, O'Brien C, Wannomae KK, Muratoglu OK. Chemically Cross-Linked UHMWPE With Superior Toughness. J Orthop Res. 2019 10; 37(10):2182-2188. PMID: 31206815.
  6. Grindy SC, Gil D, Suhardi JV, Muratoglu OK, Bedair H, Oral E. Delivery of bupivacaine from UHMWPE and its implications for managing pain after joint arthroplasty. Acta Biomater. 2019 07 15; 93:63-73. PMID: 31173960.
  7. Gil D, Grindy S, Muratoglu O, Bedair H, Oral E. Antimicrobial effect of anesthetic-eluting ultra-high molecular weight polyethylene for post-arthroplasty antibacterial prophylaxis. J Orthop Res. 2019 04; 37(4):981-990. PMID: 30737817.
  8. Oral E, Wannomae KK, Bichara DA, Micheli B, Doshi BN, O'Brien C, Nielsen GP, Muratoglu OK. An antioxidant stabilized, chemically cross-linked UHMWPE with superior toughness. J Biomed Mater Res B Appl Biomater. 2019 Aug; 107(6):1945-1952. PMID: 30585407.
    Citations:    Fields:    
  9. Xu JZ, Muratoglu OK, Oral E. Improved oxidation and wear resistance of ultrahigh molecular weight polyethylene using cross-linked powder reinforcement. J Biomed Mater Res B Appl Biomater. 2019 04; 107(3):716-723. PMID: 30080312.
    Citations:    Fields:    
  10. Bichara DA, O'Brien CC, Doshi BN, Nielsen GP, Oral E, Muratoglu OK. Residual Byproducts of Peroxide Crosslinked Vitamin E-Blended Ultrahigh Molecular Weight Polyethylene. J Arthroplasty. 2018 08; 33(8):2666-2670. PMID: 29784551.
    Citations:    Fields:    
  11. Oral E, Fung M, Rowell SL, Muratoglu OK. In-vitro oxidation model for UHMWPE incorporating synovial fluid lipids. J Orthop Res. 2018 07; 36(7):1833-1839. PMID: 29314179.
    Citations:    Fields:    
  12. Xu JZ, Wannomae KK, Muratoglu OK, Oral E. Increased oxidative protection by high active vitamin E content and partial radiation crosslinking of UHMWPE. J Orthop Res. 2018 07; 36(7):1860-1867. PMID: 29232007.
    Citations:    Fields:    
  13. Kayandan S, Doshi BN, Oral E, Muratoglu OK. Surface cross-linked ultra high molecular weight polyethylene by emulsified diffusion of dicumyl peroxide. J Biomed Mater Res B Appl Biomater. 2018 05; 106(4):1517-1523. PMID: 28741857.
    Citations:    Fields:    
  14. V. J. Suhardi, D. A. Bichara, S. J. J. Kwok, A. A. Freiberg, H. Rubash, H. Malchau, S. H. Yun, O. K. Muratoglu E. Oral . A fully functional drug-eluting joint implant. Nature Biomedical Engineering. 2017; 1:0080. View Publication.
  15. Gul RM, Fung K, Doshi BN, Oral E, Muratoglu OK. Surface cross-linked UHMWPE using peroxides. J Orthop Res. 2017 11; 35(11):2551-2556. PMID: 28374917.
    Citations:    Fields:    
  16. Oral E, O'Brien C, Doshi B, Muratoglu OK. High temperature homogenization improves impact toughness of vitamin E-diffused, irradiated UHMWPE. J Orthop Res. 2017 06; 35(6):1343-1347. PMID: 27487014.
    Citations:    Fields:    
  17. Oral E, Doshi BN, Gul RM, Neils AL, Kayandan S, Muratoglu OK. Peroxide cross-linked UHMWPE blended with vitamin E. J Biomed Mater Res B Appl Biomater. 2017 08; 105(6):1379-1389. PMID: 27080171.
    Citations:    Fields:    Translation:Humans
  18. Doshi B, Ward JS, Oral E, Muratoglu OK. Fatigue toughness of irradiated vitamin E/UHMWPE blends. J Orthop Res. 2016 09; 34(9):1514-20. PMID: 26773556.
    Citations:    Fields:    
  19. Oral E, Neils AL, Doshi BN, Fu J, Muratoglu OK. Effects of simulated oxidation on the in vitro wear and mechanical properties of irradiated and melted highly crosslinked UHMWPE. J Biomed Mater Res B Appl Biomater. 2016 Feb; 104(2):316-22. PMID: 25766106.
    Citations:    Fields:    Translation:HumansCells
  20. Oral, E, Doshi BN, Godleski-Beckos CM, Muratoglu OK. High pressure crystallization of vitamin E-containing, highly cross-linked UHMWPE. Macromolecular Materials and Engineering. 2015; 300:458-465.
  21. Oral E, Neils A, Muratoglu OK. High vitamin E content, impact resistant UHMWPE blend without loss of wear resistance. J Biomed Mater Res B Appl Biomater. 2015 May; 103(4):790-7. PMID: 25115567.
    Citations: 1     Fields:    Translation:Cells
  22. Oral E, Neils A, Yabannavar P, Muratoglu OK. The effect of an additional phosphite stabilizer on the properties of radiation cross-linked vitamin E blends of UHMWPE. J Orthop Res. 2014 Jun; 32(6):757-61. PMID: 24536024.
    Citations:    Fields:    
  23. Oral E, Neils AL, Rowell SL, Lozynsky AJ, Muratoglu OK. Increasing irradiation temperature maximizes vitamin E grafting and wear resistance of ultrahigh molecular weight polyethylene. J Biomed Mater Res B Appl Biomater. 2013 Apr; 101(3):436-40. PMID: 23115033.
    Citations: 6     Fields:    
  24. Oral E, Neils AL, Lyons C, Fung M, Doshi B, Muratoglu OK. Surface cross-linked UHMWPE can enable the use of larger femoral heads in total joints. J Orthop Res. 2013 Jan; 31(1):59-66. PMID: 22847503.
    Citations: 1     Fields:    Translation:Humans
  25. Oral E, Ghali BW, Neils A, Muratoglu OK. A new mechanism of oxidation in ultrahigh molecular weight polyethylene caused by squalene absorption. J Biomed Mater Res B Appl Biomater. 2012 Apr; 100(3):742-51. PMID: 22190411.
    Citations: 6     Fields:    Translation:Cells
  26. Bracco P, Oral E. Vitamin E-stabilized UHMWPE for total joint implants: a review. Clin Orthop Relat Res. 2011 Aug; 469(8):2286-93. PMID: 21132413.
    Citations: 17     Fields:    Translation:HumansCells
  27. Oral E, Ghali BW, Muratoglu OK. The elimination of free radicals in irradiated UHMWPEs with and without vitamin E stabilization by annealing under pressure. J Biomed Mater Res B Appl Biomater. 2011 Apr; 97(1):167-74. PMID: 21381192.
    Citations: 1     Fields:    Translation:Humans
  28. Rowell SL, Oral E, Muratoglu OK. Comparative oxidative stability of a-tocopherol blended and diffused UHMWPEs at 3 years of real-time aging. J Orthop Res. 2011 May; 29(5):773-80. PMID: 21437958.
    Citations: 3     Fields:    Translation:Cells
  29. Oral E, Muratoglu OK. Vitamin E diffused, highly crosslinked UHMWPE: a review. Int Orthop. 2011 Feb; 35(2):215-23. PMID: 21120476.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  30. Jarrett BT, Cofske J, Rosenberg AE, Oral E, Muratoglu O, Malchau H. In vivo biological response to vitamin E and vitamin-E-doped polyethylene. J Bone Joint Surg Am. 2010 Nov 17; 92(16):2672-81. PMID: 21084577.
    Citations: 6     Fields:    Translation:Animals
  31. Bichara DA, Zhao X, Bodugoz-Senturk H, Ballyns FP, Oral E, Randolph MA, Bonassar LJ, Gill TJ, Muratoglu OK. Porous poly(vinyl alcohol)-hydrogel matrix-engineered biosynthetic cartilage. Tissue Eng Part A. 2011 Feb; 17(3-4):301-9. PMID: 20799889.
    Citations: 4     Fields:    Translation:AnimalsCells
  32. Oral E, Ghali BW, Rowell SL, Micheli BR, Lozynsky AJ, Muratoglu OK. A surface crosslinked UHMWPE stabilized by vitamin E with low wear and high fatigue strength. Biomaterials. 2010 Sep; 31(27):7051-60. PMID: 20579730.
    Citations: 5     Fields:    
  33. Oral E, Godleski-Beckos C, Ghali BW, Lozynsky AJ, Muratoglu OK. Effect of cross-link density on the high pressure crystallization of UHMWPE. J Biomed Mater Res B Appl Biomater. 2009 Aug; 90(2):720-9. PMID: 19213055.
    Citations: 2     Fields:    Translation:Cells
  34. Oral E, Godleski Beckos CA, Lozynsky AJ, Malhi AS, Muratoglu OK. Improved resistance to wear and fatigue fracture in high pressure crystallized vitamin E-containing ultra-high molecular weight polyethylene. Biomaterials. 2009 Apr; 30(10):1870-80. PMID: 19135247.
    Citations: 1     Fields:    Translation:Cells
    Citations: 2     
  36. Oral E, Malhi AS, Wannomae KK, Muratoglu OK. Highly cross-linked ultrahigh molecular weight polyethylene with improved fatigue resistance for total joint arthroplasty: recipient of the 2006 Hap Paul Award. J Arthroplasty. 2008 Oct; 23(7):1037-44. PMID: 18547783.
    Citations: 5     Fields:    
  37. Oral E, Godleski Beckos C, Malhi AS, Muratoglu OK. The effects of high dose irradiation on the cross-linking of vitamin E-blended ultrahigh molecular weight polyethylene. Biomaterials. 2008 Sep; 29(26):3557-60. PMID: 18514813.
    Citations: 11     Fields:    
  38. Oral E, Muratoglu OK. Radiation cross-linking in ultra-high molecular weight polyethylene for orthopaedic applications. Nucl Instrum Methods Phys Res B. 2007 Dec; 265(1):18-22. PMID: 19050735.
    Citations: 2     
  39. Bodugoz-Senturk H, Choi J, Oral E, Kung JH, Macias CE, Braithwaite G, Muratoglu OK. The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing. Biomaterials. 2008 Jan; 29(2):141-9. PMID: 17950839.
    Citations: 3     Fields:    Translation:Cells
  40. Oral E, Muratoglu OK. Radiation cross-linking in ultrahigh molecular weight polyethylene for orthopaedic applications. Nuclear Instruments and Methods B. 2007; 265:18-22.
  41. Oral E, Wannomae KK, Huang A, Rowell SL, Muratoglu OK. Diffusion of vitamin E in UHMWPE. Biomaterials. 2007; 28:5525-5237.
  42. Oral E, Bodugoz-Senturk H, Macias CE, Muratoglu OK. Vitamin E prevents radiation cross-linking in aqueous poly(vinyl alcohol) solutions. Nuclear Instruments and Methods in Physics Research B. 2007; 265:92-97.
  43. Oral E, Rowell SL, Muratoglu OK. The effect of alpha-tocopherol on the oxidation and free radical decay in irradiated UHMWPE. Biomaterials. 2006 Nov; 27(32):5580-7. PMID: 16887182.
    Citations: 12     Fields:    Translation:Cells
  44. Oral E, Peppas NA. Hydrophilic molecularly imprinted poly(hydroxyethyl-methacrylate) polymers. J Biomed Mater Res A. 2006 Jul; 78(1):205-10. PMID: 16602126.
    Citations: 4     Fields:    Translation:Cells
  45. Oral E, Christensen SD, Malhi AS, Wannomae KK and Muratoglu OK. Wear resistance and mechanical properties of highly crosslinked UHMWPE doped with vitamin E. Journal of Arthroplasty. 2006; 21(4):580-591.
  46. Oral E, Wannomae KK,Christensen SD, Muratoglu OK. Migration stability of vitamin E in doped, irradiated UHMWPE. Biomaterials. 2006; 27:2434-2439.
  47. Oral E, Greenbaum ES, Malhi AS, Harris WH, Muratoglu OK. Characterization of irradiated blends of alpha-tocopherol and UHMWPE. Biomaterials. 2005 Nov; 26(33):6657-63. PMID: 15993487.
    Citations: 21     Fields:    
  48. Oral E, Malhi AS, Muratoglu OK. Mechanisms of decrease in fatigue crack propagation resistance in irradiated and melted UHMWPE. Biomaterials. 2006 Feb; 27(6):917-25. PMID: 16105682.
    Citations: 26     Fields:    Translation:Cells
  49. Oral E, Wannomae KK, Hawkins N, Harris WH, Muratoglu OK. Alpha-tocopherol-doped irradiated UHMWPE for high fatigue resistance and low wear. Biomaterials. 2004 Nov; 25(24):5515-22. PMID: 15142733.
    Citations: 32     Fields:    Translation:Cells
  50. Oral E, Peppas NA. Responsive and recognitive hydrogels using star polymers. J Biomed Mater Res A. 2004 Mar 01; 68(3):439-47. PMID: 14762923.
    Citations: 2     Fields:    
  51. Oral E, Wannomae, KK, Harris WH and Muratoglu OK. Alpha-tocopherol doped crosslinked UHMWPE for high fatigue resistance and low wear. Biomaterials. 2004; 25:5515-5522.
  52. Oral E and Peppas NA. Dynamic polymerization kinetics of molecularly imprinted polymers. Polymer. 2004; 45:6163-6173.
  53. Oral E. Recognitive Polymer Networks for Therapeutic and Diagnostic Devices. 2003.
  54. Byrne, ME, Hilt, JZ, Oral, E and Peppas, NA. UV Free-radical polymerizations for micropatterning and microimprinting of poly(ethylene glycol)-containing films. Polym. Advan. Technol.,. 2002; 13(10-12):798-816.
  55. Bures, P, Huang, Y, Oral, E, and Peppas, NA. Surface modification and molecular imprinting of polymers in medical and pharmaceutical applications. J. Controlled Release. 2001; 72:25-33.
  56. • Oral E. and Peppas NA. Molecular Imprinting in Biological Applications. STP Pharma Sciences. 2000; 10(4):261-267.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.