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Bernardo Lemos Silva, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Faria TC, Maldonado HL, Santos LC, DeLabio R, Payao SLM, Turecki G, Mechawar N, Santana DA, Gigek CO, Lemos B, Smith MAC, Chen ES. Characterization of Cerebellum-Specific Ribosomal DNA Epigenetic Modifications in Alzheimer's Disease: Should the Cerebellum Serve as a Control Tissue After All? Mol Neurobiol. 2020 Jun; 57(6):2563-2571. PMID: 32232768.
  2. Feng L, Du J, Yao C, Jiang Z, Li T, Zhang Q, Guo X, Yu M, Xia H, Shi L, Jia J, Tong Y, Ju L, Liu J, Lou J, Lemos B. Ribosomal DNA copy number is associated with P53 status and levels of heavy metals in gastrectomy specimens from gastric cancer patients. Environ Int. 2020 May; 138:105593. PMID: 32120062.
  3. Barbosa RH, Dos Santos MLB, Silva TP, Rosa-Fernandes L, Pinto AMV, Spínola PS, Bonvicino CR, Fernandes PV, Lucena E, Palmisano G, Melo RCN, Cardoso CAA, Lemos B. Impression Cytology Is a Non-invasive and Effective Method for Ocular Cell Retrieval of Zika Infected Babies: Perspectives in OMIC Studies. Front Mol Neurosci. 2019; 12:279. PMID: 31866819.
  4. Drinnenberg IA, Berger F, Elsässer SJ, Andersen PR, Ausió J, Bickmore WA, Blackwell AR, Erwin DH, Gahan JM, Gaut BS, Harvey ZH, Henikoff S, Kao JY, Kurdistani SK, Lemos B, Levine MT, Luger K, Malik HS, Martín-Durán JM, Peichel CL, Renfree MB, Rutowicz K, Sarkies P, Schmitz RJ, Technau U, Thornton JW, Warnecke T, Wolfe KH. EvoChromo: towards a synthesis of chromatin biology and evolution. Development. 2019 09 26; 146(19). PMID: 31558570.
  5. Cerqueira AV, Lemos B. Ribosomal DNA and the Nucleolus as Keystones of Nuclear Architecture, Organization, and Function. Trends Genet. 2019 10; 35(10):710-723. PMID: 31447250.
  6. Scarano WR, Bedrat A, Alonso-Costa LG, Aquino AM, Fantinatti B, Justulin LA, Barbisan LF, Freire PP, Flaws JA, Bernardo L. Exposure to an environmentally relevant phthalate mixture during prostate development induces microRNA upregulation and transcriptome modulation in rats. Toxicol Sci. 2019 Jun 14. PMID: 31199487.
  7. Guo X, Feng L, Lemos B, Lou J. DNA methylation modifications induced by hexavalent chromium. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2019; 37(3):133-145. PMID: 31084241.
  8. Wang M, Lemos B. Ribosomal DNA harbors an evolutionarily conserved clock of biological aging. Genome Res. 2019 03; 29(3):325-333. PMID: 30765617.
  9. Qiao R, Sheng C, Lu Y, Zhang Y, Ren H, Lemos B. Microplastics induce intestinal inflammation, oxidative stress, and disorders of metabolome and microbiome in zebrafish. Sci Total Environ. 2019 Apr 20; 662:246-253. PMID: 30690359.
  10. Barbosa FB, Simioni M, Wiezel CEV, Torres FR, Molck MC, Bonilla MM, de Araujo TK, Donadi EA, Gil-da-Silva-Lopes VL, Lemos B, Simões AL. Copy number variation in the susceptibility to systemic lupus erythematosus. PLoS One. 2018; 13(11):e0206683. PMID: 30485348.
  11. Xia H, Ying S, Feng L, Wang H, Yao C, Li T, Zhang Y, Fu S, Ding D, Guo X, Tong Y, Wang X, Chen Z, Jiang Z, Zhang X, Lemos B, Lou J. Decreased 8-oxoguanine DNA glycosylase 1 (hOGG1) expression and DNA oxidation damage induced by Cr (VI). Chem Biol Interact. 2019 Feb 01; 299:44-51. PMID: 30496737.
  12. Chang CH, MacIntosh D, Lemos B, Zhang Q, Lu C. Characterization of Daily Dietary Intake and the Health Risk of Neonicotinoid Insecticides for the U.S. Population. J Agric Food Chem. 2018 Sep 26; 66(38):10097-10105. PMID: 30192531.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  13. Deng Y, Zhang Y, Qiao R, Bonilla MM, Yang X, Ren H, Lemos B. Evidence that microplastics aggravate the toxicity of organophosphorus flame retardants in mice (Mus musculus). J Hazard Mater. 2018 09 05; 357:348-354. PMID: 29908513.
  14. Palacios-Gimenez OM, Bardella VB, Lemos B, Cabral-de-Mello DC. Satellite DNAs are conserved and differentially transcribed among Gryllus cricket species. DNA Res. 2018 Apr 01; 25(2):137-147. PMID: 29096008.
    Citations:    Fields:    Translation:AnimalsCells
  15. Yu S, Lemos B. The long-range interaction map of ribosomal DNA arrays. PLoS Genet. 2018 03; 14(3):e1007258. PMID: 29570716.
    Citations: 1     Fields:    Translation:HumansCells
  16. Palacios-Gimenez OM, Milani D, Lemos B, Castillo ER, Martí DA, Ramos E, Martins C, Cabral-de-Mello DC. Uncovering the evolutionary history of neo-XY sex chromosomes in the grasshopper Ronderosia bergii (Orthoptera, Melanoplinae) through satellite DNA analysis. BMC Evol Biol. 2018 01 08; 18(1):2. PMID: 29329524.
    Citations:    Fields:    Translation:AnimalsCells
  17. Wang M, Branco AT, Lemos B. The Y Chromosome Modulates Splicing and Sex-Biased Intron Retention Rates in Drosophila. Genetics. 2018 03; 208(3):1057-1067. PMID: 29263027.
    Citations:    Fields:    Translation:AnimalsCells
  18. Branco AT, Brito RM, Lemos B. Sex-specific adaptation and genomic responses to Y chromosome presence in female reproductive and neural tissues. Proc Biol Sci. 2017 Dec 20; 284(1869). PMID: 29237855.
    Citations: 1     Fields:    Translation:AnimalsCells
  19. Nwanaji-Enwerem JC, Colicino E, Dai L, Di Q, Just AC, Hou L, Vokonas P, De Vivo I, Lemos B, Lu Q, Weisskopf MG, Baccarelli AA, Schwartz JD. miRNA processing gene polymorphisms, blood DNA methylation age and long-term ambient PM2.5 exposure in elderly men. Epigenomics. 2017 12; 9(12):1529-1542. PMID: 29106301.
    Citations: 2     Fields:    Translation:HumansCells
  20. Wang M, Lemos B. Ribosomal DNA copy number amplification and loss in human cancers is linked to tumor genetic context, nucleolus activity, and proliferation. PLoS Genet. 2017 Sep; 13(9):e1006994. PMID: 28880866.
    Citations: 7     Fields:    Translation:HumansCells
  21. Deng Y, Zhang Y, Lemos B, Ren H. Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure. Sci Rep. 2017 04 24; 7:46687. PMID: 28436478.
    Citations: 2     Fields:    
  22. Yu S, Lemos B. A Portrait of Ribosomal DNA Contacts with Hi-C Reveals 5S and 45S rDNA Anchoring Points in the Folded Human Genome. Genome Biol Evol. 2016 12 31; 8(11):3545-3558. PMID: 27797956.
    Citations: 5     Fields:    Translation:HumansCells
  23. Branco AT, Schilling L, Silkaitis K, Dowling DK, Lemos B. Reproductive activity triggers accelerated male mortality and decreases lifespan: genetic and gene expression determinants in Drosophila. Heredity (Edinb). 2017 03; 118(3):221-228. PMID: 27731328.
    Citations: 1     Fields:    Translation:AnimalsCells
  24. Reis AH, Vargas FR, Lemos B. Biomarkers of genome instability and cancer epigenetics. Tumour Biol. 2016 Oct; 37(10):13029-13038. PMID: 27468720.
    Citations: 2     Fields:    Translation:Humans
  25. Yee WK, Rogell B, Lemos B, Dowling DK. Intergenomic interactions between mitochondrial and Y-linked genes shape male mating patterns and fertility in Drosophila melanogaster. Evolution. 2015 11; 69(11):2876-90. PMID: 26419212.
    Citations: 1     Fields:    Translation:Animals
  26. Case LK, Wall EH, Osmanski EE, Dragon JA, Saligrama N, Zachary JF, Lemos B, Blankenhorn EP, Teuscher C. Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring. Genome Biol. 2015 Feb 10; 16:28. PMID: 25886764.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  27. Gibbons JG, Branco AT, Godinho SA, Yu S, Lemos B. Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2485-90. PMID: 25583482.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  28. Branco AT, Lemos B. Interaction between bisphenol A and dietary sugar affects global gene transcription in Drosophila melanogaster. Genom Data. 2014 Dec; 2:308-11. PMID: 26484116.
  29. Gibbons JG, Branco AT, Yu S, Lemos B. Ribosomal DNA copy number is coupled with gene expression variation and mitochondrial abundance in humans. Nat Commun. 2014 Sep 11; 5:4850. PMID: 25209200.
    Citations: 20     Fields:    Translation:HumansCells
  30. Rogell B, Dean R, Lemos B, Dowling DK. Mito-nuclear interactions as drivers of gene movement on and off the X-chromosome. BMC Genomics. 2014 May 02; 15:330. PMID: 24885291.
    Citations: 5     Fields:    Translation:AnimalsCells
  31. Francisco FO, Lemos B. How do y-chromosomes modulate genome-wide epigenetic States: genome folding, chromatin sinks, and gene expression. J Genomics. 2014; 2:94-103. PMID: 25057325.
    Citations: 9     
  32. Pyrgiotakis G, McDevitt J, Gao Y, Branco A, Eleftheriadou M, Lemos B, Nardell E, Demokritou P. Mycobacteria inactivation using Engineered Water Nanostructures (EWNS). Nanomedicine. 2014 Aug; 10(6):1175-83. PMID: 24632246.
    Citations: 9     Fields:    Translation:CellsPHPublic Health
  33. Branco AT, Lemos B. High intake of dietary sugar enhances bisphenol A (BPA) disruption and reveals ribosome-mediated pathways of toxicity. Genetics. 2014 May; 197(1):147-57. PMID: 24614930.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  34. Hajjari M, Khoshnevisan A, Lemos B. Characterizing the Retinoblastoma 1 locus: putative elements for Rb1 regulation by in silico analysis. Front Genet. 2014; 5:2. PMID: 24478791.
    Citations: 3     
  35. Silkaitis K, Lemos B. Sex-biased chromatin and regulatory cross-talk between sex chromosomes, autosomes, and mitochondria. Biol Sex Differ. 2014 Jan 15; 5(1):2. PMID: 24422881.
    Citations: 2     Fields:    
  36. Lemos B, Branco AT, Jiang PP, Hartl DL, Meiklejohn CD. Genome-wide gene expression effects of sex chromosome imprinting in Drosophila. G3 (Bethesda). 2014 Jan 10; 4(1):1-10. PMID: 24318925.
    Citations: 7     Fields:    Translation:AnimalsCells
  37. Branco AT, Hartl DL, Lemos B. Chromatin-associated proteins HP1 and Mod(mdg4) modify Y-linked regulatory variation in the drosophila testis. Genetics. 2013 Jul; 194(3):609-18. PMID: 23636736.
    Citations: 3     Fields:    Translation:AnimalsCells
  38. Branco AT, Tao Y, Hartl DL, Lemos B. Natural variation of the Y chromosome suppresses sex ratio distortion and modulates testis-specific gene expression in Drosophila simulans. Heredity (Edinb). 2013 Jul; 111(1):8-15. PMID: 23591516.
    Citations: 4     Fields:    Translation:AnimalsCells
  39. Reis AH, Vargas FR, Lemos B. More epigenetic hits than meets the eye: microRNAs and genes associated with the tumorigenesis of retinoblastoma. Front Genet. 2012; 3:284. PMID: 23233862.
    Citations: 13     
  40. Zhou J, Sackton TB, Martinsen L, Lemos B, Eickbush TH, Hartl DL. Y chromosome mediates ribosomal DNA silencing and modulates the chromatin state in Drosophila. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9941-6. PMID: 22665801.
    Citations: 12     Fields:    Translation:AnimalsCells
  41. Sackton TB, Montenegro H, Hartl DL, Lemos B. Interspecific Y chromosome introgressions disrupt testis-specific gene expression and male reproductive phenotypes in Drosophila. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17046-51. PMID: 21969588.
    Citations: 9     Fields:    Translation:AnimalsCells
  42. Paredes S, Branco AT, Hartl DL, Maggert KA, Lemos B. Ribosomal DNA deletions modulate genome-wide gene expression: "rDNA-sensitive" genes and natural variation. PLoS Genet. 2011 Apr; 7(4):e1001376. PMID: 21533076.
    Citations: 30     Fields:    Translation:AnimalsCells
  43. Zhou J, Lemos B, Dopman EB, Hartl DL. Copy-number variation: the balance between gene dosage and expression in Drosophila melanogaster. Genome Biol Evol. 2011; 3:1014-24. PMID: 21979154.
    Citations: 27     Fields:    Translation:AnimalsCells
  44. Araripe LO, Montenegro H, Lemos B, Hartl DL. Fine-scale genetic mapping of a hybrid sterility factor between Drosophila simulans and D. mauritiana: the varied and elusive functions of "speciation genes". BMC Evol Biol. 2010 Dec 14; 10:385. PMID: 21144061.
    Citations: 4     Fields:    Translation:Animals
  45. Lemos B, Branco AT, Hartl DL. Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict. Proc Natl Acad Sci U S A. 2010 Sep 07; 107(36):15826-31. PMID: 20798037.
    Citations: 40     Fields:    Translation:AnimalsCells
  46. Jiang PP, Hartl DL, Lemos B. Y not a dead end: epistatic interactions between Y-linked regulatory polymorphisms and genetic background affect global gene expression in Drosophila melanogaster. Genetics. 2010 Sep; 186(1):109-18. PMID: 20551438.
    Citations: 18     Fields:    Translation:AnimalsCells
  47. Lemos B, Araripe LO, Fontanillas P, Hartl DL. Dominance and the evolutionary accumulation of cis- and trans-effects on gene expression. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14471-6. PMID: 18791071.
    Citations: 45     Fields:    Translation:AnimalsCells
  48. Lemos B. Gene expression: an X chromosome look beyond additive and nonadditive effects. Heredity (Edinb). 2008 Jun; 100(6):543-4. PMID: 18349878.
    Citations:    Fields:    Translation:AnimalsCells
  49. Lemos B, Araripe LO, Hartl DL. Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Science. 2008 Jan 04; 319(5859):91-3. PMID: 18174442.
    Citations: 63     Fields:    Translation:AnimalsCells
  50. Landry CR, Lemos B, Rifkin SA, Dickinson WJ, Hartl DL. Genetic properties influencing the evolvability of gene expression. Science. 2007 Jul 06; 317(5834):118-21. PMID: 17525304.
    Citations: 105     Fields:    Translation:AnimalsCells
  51. Lemos B. The Opossum genome reveals further evidence for regulatory evolution in mammalian diversification. Genome Biol. 2007; 8(8):223. PMID: 17688679.
    Citations:    Fields:    Translation:Animals
  52. Bonvicino CR, Lemos B, Weksler M. Small mammals of Chapada dos Veadeiros National Park (Cerrado of Central Brazil): ecologic, karyologic, and taxonomic considerations. Braz J Biol. 2005 Aug; 65(3):395-406. PMID: 16341417.
    Citations: 8     Fields:    Translation:Animals
  53. David JR, Araripe LO, Chakir M, Legout H, Lemos B, Pétavy G, Rohmer C, Joly D, Moreteau B. Male sterility at extreme temperatures: a significant but neglected phenomenon for understanding Drosophila climatic adaptations. J Evol Biol. 2005 Jul; 18(4):838-46. PMID: 16033555.
    Citations: 17     Fields:    Translation:AnimalsCells
  54. Lemos B, Bettencourt BR, Meiklejohn CD, Hartl DL. Evolution of proteins and gene expression levels are coupled in Drosophila and are independently associated with mRNA abundance, protein length, and number of protein-protein interactions. Mol Biol Evol. 2005 May; 22(5):1345-54. PMID: 15746013.
    Citations: 101     Fields:    Translation:Animals
  55. Lemos B, Meiklejohn CD, Cáceres M, Hartl DL. Rates of divergence in gene expression profiles of primates, mice, and flies: stabilizing selection and variability among functional categories. Evolution. 2005 Jan; 59(1):126-37. PMID: 15792233.
    Citations: 36     Fields:    Translation:HumansAnimals
  56. Lemos B, Meiklejohn CD, Hartl DL. Regulatory evolution across the protein interaction network. Nat Genet. 2004 Oct; 36(10):1059-60. PMID: 15378060.
    Citations: 24     Fields:    Translation:Animals
  57. Lemos B, Yunes JA, Vargas FR, Moreira MA, Cardoso AA, Seuánez HN. Phylogenetic footprinting reveals extensive conservation of Sonic Hedgehog (SHH) regulatory elements. Genomics. 2004 Sep; 84(3):511-23. PMID: 15498458.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  58. Bonvicino CR, Penna-Firme V, do Nascimento FF, Lemos B, Stanyon R, Seuánez HN. The lowest diploid number (2n = 16) yet found in any primate: Callicebus lugens (Humboldt, 1811). Folia Primatol (Basel). 2003 May-Jun; 74(3):141-9. PMID: 12826733.
    Citations: 4     Fields:    Translation:Animals
  59. Bonvicino CR, Lemos B, Seuánez HN. Molecular phylogenetics of howler monkeys (Alouatta, Platyrrhini). A comparison with karyotypic data. Chromosoma. 2001 Jul; 110(3):241-6. PMID: 11513299.
    Citations: 5     Fields:    Translation:AnimalsCells
  60. Seuánez HN, Lima CR, Lemos B, Bonvicino CR, Moreira MA, Canavez FC. Gene assignment in Ateles paniscus chamek (Platyrrhini, Primates). Allocation of 18 markers of human syntenic groups 1, 2, 7, 14, 15, 17 and 22. Chromosome Res. 2001; 9(8):631-9. PMID: 11778686.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  61. Lemos B, Canavez F, Moreira MA. Mitochondrial DNA-like sequences in the nuclear genome of the opossum genus Didelphis (Marsupialia: Didelphidae). J Hered. 1999 Sep-Oct; 90(5):543-7. PMID: 10544498.
    Citations: 1     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.