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Kathryn Gray, M.D.,Ph.D.


University of Wisconsin-Madison, Madison, WisconsinBS05/1999Biochemistry
University of Michigan, Ann Arbor, MIMD, PhD05/2007Medicine / Immunology
Emory University, Atlanta, GAResidency06/2011Obstetrics & Gynecology
Brigham & Women's Hospital, Boston, MAFellowship06/2016Maternal-Fetal Medicine/ Clinical Genetics
ACOG Mentor of the Year
2017 - 2019
BIRCWH Scholar
2017 - 2018
Obstetrics & Gynecology Foundation Fellowship


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08HL146963 (GRAY, KATHRYN JOHNSON) Apr 3, 2019 - Sep 30, 2023
    Signatures of dysfunctional mitochondrial fatty acid oxidation that predispose to early-onset preeclampsia
    Role: Principal Investigator
  2. F32HD086948 (GRAY, KATHRYN JOHNSON) Aug 5, 2016 - Aug 4, 2018
    Longitudinal metabolic profiling throughout gestation in the plasma and urine of women who develop early-onset preeclampsia
    Role: Principal Investigator

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wood ME, Chen ST, Huybrechts KF, Bateman BT, Gray KJ, Seely EW, Zhu Y, Mogun H, Patorno E, Hernández-Díaz S. Validation of a Claims-based Algorithm to Identify Pregestational Diabetes Among Pregnant Women in the United States. Epidemiology. 2021 11 01; 32(6):855-859. PMID: 34183529.
    Citations:    Fields:    
  2. Bordt EA, Shook LL, Atyeo C, Pullen KM, De Guzman RM, Meinsohn MC, Chauvin M, Fischinger S, Yockey LJ, James K, Lima R, Yonker LM, Fasano A, Brigida S, Bebell LM, Roberts DJ, Pépin D, Huh JR, Bilbo SD, Li JZ, Kaimal A, Schust DJ, Gray KJ, Lauffenburger D, Alter G, Edlow AG. Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses. Sci Transl Med. 2021 10 27; 13(617):eabi7428. PMID: 34664987.
    Citations:    Fields:    
  3. Atyeo C, DeRiso EA, Davis C, Bordt EA, De Guzman RM, Shook LL, Yonker LM, Fasano A, Akinwunmi B, Lauffenburger DA, Elovitz MA, Gray KJ, Edlow AG, Alter G. COVID-19 mRNA vaccines drive differential antibody Fc-functional profiles in pregnant, lactating, and nonpregnant women. Sci Transl Med. 2021 10 27; 13(617):eabi8631. PMID: 34664972.
    Citations: 1     Fields:    
  4. Pullen KM, Atyeo C, Collier AY, Gray KJ, Belfort MB, Lauffenburger DA, Edlow AG, Alter G. Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection. Cell Rep. 2021 11 09; 37(6):109959. PMID: 34739850.
  5. Straub L, Huybrechts KF, Hernandez-Diaz S, Zhu Y, Vine S, Desai RJ, Gray KJ, Bateman BT. Trajectories of Prescription Opioid Utilization During Pregnancy Among Pre-Pregnancy Chronic Users and Risk of Neonatal Opioid Withdrawal Syndrome. Am J Epidemiol. 2021 Oct 13. PMID: 34643225.
    Citations:    Fields:    
  6. Gbur S, Mauney L, Gray KJ, Wilkins-Haug L, Guseh S. Counseling for personal health implications identified during reproductive genetic carrier screening. Prenat Diagn. 2021 Oct; 41(11):1460-1466. PMID: 34426984.
    Citations:    Fields:    
  7. Gray KJ. Maternal COVID-19 vaccine antibody response and passage into cord blood. J Pediatr. 2021 09; 236:325-328. PMID: 34446174.
    Citations:    Fields:    Translation:Humans
  8. Shook LL, Bordt EA, Meinsohn MC, Pepin D, De Guzman RM, Brigida S, Yockey LJ, James KE, Sullivan MW, Bebell LM, Roberts DJ, Kaimal AJ, Li JZ, Schust D, Gray KJ, Edlow AG. Placental expression of ACE2 and TMPRSS2 in maternal SARS-CoV-2 infection: are placental defenses mediated by fetal sex? J Infect Dis. 2021 Jul 22. PMID: 34293137.
    Citations:    Fields:    
  9. Shook LL, Collier AY, Goldfarb IT, Diouf K, Akinwunmi BO, Young N, Brown A, Hacker MR, Kaimal AJ, Gray KJ, Edlow AG. Vertical transmission of SARS-CoV-2: consider the denominator. Am J Obstet Gynecol MFM. 2021 07; 3(4):100386. PMID: 33932627.
    Citations: 1     Translation:Humans
  10. Gray KJ. Providing Data to Empower Pregnant Patients to Make Evidence-Based Choices. JAMA Netw Open. 2021 04 01; 4(4):e215359. PMID: 33890997.
    Citations:    Fields:    Translation:Humans
  11. Guseh S, Wilkins-Haug L, Kaimal A, Dunn-Albanese L, Adams S, Carroll S, Discenza M, Dobson L, Brillinger M, Foster J, Gbur S, Green H, Herrig N, Mandigo C, Pacione M, Roberts P, Sassaman A, Steinberg K, Studwell C, Gray KJ. Utility of noninvasive genome-wide screening: a prospective cohort of obstetric patients undergoing diagnostic testing. Genet Med. 2021 07; 23(7):1341-1348. PMID: 33782554.
    Citations:    Fields:    Translation:Humans
  12. Gray KJ, Bordt EA, Atyeo C, Deriso E, Akinwunmi B, Young N, Baez AM, Shook LL, Cvrk D, James K, De Guzman R, Brigida S, Diouf K, Goldfarb I, Bebell LM, Yonker LM, Fasano A, Rabi SA, Elovitz MA, Alter G, Edlow AG. Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study. Am J Obstet Gynecol. 2021 09; 225(3):303.e1-303.e17. PMID: 33775692.
    Citations: 43     Fields:    
  13. Gray KJ, Bordt EA, Atyeo C, Deriso E, Akinwunmi B, Young N, Baez AM, Shook LL, Cvrk D, James K, De Guzman RM, Brigida S, Diouf K, Goldfarb I, Bebell LM, Yonker LM, Fasano A, Rabi SA, Elovitz MA, Alter G, Edlow AG. COVID-19 vaccine response in pregnant and lactating women: a cohort study. medRxiv. 2021 Mar 08. PMID: 33758889.
  14. Bateman BT, Hernandez-Diaz S, Straub L, Zhu Y, Gray KJ, Desai RJ, Mogun H, Gautam N, Huybrechts KF. Association of first trimester prescription opioid use with congenital malformations in the offspring: population based cohort study. BMJ. 2021 02 10; 372:n102. PMID: 33568363.
    Citations: 1     Fields:    Translation:Humans
  15. Straub L, Huybrechts KF, Hernandez-Diaz S, Zhu Y, Vine S, Desai RJ, Gray KJ, Bateman BT. Chronic prescription opioid use in pregnancy in the United States. Pharmacoepidemiol Drug Saf. 2021 04; 30(4):504-513. PMID: 33428239.
    Citations: 1     Fields:    
  16. Atyeo C, Pullen KM, Bordt EA, Fischinger S, Burke J, Michell A, Slein MD, Loos C, Shook LL, Boatin AA, Yockey LJ, Pepin D, Meinsohn MC, Nguyen NMP, Chauvin M, Roberts D, Goldfarb IT, Matute JD, James KE, Yonker LM, Bebell LM, Kaimal AJ, Gray KJ, Lauffenburger D, Edlow AG, Alter G. Compromised SARS-CoV-2-specific placental antibody transfer. Cell. 2021 02 04; 184(3):628-642.e10. PMID: 33476549.
    Citations: 21     Fields:    Translation:HumansCells
  17. Edlow AG, Li JZ, Collier AY, Atyeo C, James KE, Boatin AA, Gray KJ, Bordt EA, Shook LL, Yonker LM, Fasano A, Diouf K, Croul N, Devane S, Yockey LJ, Lima R, Shui J, Matute JD, Lerou PH, Akinwunmi BO, Schmidt A, Feldman J, Hauser BM, Caradonna TM, De la Flor D, D'Avino P, Regan J, Corry H, Coxen K, Fajnzylber J, Pepin D, Seaman MS, Barouch DH, Walker BD, Yu XG, Kaimal AJ, Roberts DJ, Alter G. Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic. JAMA Netw Open. 2020 12 01; 3(12):e2030455. PMID: 33351086.
    Citations: 42     Fields:    Translation:HumansCells
  18. McElrath TF, Cantonwine DE, Gray KJ, Mirzakhani H, Doss RC, Khaja N, Khalid M, Page G, Brohman B, Zhang Z, Sarracino D, Rosenblatt KP. Late first trimester circulating microparticle proteins predict the risk of preeclampsia PMID: 33087742.
    Citations:    Fields:    Translation:HumansCells
  19. Gray KJ. Tolerance of uncertainty: a unifying theme in pregnancy care. BJOG. 2021 01; 128(2):439. PMID: 32892454.
    Citations:    Fields:    Translation:Humans
  20. Gray KJ, Kovacheva VP, Mirzakhani H, Bjonnes AC, Almoguera B, Wilson ML, Ingles SA, Lockwood CJ, Hakonarson H, McElrath TF, Murray JC, Norwitz ER, Karumanchi SA, Bateman BT, Keating BJ, Saxena R. Risk of pre-eclampsia in patients with a maternal genetic predisposition to common medical conditions: a case-control study. BJOG. 2021 01; 128(1):55-65. PMID: 32741103.
    Citations: 2     Fields:    Translation:Humans
  21. Gray KJ, Wilkins-Haug L. Special issue on "Feto-Maternal Genomic Medicine": a decade of incredible advances. Hum Genet. 2020 Sep; 139(9):1119-1120. PMID: 32840692.
    Citations:    Fields:    Translation:Humans
  22. Zhu Y, Bateman BT, Gray KJ, Hernandez-Diaz S, Mogun H, Straub L, Huybrechts KF. Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study. BMJ. 2020 May 20; 369:m1494. PMID: 32434758.
    Citations: 4     Fields:    Translation:Humans
  23. He M, Huybrechts KF, Dejene SZ, Straub L, Bartels D, Burns S, Combs DJ, Cottral J, Gray KJ, Manning-Geist BL, Mogun H, Reimers RM, Hernandez-Diaz S, Bateman BT. Validation of algorithms to identify adverse perinatal outcomes in the Medicaid Analytic Extract database. Pharmacoepidemiol Drug Saf. 2020 04; 29(4):419-426. PMID: 32124511.
    Citations: 2     Fields:    Translation:Humans
  24. Huybrechts KF, Hernandez-Diaz S, Straub L, Gray KJ, Zhu Y, Mogun H, Bateman BT. Intravenous Ondansetron in Pregnancy and Risk of Congenital Malformations. JAMA. 2020 01 28; 323(4):372-374. PMID: 31730152.
    Citations: 3     Fields:    Translation:Humans
  25. Straub L, Huybrechts KF, Bateman BT, Mogun H, Gray KJ, Holmes LB, Hernandez-Diaz S. The Impact of Technology on the Diagnosis of Congenital Malformations. Am J Epidemiol. 2019 11 01; 188(11):1892-1901. PMID: 31241162.
    Citations: 1     Fields:    Translation:Humans
  26. Gray KJ, Wilkins-Haug LE, Herrig NJ, Vora NL. Fetal phenotypes emerge as genetic technologies become robust. Prenat Diagn. 2019 08; 39(9):811-817. PMID: 31330568.
    Citations: 6     Fields:    Translation:Humans
  27. Reale SC, Gray KJ, Boyer EW, Arce DY, Farber MK. Toxic Ingestion of Acetaminophen and Acetylsalicylic Acid in a Parturient at 33 Weeks Gestation: A Case Report. A A Pract. 2019 May 01; 12(9):302-304. PMID: 30312176.
    Citations: 1     Fields:    Translation:Humans
  28. Naoum EE, Leffert LR, Chitilian HV, Gray KJ, Bateman BT. Acute Fatty Liver of Pregnancy: Pathophysiology, Anesthetic Implications, and Obstetrical Management. Anesthesiology. 2019 03; 130(3):446-461. PMID: 30707120.
    Citations: 10     Fields:    Translation:Humans
  29. Huybrechts KF, Hernández-Díaz S, Straub L, Gray KJ, Zhu Y, Patorno E, Desai RJ, Mogun H, Bateman BT. Association of Maternal First-Trimester Ondansetron Use With Cardiac Malformations and Oral Clefts in Offspring. JAMA. 2018 12 18; 320(23):2429-2437. PMID: 30561479.
    Citations: 16     Fields:    Translation:Humans
  30. Covarrubias AE, Lecarpentier E, Lo A, Salahuddin S, Gray KJ, Karumanchi SA, Zsengellér ZK. AP39, a Modulator of Mitochondrial Bioenergetics, Reduces Antiangiogenic Response and Oxidative Stress in Hypoxia-Exposed Trophoblasts: Relevance for Preeclampsia Pathogenesis. Am J Pathol. 2019 01; 189(1):104-114. PMID: 30315766.
    Citations: 10     Fields:    Translation:HumansCells
  31. Panchaud A, Cohen JM, Patorno E, Huybrechts KF, Desai RJ, Gray KJ, Mogun H, Hernandez-Diaz S, Bateman BT. Anticonvulsants and the risk of perinatal bleeding complications: A pregnancy cohort study. Neurology. 2018 08 07; 91(6):e533-e542. PMID: 29980637.
    Citations:    Fields:    Translation:Humans
  32. Gray KJ, Kovacheva VP, Mirzakhani H, Bjonnes AC, Almoguera B, DeWan AT, Triche EW, Saftlas AF, Hoh J, Bodian DL, Klein E, Huddleston KC, Ingles SA, Lockwood CJ, Hakonarson H, McElrath TF, Murray JC, Wilson ML, Norwitz ER, Karumanchi SA, Bateman BT, Keating BJ, Saxena R. Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1. Hypertension. 2018 08; 72(2):408-416. PMID: 29967039.
    Citations: 11     Fields:    Translation:Humans
  33. Gray KJ, Wilkins-Haug LE. Have we done our last amniocentesis? Updates on cell-free DNA for Down syndrome screening. Pediatr Radiol. 2018 04; 48(4):461-470. PMID: 29550862.
    Citations: 3     Fields:    Translation:Humans
  34. Cohen JM, Hernández-Díaz S, Bateman BT, Park Y, Desai RJ, Gray KJ, Patorno E, Mogun H, Huybrechts KF. Placental Complications Associated With Psychostimulant Use in Pregnancy. Obstet Gynecol. 2017 12; 130(6):1192-1201. PMID: 29112657.
    Citations: 8     Fields:    Translation:Humans
  35. Gray KJ, Saxena R, Karumanchi SA. Genetic predisposition to preeclampsia is conferred by fetal DNA variants near FLT1, a gene involved in the regulation of angiogenesis. Am J Obstet Gynecol. 2018 02; 218(2):211-218. PMID: 29138037.
    Citations: 14     Fields:    Translation:Humans
  36. Gansner JM, Achebe MM, Gray KJ, Yefidoff-Freedman R, Labovitis E, Parnes A, Connors JM, Connell NT, Discenza MN, Handin RI, Berliner N, Shimamura A, Ginsburg ES, Smith NA. Pregnancy outcomes in inherited bone marrow failure syndromes. Blood. 2017 10 05; 130(14):1671-1674. PMID: 28798157.
    Citations: 5     Fields:    Translation:Humans
  37. Kelly RS, Giorgio RT, Chawes BL, Palacios NI, Gray KJ, Mirzakhani H, Wu A, Blighe K, Weiss ST, Lasky-Su J. Applications of Metabolomics in the Study and Management of Preeclampsia; A Review of the Literature. Metabolomics. 2017 07; 13(7). PMID: 30473646.
    Citations: 11     Fields:    
  38. Kelly RS, Croteau-Chonka DC, Dahlin A, Mirzakhani H, Wu AC, Wan ES, McGeachie MJ, Qiu W, Sordillo JE, Al-Garawi A, Gray KJ, McElrath TF, Carey VJ, Clish CB, Litonjua AA, Weiss ST, Lasky-Su JA. Integration of metabolomic and transcriptomic networks in pregnant women reveals biological pathways and predictive signatures associated with preeclampsia. Metabolomics. 2017 Jan; 13(1). PMID: 28596717.
    Citations: 18     Fields:    
  39. Lamont RE, Tan WH, Innes AM, Parboosingh JS, Schneidman-Duhovny D, Rajkovic A, Pappas J, Altschwager P, DeWard S, Fulton A, Gray KJ, Krall M, Mehta L, Rodan LH, Saller DN, Steele D, Stein D, Yatsenko SA, Bernier FP, Slavotinek AM. Expansion of phenotype and genotypic data in CRB2-related syndrome. Eur J Hum Genet. 2016 10; 24(10):1436-44. PMID: 27004616.
    Citations: 11     Fields:    Translation:Humans
  40. Wessel AE, Mogensen KM, Rohr F, Erick M, Neilan EG, Chopra S, Levy HL, Gray KJ, Wilkins-Haug L, Berry GT. Management of a Woman With Maple Syrup Urine Disease During Pregnancy, Delivery, and Lactation. JPEN J Parenter Enteral Nutr. 2015 Sep; 39(7):875-9. PMID: 24618664.
    Citations: 6     Fields:    Translation:Humans
  41. Johnson KM, Swenson L, Opipari AW, Reuter R, Zarrabi N, Fierke CA, Börsch M, Glick GD. Mechanistic basis for differential inhibition of the F1Fo-ATPase by aurovertin. Biopolymers. 2009 Oct; 91(10):830-40. PMID: 19462418.
    Citations: 12     Fields:    Translation:AnimalsCells
  42. Cleary J, Johnson KM, Opipari AW, Glick GD. Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor. Bioorg Med Chem Lett. 2007 Mar 15; 17(6):1667-70. PMID: 17251020.
    Citations: 20     Fields:    Translation:HumansCells
  43. Johnson KM, Cleary J, Fierke CA, Opipari AW, Glick GD. Mechanistic basis for therapeutic targeting of the mitochondrial F1F0-ATPase. ACS Chem Biol. 2006 Jun 20; 1(5):304-8. PMID: 17163759.
    Citations: 17     Fields:    Translation:Animals
  44. Johnson KM, Chen X, Boitano A, Swenson L, Opipari AW, Glick GD. Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423. Chem Biol. 2005 Apr; 12(4):485-96. PMID: 15850986.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  45. Schuster MC, Mann DA, Buchholz TJ, Johnson KM, Thomas WD, Kiessling LL. Parallel synthesis of glycomimetic libraries: targeting a C-type lectin. Org Lett. 2003 May 01; 5(9):1407-10. PMID: 12713285.
    Citations: 9     Fields:    Translation:Cells
  46. Blatt NB, Bednarski JJ, Warner RE, Leonetti F, Johnson KM, Boitano A, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW, Glick GD. Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. J Clin Invest. 2002 Oct; 110(8):1123-32. PMID: 12393848.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.