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Alice Lam, M.D.,Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21AG064413 (LAM, ALICE D) Jul 15, 2019 - Mar 31, 2021
    NIH
    Investigation of silent mesial temporal lobe hyperexcitability in Alzheimer's disease
    Role: Principal Investigator
  2. K23NS101037 (LAM, ALICE D) Jul 1, 2018 - Mar 31, 2023
    NIH
    Exploring the role of epileptiform activity in Alzheimer's Disease
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ye EM, Sun H, Krishnamurthy PV, Adra N, Ganglberger W, Thomas RJ, Lam AD, Westover MB. Dementia detection from brain activity during sleep. Sleep. 2023 Mar 09; 46(3). PMID: 36448766; PMCID: PMC9995788.
    Citations: 1     Fields:    Translation:Humans
  2. Azami H, Moguilner S, Penagos H, Sarkis RA, Arnold SE, Gomperts SN, Lam AD. EEG Entropy in REM Sleep as a Physiologic Biomarker in Early Clinical Stages of Alzheimer's Disease. J Alzheimers Dis. 2023; 91(4):1557-1572. PMID: 36641682.
    Citations:    Fields:    Translation:Humans
  3. Sarkis RA, Gale SA, Yang HS, Lam AD, Singhal T, Cicero S, Willment K, McGinnis SM. Utility of Amyloid Positron Emission Tomography Imaging in Older Adults With Epilepsy and Cognitive Decline. Am J Alzheimers Dis Other Demen. 2023 Jan-Dec; 38:15333175231160005. PMID: 36892007.
    Citations:    Fields:    Translation:Humans
  4. Abou Jaoude M, Jacobs CS, Sarkis RA, Jing J, Pellerin KR, Cole AJ, Cash SS, Westover MB, Lam AD. Noninvasive Detection of Hippocampal Epileptiform Activity on Scalp Electroencephalogram. JAMA Neurol. 2022 06 01; 79(6):614-622. PMID: 35499837; PMCID: PMC9062772.
    Citations:    Fields:    Translation:Humans
  5. Lam AD, Shafi MM. Towards a coherent view of network hyperexcitability in Alzheimer's disease. Brain. 2022 04 18; 145(2):423-425. PMID: 35259227.
    Citations:    Fields:    Translation:Humans
  6. Harid NM, Jing J, Hogan J, Nascimento FA, Ouyang A, Zheng WL, Ge W, Zafar SF, Kim JA, Lam AD, Herlopian A, Maus D, Karakis I, Ng M, Hong S, Zhu Y, Kaplan PW, Cash S, Shafi M, Martz G, Halford JJ, Westover MB. Measuring expertise in identifying interictal epileptiform discharges. Epileptic Disord. 2022 Jan 14. PMID: 35031528.
    Citations:    Fields:    
  7. Johnson EL, Krauss GL, Kucharska-Newton A, Lam AD, Sarkis R, Gottesman RF. Mortality in Patients With Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study. Neurology. 2021 09 14; 97(11):e1132-e1140. PMID: 34282048; PMCID: PMC8456359.
    Citations: 2     Fields:    Translation:Humans
  8. Nascimento FA, Laze J, Friedman D, Lam A, Devinsky O. SUDEP education among U.S. and international neurology trainees. Epilepsy Behav. 2021 08; 121(Pt A):108098. PMID: 34111766.
    Citations:    Fields:    Translation:Humans
  9. Yang JC, Harid NM, Nascimento FA, Kokkinos V, Shaughnessy A, Lam AD, Westover MB, Leslie-Mazwi TM, Hochberg LR, Rosenthal ES, Cole AJ, Richardson RM, Cash SS. Responsive neurostimulation for focal motor status epilepticus. Ann Clin Transl Neurol. 2021 06; 8(6):1353-1361. PMID: 33955717; PMCID: PMC8164849.
    Citations: 1     Fields:    Translation:Humans
  10. Babiloni C, Arakaki X, Azami H, Bennys K, Blinowska K, Bonanni L, Bujan A, Carrillo MC, Cichocki A, de Frutos-Lucas J, Del Percio C, Dubois B, Edelmayer R, Egan G, Epelbaum S, Escudero J, Evans A, Farina F, Fargo K, Fernández A, Ferri R, Frisoni G, Hampel H, Harrington MG, Jelic V, Jeong J, Jiang Y, Kaminski M, Kavcic V, Kilborn K, Kumar S, Lam A, Lim L, Lizio R, Lopez D, Lopez S, Lucey B, Maestú F, McGeown WJ, McKeith I, Moretti DV, Nobili F, Noce G, Olichney J, Onofrj M, Osorio R, Parra-Rodriguez M, Rajji T, Ritter P, Soricelli A, Stocchi F, Tarnanas I, Taylor JP, Teipel S, Tucci F, Valdes-Sosa M, Valdes-Sosa P, Weiergräber M, Yener G, Guntekin B. Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel. Alzheimers Dement. 2021 09; 17(9):1528-1553. PMID: 33860614; PMCID: PMC8647863.
    Citations: 16     Fields:    Translation:Humans
  11. Abou Jaoude M, Sun H, Pellerin KR, Pavlova M, Sarkis RA, Cash SS, Westover MB, Lam AD. Expert-level automated sleep staging of long-term scalp electroencephalography recordings using deep learning. Sleep. 2020 11 12; 43(11). PMID: 32478820.
    Citations: 10     Fields:    Translation:Humans
  12. Lam AD, Noebels J. Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease. Epilepsy Curr. 2020 Nov-Dec; 20(6):369-374. PMID: 33081517.
    Citations: 3     
  13. Ye E, Sun H, Leone MJ, Paixao L, Thomas RJ, Lam AD, Westover MB. Association of Sleep Electroencephalography-Based Brain Age Index With Dementia. JAMA Netw Open. 2020 09 01; 3(9):e2017357. PMID: 32986106.
    Citations: 7     Fields:    Translation:Humans
  14. Lam AD, Sarkis RA, Pellerin KR, Jing J, Dworetzky BA, Hoch DB, Jacobs CS, Lee JW, Weisholtz DS, Zepeda R, Westover MB, Cole AJ, Cash SS. Association of epileptiform abnormalities and seizures in Alzheimer disease. Neurology. 2020 10 20; 95(16):e2259-e2270. PMID: 32764101.
    Citations: 29     Fields:    Translation:Humans
  15. Jing J, Sun H, Kim JA, Herlopian A, Karakis I, Ng M, Halford JJ, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Dauwels J, Lam A, Cole AJ, Cash SS, Westover MB. Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation. JAMA Neurol. 2020 01 01; 77(1):103-108. PMID: 31633740; PMCID: PMC6806668.
    Citations: 25     Fields:    Translation:Humans
  16. Jing J, Herlopian A, Karakis I, Ng M, Halford JJ, Lam A, Maus D, Chan F, Dolatshahi M, Muniz CF, Chu C, Sacca V, Pathmanathan J, Ge W, Sun H, Dauwels J, Cole AJ, Hoch DB, Cash SS, Westover MB. Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms. JAMA Neurol. 2020 01 01; 77(1):49-57. PMID: 31633742; PMCID: PMC6806666.
    Citations: 21     Fields:    Translation:Humans
  17. Abou Jaoude M, Jing J, Sun H, Jacobs CS, Pellerin KR, Westover MB, Cash SS, Lam AD. Detection of mesial temporal lobe epileptiform discharges on intracranial electrodes using deep learning. Clin Neurophysiol. 2020 01; 131(1):133-141. PMID: 31760212.
    Citations: 7     Fields:    Translation:Humans
  18. Lam AD, Cole AJ, Cash SS. New Approaches to Studying Silent Mesial Temporal Lobe Seizures in Alzheimer's Disease. Front Neurol. 2019; 10:959. PMID: 31551916; PMCID: PMC6737997.
    Citations: 6     
  19. Williams JA, Cisse FA, Schaekermann M, Sakadi F, Tassiou NR, Hotan GC, Bah AK, Hamani ABD, Lim A, Leung ECW, Fantaneanu TA, Milligan TA, Khatri V, Hoch DB, Vyas MV, Lam AD, Cohen JM, Vogel AC, Law E, Mateen FJ. Smartphone EEG and remote online interpretation for children with epilepsy in the Republic of Guinea: Quality, characteristics, and practice implications. Seizure. 2019 Oct; 71:93-99. PMID: 31229939.
    Citations: 6     Fields:    Translation:Humans
  20. Brown R, Lam AD, Gonzalez-Sulser A, Ying A, Jones M, Chou RC, Tzioras M, Jordan CY, Jedrasiak-Cape I, Hemonnot AL, Abou Jaoude M, Cole AJ, Cash SS, Saito T, Saido T, Ribchester RR, Hashemi K, Oren I. Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease. eNeuro. 2018 Mar-Apr; 5(2). PMID: 29780880; PMCID: PMC5956746.
    Citations: 12     Fields:    Translation:Animals
  21. Lam AD, Maus D, Zafar SF, Cole AJ, Cash SS. SCOPE-mTL: A non-invasive tool for identifying and lateralizing mesial temporal lobe seizures prior to scalp EEG ictal onset. Clin Neurophysiol. 2017 09; 128(9):1647-1655. PMID: 28732342.
    Citations: 5     Fields:    Translation:Humans
  22. Lam AD, Deck G, Goldman A, Eskandar EN, Noebels J, Cole AJ. Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease. Nat Med. 2017 Jun; 23(6):678-680. PMID: 28459436; PMCID: PMC5461182.
    Citations: 133     Fields:    Translation:Humans
  23. McKenzie ED, Lim AS, Leung EC, Cole AJ, Lam AD, Eloyan A, Nirola DK, Tshering L, Thibert R, Garcia RZ, Bui E, Deki S, Lee L, Clark SJ, Cohen JM, Mantia J, Brizzi KT, Sorets TR, Wahlster S, Borzello M, Stopczynski A, Cash SS, Mateen FJ. Validation of a smartphone-based EEG among people with epilepsy: A prospective study. Sci Rep. 2017 04 03; 7:45567. PMID: 28367974.
    Citations: 12     Fields:    Translation:Humans
  24. McGrath ER, Batra A, Lam AD, Rizzo JF, Cole AJ. Clinical Reasoning: A 64-year-old man with visual distortions. Neurology. 2016 11 22; 87(21):e252-e256. PMID: 27872229; PMCID: PMC5123557.
    Citations: 1     Fields:    Translation:Humans
  25. Lam AD, Zepeda R, Cole AJ, Cash SS. Widespread changes in network activity allow non-invasive detection of mesial temporal lobe seizures. Brain. 2016 Oct; 139(Pt 10):2679-2693. PMID: 27474219.
    Citations: 13     Fields:    
  26. McKenzie ED, Nirola DK, Deki S, Tshering L, Patenaude B, Clark SJ, Cash SS, Thibert R, Zepeda R, Leung EC, Lam AD, Lim AS, Mantia J, Cohen J, Cole AJ, Mateen FJ. Medication prescribing and patient-reported outcome measures in people with epilepsy in Bhutan. Epilepsy Behav. 2016 06; 59:122-7. PMID: 27131914.
    Citations: 7     Fields:    Translation:Humans
  27. Mukerji SS, Lam AD, Wilson MR. Eastern Equine Encephalitis Treated With Intravenous Immunoglobulins. Neurohospitalist. 2016 Jan; 6(1):29-31. PMID: 26740855; PMCID: PMC4680893.
    Citations: 10     
  28. Ben-Simon Y, Rodenas-Ruano A, Alviña K, Lam AD, Stuenkel EL, Castillo PE, Ashery U. A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity. Cell Rep. 2015 Jul 21; 12(3):396-404. PMID: 26166572.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  29. Bielopolski N, Lam AD, Bar-On D, Sauer M, Stuenkel EL, Ashery U. Differential interaction of tomosyn with syntaxin and SNAP25 depends on domains in the WD40 ß-propeller core and determines its inhibitory activity. J Biol Chem. 2014 Jun 13; 289(24):17087-99. PMID: 24782308.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  30. Williams AL, Bielopolski N, Meroz D, Lam AD, Passmore DR, Ben-Tal N, Ernst SA, Ashery U, Stuenkel EL. Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation. J Biol Chem. 2011 Apr 22; 286(16):14542-53. PMID: 21330375.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  31. Lam AD, Ismail S, Wu R, Yizhar O, Passmore DR, Ernst SA, Stuenkel EL. Mapping dynamic protein interactions to insulin secretory granule behavior with TIRF-FRET. Biophys J. 2010 Aug 09; 99(4):1311-20. PMID: 20713017.
    Citations: 9     Fields:    Translation:AnimalsCells
  32. Lam AD, Tryoen-Toth P, Tsai B, Vitale N, Stuenkel EL. SNARE-catalyzed fusion events are regulated by Syntaxin1A-lipid interactions. Mol Biol Cell. 2008 Feb; 19(2):485-97. PMID: 18003982.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  33. Gladycheva SE, Lam AD, Liu J, D'Andrea-Merrins M, Yizhar O, Lentz SI, Ashery U, Ernst SA, Stuenkel EL. Receptor-mediated regulation of tomosyn-syntaxin 1A interactions in bovine adrenal chromaffin cells. J Biol Chem. 2007 Aug 03; 282(31):22887-99. PMID: 17545156.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  34. D'Andrea-Merrins M, Chang L, Lam AD, Ernst SA, Stuenkel EL. Munc18c interaction with syntaxin 4 monomers and SNARE complex intermediates in GLUT4 vesicle trafficking. J Biol Chem. 2007 Jun 01; 282(22):16553-66. PMID: 17412693.
    Citations: 27     Fields:    Translation:AnimalsCells
  35. Lam AD, Chikina MD, McNulty MM, Glaaser IW, Hanck DA. Role of Domain IV/S4 outermost arginines in gating of T-type calcium channels. Pflugers Arch. 2005 Nov; 451(2):349-61. PMID: 16133267.
    Citations: 12     Fields:    Translation:HumansCells
  36. Khan A, Romantseva L, Lam A, Lipkind G, Fozzard HA. Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block. J Physiol. 2002 Aug 15; 543(Pt 1):71-84. PMID: 12181282; PMCID: PMC2290475.
    Citations: 34     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.