Harvard Catalyst Profiles

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Christian A Webb, Ph.D.

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Overview

Mentoring
current student opportunities
Available: 04/05/22, Expires: 06/01/23

My lab (Treatment and Etiology of Depression in Youth Laboratory) is located at McLean Hospital. We use a multimodal approach (EEG, fMRI, ecological momentary assessment, and laboratory-based experiments) to investigate the etiology and pathophysiology of depression. We have ongoing studies focused on the processes of change in Behavioral Activation for depression, using EEG and machine learning to predict treatment outcome, and some recent work on mindfulness-based approaches to treatment and smartphone sensors to predict affective states. Applicants with background in data analysis of complex data/engineering are encouraged to apply.


Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AT011002 (WEBB, CHRISTIAN ANTHONY) Jun 15, 2021 - May 31, 2026
    NIH
    Mechanisms and Predictors of Change in App-Based Mindfulness Training for Adolescents
    Role: Principal Investigator
  2. R01MH116969 (WEBB, CHRISTIAN ANTHONY) Dec 11, 2018 - Oct 31, 2023
    NIH
    Predicting the onset of depression in at-risk adolescents from endophenotype profiles
    Role: Principal Investigator
  3. K23MH108752 (WEBB, CHRISTIAN ANTHONY) Sep 25, 2015 - Aug 31, 2019
    NIH
    Examining Reward-Related Predictors and Mechanisms of Change in BA Treatment for Anhedonic Adolescents
    Role: Principal Investigator
  4. F32MH099801 (WEBB, CHRISTIAN ANTHONY) Feb 1, 2013 - Jan 31, 2016
    NIH
    Investigating Neural and Psychotherapeutic Mediators of Placebo Response in MDD
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Slavich GM, Roos LG, Mengelkoch S, Webb CA, Shattuck EC, Moriarity DP, Alley JC. Social Safety Theory: Conceptual Foundation, Underlying Mechanisms, and Future Directions. Health Psychol Rev. 2023 Jan 30; 1-65. PMID: 36718584.
    Citations:    Fields:    
  2. Hilt LM, Swords CM, Webb CA. Randomized Controlled Trial of a Mindfulness Mobile Application for Ruminative Adolescents. J Clin Child Adolesc Psychol. 2023 Jan 09; 1-14. PMID: 36622879.
    Citations: 1     Fields:    
  3. Webb CA, Tierney AO, Brown HA, Forbes EE, Pizzagalli DA, Ren B. Spontaneous Thought Characteristics are Differentially Related to Heightened Negative Affect vs. Blunted Positive Affect in Adolescents: An Experience Sampling Study. JCPP Adv. 2022 Dec; 2(4). PMID: 36817188; PMCID: PMC9937432.
    Citations:    
  4. Webb CA, Hirshberg MJ, Davidson RJ, Goldberg SB. Personalized Prediction of Response to Smartphone-Delivered Meditation Training: Randomized Controlled Trial. J Med Internet Res. 2022 11 08; 24(11):e41566. PMID: 36346668; PMCID: PMC9682449.
    Citations:    Fields:    Translation:HumansPHPublic Health
  5. Webb CA, Murray L, Tierney AO, Forbes EE, Pizzagalli DA. Reward-related predictors of symptom change in behavioral activation therapy for anhedonic adolescents: a multimodal approach. Neuropsychopharmacology. 2023 03; 48(4):623-632. PMID: 36307561; PMCID: PMC9938220.
    Citations: 1     Fields:    Translation:Humans
  6. Webb CA, Swords CM, Lawrence HR, Hilt LM. Which adolescents are well-suited to app-based mindfulness training? A randomized clinical trial and data-driven approach for personalized recommendations. J Consult Clin Psychol. 2022 Sep; 90(9):655-669. PMID: 36279218; PMCID: PMC9886135.
    Citations: 2     Fields:    Translation:Humans
  7. Ren B, Balkind EG, Pastro B, Israel ES, Pizzagalli DA, Rahimi-Eichi H, Baker JT, Webb CA. Predicting states of elevated negative affect in adolescents from smartphone sensors: a novel personalized machine learning approach. Psychol Med. 2022 Jul 27; 1-9. PMID: 35894246.
    Citations:    Fields:    
  8. Hanuka S, Olson EA, Admon R, Webb CA, Killgore WDS, Rauch SL, Rosso IM, Pizzagalli DA. Reduced anhedonia following internet-based cognitive-behavioral therapy for depression is mediated by enhanced reward circuit activation. Psychol Med. 2022 Jun 17; 1-10. PMID: 35713110.
    Citations:    Fields:    
  9. Murray L, Israel ES, Balkind EG, Pastro B, Lovell-Smith N, Lukas SE, Forbes EE, Pizzagalli DA, Webb CA. Multi-modal assessment of reward functioning in adolescent anhedonia. Psychol Med. 2022 Jun 17; 1-10. PMID: 35711146.
    Citations:    Fields:    
  10. Trombello JM, Cooper CM, Fatt CC, Grannemann BD, Carmody TJ, Jha MK, Mayes TL, Greer TL, Yezhuvath U, Aslan S, Pizzagalli DA, Weissman MM, Webb CA, Dillon DG, McGrath PJ, Fava M, Parsey RV, McInnis MG, Etkin A, Trivedi MH. Neural substrates of emotional conflict with anxiety in major depressive disorder: Findings from the Establishing Moderators and biosignatures of Antidepressant Response in Clinical Care (EMBARC) randomized controlled trial. J Psychiatr Res. 2022 05; 149:243-251. PMID: 35290819; PMCID: PMC9746288.
    Citations:    Fields:    Translation:Humans
  11. Falkenstein MJ, Kelley KN, Dattolico D, Kuckertz JM, Bezahler A, Krompinger J, Webb CA, Beard C. Feasibility and Acceptability of Cognitive Bias Modification for Interpretation as an Adjunctive Treatment for OCD and Related Disorders: A Pilot Randomized Controlled Trial. Behav Ther. 2022 03; 53(2):294-309. PMID: 35227405.
    Citations:    Fields:    Translation:Humans
  12. Webb CA, Swords CM, Murray L, Hilt LM. App-based Mindfulness Training for Adolescent Rumination: Predictors of Immediate and Cumulative Benefit. Mindfulness (N Y). 2021 Oct; 12(10):2498-2509. PMID: 35432625; PMCID: PMC9009760.
    Citations:    
  13. Webb CA, Forgeard M, Israel ES, Lovell-Smith N, Beard C, Björgvinsson T. Personalized prescriptions of therapeutic skills from patient characteristics: An ecological momentary assessment approach. J Consult Clin Psychol. 2022 Jan; 90(1):51-60. PMID: 33829818; PMCID: PMC8497649.
    Citations:    Fields:    Translation:Humans
  14. Webb CA, Cohen ZD. Progress towards clinically informative data-driven decision support tools in psychotherapy. Lancet Digit Health. 2021 04; 3(4):e207-e208. PMID: 33766285.
    Citations:    Fields:    
  15. Cardinale R, Menkes MW, Andrews CM, Webb CA, Jha MK, Trombello JM, Trivedi MH, McInnis MG, Deldin PJ. Preliminary Evidence for Sociotropy and Autonomy in Relation to Antidepressant Treatment Outcome. Psychiatr Q. 2021 09; 92(3):1069-1077. PMID: 33566317; PMCID: PMC9746245.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  16. Zilcha-Mano S, Webb CA. Disentangling Trait-Like Between-Individual vs. State-Like Within-Individual Effects in Studying the Mechanisms of Change in CBT. Front Psychiatry. 2020; 11:609585. PMID: 33551873.
    Citations:    
  17. Ang YS, Bruder GE, Keilp JG, Rutherford A, Alschuler DM, Pechtel P, Webb CA, Carmody T, Fava M, Cusin C, McGrath PJ, Weissman M, Parsey R, Oquendo MA, McInnis MG, Cooper CM, Deldin P, Trivedi MH, Pizzagalli DA. Exploration of baseline and early changes in neurocognitive characteristics as predictors of treatment response to bupropion, sertraline, and placebo in the EMBARC clinical trial. Psychol Med. 2022 10; 52(13):2441-2449. PMID: 33213541; PMCID: PMC7613805.
    Citations:    Fields:    
  18. Flückiger C, Rubel J, Del Re AC, Horvath AO, Wampold BE, Crits-Christoph P, Atzil-Slonim D, Compare A, Falkenström F, Ekeblad A, Errázuriz P, Fisher H, Hoffart A, Huppert JD, Kivity Y, Kumar M, Lutz W, Muran JC, Strunk DR, Tasca GA, Vîsla A, Voderholzer U, Webb CA, Xu H, Zilcha-Mano S, Barber JP. The reciprocal relationship between alliance and early treatment symptoms: A two-stage individual participant data meta-analysis. J Consult Clin Psychol. 2020 Sep; 88(9):829-843. PMID: 32757587.
    Citations: 13     Fields:    Translation:Humans
  19. Webb CA, Auerbach RP, Bondy E, Stanton CH, Appleman L, Pizzagalli DA. Reward-Related Neural Predictors and Mechanisms of Symptom Change in Cognitive Behavioral Therapy for Depressed Adolescent Girls. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 01; 6(1):39-49. PMID: 32948509.
    Citations: 3     Fields:    Translation:Humans
  20. Webb CA, Israel ES, Belleau E, Appleman L, Forbes EE, Pizzagalli DA. Mind-Wandering in Adolescents Predicts Worse Affect and Is Linked to Aberrant Default Mode Network-Salience Network Connectivity. J Am Acad Child Adolesc Psychiatry. 2021 03; 60(3):377-387. PMID: 32553785; PMCID: PMC7736484.
    Citations: 3     Fields:    Translation:Humans
  21. Ang YS, Kaiser R, Deckersbach T, Almeida J, Phillips ML, Chase HW, Webb CA, Parsey R, Fava M, McGrath P, Weissman M, Adams P, Deldin P, Oquendo MA, McInnis MG, Carmody T, Bruder G, Cooper CM, Chin Fatt CR, Trivedi MH, Pizzagalli DA. Pretreatment Reward Sensitivity and Frontostriatal Resting-State Functional Connectivity Are Associated With Response to Bupropion After Sertraline Nonresponse. Biol Psychiatry. 2020 10 15; 88(8):657-667. PMID: 32507389.
    Citations: 7     Fields:    Translation:Humans
  22. Webb CA, Cohen ZD, Beard C, Forgeard M, Peckham AD, Björgvinsson T. Personalized prognostic prediction of treatment outcome for depressed patients in a naturalistic psychiatric hospital setting: A comparison of machine learning approaches. J Consult Clin Psychol. 2020 Jan; 88(1):25-38. PMID: 31841022.
    Citations: 13     Fields:    Translation:Humans
  23. Lawlor VM, Webb CA, Wiecki TV, Frank MJ, Trivedi M, Pizzagalli DA, Dillon DG. Dissecting the impact of depression on decision-making. Psychol Med. 2020 07; 50(10):1613-1622. PMID: 31280757.
    Citations: 7     Fields:    Translation:Humans
  24. Webb CA, Stanton CH, Bondy E, Singleton P, Pizzagalli DA, Auerbach RP. Cognitive versus behavioral skills in CBT for depressed adolescents: Disaggregating within-patient versus between-patient effects on symptom change. J Consult Clin Psychol. 2019 May; 87(5):484-490. PMID: 30998049.
    Citations: 2     Fields:    Translation:Humans
  25. Whitton AE, Webb CA, Dillon DG, Kayser J, Rutherford A, Goer F, Fava M, McGrath P, Weissman M, Parsey R, Adams P, Trombello JM, Cooper C, Deldin P, Oquendo MA, McInnis MG, Carmody T, Bruder G, Trivedi MH, Pizzagalli DA. Pretreatment Rostral Anterior Cingulate Cortex Connectivity With Salience Network Predicts Depression Recovery: Findings From the EMBARC Randomized Clinical Trial. Biol Psychiatry. 2019 05 15; 85(10):872-880. PMID: 30718038.
    Citations: 15     Fields:    Translation:Humans
  26. Liao A, Walker R, Carmody TJ, Cooper C, Shaw MA, Grannemann BD, Adams P, Bruder GE, McInnis MG, Webb CA, Dillon DG, Pizzagalli DA, Phillips ML, Kurian BT, Fava M, Parsey RV, McGrath PJ, Weissman MM, Trivedi MH. Anxiety and anhedonia in depression: Associations with neuroticism and cognitive control. J Affect Disord. 2019 02 15; 245:1070-1078. PMID: 30699849; PMCID: PMC9667857.
    Citations: 4     Fields:    Translation:Humans
  27. Trivedi MH, South C, Jha MK, Rush AJ, Cao J, Kurian B, Phillips M, Pizzagalli DA, Trombello JM, Oquendo MA, Cooper C, Dillon DG, Webb C, Grannemann BD, Bruder G, McGrath PJ, Parsey R, Weissman M, Fava M. A Novel Strategy to Identify Placebo Responders: Prediction Index of Clinical and Biological Markers in the EMBARC Trial. Psychother Psychosom. 2018; 87(5):285-295. PMID: 30110685; PMCID: PMC9764260.
    Citations: 10     Fields:    Translation:Humans
  28. Webb CA, Trivedi MH, Cohen ZD, Dillon DG, Fournier JC, Goer F, Fava M, McGrath PJ, Weissman M, Parsey R, Adams P, Trombello JM, Cooper C, Deldin P, Oquendo MA, McInnis MG, Huys Q, Bruder G, Kurian BT, Jha M, DeRubeis RJ, Pizzagalli DA. Personalized prediction of antidepressant v. placebo response: evidence from the EMBARC study. Psychol Med. 2019 05; 49(7):1118-1127. PMID: 29962359.
    Citations: 27     Fields:    Translation:Humans
  29. Pizzagalli DA, Webb CA, Dillon DG, Tenke CE, Kayser J, Goer F, Fava M, McGrath P, Weissman M, Parsey R, Adams P, Trombello J, Cooper C, Deldin P, Oquendo MA, McInnis MG, Carmody T, Bruder G, Trivedi MH. Pretreatment Rostral Anterior Cingulate Cortex Theta Activity in Relation to Symptom Improvement in Depression: A Randomized Clinical Trial. JAMA Psychiatry. 2018 06 01; 75(6):547-554. PMID: 29641834; PMCID: PMC6083825.
    Citations: 44     Fields:    Translation:Humans
  30. Trombello JM, Pizzagalli DA, Weissman MM, Grannemann BD, Cooper CM, Greer TL, Malchow AL, Jha MK, Carmody TJ, Kurian BT, Webb CA, Dillon DG, McGrath PJ, Bruder G, Fava M, Parsey RV, McInnis MG, Adams P, Trivedi MH. Characterizing anxiety subtypes and the relationship to behavioral phenotyping in major depression: Results from the EMBARC study. J Psychiatr Res. 2018 07; 102:207-215. PMID: 29689518.
    Citations: 2     Fields:    Translation:Humans
  31. Webb CA, Olson EA, Killgore WDS, Pizzagalli DA, Rauch SL, Rosso IM. Rostral Anterior Cingulate Cortex Morphology Predicts Treatment Response to Internet-Based Cognitive Behavioral Therapy for Depression. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 03; 3(3):255-262. PMID: 29486867.
    Citations: 10     Fields:    Translation:Humans
  32. Webb CA, Rosso IM, Rauch SL. Internet-Based Cognitive-Behavioral Therapy for Depression: Current Progress and Future Directions. Harv Rev Psychiatry. 2017 May/Jun; 25(3):114-122. PMID: 28475503.
    Citations: 41     Fields:    Translation:Humans
  33. Tenke CE, Kayser J, Pechtel P, Webb CA, Dillon DG, Goer F, Murray L, Deldin P, Kurian BT, McGrath PJ, Parsey R, Trivedi M, Fava M, Weissman MM, McInnis M, Abraham K, E Alvarenga J, Alschuler DM, Cooper C, Pizzagalli DA, Bruder GE. Demonstrating test-retest reliability of electrophysiological measures for healthy adults in a multisite study of biomarkers of antidepressant treatment response. Psychophysiology. 2017 01; 54(1):34-50. PMID: 28000259.
    Citations: 21     Fields:    Translation:Humans
  34. Rosso IM, Killgore WD, Olson EA, Webb CA, Fukunaga R, Auerbach RP, Gogel H, Buchholz JL, Rauch SL. Internet-based cognitive behavior therapy for major depressive disorder: A randomized controlled trial. Depress Anxiety. 2017 03; 34(3):236-245. PMID: 28009467.
    Citations: 13     Fields:    Translation:Humans
  35. Webb CA, Auerbach RP, Bondy E, Stanton CH, Foti D, Pizzagalli DA. Abnormal neural responses to feedback in depressed adolescents. J Abnorm Psychol. 2017 Jan; 126(1):19-31. PMID: 27935729.
    Citations: 27     Fields:    Translation:Humans
  36. Auerbach RP, Bondy E, Stanton CH, Webb CA, Shankman SA, Pizzagalli DA. Self-referential processing in adolescents: Stability of behavioral and ERP markers. Psychophysiology. 2016 09; 53(9):1398-406. PMID: 27302282.
    Citations: 14     Fields:    Translation:Humans
  37. Webb CA, Beard C, Kertz SJ, Hsu KJ, Björgvinsson T. Differential role of CBT skills, DBT skills and psychological flexibility in predicting depressive versus anxiety symptom improvement. Behav Res Ther. 2016 06; 81:12-20. PMID: 27057997.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  38. Keefe JR, Webb CA, DeRubeis RJ. In cognitive therapy for depression, early focus on maladaptive beliefs may be especially efficacious for patients with personality disorders. J Consult Clin Psychol. 2016 Apr; 84(4):353-64. PMID: 26727410.
    Citations: 9     Fields:    Translation:Humans
  39. Rosmarin DH, Forester BP, Shassian DM, Webb CA, Björgvinsson T. Interest in spiritually integrated psychotherapy among acute psychiatric patients. J Consult Clin Psychol. 2015 Dec; 83(6):1149-53. PMID: 26280491.
    Citations: 2     Fields:    Translation:Humans
  40. Webb CA, Dillon DG, Pechtel P, Goer FK, Murray L, Huys QJ, Fava M, McGrath PJ, Weissman M, Parsey R, Kurian BT, Adams P, Weyandt S, Trombello JM, Grannemann B, Cooper CM, Deldin P, Tenke C, Trivedi M, Bruder G, Pizzagalli DA. Neural Correlates of Three Promising Endophenotypes of Depression: Evidence from the EMBARC Study. Neuropsychopharmacology. 2016 Jan; 41(2):454-63. PMID: 26068725.
    Citations: 42     Fields:    Translation:HumansCTClinical Trials
  41. Webb CA, Beard C, Auerbach RP, Menninger E, Björgvinsson T. The therapeutic alliance in a naturalistic psychiatric setting: temporal relations with depressive symptom change. Behav Res Ther. 2014 Oct; 61:70-7. PMID: 25156322.
    Citations: 4     Fields:    Translation:Humans
  42. Webb CA, DelDonno S, Killgore WD. The role of cognitive versus emotional intelligence in Iowa Gambling Task performance: What's emotion got to do with it? Intelligence. 2014 May-June; 44:112-119. PMID: 25635149.
    Citations: 20     
  43. Webb CA, Weber M, Mundy EA, Killgore WD. Reduced gray matter volume in the anterior cingulate, orbitofrontal cortex and thalamus as a function of mild depressive symptoms: a voxel-based morphometric analysis. Psychol Med. 2014 Oct; 44(13):2833-43. PMID: 25066703.
    Citations: 42     Fields:    Translation:Humans
  44. Lorenzo-Luaces L, DeRubeis RJ, Webb CA. Client characteristics as moderators of the relation between the therapeutic alliance and outcome in cognitive therapy for depression. J Consult Clin Psychol. 2014 Apr; 82(2):368-73. PMID: 24547921.
    Citations: 11     Fields:    Translation:Humans
  45. Webb CA, Derubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC. Convergence and divergence in the delivery of cognitive therapy in two randomized clinical trials. Behav Res Ther. 2013 Aug; 51(8):493-8. PMID: 23792178.
    Citations: 3     Fields:    Translation:Humans
  46. Weber M, Webb CA, Deldonno SR, Kipman M, Schwab ZJ, Weiner MR, Killgore WD. Habitual 'sleep credit' is associated with greater grey matter volume of the medial prefrontal cortex, higher emotional intelligence and better mental health. J Sleep Res. 2013 Oct; 22(5):527-34. PMID: 23593990.
    Citations: 13     Fields:    Translation:HumansCells
  47. Webb CA, Kertz SJ, Bigda-Peyton JS, Björgvinsson T. The role of pretreatment outcome expectancies and cognitive-behavioral skills in symptom improvement in an acute psychiatric setting. J Affect Disord. 2013 Jul; 149(1-3):375-82. PMID: 23489399.
    Citations: 7     Fields:    Translation:Humans
  48. Killgore WD, Weber M, Schwab ZJ, Kipman M, DelDonno SR, Webb CA, Rauch SL. Cortico-limbic responsiveness to high-calorie food images predicts weight status among women. Int J Obes (Lond). 2013 Nov; 37(11):1435-42. PMID: 23459322.
    Citations: 10     Fields:    Translation:Humans
  49. Killgore WD, Schwab ZJ, Tkachenko O, Webb CA, DelDonno SR, Kipman M, Rauch SL, Weber M. Emotional intelligence correlates with functional responses to dynamic changes in facial trustworthiness. Soc Neurosci. 2013; 8(4):334-46. PMID: 23802123.
    Citations: 12     Fields:    Translation:Humans
  50. Webb CA, Auerbach RP, Derubeis RJ. Processes of change in CBT of adolescent depression: review and recommendations. J Clin Child Adolesc Psychol. 2012; 41(5):654-65. PMID: 22867130.
    Citations: 16     Fields:    Translation:Humans
  51. Webb CA, Derubeis RJ, Dimidjian S, Hollon SD, Amsterdam JD, Shelton RC. Predictors of patient cognitive therapy skills and symptom change in two randomized clinical trials: the role of therapist adherence and the therapeutic alliance. J Consult Clin Psychol. 2012 Jun; 80(3):373-81. PMID: 22468907.
    Citations: 13     Fields:    Translation:Humans
  52. Webb CA, DeRubeis RJ, Amsterdam JD, Shelton RC, Hollon SD, Dimidjian S. Two aspects of the therapeutic alliance: differential relations with depressive symptom change. J Consult Clin Psychol. 2011 Jun; 79(3):279-83. PMID: 21480694.
    Citations: 29     Fields:    Translation:Humans
  53. Auerbach RP, Bigda-Peyton JS, Eberhart NK, Webb CA, Ho MH. Conceptualizing the prospective relationship between social support, stress, and depressive symptoms among adolescents. J Abnorm Child Psychol. 2011 May; 39(4):475-87. PMID: 21188628.
    Citations: 58     Fields:    Translation:Humans
  54. Webb CA, Derubeis RJ, Barber JP. Therapist adherence/competence and treatment outcome: A meta-analytic review. J Consult Clin Psychol. 2010 Apr; 78(2):200-11. PMID: 20350031.
    Citations: 130     Fields:    Translation:Humans
  55. Abela JR, Webb CA, Wagner C, Ho MH, Adams P. The role of self-criticism, dependency, and hassles in the course of depressive illness: a multiwave longitudinal study. Pers Soc Psychol Bull. 2006 Mar; 32(3):328-38. PMID: 16455860.
    Citations: 9     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.