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Joseph Jordan Romano, D.O.

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selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Haile PA, Casillas LN, Bury MJ, Mehlmann JF, Singhaus R, Charnley AK, Hughes TV, DeMartino MP, Wang GZ, Romano JJ, Dong X, Plotnikov NV, Lakdawala AS, Duraiswami C, Convery MA, Votta BJ, Lipshutz DB, Desai BM, Swift B, Capriotti CA, Berger SB, Mahajan MK, Reilly MA, Rivera EJ, Sun HH, Nagilla R, LePage C, Ouellette MT, Totoritis RD, Donovan BT, Brown BS, Chaudhary KW, Gough PJ, Bertin J, Marquis RW. Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel. ACS Med Chem Lett. 2020 Jun 11; 11(6):1353. PMID: 32551024; PMCID: PMC7294718.
    Citations:    
  2. Haile PA, Casillas LN, Votta BJ, Wang GZ, Charnley AK, Dong X, Bury MJ, Romano JJ, Mehlmann JF, King BW, Erhard KF, Hanning CR, Lipshutz DB, Desai BM, Capriotti CA, Schaeffer MC, Berger SB, Mahajan MK, Reilly MA, Nagilla R, Rivera EJ, Sun HH, Kenna JK, Beal AM, Ouellette MT, Kelly M, Stemp G, Convery MA, Vossenkämper A, MacDonald TT, Gough PJ, Bertin J, Marquis RW. Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases. J Med Chem. 2019 07 25; 62(14):6482-6494. PMID: 31265286.
    Citations: 8     Fields:    Translation:HumansAnimals
  3. Haile PA, Casillas LN, Bury MJ, Mehlmann JF, Singhaus R, Charnley AK, Hughes TV, DeMartino MP, Wang GZ, Romano JJ, Dong X, Plotnikov NV, Lakdawala AS, Convery MA, Votta BJ, Lipshutz DB, Desai BM, Swift B, Capriotti CA, Berger SB, Mahajan MK, Reilly MA, Rivera EJ, Sun HH, Nagilla R, LePage C, Ouellette MT, Totoritis RD, Donovan BT, Brown BS, Chaudhary KW, Gough PJ, Bertin J, Marquis RW. Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel. ACS Med Chem Lett. 2018 Oct 11; 9(10):1039-1044. PMID: 30344914; PMCID: PMC6187414.
    Citations: 7     
  4. Rudd MT, Butcher JW, Nguyen KT, McIntyre CJ, Romano JJ, Gilbert KF, Bush KJ, Liverton NJ, Holloway MK, Harper S, Ferrara M, DiFilippo M, Summa V, Swestock J, Fritzen J, Carroll SS, Burlein C, DiMuzio JM, Gates A, Graham DJ, Huang Q, McClain S, McHale C, Stahlhut MW, Black S, Chase R, Soriano A, Fandozzi CM, Taylor A, Trainor N, Olsen DB, Coleman PJ, Ludmerer SW, McCauley JA. P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325. ChemMedChem. 2015 Apr; 10(4):727-35. PMID: 25759009.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  5. Rudd MT, McIntyre CJ, Romano JJ, Butcher JW, Holloway MK, Bush K, Nguyen KT, Gilbert KF, Lyle TA, Liverton NJ, Wan BL, Summa V, Harper S, Rowley M, Vacca JP, Carroll SS, Burlein C, DiMuzio JM, Gates A, Graham DJ, Huang Q, Ludmerer SW, McClain S, McHale C, Stahlhut M, Fandozzi C, Taylor A, Trainor N, Olsen DB, McCauley JA. Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers. Bioorg Med Chem Lett. 2012 Dec 01; 22(23):7207-13. PMID: 23084906.
    Citations:    Fields:    Translation:AnimalsCells
  6. Rudd MT, McCauley JA, Romano JJ, Butcher JW, Bush K, McIntyre CJ, Nguyen KT, Gilbert KF, Lyle TA, Holloway MK, Wan BL, Vacca JP, Summa V, Harper S, Rowley M, Carroll SS, Burlein C, DiMuzio JM, Gates A, Graham DJ, Huang Q, Ludmerer SW, McClain S, McHale C, Stahlhut M, Fandozzi C, Taylor A, Trainor N, Olsen DB, Liverton NJ. Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease. Bioorg Med Chem Lett. 2012 Dec 01; 22(23):7201-6. PMID: 23021993.
    Citations:    Fields:    Translation:AnimalsCells
  7. Sethi HS, Lam BL, Romano JG. Reversible prolonged bilateral inferior altitudinal visual field defects associated with migraine. J Neuroophthalmol. 2012 Sep; 32(3):252-5. PMID: 22418086.
    Citations: 2     Fields:    Translation:Humans
  8. Romano JG, Liebeskind DS. Revascularization of collaterals for hemodynamic stroke: insight on pathophysiology from the carotid occlusion surgery study. Stroke. 2012 Jul; 43(7):1988-91. PMID: 22649169.
    Citations: 3     Fields:    Translation:Humans
  9. Haussen DC, Katsnelson M, Rodriguez A, Campo N, Campo-Bustillo I, Romano JG, Koch S. Moderate correlation between breath-holding and CO(2) inhalation/hyperventilation methods for transcranial doppler evaluation of cerebral vasoreactivity. J Clin Ultrasound. 2012 Nov-Dec; 40(9):554-8. PMID: 22638984.
    Citations:    Fields:    Translation:Humans
  10. Harper S, McCauley JA, Rudd MT, Ferrara M, DiFilippo M, Crescenzi B, Koch U, Petrocchi A, Holloway MK, Butcher JW, Romano JJ, Bush KJ, Gilbert KF, McIntyre CJ, Nguyen KT, Nizi E, Carroll SS, Ludmerer SW, Burlein C, DiMuzio JM, Graham DJ, McHale CM, Stahlhut MW, Olsen DB, Monteagudo E, Cianetti S, Giuliano C, Pucci V, Trainor N, Fandozzi CM, Rowley M, Coleman PJ, Vacca JP, Summa V, Liverton NJ. Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor. ACS Med Chem Lett. 2012 Apr 12; 3(4):332-6. PMID: 24900473.
    Citations: 50     
  11. Koch S, Gupta R, McClendon MS, Romano JG. Racial-ethnic differences in lacunar infarction in a multiethnic stroke population. J Stroke Cerebrovasc Dis. 2013 Feb; 22(2):107-12. PMID: 21821432.
    Citations: 5     Fields:    Translation:Humans
  12. Forteza A, Romano JG, Campo-Bustillo I, Campo N, Haussen DC, Gutierrez J, Koch S. High-dose atorvastatin enhances impaired cerebral vasomotor reactivity. J Stroke Cerebrovasc Dis. 2012 Aug; 21(6):487-92. PMID: 21334223.
    Citations: 10     Fields:    Translation:Humans
  13. Rudd MT, McCauley JA, Butcher JW, Romano JJ, McIntyre CJ, Nguyen KT, Gilbert KF, Bush KJ, Holloway MK, Swestock J, Wan BL, Carroll SS, DiMuzio JM, Graham DJ, Ludmerer SW, Stahlhut MW, Fandozzi CM, Trainor N, Olsen DB, Vacca JP, Liverton NJ. Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure. ACS Med Chem Lett. 2011 Mar 10; 2(3):207-12. PMID: 24900304.
    Citations: 3     
  14. McCauley JA, McIntyre CJ, Rudd MT, Nguyen KT, Romano JJ, Butcher JW, Gilbert KF, Bush KJ, Holloway MK, Swestock J, Wan BL, Carroll SS, DiMuzio JM, Graham DJ, Ludmerer SW, Mao SS, Stahlhut MW, Fandozzi CM, Trainor N, Olsen DB, Vacca JP, Liverton NJ. Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor. J Med Chem. 2010 Mar 25; 53(6):2443-63. PMID: 20163176.
    Citations: 29     Fields:    Translation:AnimalsCells
  15. McIntyre CJ, McCauley JA, Bednar B, Bednar RA, Butcher JW, Claremon DA, Cunningham ME, Freidinger RM, Gaul SL, Homnick CF, Koblan KS, Mosser SD, Romano JJ, Liverton NJ. Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists. Bioorg Med Chem Lett. 2009 Sep 01; 19(17):5132-5. PMID: 19648007.
    Citations: 3     Fields:    Translation:HumansCells
  16. Romano JG. Progress in rehabilitation of hemianopic visual field defects. Cerebrovasc Dis. 2009; 27 Suppl 1:187-90. PMID: 19342850.
    Citations: 9     Fields:    Translation:Humans
  17. Koch S, Romano JG, Park H, Amir M, Forteza AM. Ultrasound velocity criteria for vertebral origin stenosis. J Neuroimaging. 2009 Jul; 19(3):242-5. PMID: 18681927.
    Citations: 5     Fields:    Translation:Humans
  18. Romano JG, Rabinstein AA, Arheart KL, Nathan S, Campo-Bustillo I, Koch S, Forteza AM. Microemboli in aneurysmal subarachnoid hemorrhage. J Neuroimaging. 2008 Oct; 18(4):396-401. PMID: 18494776.
    Citations: 17     Fields:    Translation:Humans
  19. Romano JG, Sacco RL. Progress in secondary stroke prevention. Ann Neurol. 2008 Apr; 63(4):418-27. PMID: 18438951.
    Citations: 2     Fields:    Translation:HumansAnimalsPHPublic Health
  20. Liverton NJ, Holloway MK, McCauley JA, Rudd MT, Butcher JW, Carroll SS, DiMuzio J, Fandozzi C, Gilbert KF, Mao SS, McIntyre CJ, Nguyen KT, Romano JJ, Stahlhut M, Wan BL, Olsen DB, Vacca JP. Molecular modeling based approach to potent P2-P4 macrocyclic inhibitors of hepatitis C NS3/4A protease. J Am Chem Soc. 2008 Apr 09; 130(14):4607-9. PMID: 18338894.
    Citations: 21     Fields:    Translation:AnimalsCells
  21. Koch S, Romano JG, Forteza AM, Otero CM, Rabinstein AA. Rapid blood pressure reduction in acute intracerebral hemorrhage: feasibility and safety. Neurocrit Care. 2008; 8(3):316-21. PMID: 18360781.
    Citations: 26     Fields:    Translation:Humans
  22. McCauley JA, Rudd MT, Nguyen KT, McIntyre CJ, Romano JJ, Bush KJ, Varga SL, Ross CW, Carroll SS, DiMuzio J, Stahlhut MW, Olsen DB, Lyle TA, Vacca JP, Liverton NJ. Bismacrocyclic inhibitors of hepatitis C NS3/4a protease. Angew Chem Int Ed Engl. 2008; 47(47):9104-7. PMID: 18925594.
    Citations: 1     Fields:    Translation:Cells
  23. Romano JG, Muller N, Merino JG, Forteza AM, Koch S, Rabinstein AA. In-hospital delays to stroke thrombolysis: paradoxical effect of early arrival. Neurol Res. 2007 Oct; 29(7):664-6. PMID: 18173904.
    Citations: 11     Fields:    Translation:Humans
  24. Koch S, Forteza A, Lavernia C, Romano JG, Campo N, Bhatia R, Campo-Bustillo I. MR imaging after hip and knee replacement. J Neuroimaging. 2007 Oct; 17(4):332-5. PMID: 17894622.
    Citations:    Fields:    Translation:Humans
  25. Koch S, Zuniga S, Rabinstein AA, Romano JG, Nolan B, Chirinos J, Forteza A. Signs and symptoms of sleep apnea and acute stroke severity: is sleep apnea neuroprotective? J Stroke Cerebrovasc Dis. 2007 May-Jun; 16(3):114-8. PMID: 17689405.
    Citations: 5     Fields:    Translation:Humans
  26. Ortiz G, Koch S, Romano JG, Forteza AM, Rabinstein AA. Mechanisms of ischemic stroke in HIV-infected patients. Neurology. 2007 Apr 17; 68(16):1257-61. PMID: 17438215.
    Citations: 56     Fields:    Translation:Humans
  27. Koch S, Forteza A, Lavernia C, Romano JG, Campo-Bustillo I, Campo N, Gold S. Cerebral fat microembolism and cognitive decline after hip and knee replacement. Stroke. 2007 Mar; 38(3):1079-81. PMID: 17255544.
    Citations: 20     Fields:    Translation:Humans
  28. Koch S, Pabon D, Rabinstein AA, Chirinos J, Romano JG, Forteza A. Stroke etiology among Haitians living in Miami. Neuroepidemiology. 2005; 25(4):192-5. PMID: 16103730.
    Citations: 5     Fields:    Translation:Humans
  29. Koch S, Amir M, Rabinstein AA, Reyes-Iglesias Y, Romano JG, Forteza A. Diffusion-weighted magnetic resonance imaging in symptomatic vertebrobasilar atherosclerosis and dissection. Arch Neurol. 2005 Aug; 62(8):1228-31. PMID: 16087763.
    Citations: 10     Fields:    Translation:Humans
  30. Rabinstein AA, Giovanelli C, Romano JG, Koch S, Forteza AM, Ricci M. Surgical treatment of nonbacterial thrombotic endocarditis presenting with stroke. J Neurol. 2005 Mar; 252(3):352-5. PMID: 15726268.
    Citations: 16     Fields:    Translation:Humans
  31. McCauley JA, Theberge CR, Romano JJ, Billings SB, Anderson KD, Claremon DA, Freidinger RM, Bednar RA, Mosser SD, Gaul SL, Connolly TM, Condra CL, Xia M, Cunningham ME, Bednar B, Stump GL, Lynch JJ, Macaulay A, Wafford KA, Koblan KS, Liverton NJ. NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 08; 47(8):2089-96. PMID: 15056006.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  32. Rabinstein AA, Romano JG, Forteza AM, Koch S. Rapidly progressive dementia due to bilateral internal carotid artery occlusion with infarction of the total length of the corpus callosum. J Neuroimaging. 2004 Apr; 14(2):176-9. PMID: 15095565.
    Citations: 4     Fields:    Translation:Humans
  33. Koch S, Rabinstein AA, Romano JG, Forteza A. Diffusion-weighted magnetic resonance imaging in internal carotid artery dissection. Arch Neurol. 2004 Apr; 61(4):510-2. PMID: 15096398.
    Citations: 2     Fields:    Translation:Humans
  34. Koch S, Concha M, Wazzan T, Romano JG, Forteza A. High dose human serum albumin for the treatment of acute ischemic stroke: a safety study. Neurocrit Care. 2004; 1(3):335-41. PMID: 16174931.
    Citations: 4     Fields:    Translation:Humans
  35. Brozman B, Romano JG, Tusa RJ, Forteza AM. Postural vertigo and impaired vasoreflexes caused by a posterior inferior cerebellar artery infarct. Neurology. 2002 Nov 12; 59(9):1469-70. PMID: 12427912.
    Citations: 2     Fields:    Translation:Humans
  36. Romano JG, Forteza AM, Concha M, Koch S, Heros RC, Morcos JJ, Babikian VL. Detection of microemboli by transcranial Doppler ultrasonography in aneurysmal subarachnoid hemorrhage. Neurosurgery. 2002 May; 50(5):1026-30; discussion 1030-1. PMID: 11950405.
    Citations: 27     Fields:    Translation:Humans
  37. Koch S, Romano JG, Forteza A. Subclavian steal and a persistent trigeminal artery. J Neuroimaging. 2002 Apr; 12(2):190-2. PMID: 11977918.
    Citations: 3     Fields:    Translation:Humans
  38. Forteza AM, Rabinstein A, Koch S, Zych G, Chandar J, Romano JG, Bustillo IC. Endovascular closure of a patent foramen ovale in the fat embolism syndrome: changes in the embolic patterns as detected by transcranial Doppler. Arch Neurol. 2002 Mar; 59(3):455-9. PMID: 11890852.
    Citations: 4     Fields:    Translation:Humans
  39. Forteza AM, Brozman B, Rabinstein AA, Romano JG, Bradley WG. Acetazolamide for the treatment of migraine with aura in CADASIL. Neurology. 2001 Dec 11; 57(11):2144-5. PMID: 11739850.
    Citations: 11     Fields:    Translation:Humans
  40. Koch S, Romano JG, Bustillo IC, Concha M, Forteza AM. Anticoagulation and microembolus detection in a case of internal carotid artery dissection. J Neuroimaging. 2001 Jan; 11(1):63-6. PMID: 11198532.
    Citations: 3     Fields:    Translation:Humans
  41. Forteza AM, Koch S, Romano JG, Babikian VL. [Detection of microembolus with transcranial doppler]. Rev Neurol. 2000 Dec 1-15; 31(11):1046-53. PMID: 11190873.
    Citations: 1     Fields:    Translation:Humans
  42. Forteza AM, Koch S, Romano JG, Zych G, Bustillo IC, Duncan RC, Babikian VL. Transcranial doppler detection of fat emboli. Stroke. 1999 Dec; 30(12):2687-91. PMID: 10582998.
    Citations: 8     Fields:    Translation:Humans
  43. Strasser S, Forteza AM, Romano JG. Transcranial sonography in a patient with a persistent trigeminal artery. J Neuroimaging. 1999 Oct; 9(4):236-8. PMID: 10540605.
    Citations:    Fields:    Translation:Humans
  44. Rotta FT, Romano JG. Skull base metastases causing acute bilateral hypoglossal nerve palsy. J Neurol Sci. 1997 May 01; 148(1):127-9. PMID: 9125401.
    Citations: 4     Fields:    Translation:Humans
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