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Daniel Patrick Kelly, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL128349 (KELLY, DANIEL PATRICK) Apr 1, 2016 - Mar 31, 2020
    NIH/NHLBI
    Probing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing Heart
    Role: Principal Investigator
  2. R24DK092781 (KELLY, DANIEL PATRICK) Sep 6, 2011 - Aug 31, 2013
    NIH/NIDDK
    An interdisciplinary approach to elucidate mechanisms of muscle lipotoxicity
    Role: Co-Principal Investigator
  3. R01HL101189 (KELLY, DANIEL PATRICK) Apr 15, 2010 - Mar 31, 2014
    NIH/NHLBI
    A Genomic/Metabolomic Strategy to Characterize Cardiac Mitochondrial Dysfunction
    Role: Principal Investigator
  4. R24DK084969 (BODMER, ROLF) Jan 12, 2010 - Dec 31, 2011
    NIH/NIDDK
    Probing the adipocyte-myocyte axis: An Interdisciplinary Approach
    Role: Co-Principal Investigator
  5. P50HL077113 (KELLY, DANIEL PATRICK) Feb 22, 2005 - Dec 31, 2009
    NIH/NHLBI
    SCCOR in Cardiac Dysfunction and Disease
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM. Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics. Cell Rep. 2019 Feb 05; 26(6):1557-1572.e8. PMID: 30726738.
    Citations:    
  2. Horton JL, Davidson MT, Kurishima C, Vega RB, Powers JC, Matsuura TR, Petucci C, Lewandowski ED, Crawford PA, Muoio DM, Recchia FA, Kelly DP. The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense. JCI Insight. 2019 Jan 22. PMID: 30668551.
    Citations:    Fields:    
  3. Liu X, Zhang SM, McGeary MK, Krykbaeva I, Lai L, Jansen DJ, Kales SC, Simeonov A, Hall MD, Kelly DP, Bosenberg MW, Yan Q. KDM5B Promotes Drug Resistance by Regulating Melanoma Propagating Cell Subpopulations. Mol Cancer Ther. 2018 Dec 06. PMID: 30523048.
    Citations:    Fields:    
  4. Barch DM, Whalen D, Gilbert K, Kelly D, Kappenman ES, Hajcak G, Luby JL. Neural Indicators of Anhedonia: Predictors and Mechanisms of Treatment Change in a Randomized Clinical Trial in Early Childhood Depression. Biol Psychiatry. 2018 Dec 04. PMID: 30583852.
    Citations:    Fields:    
  5. Tamura N, Maejima Y, Matsumura T, Vega RB, Amiya E, Ito Y, Shiheido-Watanabe Y, Ashikaga T, Komuro I, Kelly DP, Hirao K, Isobe M. Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis. Circ Genom Precis Med. 2018 Oct; 11(10):e002296. PMID: 30354298.
    Citations:    
  6. Maurya SK, Herrera JL, Sahoo SK, Reis FCG, Vega RB, Kelly DP, Periasamy M. Sarcolipin Signaling Promotes Mitochondrial Biogenesis and Oxidative Metabolism in Skeletal Muscle. Cell Rep. 2018 Sep 11; 24(11):2919-2931. PMID: 30208317.
    Citations: 1     Fields:    
  7. Zhang X, Trevino MB, Wang M, Gardell SJ, Ayala JE, Han X, Kelly DP, Goodpaster BH, Vega RB, Coen PM. Impaired Mitochondrial Energetics Characterize Poor Early Recovery of Muscle Mass Following Hind Limb Unloading in Old Mice. J Gerontol A Biol Sci Med Sci. 2018 Sep 11; 73(10):1313-1322. PMID: 29562317.
    Citations:    Fields:    
  8. Gan Z, Fu T, Kelly DP, Vega RB. Skeletal muscle mitochondrial remodeling in exercise and diseases. Cell Res. 2018 Oct; 28(10):969-980. PMID: 30108290.
    Citations:    Fields:    
  9. Mann DL, Kelly DP. Empagliflozin and the Prevention of Heart Failure: Will Reverse Translation Lead to New Paradigms for the Treatment of Heart Failure? JACC Basic Transl Sci. 2017 Aug; 2(4):355-357. PMID: 30062156.
    Citations:    
  10. Vega RB, Konhilas JP, Kelly DP, Leinwand LA. Molecular Mechanisms Underlying Cardiac Adaptation to Exercise. Cell Metab. 2017 May 02; 25(5):1012-1026. PMID: 28467921.
    Citations: 9     Fields:    Translation:HumansAnimals
  11. Agulnik A, Kelly DP, Bruccoleri R, Yuskaitis C, Ebrahimi-Fakhari D, Sahin M, Burns MM, Kohane DS. Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose. Pediatrics. 2017 May; 139(5). PMID: 28557718.
    Citations:    Fields:    Translation:HumansPHPublic Health
  12. Lee S, Leone TC, Rogosa L, Rumsey J, Ayala J, Coen PM, Fitts RH, Vega RB, Kelly DP. Skeletal muscle PGC-1ß signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice. Am J Physiol Endocrinol Metab. 2017 05 01; 312(5):E394-E406. PMID: 28270443.
    Citations: 3     Fields:    Translation:Animals
  13. Vega RB, Kelly DP. Cardiac nuclear receptors: architects of mitochondrial structure and function. J Clin Invest. 2017 Apr 03; 127(4):1155-1164. PMID: 28192373.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  14. Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu J, Kong Y, Xie H, Yi F, Lai L, Vega RB, Kelly DP, Smith SR, Gan Z. Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle. J Biol Chem. 2016 Dec 02; 291(49):25306-25318. PMID: 27738103.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  15. Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega RB, Zhu MS, Kelly DP, Gao X, Gan Z. Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO Mol Med. 2016 10; 8(10):1212-1228. PMID: 27506764.
    Citations: 6     Fields:    Translation:AnimalsCells
  16. Muszynski JA, Spinella PC, Cholette JM, Acker JP, Hall MW, Juffermans NP, Kelly DP, Blumberg N, Nicol K, Liedel J, Doctor A, Remy KE, Tucci M, Lacroix J, Norris PJ. Transfusion-related immunomodulation: review of the literature and implications for pediatric critical illness. Transfusion. 2017 01; 57(1):195-206. PMID: 27696473.
    Citations: 16     Fields:    Translation:Humans
  17. Ahn B, Soundarapandian MM, Sessions H, Peddibhotla S, Roth GP, Li JL, Sugarman E, Koo A, Malany S, Wang M, Yea K, Brooks J, Leone TC, Han X, Vega RB, Kelly DP. MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest. 2016 09 01; 126(9):3567-79. PMID: 27500491.
    Citations: 1     Fields:    Translation:AnimalsCells
  18. Kelly DP, Bairdain S, Zurakowski D, Dodson B, Harney KM, Jennings RW, Trenor CC. Quality improvement program reduces venous thromboembolism in infants and children with long-gap esophageal atresia (LGEA). Pediatr Surg Int. 2016 Jul; 32(7):691-6. PMID: 27262479.
    Citations:    Fields:    Translation:Humans
  19. Horton JL, Martin OJ, Lai L, Riley NM, Richards AL, Vega RB, Leone TC, Pagliarini DJ, Muoio DM, Bedi KC, Margulies KB, Coon JJ, Kelly DP. Mitochondrial protein hyperacetylation in the failing heart. JCI Insight. 2016 Feb; 2(1). PMID: 26998524.
    Citations: 15     Fields:    
  20. Mann DL, Annex BH, Bishopric NH, Force T, Kelly DP, Libby P, Roberts R, van Rooij E, Tomaselli G, Newby LK. Introducing JACC: Basic to Translational Science: Why Now? JACC Basic Transl Sci. 2016 Jan-Feb; 1(1-2):1-2. PMID: 30167503.
    Citations:    
  21. Aubert G, Martin OJ, Horton JL, Lai L, Vega RB, Leone TC, Koves T, Gardell SJ, Krüger M, Hoppel CL, Lewandowski ED, Crawford PA, Muoio DM, Kelly DP. The Failing Heart Relies on Ketone Bodies as a Fuel. Circulation. 2016 Feb 23; 133(8):698-705. PMID: 26819376.
    Citations: 41     Fields:    Translation:Animals
  22. Gong G, Song M, Csordas G, Kelly DP, Matkovich SJ, Dorn GW. Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science. 2015 Dec 04; 350(6265):aad2459. PMID: 26785495; PMCID: PMC4747105.
    Citations: 50     Fields:    Translation:AnimalsCells
  23. Dorn GW, Vega RB, Kelly DP. Mitochondrial biogenesis and dynamics in the developing and diseased heart. Genes Dev. 2015 Oct 01; 29(19):1981-91. PMID: 26443844; PMCID: PMC4604339.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  24. Vega RB, Horton JL, Kelly DP. Maintaining ancient organelles: mitochondrial biogenesis and maturation. Circ Res. 2015 May 22; 116(11):1820-34. PMID: 25999422; PMCID: PMC4443496.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  25. Weinheimer CJ, Lai L, Kelly DP, Kovacs A. Novel mouse model of left ventricular pressure overload and infarction causing predictable ventricular remodelling and progression to heart failure. Clin Exp Pharmacol Physiol. 2015 Jan; 42(1):33-40. PMID: 25311547; PMCID: PMC4524882.
    Citations: 7     Fields:    Translation:Animals
  26. Theodosakis N, Micevic G, Kelly DP, Bosenberg M. Mitochondrial function in melanoma. Arch Biochem Biophys. 2014 Dec 01; 563:56-9. PMID: 24997363.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  27. Bairdain S, Kelly DP, Tan C, Dodson B, Zurakowski D, Zurakowksi D, Jennings RW, Trenor CC. High incidence of catheter-associated venous thromboembolic events in patients with long gap esophageal atresia treated with the Foker process. J Pediatr Surg. 2014 Feb; 49(2):370-3. PMID: 24528989.
    Citations: 3     Fields:    Translation:Humans
  28. Kelly D, C Zhang Q, M Soucie J, Manco-Johnson M, Dimichele D. Prevalence of clinical hip abnormalities in haemophilia A and B: an analysis of the UDC database. Haemophilia. 2013 May; 19(3):426-31. PMID: 23252621; PMCID: PMC4467530.
    Citations: 2     Fields:    Translation:Humans
  29. Silver G, Traube C, Kearney J, Kelly D, Yoon MJ, Nash Moyal W, Gangopadhyay M, Shao H, Ward MJ. Detecting pediatric delirium: development of a rapid observational assessment tool. Intensive Care Med. 2012 Jun; 38(6):1025-31. PMID: 22407142.
    Citations: 21     Fields:    Translation:HumansPHPublic Health
  30. Kelly DP. Novel communication between myocyte lipid storage and fat burning unveiled. Circ Res. 2012 Mar 02; 110(5):655-7. PMID: 22383707.
    Citations:    Fields:    
  31. Gan Z, Burkart-Hartman EM, Han DH, Finck B, Leone TC, Smith EY, Ayala JE, Holloszy J, Kelly DP. The nuclear receptor PPARß/d programs muscle glucose metabolism in cooperation with AMPK and MEF2. Genes Dev. 2011 Dec 15; 25(24):2619-30. PMID: 22135324; PMCID: PMC3248683.
    Citations: 35     Fields:    Translation:AnimalsCells
  32. Mitra R, Nogee DP, Zechner JF, Yea K, Gierasch CM, Kovacs A, Medeiros DM, Kelly DP, Duncan JG. The transcriptional coactivators, PGC-1a and ß, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance. J Mol Cell Cardiol. 2012 Mar; 52(3):701-10. PMID: 22080103; PMCID: PMC3294189.
    Citations: 12     Fields:    Translation:AnimalsCells
  33. Schilling J, Lai L, Sambandam N, Dey CE, Leone TC, Kelly DP. Toll-like receptor-mediated inflammatory signaling reprograms cardiac energy metabolism by repressing peroxisome proliferator-activated receptor ? coactivator-1 signaling. Circ Heart Fail. 2011 Jul; 4(4):474-82. PMID: 21558447; PMCID: PMC3144030.
    Citations: 35     Fields:    Translation:AnimalsCells
  34. Chambers KT, Leone TC, Sambandam N, Kovacs A, Wagg CS, Lopaschuk GD, Finck BN, Kelly DP. Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response. J Biol Chem. 2011 Apr 01; 286(13):11155-62. PMID: 21321124; PMCID: PMC3064169.
    Citations: 33     Fields:    Translation:AnimalsCells
  35. Kelly DP. Cell biology: Ageing theories unified. Nature. 2011 Feb 17; 470(7334):342-3. PMID: 21307852.
    Citations: 21     Fields:    Translation:AnimalsCells
  36. Zechner C, Lai L, Zechner JF, Geng T, Yan Z, Rumsey JW, Collia D, Chen Z, Wozniak DF, Leone TC, Kelly DP. Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. Cell Metab. 2010 Dec 01; 12(6):633-42. PMID: 21109195; PMCID: PMC2999961.
    Citations: 85     Fields:    Translation:AnimalsCells
  37. Schilling J, Kelly DP. The PGC-1 cascade as a therapeutic target for heart failure. J Mol Cell Cardiol. 2011 Oct; 51(4):578-83. PMID: 20888832; PMCID: PMC3042046.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  38. Cresci S, Huss JM, Beitelshees AL, Jones PG, Minton MR, Dorn GW, Kelly DP, Spertus JA, McLeod HL. A PPARa promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes. PLoS One. 2010 Sep 03; 5(9):e12584. PMID: 20838448; PMCID: PMC2933242.
    Citations: 6     Fields:    Translation:HumansCells
  39. Trausch-Azar J, Leone TC, Kelly DP, Schwartz AL. Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1{alpha} via the N-terminal pathway. J Biol Chem. 2010 Dec 17; 285(51):40192-200. PMID: 20713359; PMCID: PMC3001001.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  40. Gardell SJ, Roth GP, Kelly DP. Cardiovascular drug discovery in the academic setting: building infrastructure, harnessing strengths, and seeking synergies. J Cardiovasc Transl Res. 2010 Oct; 3(5):431-7. PMID: 20625868.
    Citations:    Fields:    Translation:HumansAnimals
  41. Banke NH, Wende AR, Leone TC, O'Donnell JM, Abel ED, Kelly DP, Lewandowski ED. Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha. Circ Res. 2010 Jul 23; 107(2):233-41. PMID: 20522803; PMCID: PMC2921193.
    Citations: 55     Fields:    Translation:AnimalsCells
  42. Kelly DP. Introduction to the nuclear receptor review series. Circ Res. 2010 May 28; 106(10):1557-8. PMID: 20508199.
    Citations:    Fields:    Translation:HumansAnimals
  43. Beitelshees AL, Finck BN, Leone TC, Cresci S, Wu J, Province MA, Fabbrini E, Kirk E, Zineh I, Klein S, Spertus JA, Kelly DP. Interaction between the UCP2 -866 G>A polymorphism, diabetes, and beta-blocker use among patients with acute coronary syndromes. Pharmacogenet Genomics. 2010 Apr; 20(4):231-8. PMID: 20145583; PMCID: PMC2842450.
    Citations: 4     Fields:    Translation:HumansCells
  44. Duncan JG, Bharadwaj KG, Fong JL, Mitra R, Sambandam N, Courtois MR, Lavine KJ, Goldberg IJ, Kelly DP. Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators. Circulation. 2010 Jan 26; 121(3):426-35. PMID: 20065164; PMCID: PMC2825753.
    Citations: 45     Fields:    Translation:AnimalsCells
  45. Schaeffer PJ, Desantiago J, Yang J, Flagg TP, Kovacs A, Weinheimer CJ, Courtois M, Leone TC, Nichols CG, Bers DM, Kelly DP. Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol. 2009 Oct; 297(4):H1263-73. PMID: 19700627; PMCID: PMC2770758.
    Citations: 11     Fields:    Translation:AnimalsCells
  46. Yang J, Williams RS, Kelly DP. Bcl3 interacts cooperatively with peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha to coactivate nuclear receptors estrogen-related receptor alpha and PPARalpha. Mol Cell Biol. 2009 Aug; 29(15):4091-102. PMID: 19451226; PMCID: PMC2715798.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  47. Cresci S, Jones PG, Sucharov CC, Marsh S, Lanfear DE, Garsa A, Courtois M, Weinheimer CJ, Wu J, Province MA, Kelly DP, McLeod HL, Spertus JA. Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes. Pharmacogenomics. 2008 Oct; 9(10):1403-17. PMID: 18855529; PMCID: PMC2586954.
    Citations: 5     Fields:    Translation:Humans
  48. Lai L, Leone TC, Zechner C, Schaeffer PJ, Kelly SM, Flanagan DP, Medeiros DM, Kovacs A, Kelly DP. Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes Dev. 2008 Jul 15; 22(14):1948-61. PMID: 18628400; PMCID: PMC2492740.
    Citations: 117     Fields:    Translation:AnimalsCells
  49. Robinson EK, Kelly DP, Mercer DW, Kozar RA. Differential effects of luminal arginine and glutamine on metalloproteinase production in the postischemic gut. JPEN J Parenter Enteral Nutr. 2008 Jul-Aug; 32(4):433-8. PMID: 18596315; PMCID: PMC3295226.
    Citations: 6     Fields:    Translation:Animals
  50. Lopaschuk GD, Kelly DP. Signalling in cardiac metabolism. Cardiovasc Res. 2008 Jul 15; 79(2):205-7. PMID: 18515845.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  51. Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP. The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. Am J Physiol Heart Circ Physiol. 2008 Jul; 295(1):H185-96. PMID: 18487436; PMCID: PMC2494758.
    Citations: 57     Fields:    Translation:AnimalsCells
  52. Marionneau C, Aimond F, Brunet S, Niwa N, Finck B, Kelly DP, Nerbonne JM. PPARalpha-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy. J Mol Cell Cardiol. 2008 Jun; 44(6):1002-15. PMID: 18482733; PMCID: PMC2577840.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  53. Madrazo JA, Kelly DP. The PPAR trio: regulators of myocardial energy metabolism in health and disease. J Mol Cell Cardiol. 2008 Jun; 44(6):968-75. PMID: 18462747.
    Citations: 88     Fields:    Translation:HumansAnimals
  54. Kelly DP. Hypoxic reprogramming. Nat Genet. 2008 Feb; 40(2):132-4. PMID: 18227870.
    Citations: 9     Fields:    Translation:AnimalsCells
  55. Burkart EM, Sambandam N, Han X, Gross RW, Courtois M, Gierasch CM, Shoghi K, Welch MJ, Kelly DP. Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart. J Clin Invest. 2007 Dec; 117(12):3930-9. PMID: 18037994; PMCID: PMC2082147.
    Citations: 94     Fields:    Translation:AnimalsCells
  56. Wende AR, Schaeffer PJ, Parker GJ, Zechner C, Han DH, Chen MM, Hancock CR, Lehman JJ, Huss JM, McClain DA, Holloszy JO, Kelly DP. A role for the transcriptional coactivator PGC-1alpha in muscle refueling. J Biol Chem. 2007 Dec 14; 282(50):36642-51. PMID: 17932032.
    Citations: 93     Fields:    Translation:AnimalsCells
  57. Huss JM, Imahashi K, Dufour CR, Weinheimer CJ, Courtois M, Kovacs A, Giguère V, Murphy E, Kelly DP. The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell Metab. 2007 Jul; 6(1):25-37. PMID: 17618854.
    Citations: 95     Fields:    Translation:AnimalsCells
  58. Finck BN, Kelly DP. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. Circulation. 2007 May 15; 115(19):2540-8. PMID: 17502589.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  59. Dufour CR, Wilson BJ, Huss JM, Kelly DP, Alaynick WA, Downes M, Evans RM, Blanchette M, Giguère V. Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab. 2007 May; 5(5):345-56. PMID: 17488637.
    Citations: 148     Fields:    Translation:AnimalsCells
  60. Yang J, Sambandam N, Han X, Gross RW, Courtois M, Kovacs A, Febbraio M, Finck BN, Kelly DP. CD36 deficiency rescues lipotoxic cardiomyopathy. Circ Res. 2007 Apr 27; 100(8):1208-17. PMID: 17363697.
    Citations: 75     Fields:    Translation:AnimalsCells
  61. Duncan JG, Fong JL, Medeiros DM, Finck BN, Kelly DP. Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway. Circulation. 2007 Feb 20; 115(7):909-17. PMID: 17261654; PMCID: PMC4322937.
    Citations: 73     Fields:    Translation:AnimalsCells
  62. Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC, Kelly DP. Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab. 2006 Sep; 4(3):199-210. PMID: 16950137.
    Citations: 193     Fields:    Translation:HumansAnimalsCells
  63. Finck BN, Kelly DP. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest. 2006 Mar; 116(3):615-22. PMID: 16511594; PMCID: PMC1386111.
    Citations: 403     Fields:    Translation:HumansAnimals
  64. Wende AR, Huss JM, Schaeffer PJ, Giguère V, Kelly DP. PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol. 2005 Dec; 25(24):10684-94. PMID: 16314495; PMCID: PMC1316952.
    Citations: 113     Fields:    Translation:AnimalsCells
  65. Luptak I, Balschi JA, Xing Y, Leone TC, Kelly DP, Tian R. Decreased contractile and metabolic reserve in peroxisome proliferator-activated receptor-alpha-null hearts can be rescued by increasing glucose transport and utilization. Circulation. 2005 Oct 11; 112(15):2339-46. PMID: 16203912.
    Citations: 47     Fields:    Translation:Animals
  66. Sambandam N, Morabito D, Wagg C, Finck BN, Kelly DP, Lopaschuk GD. Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia. Am J Physiol Heart Circ Physiol. 2006 Jan; 290(1):H87-95. PMID: 16155108.
    Citations: 37     Fields:    Translation:AnimalsCells
  67. Park SY, Cho YR, Finck BN, Kim HJ, Higashimori T, Hong EG, Lee MK, Danton C, Deshmukh S, Cline GW, Wu JJ, Bennett AM, Rothermel B, Kalinowski A, Russell KS, Kim YB, Kelly DP, Kim JK. Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver. Diabetes. 2005 Sep; 54(9):2514-24. PMID: 16123338.
    Citations: 37     Fields:    Translation:AnimalsCells
  68. You M, Considine RV, Leone TC, Kelly DP, Crabb DW. Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology. 2005 Sep; 42(3):568-77. PMID: 16108051; PMCID: PMC1398076.
    Citations: 81     Fields:    Translation:AnimalsCells
  69. Schaeffer PJ, Villarin JJ, Pierotti DJ, Kelly DP, Lindstedt SL. Cost of transport is increased after cold exposure in Monodelphis domestica: training for inefficiency. J Exp Biol. 2005 Aug; 208(Pt 16):3159-67. PMID: 16081613.
    Citations: 2     Fields:    Translation:Animals
  70. Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 2005 Apr; 3(4):e101. PMID: 15760270; PMCID: PMC1064854.
    Citations: 328     Fields:    Translation:AnimalsCells
  71. Huss JM, Kelly DP. Mitochondrial energy metabolism in heart failure: a question of balance. J Clin Invest. 2005 Mar; 115(3):547-55. PMID: 15765136; PMCID: PMC1052011.
    Citations: 159     Fields:    Translation:HumansAnimalsCells
  72. Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, Kelly DP. A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell Metab. 2005 Feb; 1(2):133-44. PMID: 16054054.
    Citations: 86     Fields:    Translation:AnimalsCells
  73. Russell LK, Finck BN, Kelly DP. Mouse models of mitochondrial dysfunction and heart failure. J Mol Cell Cardiol. 2005 Jan; 38(1):81-91. PMID: 15623424.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  74. Harris IS, Treskov I, Rowley MW, Heximer S, Kaltenbronn K, Finck BN, Gross RW, Kelly DP, Blumer KJ, Muslin AJ. G-protein signaling participates in the development of diabetic cardiomyopathy. Diabetes. 2004 Dec; 53(12):3082-90. PMID: 15561937.
    Citations: 15     Fields:    Translation:Animals
  75. Huss JM, Torra IP, Staels B, Giguère V, Kelly DP. Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol. 2004 Oct; 24(20):9079-91. PMID: 15456881; PMCID: PMC517878.
    Citations: 165     Fields:    Translation:HumansAnimalsCells
  76. Huss JM, Kelly DP. Nuclear receptor signaling and cardiac energetics. Circ Res. 2004 Sep 17; 95(6):568-78. PMID: 15375023.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  77. Schaeffer PJ, Wende AR, Magee CJ, Neilson JR, Leone TC, Chen F, Kelly DP. Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle. J Biol Chem. 2004 Sep 17; 279(38):39593-603. PMID: 15262994.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  78. Kelly DP, Scarpulla RC. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 2004 Feb 15; 18(4):357-68. PMID: 15004004.
    Citations: 362     Fields:    Translation:HumansAnimalsCells
  79. Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML, McDonald JA, Kelly DP. Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res. 2004 Mar 05; 94(4):525-33. PMID: 14726475.
    Citations: 130     Fields:    Translation:AnimalsCells
  80. Erol E, Kumar LS, Cline GW, Shulman GI, Kelly DP, Binas B. Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice. FASEB J. 2004 Feb; 18(2):347-9. PMID: 14656998.
    Citations: 39     Fields:    Translation:AnimalsCells
  81. Faury G, Pezet M, Knutsen RH, Boyle WA, Heximer SP, McLean SE, Minkes RK, Blumer KJ, Kovacs A, Kelly DP, Li DY, Starcher B, Mecham RP. Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. J Clin Invest. 2003 Nov; 112(9):1419-28. PMID: 14597767; PMCID: PMC228452.
    Citations: 74     Fields:    Translation:Animals
  82. Bernal-Mizrachi C, Weng S, Feng C, Finck BN, Knutsen RH, Leone TC, Coleman T, Mecham RP, Kelly DP, Semenkovich CF. Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med. 2003 Aug; 9(8):1069-75. PMID: 12847522.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  83. Kelly DP. PPARs of the heart: three is a crowd. Circ Res. 2003 Mar 21; 92(5):482-4. PMID: 12649261.
    Citations: 13     Fields:    Translation:Animals
  84. Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, Kovacs A, Gross RW, Kelly DP. A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1226-31. PMID: 12552126; PMCID: PMC298755.
    Citations: 151     Fields:    Translation:Animals
  85. de las Fuentes L, Herrero P, Peterson LR, Kelly DP, Gropler RJ, Dávila-Román VG. Myocardial fatty acid metabolism: independent predictor of left ventricular mass in hypertensive heart disease. Hypertension. 2003 Jan; 41(1):83-7. PMID: 12511534.
    Citations: 48     Fields:    Translation:HumansCells
  86. Clabby ML, Robison TA, Quigley HF, Wilson DB, Kelly DP. Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2. J Biol Chem. 2003 Feb 21; 278(8):5760-7. PMID: 12480945.
    Citations: 13     Fields:    Translation:AnimalsCells
  87. Baar K, Wende AR, Jones TE, Marison M, Nolte LA, Chen M, Kelly DP, Holloszy JO. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J. 2002 Dec; 16(14):1879-86. PMID: 12468452.
    Citations: 252     Fields:    Translation:AnimalsCells
  88. Finck BN, Kelly DP. Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart. J Mol Cell Cardiol. 2002 Oct; 34(10):1249-57. PMID: 12425323.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  89. Huss JM, Kopp RP, Kelly DP. Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. J Biol Chem. 2002 Oct 25; 277(43):40265-74. PMID: 12181319.
    Citations: 150     Fields:    Translation:HumansCells
  90. Dávila-Román VG, Vedala G, Herrero P, de las Fuentes L, Rogers JG, Kelly DP, Gropler RJ. Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 2002 Jul 17; 40(2):271-7. PMID: 12106931.
    Citations: 112     Fields:    Translation:Humans
  91. Tordjman K, Standley KN, Bernal-Mizrachi C, Leone TC, Coleman T, Kelly DP, Semenkovich CF. PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells. J Lipid Res. 2002 Jun; 43(6):936-43. PMID: 12032169.
    Citations: 18     Fields:    Translation:AnimalsCells
  92. Lehman JJ, Kelly DP. Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin Exp Pharmacol Physiol. 2002 Apr; 29(4):339-45. PMID: 11985547.
    Citations: 81     Fields:    Translation:HumansAnimals
  93. Lehman JJ, Kelly DP. Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth. Heart Fail Rev. 2002 Apr; 7(2):175-85. PMID: 11988641.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  94. Kelly DP. Peroxisome proliferator-activated receptor alpha as a genetic determinant of cardiac hypertrophic growth: culprit or innocent bystander? Circulation. 2002 Mar 05; 105(9):1025-7. PMID: 11877347.
    Citations: 3     Fields:    Translation:Humans
  95. Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, Kovacs A, Han X, Gross RW, Kozak R, Lopaschuk GD, Kelly DP. The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest. 2002 Jan; 109(1):121-30. PMID: 11781357; PMCID: PMC150824.
    Citations: 256     Fields:    Translation:Animals
  96. Campbell FM, Kozak R, Wagner A, Altarejos JY, Dyck JR, Belke DD, Severson DL, Kelly DP, Lopaschuk GD. A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. J Biol Chem. 2002 Feb 08; 277(6):4098-103. PMID: 11734553.
    Citations: 63     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.