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Kassem Safa, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Heldman MR, Kates OS, Safa K, Kotton CN, Georgia SJ, Steinbrink JM, Alexander BD, Hemmersbach-Miller M, Blumberg EA, Multani A, Haydel B, La Hoz RM, Moni L, Condor Y, Flores S, Munoz CG, Guitierrez J, Diaz EI, Diaz D, Vianna R, Guerra G, Loebe M, Rakita RM, Malinis M, Azar MM, Hemmige V, McCort ME, Chaudhry ZS, Singh PP, Hughes Kramer K, Velioglu A, Yabu JM, Morillis JA, Mehta SA, Tanna SD, Ison MG, Derenge AC, van Duin D, Maximin A, Gilbert C, Goldman JD, Lease ED, Fisher CE, Limaye AP. Changing trends in mortality among solid organ transplant recipients hospitalized for COVID-19 during the course of the pandemic. Am J Transplant. 2021 Sep 12. PMID: 34514710.
    Citations:    Fields:    
  2. Heldman MR, Kates OS, Safa K, Kotton CN, Georgia SJ, Steinbrink JM, Alexander BD, Hemmersbach-Miller M, Blumberg EA, Crespo MM, Multani A, Lewis AV, Eugene Beaird O, Haydel B, La Hoz RM, Moni L, Condor Y, Flores S, Munoz CG, Guitierrez J, Diaz EI, Diaz D, Vianna R, Guerra G, Loebe M, Rakita RM, Malinis M, Azar MM, Hemmige V, McCort ME, Chaudhry ZS, Singh P, Hughes K, Velioglu A, Yabu JM, Morillis JA, Mehta SA, Tanna SD, Ison MG, Tomic R, Candace Derenge A, van Duin D, Maximin A, Gilbert C, Goldman JD, Sehgal S, Weisshaar D, Girgis RE, Nelson J, Lease ED, Limaye AP, Fisher CE. COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study. Am J Transplant. 2021 08; 21(8):2774-2784. PMID: 34008917.
    Citations: 1     Fields:    Translation:Humans
  3. Roll GR, Safa K, Yeh H. Navigating in the Dark, Challenges Assessing the Liver-kidney Safety Net. Transplantation. 2021 06 01; 105(6):1167-1168. PMID: 33988351.
    Citations:    Fields:    
  4. El Fekih R, Hurley J, Tadigotla V, Alghamdi A, Srivastava A, Coticchia C, Choi J, Allos H, Yatim K, Alhaddad J, Eskandari S, Chu P, Mihali AB, Lape IT, Lima Filho MP, Aoyama BT, Chandraker A, Safa K, Markmann JF, Riella LV, Formica RN, Skog J, Azzi JR. Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection. J Am Soc Nephrol. 2021 Mar 03. PMID: 33658284.
    Citations: 1     Fields:    
  5. Safa K, Elias N, Gilligan HM, Kawai T, Kotton CN. Successful Living Kidney Donation After COVID-19 Infection. Transplantation. 2021 01 01; 105(1):e4-e5. PMID: 33350629.
    Citations: 1     Fields:    Translation:Humans
  6. Hundemer GL, Srivastava A, Jacob KA, Krishnasamudram N, Ahmed S, Boerger E, Sharma S, Pokharel KK, Hirji SA, Pelletier M, Safa K, Kulvichit W, Kellum JA, Riella LV, Leaf DE. Acute kidney injury in renal transplant recipients undergoing cardiac surgery. Nephrol Dial Transplant. 2021 01 01; 36(1):185-196. PMID: 32892219.
    Citations:    Fields:    Translation:Humans
  7. Heldman MR, Kates OS, Haydel BM, Florman SS, Rana MM, Chaudhry ZS, Ramesh MS, Safa K, Kotton CN, Blumberg EA, Besharatian BD, Tanna SD, Ison MG, Malinis M, Azar MM, Rakita RM, Morillas JA, Majeed A, Sait AS, Spaggiari M, Hemmige V, Mehta SA, Neumann H, Badami A, Jeng A, Goldman JD, Lala A, Hemmersbach-Miller M, McCort ME, Bajrovic V, Ortiz-Bautista C, Friedman-Moraco R, Sehgal S, Lease ED, Limaye AP, Fisher CE. Healthcare resource use among solid organ transplant recipients hospitalized with COVID-19. Clin Transplant. 2021 02; 35(2):e14174. PMID: 33349940.
    Citations:    Fields:    Translation:HumansPHPublic Health
  8. Abou Diwan E, Patel AB, Cuenca AG, Elias N, Gilligan HM, Heher E, Leaf DE, Wojciechowski D, Safa K. Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide. Case Rep Transplant. 2020; 2020:8819345. PMID: 33083084.
    Citations:    
  9. Cravedi P, Schold JD, Safa K, Kates OS, Elfadawy N, Mannon RB, Shah MB, Hammond SP, Avery R, Guerrero Miranda C, Riella LV, Jowsey-Gregoire S, Akalin E, Camirand G, Alegre ML, Azzi J. The COVID-19 pandemic: A community approach. Clin Transplant. 2020 11; 34(11):e14059. PMID: 32762055.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  10. Kates OS, Haydel BM, Florman SS, Rana MM, Chaudhry ZS, Ramesh MS, Safa K, Kotton CN, Blumberg EA, Besharatian BD, Tanna SD, Ison MG, Malinis M, Azar MM, Rakita RM, Morillas JA, Majeed A, Sait AS, Spaggiari M, Hemmige V, Mehta SA, Neumann H, Badami A, Goldman JD, Lala A, Hemmersbach-Miller M, McCort ME, Bajrovic V, Ortiz-Bautista C, Friedman-Moraco R, Sehgal S, Lease ED, Fisher CE, Limaye AP. COVID-19 in solid organ transplant: A multi-center cohort study. Clin Infect Dis. 2020 Aug 07. PMID: 32766815.
    Citations: 47     Fields:    
  11. Bethea E, Arvind A, Gustafson J, Andersson K, Pratt D, Bhan I, Thiim M, Corey K, Bloom P, Markmann J, Yeh H, Elias N, Kimura S, Dageforde LA, Cuenca A, Kawai T, Safa K, Williams W, Gilligan H, Sise M, Fishman J, Kotton C, Kim A, Rogers CC, Shao S, Cote M, Irwin L, Myoung P, Chung RT. Immediate administration of antiviral therapy after transplantation of hepatitis C-infected livers into uninfected recipients: Implications for therapeutic planning. Am J Transplant. 2020 06; 20(6):1619-1628. PMID: 31887236.
    Citations: 4     Fields:    Translation:HumansCells
  12. Bethea ED, Gaj K, Gustafson JL, Axtell A, Lebeis T, Schoenike M, Turvey K, Coglianese E, Thomas S, Newton-Cheh C, Ibrahim N, Carlson W, Ho JE, Shah R, Nayor M, Gift T, Shao S, Dugal A, Markmann J, Elias N, Yeh H, Andersson K, Pratt D, Bhan I, Safa K, Fishman J, Kotton C, Myoung P, Villavicencio MA, D'Alessandro D, Chung RT, Lewis GD. Pre-emptive pangenotypic direct acting antiviral therapy in donor HCV-positive to recipient HCV-negative heart transplantation: an open-label study. Lancet Gastroenterol Hepatol. 2019 10; 4(10):771-780. PMID: 31353243.
    Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
  13. Magee CN, Murakami N, Borges TJ, Shimizu T, Safa K, Ohori S, Cai S, Uffing A, Azzi J, Elyaman W, Charbonnier LM, Liu K, Toprak D, Visner G, Chatila TA, Siebel CW, Najafian N, Riella LV. Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms. Circulation. 2019 09 09; 140(10):846-863. PMID: 31266349.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  14. Chahine E, Baghdady R, Chahine C, Doghman G, El Kary N, El Khoury L, Safa K, Chouillard MA, Chouillard E. Complete resolution of obstructive colonic amebic pseudotumor with conservative treatment: A case report and literature review. Int J Surg Case Rep. 2019; 59:1-3. PMID: 31085385.
    Citations: 1     
  15. Chong AS, Rothstein DM, Safa K, Riella LV. Outstanding questions in transplantation: B cells, alloantibodies, and humoral rejection. Am J Transplant. 2019 08; 19(8):2155-2163. PMID: 30803121.
    Citations: 14     Fields:    Translation:HumansCells
  16. Uffing A, Pérez-Sáez MJ, La Manna G, Comai G, Fischman C, Farouk S, Manfro RC, Bauer AC, Lichtenfels B, Mansur JB, Tedesco-Silva H, Kirsztajn GM, Manonelles A, Bestard O, Riella MC, Hokazono SR, Arias-Cabrales C, David-Neto E, Ventura CG, Akalin E, Mohammed O, Khankin EV, Safa K, Malvezzi P, O'Shaughnessy MM, Cheng XS, Cravedi P, Riella LV. A large, international study on post-transplant glomerular diseases: the TANGO project. BMC Nephrol. 2018 09 12; 19(1):229. PMID: 30208881.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  17. Safa K, Magee CN, Azzi J. A critical review of biomarkers in kidney transplantation. Curr Opin Nephrol Hypertens. 2017 11; 26(6):509-515. PMID: 28857783.
    Citations:    Fields:    Translation:Humans
  18. Azzi J, Raimondi G, Mas V, Riella LV, Elfadawy N, Safa K, Wojciechowski D, Kanak M, Nog R, Maltzman JS, Ford ML, Pober JS, Luo XR, Rothstein D, Miller ML, Matthews D, Burlingham W, Levings M, Heeger P, Higdon L, Gill J, Gill RG, Alegre ML. The outstanding questions in transplantation: It's about time…. Am J Transplant. 2018 01; 18(1):271-272. PMID: 28758364.
    Citations: 1     Fields:    Translation:Humans
  19. Sircar M, Kotton C, Wojciechowski D, Safa K, Gilligan H, Heher E, Williams W, Thadhani R, Tolkoff-Rubin N. Voriconazole-Induced Periostitis & Enthesopathy in Solid Organ Transplant Patients: Case Reports. J Biosci Med (Irvine). 2016 Nov; 4(11):8-17. PMID: 27990445.
    Citations: 1     
  20. Safa K, Chandran S, Wojciechowski D. Erratum to: Pharmacologic Targeting of Regulatory T Cells for Solid Organ Transplantation: Current and Future Prospects. Drugs. 2015 Dec; 75(18):2171. PMID: 26553341.
    Citations:    Fields:    
  21. Safa K, Chandran S, Wojciechowski D. Pharmacologic targeting of regulatory T cells for solid organ transplantation: current and future prospects. Drugs. 2015 Nov; 75(16):1843-52. PMID: 26493288.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  22. Batal I, De Serres SA, Safa K, Bijol V, Ueno T, Onozato ML, Iafrate AJ, Herter JM, Lichtman AH, Mayadas TN, Guleria I, Rennke HG, Najafian N, Chandraker A. Dendritic Cells in Kidney Transplant Biopsy Samples Are Associated with T Cell Infiltration and Poor Allograft Survival. J Am Soc Nephrol. 2015 Dec; 26(12):3102-13. PMID: 25855773.
    Citations: 13     Fields:    Translation:HumansCells
  23. Safa K, Ohori S, Borges TJ, Uehara M, Batal I, Shimizu T, Magee CN, Belizaire R, Abdi R, Wu C, Chandraker A, Riella LV. Salt Accelerates Allograft Rejection through Serum- and Glucocorticoid-Regulated Kinase-1-Dependent Inhibition of Regulatory T Cells. J Am Soc Nephrol. 2015 Oct; 26(10):2341-7. PMID: 25833841.
    Citations: 20     Fields:    Translation:AnimalsCells
  24. Safa K, Logan MS, Batal I, Gabardi S, Rennke HG, Abdi R. Eculizumab for drug-induced de novo posttransplantation thrombotic microangiopathy: A case report. Clin Nephrol. 2015 Feb; 83(2):125-9. PMID: 24495904.
    Citations: 9     Fields:    Translation:Humans
  25. Safa K, Heher E, Gilligan H, Williams W, Tolkoff-Rubin N, Wojciechowski D. BK Virus After Kidney Transplantation: A Review of Screening and Treatment Strategies and a Summary of the Massachusetts General Hospital Experience. Clin Transpl. 2015; 31:257-263. PMID: 28514587.
    Citations:    Fields:    
  26. Azzi J, Ohori S, Ting C, Uehara M, Abdoli R, Smith BD, Safa K, Solhjou Z, Lukyanchykov P, Patel J, McGrath M, Abdi R. Serine protease inhibitor-6 differentially affects the survival of effector and memory alloreactive CD8-T cells. Am J Transplant. 2015 Jan; 15(1):234-41. PMID: 25534448.
    Citations: 6     Fields:    Translation:AnimalsCells
  27. Batal I, Schlossman RL, Safa K, Rennke HG, Campenot ES. Anemia, fatigue, and late-failing kidney transplant. Am J Kidney Dis. 2014 Nov; 64(5):xvi-xix. PMID: 25344006.
    Citations:    Fields:    Translation:Humans
  28. Riella LV, Safa K, Yagan J, Lee B, Azzi J, Najafian N, Abdi R, Milford E, Mah H, Gabardi S, Malek S, Tullius SG, Magee C, Chandraker A. Long-term outcomes of kidney transplantation across a positive complement-dependent cytotoxicity crossmatch. Transplantation. 2014 Jun 27; 97(12):1247-52. PMID: 24854670.
    Citations: 12     Fields:    Translation:Humans
  29. Safa K, Riella LV, Chandraker A. Beyond calcineurin inhibitors: emerging agents in kidney transplantation. Curr Opin Nephrol Hypertens. 2013 Nov; 22(6):689-97. PMID: 24100221.
    Citations: 6     Fields:    Translation:HumansCells
  30. Townamchai N, Safa K, Chandraker A. Immunologic monitoring in kidney transplant recipients. Kidney Res Clin Pract. 2013 Jun; 32(2):52-61. PMID: 26877913.
    Citations: 3     
  31. Riella LV, Yang J, Chock S, Safa K, Magee CN, Vanguri V, Elyaman W, Lahoud Y, Yagita H, Abdi R, Najafian N, Medina-Pestana JO, Chandraker A. Jagged2-signaling promotes IL-6-dependent transplant rejection. Eur J Immunol. 2013 Jun; 43(6):1449-58. PMID: 23526606.
    Citations: 16     Fields:    Translation:AnimalsCells
  32. Safa K, El Ghazal R. Better late than never: diagnosis and successful treatment in late adulthood of supravalvular aortic stenosis secondary to Williams-Beuren syndrome. Conn Med. 2011 Jan; 75(1):21-3. PMID: 21329288.
    Citations: 2     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.