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Michael Joe Worley Jr., M.D.

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Biography
New York Presbyterian Hospital - Weill Cornell Medical College, New York, NY2011Obstetrics and Gynecology
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA2014Gynecologic Oncology
2017
Eleanor and Miles Shore 50th Anniversary Fellowship Program for Scholars in Medicine
2015
Physician of the Month (September)
2014
Outstanding Teacher of Obstetrics and Gynecology
2011
Jerome S. Seiler MD Award, Excellence in Pelvic Surgery
2011
Special Resident in Minimally Invasive Gynecology

Overview
For patients with advanced-stage ovarian/fallopian tube/peritoneal cancer, the quality of their initial surgery remains the most influential factor related to long-term survival. My research interests include improving the quality of surgical care delivered to these patients, so both short-term postoperative outcomes, as well as long-term survival, can be optimized.

I have published numerous articles regarding the appropriate use of primary cytoreductive surgery and neoadjuvant chemotherapy. These publications have provided clarity into what patient populations are ideally suited for each treatment approach. In addition, my research efforts have helped refine the overall goals of surgical resection, as well as management strategies to achieve the best surgical outcome.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Piedimonte S, Li S, Laframboise S, Ferguson SE, Bernardini MQ, Bouchard-Fortier G, Hogen L, Cybulska P, Worley MJ, May T. Gynecologic oncology treatment modifications or delays in response to the COVID-19 pandemic in a publicly funded versus privately funded North American tertiary cancer center. Gynecol Oncol. 2021 Apr 28. PMID: 33941382.
    Citations:    Fields:    
  2. Manning-Geist BL, Sullivan MW, Sarda V, Gockley AA, Del Carmen MG, Matulonis U, Growdon WB, Horowitz NS, Berkowitz RS, Clark RM, Worley MJ. Disease Distribution at Presentation Impacts Benefit of IP Chemotherapy Among Patients with Advanced-Stage Ovarian Cancer. Ann Surg Oncol. 2021 Mar 08. PMID: 33683525.
    Citations:    Fields:    
  3. Leung SOA, Feldman S, Kalyanaraman R, Shanmugam V, Worley MJ, Berkowitz RS, Horowitz NS, Feltmate CM, Muto MG, Lee LJ, King MT, Einarsson JI, Ajao MO, Elias KM. Triaging abnormal cervical cancer screening tests using p16INK4a detection by ELISA on fresh cervical samples. Am J Reprod Immunol. 2021 Jan 27; e13394. PMID: 33501727.
    Citations:    Fields:    
  4. Wan C, Keany MP, Dong H, Al-Alem LF, Pandya UM, Lazo S, Boehnke K, Lynch KN, Xu R, Zarrella DT, Gu S, Cejas P, Lim K, Long HW, Elias KM, Horowitz NS, Feltmate CM, Muto MG, Worley MJ, Berkowitz RS, Matulonis UA, Nucci MR, Crum CP, Rueda BR, Brown M, Liu XS, Hill SJ. Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer. Cancer Res. 2021 01 01; 81(1):158-173. PMID: 33158814.
    Citations: 4     Fields:    
  5. Kanbergs AN, Manning-Geist BL, Pelletier A, Sullivan MW, Del Carmen MG, Horowitz NS, Growdon WB, Clark RM, Muto MG, Worley MJ. Neoadjuvant chemotherapy does not disproportionately influence post-operative complication rates or time to chemotherapy in obese patients with advanced-stage ovarian cancer. Gynecol Oncol. 2020 12; 159(3):687-691. PMID: 32951891.
    Citations:    Fields:    Translation:Humans
  6. Li S, Manning-Geist B, Gockley A, Ramos A, Sisodia RC, Del Carmen M, Growdon WB, Horowitz N, Berkowitz R, Worley M. Use of ablation and ultrasonic aspiration at primary debulking surgery in advanced stage ovarian, fallopian tube, and primary peritoneal cancer. Int J Gynecol Cancer. 2020 07; 30(7):1052-1057. PMID: 32487686.
    Citations:    Fields:    
  7. St Laurent JD, Gockley AA, Cathcart AM, Baranov E, Kolin DL, Worley MJ. Serous borderline tumor of the ovary with isolated cardiophrenic lymph node spread at diagnosis. Gynecol Oncol Rep. 2020 Aug; 33:100586. PMID: 32529019.
    Citations:    
  8. Gonzalez R, Gockley AA, Melamed A, Sugrue R, Clark RM, Del Carmen MG, Growdon W, Berkowitz RS, Horowitz NS, Worley MJ. Multivariable analysis of association of beta-blocker use and survival in advanced ovarian cancer. Gynecol Oncol. 2020 06; 157(3):700-705. PMID: 32222327.
    Citations: 2     Fields:    Translation:Humans
  9. Alimena S, Yang DD, Melamed A, Mahal BA, Worley MJ, Feldman S, Elias KM, Orio PF, Lee LJ, King M. Racial disparities in brachytherapy administration and survival in women with locally advanced cervical cancer. Gynecol Oncol. 2019 09; 154(3):595-601. PMID: 31292103.
    Citations: 1     Fields:    Translation:Humans
  10. Manning-Geist BL, Hicks-Courant K, Gockley AA, Clark RM, Del Carmen MG, Growdon WB, Horowitz NS, Berkowitz RS, Muto MG, Worley MJ. A novel classification of residual disease after interval debulking surgery for advanced-stage ovarian cancer to better distinguish oncologic outcome. Am J Obstet Gynecol. 2019 10; 221(4):326.e1-326.e7. PMID: 31082382.
    Citations: 2     Fields:    Translation:Humans
  11. Cheung TH, Yim SF, Yu MY, Worley MJ, Fiascone SJ, Chiu RWK, Lo KWK, Siu NSS, Wong MCS, Yeung ACM, Wong RRY, Chen ZG, Elias KM, Chung TKH, Berkowitz RS, Wong YF, Chan PKS. Liquid biopsy of HPV DNA in cervical cancer. J Clin Virol. 2019 05; 114:32-36. PMID: 30913520.
    Citations: 5     Fields:    Translation:HumansCells
  12. Gockley AA, Fiascone S, Hicks Courant K, Pepin K, Del Carmen M, Clark RM, Goldberg J, Horowitz N, Berkowitz R, Worley M. Clinical characteristics and outcomes after bowel surgery and ostomy formation at the time of debulking surgery for advanced-stage epithelial ovarian carcinoma. Int J Gynecol Cancer. 2019 03; 29(3):585-592. PMID: 30833444.
    Citations:    Fields:    Translation:Humans
  13. Zhao Y, Cao J, Melamed A, Worley M, Gockley A, Jones D, Nia HT, Zhang Y, Stylianopoulos T, Kumar AS, Mpekris F, Datta M, Sun Y, Wu L, Gao X, Yeku O, Del Carmen MG, Spriggs DR, Jain RK, Xu L. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2210-2219. PMID: 30659155.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  14. Manning-Geist BL, Alimena S, Del Carmen MG, Goodman A, Clark RM, Growdon WB, Horowitz NS, Berkowitz RS, Muto MG, Worley MJ. Infection, thrombosis, and oncologic outcome after interval debulking surgery: Does perioperative blood transfusion matter? Gynecol Oncol. 2019 04; 153(1):63-67. PMID: 30635213.
    Citations: 3     Fields:    Translation:Humans
  15. Hill SJ, Decker B, Roberts EA, Horowitz NS, Muto MG, Worley MJ, Feltmate CM, Nucci MR, Swisher EM, Nguyen H, Yang C, Morizane R, Kochupurakkal BS, Do KT, Konstantinopoulos PA, Liu JF, Bonventre JV, Matulonis UA, Shapiro GI, Berkowitz RS, Crum CP, D'Andrea AD. Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids. Cancer Discov. 2018 11; 8(11):1404-1421. PMID: 30213835.
    Citations: 59     Fields:    Translation:HumansCells
  16. Manning-Geist BL, Hicks-Courant K, Gockley AA, Clark RM, Del Carmen MG, Growdon WB, Horowitz NS, Berkowitz RS, Muto MG, Worley MJ. Moving beyond "complete surgical resection" and "optimal": Is low-volume residual disease another option for primary debulking surgery? Gynecol Oncol. 2018 08; 150(2):233-238. PMID: 29933927.
    Citations: 3     Fields:    Translation:Humans
  17. Hicks-Courant K, Melamed A, Worley MJ, Kim YB, Schorge JO, Rauh-Hain JA. Trends in Place of Death Among Patients With Gynecologic Cancer in the United States. Obstet Gynecol. 2018 06; 131(6):1111-1120. PMID: 29742673.
    Citations: 2     Fields:    Translation:Humans
  18. Davis M, Strickland K, Easter SR, Worley M, Feltmate C, Muto M, Horowitz N, Berkowitz R, Feldman S. The impact of health insurance status on the stage of cervical cancer diagnosis at a tertiary care center in Massachusetts. Gynecol Oncol. 2018 07; 150(1):67-72. PMID: 29751992.
    Citations: 1     Fields:    Translation:Humans
  19. Worley MJ, Elias KM, Horowitz NS, Quade BJ, Berkowitz RS. Durable remission for a woman with refractory choriocarcinoma treated with anti-endoglin monoclonal antibody and bevacizumab: A case from the New England Trophoblastic Disease Center, Brigham and Women's Hospital and Dana-Farber Cancer Institute. Gynecol Oncol. 2018 01; 148(1):5-11. PMID: 29217138.
    Citations: 2     Fields:    Translation:Humans
  20. Chung TKH, Cheung TH, Yim SF, Yu MY, Chiu RWK, Lo KWK, Lee IPC, Wong RRY, Lau KKM, Wang VW, Worley MJ, Elias KM, Fiascone SJ, Smith DI, Berkowitz RS, Wong YF. Liquid biopsy of PIK3CA mutations in cervical cancer in Hong Kong Chinese women. Gynecol Oncol. 2017 08; 146(2):334-339. PMID: 28587748.
    Citations: 8     Fields:    Translation:Humans
  21. Davis M, Aviki E, Rauh-Hain JA, Worley M, Berkowitz R, Schorge J, Muto M, Clark Sisodia R, Horowitz N, Del Carmen M. Investigating the Impact of Body Mass Index on Intraperitoneal Chemotherapy Outcomes in Ovarian and Fallopian Tube Cancer. Int J Gynecol Cancer. 2016 07; 26(6):1033-40. PMID: 27206282.
    Citations: 2     Fields:    Translation:Humans
  22. Worley MJ, Liu S, Hua Y, Kwok JS, Samuel A, Hou L, Shoni M, Lu S, Sandberg EM, Keryan A, Wu D, Ng SK, Kuo WP, Parra-Herran CE, Tsui SK, Welch W, Crum C, Berkowitz RS, Ng SW. Molecular changes in endometriosis-associated ovarian clear cell carcinoma. Eur J Cancer. 2015 Sep; 51(13):1831-42. PMID: 26059197.
    Citations: 19     Fields:    Translation:HumansCells
  23. Melamed A, Katz Eriksen JL, Hinchcliff EM, Worley MJ, Berkowitz RS, Horowitz NS, Muto MG, Urman RD, Feltmate CM. Same-Day Discharge After Laparoscopic Hysterectomy for Endometrial Cancer. Ann Surg Oncol. 2016 Jan; 23(1):178-85. PMID: 25956576.
    Citations: 2     Fields:    Translation:Humans
  24. Chung TK, Van Hummelen P, Chan PK, Cheung TH, Yim SF, Yu MY, Ducar MD, Thorner AR, MacConaill LE, Doran G, Pedamallu CS, Ojesina AI, Wong RR, Wang VW, Freeman SS, Lau TS, Kwong J, Chan LK, Fromer M, May T, Worley MJ, Esselen KM, Elias KM, Lawrence M, Getz G, Smith DI, Crum CP, Meyerson M, Berkowitz RS, Wong YF. Genomic aberrations in cervical adenocarcinomas in Hong Kong Chinese women. Int J Cancer. 2015 Aug 15; 137(4):776-83. PMID: 25626421.
    Citations: 16     Fields:    Translation:HumansCells
  25. Rauh-Hain JA, Hinchcliff EM, Oduyebo T, Worley MJ, Andrade CA, Schorge JO, George S, Muto MG, del Carmen MG. Clinical outcomes of women with recurrent or persistent uterine leiomyosarcoma. Int J Gynecol Cancer. 2014 Oct; 24(8):1434-40. PMID: 25248114.
    Citations: 1     Fields:    Translation:Humans
  26. Worley MJ, Davis M, Berhie SH, Muto MG, Feltmate CM, Berkowitz RS, Horowitz NS, Campos SM. Mucinous differentiation does not impact stage or risk of recurrence among patients with grade 1, endometrioid type, endometrial carcinoma. Gynecol Oncol. 2014 Oct; 135(1):54-7. PMID: 25088333.
    Citations:    Fields:    Translation:Humans
  27. Worley MJ, Joseph NT, Berkowitz RS, Goldstein DP. Women with a partial mole during their first pregnancy and diagnosed earlier in gestation are at increased risk of developing gestational trophoblastic neoplasia. Int J Gynecol Cancer. 2014 Jun; 24(5):941-5. PMID: 24819660.
    Citations: 1     Fields:    Translation:HumansAnimals
  28. Wong RR, Worley MJ, Chung TK, Wong YF. An update on Mullerian-inhibiting substance: its potential application against ovarian cancer. Endocr Relat Cancer. 2014 Jun; 21(3):R227-33. PMID: 24623744.
    Citations: 1     Fields:    Translation:HumansAnimals
  29. Worley MJ, Guseh SH, Rauh-Hain JA, Esselen KM, Muto MG, Feltmate CM, Berkowitz RS, Del Carmen MG, Schorge JO, Horowitz NS. What is the optimal treatment for obese patients with advanced ovarian carcinoma? Am J Obstet Gynecol. 2014 Sep; 211(3):231.e1-9. PMID: 24704062.
    Citations: 5     Fields:    Translation:Humans
  30. Worley MJ, Welch WR, Berkowitz RS, Ng SW. Endometriosis-associated ovarian cancer: a review of pathogenesis. Int J Mol Sci. 2013 Mar 06; 14(3):5367-79. PMID: 23466883.
    Citations: 37     Fields:    
  31. Worley MJ, Nitschmann CC, Shoni M, Rauh-Hain JA, Williams KA, Feltmate CM. Preoperative leukocytosis imposes an increased risk of recurrence and death among patients with nonendometrioid endometrial carcinoma. Int J Gynecol Cancer. 2013 Feb; 23(2):312-7. PMID: 23358179.
    Citations: 5     Fields:    Translation:Humans
  32. Worley MJ, Guseh SH, Rauh-Hain JA, Williams KA, Muto MG, Feltmate CM, Berkowitz RS, Horowitz NS. Does neoadjuvant chemotherapy decrease the risk of hospital readmission following debulking surgery? Gynecol Oncol. 2013 Apr; 129(1):69-73. PMID: 23375727.
    Citations: 5     Fields:    Translation:Humans
  33. Worley MJ, Rauh-Hain JA, Sandberg EM, Muto MG. Venous thromboembolism prophylaxis for laparoscopic surgery: a survey of members of the Society of Gynecologic Oncology. Int J Gynecol Cancer. 2013 Jan; 23(1):208-15. PMID: 23221603.
    Citations: 4     Fields:    Translation:Humans
  34. Cheung TH, Man KN, Yu MY, Yim SF, Siu NS, Lo KW, Doran G, Wong RR, Wang VW, Smith DI, Worley MJ, Berkowitz RS, Chung TK, Wong YF. Dysregulated microRNAs in the pathogenesis and progression of cervical neoplasm. . 2012 Aug 01; 11(15):2876-84. PMID: 22801550.
    Citations: 41     Translation:Humans
  35. Frey MK, Biewald MA, Worley MJ, Taylor JS, Lin SN, Holcomb K. Lynch Syndrome: Awareness among Medical Students at a United States Medical School. Curr Womens Health Rev. 2012 Aug; 8(3):242-247. PMID: 23316129.
    Citations: 3     
  36. Worley MJ, Nitschmann CC, Shoni M, Vitonis AF, Rauh-Hain JA, Feltmate CM. The significance of preoperative leukocytosis in endometrial carcinoma. Gynecol Oncol. 2012 Jun; 125(3):561-5. PMID: 22465698.
    Citations: 11     Fields:    Translation:Humans
  37. Worley MJ, Anwandter C, Sun CC, dos Reis R, Nick AM, Frumovitz M, Soliman PT, Schmeler KM, Levenback CF, Munsell MF, Ramirez PT. Impact of surgeon volume on patient safety in laparoscopic gynecologic surgery. Gynecol Oncol. 2012 Apr; 125(1):241-4. PMID: 22240566.
    Citations: 2     Fields:    Translation:Humans
  38. Blumenthal J, Frey MK, Worley MJ, Tchabo NE, Soren K, Slomovitz BM. Adolescent Understanding and Acceptance of the HPV Vaccination in an Underserved Population in New York City. J Oncol. 2012; 2012:904034. PMID: 22187557.
    Citations: 9     
  39. Frey MK, Ward NM, Caputo TA, Taylor J, Worley MJ, Slomovitz BM. Lymphatic ascites following pelvic and paraaortic lymphadenectomy procedures for gynecologic malignancies. Gynecol Oncol. 2012 Apr; 125(1):48-53. PMID: 22101154.
    Citations: 4     Fields:    Translation:Humans
  40. Frey MK, Worley MJ, Slomovitz BM. Robotic radical parametrectomy for unstaged invasive endometrial carcinoma. Int J Gynaecol Obstet. 2011 Nov; 115(2):208-9. PMID: 21840521.
    Citations: 1     Fields:    Translation:Humans
  41. Heyman KP, Worley MJ, Frey MK, Kessler RT, Bodurka DC, Slomovitz BM. Willingness of pregnant women to vaccinate themselves and their newborns with the HPV vaccine. Vaccine. 2011 Jun 20; 29(28):4618-22. PMID: 21557976.
    Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
  42. Hinz EK, Kudesia R, Rolston R, Caputo TA, Worley MJ. Physician knowledge of and adherence to the revised breast cancer screening guidelines by the United States Preventive Services Task Force. Am J Obstet Gynecol. 2011 Sep; 205(3):201.e1-5. PMID: 21689807.
    Citations: 6     Fields:    Translation:Humans
  43. Slomovitz BM, Worley MJ, Markman M, Coleman RL. Emerging therapeutics for primary peritoneal cancer. Expert Opin Emerg Drugs. 2011 Mar; 16(1):71-84. PMID: 21352070.
    Citations:    Fields:    Translation:Humans
  44. Frey MK, Ihnow SB, Worley MJ, Heyman KP, Kessler R, Slomovitz BM, Holcomb KM. Minimally invasive staging of endometrial cancer is feasible and safe in elderly women. J Minim Invasive Gynecol. 2011 Mar-Apr; 18(2):200-4. PMID: 21354065.
    Citations: 1     Fields:    Translation:Humans
  45. Worley MJ, Landen CN, Slomovitz BM, Malpica A, Palla SL, Ramirez PT. Expression of the retinoblastoma-related gene Rb2/p130 in the pathogenesis of serous carcinoma of the ovary. Appl Immunohistochem Mol Morphol. 2010 Dec; 18(6):509-11. PMID: 20661130.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  46. Worley MJ, Dean KL, Lin SN, Caputo TA, Post RC. The significance of a thickened endometrial echo in asymptomatic postmenopausal patients. Maturitas. 2011 Feb; 68(2):179-81. PMID: 21075567.
    Citations: 4     Fields:    Translation:Humans
  47. Frey MK, Worley MJ, Heyman KP, Caputo TA. A case report of hereditary leiomyomatosis and renal cell cancer. Am J Obstet Gynecol. 2010 Jun; 202(6):e8-9. PMID: 20510956.
    Citations: 3     Fields:    Translation:Humans
  48. Worley MJ, Slomovitz BM, Pirog EC, Caputo TA, Ledger WJ. Enterobius vermicularis infestation of a hysterectomy specimen in a patient with a colonic reservoir. Am J Obstet Gynecol. 2009 Jun; 200(6):e6-7. PMID: 19268877.
    Citations: 1     Fields:    Translation:HumansAnimals
  49. Worley MJ, Slomovitz BM, Ramirez PT. Complications of laparoscopy in benign and oncologic gynecological surgery. Rev Obstet Gynecol. 2009; 2(3):169-75. PMID: 19826574.
    Citations: 4     
  50. Coleman EA, Lord JE, Bowie M, Worley MJ. A statewide breast cancer screening project. Cancer Nurs. 1993 Oct; 16(5):347-53. PMID: 8261382.
    Citations:    Fields:    Translation:HumansPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.