Harvard Catalyst Profiles

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Hugo Aerts, Ph.D.

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Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. U01CA209414 (CHRISTIANI, DAVID C) Jun 1, 2017 - May 31, 2023
    NIH/NCI
    The Boston Lung Cancer Survival Cohort
    Role: Co-Investigator
  2. U24CA194354 (AERTS, HUGO) Apr 1, 2015 - Mar 31, 2020
    NIH/NCI
    Quantitative Radiomics System Decoding the Tumor Phenotype
    Role: Principal Investigator
  3. U01CA190234 (AERTS, HUGO) Jan 9, 2015 - Dec 31, 2019
    NIH/NCI
    Genotype and Imaging Phenotype Biomarkers in Lung Cancer
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zwanenburg A, Vallières M, Abdalah MA, Aerts HJWL, Andrearczyk V, Apte A, Ashrafinia S, Bakas S, Beukinga RJ, Boellaard R, Bogowicz M, Boldrini L, Buvat I, Cook GJR, Davatzikos C, Depeursinge A, Desseroit MC, Dinapoli N, Dinh CV, Echegaray S, El Naqa I, Fedorov AY, Gatta R, Gillies RJ, Goh V, Götz M, Guckenberger M, Ha SM, Hatt M, Isensee F, Lambin P, Leger S, Leijenaar RTH, Lenkowicz J, Lippert F, Losnegård A, Maier-Hein KH, Morin O, Müller H, Napel S, Nioche C, Orlhac F, Pati S, Pfaehler EAG, Rahmim A, Rao AUK, Scherer J, Siddique MM, Sijtsema NM, Socarras Fernandez J, Spezi E, Steenbakkers RJHM, Tanadini-Lang S, Thorwarth D, Troost EGC, Upadhaya T, Valentini V, van Dijk LV, van Griethuysen J, van Velden FHP, Whybra P, Richter C, Löck S. The Image Biomarker Standardization Initiative: Standardized Quantitative Radiomics for High-Throughput Image-based Phenotyping. Radiology. 2020 May; 295(2):328-338. PMID: 32154773.
    Citations:    
  2. Kann BH, Johnson SB, Aerts HJWL, Mak RH, Nguyen PL. Changes in Length and Complexity of Clinical Practice Guidelines in Oncology, 1996-2019. JAMA Netw Open. 2020 Mar 02; 3(3):e200841. PMID: 32167566.
    Citations:    
  3. van Griethuysen JJM, Lambregts DMJ, Trebeschi S, Lahaye MJ, Bakers FCH, Vliegen RFA, Beets GL, Aerts HJWL, Beets-Tan RGH. Radiomics performs comparable to morphologic assessment by expert radiologists for prediction of response to neoadjuvant chemoradiotherapy on baseline staging MRI in rectal cancer. Abdom Radiol (NY). 2020 03; 45(3):632-643. PMID: 31734709.
    Citations:    
  4. Kamran SC, Coroller T, Milani N, Agrawal V, Baldini EH, Chen AB, Johnson BE, Kozono D, Franco I, Chopra N, Zeleznik R, Aerts HJWL, Mak R. The impact of quantitative CT-based tumor volumetric features on the outcomes of patients with limited stage small cell lung cancer. Radiat Oncol. 2020 Jan 14; 15(1):14. PMID: 31937336.
    Citations:    
  5. Hosny A, Aerts HJWL. Artificial intelligence for global health. Science. 2019 11 22; 366(6468):955-956. PMID: 31753987.
    Citations:    
  6. Shi Z, Zhovannik I, Traverso A, Dankers FJWM, Deist TM, Kalendralis P, Monshouwer R, Bussink J, Fijten R, Aerts HJWL, Dekker A, Wee L. Distributed radiomics as a signature validation study using the Personal Health Train infrastructure. Sci Data. 2019 10 22; 6(1):218. PMID: 31641134.
    Citations:    
  7. Chemi F, Rothwell DG, McGranahan N, Gulati S, Abbosh C, Pearce SP, Zhou C, Wilson GA, Jamal-Hanjani M, Birkbak N, Pierce J, Kim CS, Ferdous S, Burt DJ, Slane-Tan D, Gomes F, Moore D, Shah R, Al Bakir M, Hiley C, Veeriah S, Summers Y, Crosbie P, Ward S, Mesquita B, Dynowski M, Biswas D, Tugwood J, Blackhall F, Miller C, Hackshaw A, Brady G, Swanton C, Dive C. Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nat Med. 2019 10; 25(10):1534-1539. PMID: 31591595.
    Citations:    
  8. Biswas D, Birkbak NJ, Rosenthal R, Hiley CT, Lim EL, Papp K, Boeing S, Krzystanek M, Djureinovic D, La Fleur L, Greco M, Döme B, Fillinger J, Brunnström H, Wu Y, Moore DA, Skrzypski M, Abbosh C, Litchfield K, Al Bakir M, Watkins TBK, Veeriah S, Wilson GA, Jamal-Hanjani M, Moldvay J, Botling J, Chinnaiyan AM, Micke P, Hackshaw A, Bartek J, Csabai I, Szallasi Z, Herrero J, McGranahan N, Swanton C. A clonal expression biomarker associates with lung cancer mortality. Nat Med. 2019 10; 25(10):1540-1548. PMID: 31591602.
    Citations:    
  9. Joshi K, Robert de Massy M, Ismail M, Reading JL, Uddin I, Woolston A, Hatipoglu E, Oakes T, Rosenthal R, Peacock T, Ronel T, Noursadeghi M, Turati V, Furness AJS, Georgiou A, Wong YNS, Ben Aissa A, Werner Sunderland M, Jamal-Hanjani M, Veeriah S, Birkbak NJ, Wilson GA, Hiley CT, Ghorani E, Guerra-Assunção JA, Herrero J, Enver T, Hadrup SR, Hackshaw A, Peggs KS, McGranahan N, Swanton C, Quezada SA, Chain B. Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer. Nat Med. 2019 10; 25(10):1549-1559. PMID: 31591606.
    Citations:    
  10. Ger RB, Zhou S, Elgohari B, Elhalawani H, Mackin DM, Meier JG, Nguyen CM, Anderson BM, Gay C, Ning J, Fuller CD, Li H, Howell RM, Layman RR, Mawlawi O, Stafford RJ, Aerts H, Court LE. Radiomics features of the primary tumor fail to improve prediction of overall survival in large cohorts of CT- and PET-imaged head and neck cancer patients. PLoS One. 2019; 14(9):e0222509. PMID: 31536526.
    Citations:    
  11. Kolossváry M, Karády J, Kikuchi Y, Ivanov A, Schlett CL, Lu MT, Foldyna B, Merkely B, Aerts HJ, Hoffmann U, Maurovich-Horvat P. Radiomics versus Visual and Histogram-based Assessment to Identify Atheromatous Lesions at Coronary CT Angiography: An ex Vivo Study. Radiology. 2019 10; 293(1):89-96. PMID: 31385755.
    Citations:    
  12. Lu MT, Ivanov A, Mayrhofer T, Hosny A, Aerts HJWL, Hoffmann U. Deep Learning to Assess Long-term Mortality From Chest Radiographs. JAMA Netw Open. 2019 07 03; 2(7):e197416. PMID: 31322692.
    Citations:    
  13. Schwier M, van Griethuysen J, Vangel MG, Pieper S, Peled S, Tempany C, Aerts HJWL, Kikinis R, Fennessy FM, Fedorov A. Repeatability of Multiparametric Prostate MRI Radiomics Features. Sci Rep. 2019 07 01; 9(1):9441. PMID: 31263116.
    Citations:    
  14. Atkins KM, Rawal B, Chaunzwa TL, Lamba N, Bitterman DS, Williams CL, Kozono DE, Baldini EH, Chen AB, Nguyen PL, D'Amico AV, Nohria A, Hoffmann U, Aerts HJWL, Mak RH. Cardiac Radiation Dose, Cardiac Disease, and Mortality in Patients With Lung Cancer. J Am Coll Cardiol. 2019 06 18; 73(23):2976-2987. PMID: 31196455.
    Citations:    
  15. Campbell PT, Ambrosone CB, Nishihara R, Aerts HJWL, Bondy M, Chatterjee N, Garcia-Closas M, Giannakis M, Golden JA, Heng YJ, Kip NS, Koshiol J, Liu XS, Lopes-Ramos CM, Mucci LA, Nowak JA, Phipps AI, Quackenbush J, Schoen RE, Sholl LM, Tamimi RM, Wang M, Weijenberg MP, Wu CJ, Wu K, Yao S, Yu KH, Zhang X, Rebbeck TR, Ogino S. Proceedings of the fourth international molecular pathological epidemiology (MPE) meeting. Cancer Causes Control. 2019 Aug; 30(8):799-811. PMID: 31069578.
    Citations:    
  16. Foldyna B, Eslami P, Scholtz JE, Baltrusaitis K, Lu MT, Massaro JM, D'Agostino RB, Ferencik M, Aerts HJWL, O'Donnell CJ, Hoffmann U. Density and morphology of coronary artery calcium for the prediction of cardiovascular events: insights from the Framingham Heart Study. Eur Radiol. 2019 Nov; 29(11):6140-6148. PMID: 31049733.
    Citations:    
  17. Mak RH, Endres MG, Paik JH, Sergeev RA, Aerts H, Williams CL, Lakhani KR, Guinan EC. Use of Crowd Innovation to Develop an Artificial Intelligence-Based Solution for Radiation Therapy Targeting. JAMA Oncol. 2019 May 01; 5(5):654-661. PMID: 30998808.
    Citations:    
  18. Xu Y, Hosny A, Zeleznik R, Parmar C, Coroller T, Franco I, Mak RH, Aerts HJWL. Deep Learning Predicts Lung Cancer Treatment Response from Serial Medical Imaging. Clin Cancer Res. 2019 06 01; 25(11):3266-3275. PMID: 31010833.
    Citations:    
  19. Bi WL, Hosny A, Schabath MB, Giger ML, Birkbak NJ, Mehrtash A, Allison T, Arnaout O, Abbosh C, Dunn IF, Mak RH, Tamimi RM, Tempany CM, Swanton C, Hoffmann U, Schwartz LH, Gillies RJ, Huang RY, Aerts HJWL. Artificial intelligence in cancer imaging: Clinical challenges and applications. CA Cancer J Clin. 2019 03; 69(2):127-157. PMID: 30720861.
    Citations:    
  20. Hosny A, Parmar C, Coroller TP, Grossmann P, Zeleznik R, Kumar A, Bussink J, Gillies RJ, Mak RH, Aerts HJWL. Deep learning for lung cancer prognostication: A retrospective multi-cohort radiomics study. PLoS Med. 2018 11; 15(11):e1002711. PMID: 30500819.
    Citations:    Fields:    
  21. Welch ML, McIntosh C, Haibe-Kains B, Milosevic MF, Wee L, Dekker A, Huang SH, Purdie TG, O'Sullivan B, Aerts HJWL, Jaffray DA. Vulnerabilities of radiomic signature development: The need for safeguards. Radiother Oncol. 2019 01; 130:2-9. PMID: 30416044.
    Citations:    Fields:    
  22. Dou TH, Coroller TP, van Griethuysen JJM, Mak RH, Aerts HJWL. Peritumoral radiomics features predict distant metastasis in locally advanced NSCLC. PLoS One. 2018; 13(11):e0206108. PMID: 30388114.
    Citations:    Fields:    
  23. Napel S, Mu W, Jardim-Perassi BV, Aerts HJWL, Gillies RJ. Quantitative imaging of cancer in the postgenomic era: Radio(geno)mics, deep learning, and habitats. Cancer. 2018 12 15; 124(24):4633-4649. PMID: 30383900.
    Citations:    Fields:    
  24. Thompson RF, Valdes G, Fuller CD, Carpenter CM, Morin O, Aneja S, Lindsay WD, Aerts HJWL, Agrimson B, Deville C, Rosenthal SA, Yu JB, Thomas CR. Artificial Intelligence in Radiation Oncology Imaging. Int J Radiat Oncol Biol Phys. 2018 11 15; 102(4):1159-1161. PMID: 30353870.
    Citations:    Fields:    
  25. El Naqa I, Pandey G, Aerts H, Chien JT, Andreassen CN, Niemierko A, Ten Haken RK. Radiation Therapy Outcomes Models in the Era of Radiomics and Radiogenomics: Uncertainties and Validation. Int J Radiat Oncol Biol Phys. 2018 11 15; 102(4):1070-1073. PMID: 30353869.
    Citations:    Fields:    
  26. Blumenthal GM, Bunn PA, Chaft JE, McCoach CE, Perez EA, Scagliotti GV, Carbone DP, Aerts HJWL, Aisner DL, Bergh J, Berry DA, Jarkowski A, Botwood N, Cross DAE, Diehn M, Drezner NL, Doebele RC, Blakely CM, Eberhardt WEE, Felip E, Gianni L, Keller SP, Leavey PJ, Malik S, Pignatti F, Prowell TM, Redman MW, Rizvi NA, Rosell R, Rusch V, de Ruysscher D, Schwartz LH, Sridhara R, Stahel RA, Swisher S, Taube JM, Travis WD, Keegan P, Wiens JR, Wistuba II, Wynes MW, Hirsch FR, Kris MG. Current Status and Future Perspectives on Neoadjuvant Therapy in Lung Cancer. J Thorac Oncol. 2018 Dec; 13(12):1818-1831. PMID: 30268698.
    Citations:    Fields:    
  27. Hosny A, Parmar C, Quackenbush J, Schwartz LH, Aerts HJWL. Artificial intelligence in radiology. Nat Rev Cancer. 2018 08; 18(8):500-510. PMID: 29777175.
    Citations: 1     Fields:    
  28. Barry JD, Fagny M, Paulson JN, Aerts HJWL, Platig J, Quackenbush J. Histopathological Image QTL Discovery of Immune Infiltration Variants. iScience. 2018 Jul 27; 5:80-89. PMID: 30240647.
    Citations:    
  29. Hou Y, Hermann G, Lewis JH, Aerts HJ, Baldini EH, Chen AB, Colson YL, Hacker FL, Killoran JH, Kozono DE, Wagar M, Wee JO, Mak RH. Clinical Outcomes After Lung Stereotactic Body Radiation Therapy in Patients With or Without a Prior Lung Resection. Am J Clin Oncol. 2018 07; 41(7):695-701. PMID: 27819875.
    Citations:    Fields:    
  30. Thompson RF, Valdes G, Fuller CD, Carpenter CM, Morin O, Aneja S, Lindsay WD, Aerts HJWL, Agrimson B, Deville C, Rosenthal SA, Yu JB, Thomas CR. Artificial intelligence in radiation oncology: A specialty-wide disruptive transformation? Radiother Oncol. 2018 12; 129(3):421-426. PMID: 29907338.
    Citations: 2     Fields:    
  31. Thompson RF, Valdes G, Fuller CD, Carpenter CM, Morin O, Aneja S, Lindsay WD, Aerts HJWL, Agrimson B, Deville C, Rosenthal SA, Yu JB, Thomas CR. The Future of Artificial Intelligence in Radiation Oncology. Int J Radiat Oncol Biol Phys. 2018 10 01; 102(2):247-248. PMID: 30191856.
    Citations:    Fields:    
  32. Balagurunathan Y, Beers A, Kalpathy-Cramer J, McNitt-Gray M, Hadjiiski L, Zhao B, Zhu J, Yang H, Yip SSF, Aerts HJWL, Napel S, Cherezov D, Cha K, Chan HP, Flores C, Garcia A, Gillies R, Goldgof D. Erratum: Semi-automated pulmonary nodule interval segmentation using the NLST data. Med Phys. 2018 Jun; 45(6):2689-2690. PMID: 29894564.
    Citations:    Fields:    
  33. Parmar C, Barry JD, Hosny A, Quackenbush J, Aerts HJWL. Data Analysis Strategies in Medical Imaging. Clin Cancer Res. 2018 08 01; 24(15):3492-3499. PMID: 29581134.
    Citations:    Fields:    
  34. Balagurunathan Y, Beers A, Kalpathy-Cramer J, McNitt-Gray M, Hadjiiski L, Zhao B, Zhu J, Yang H, Yip SSF, Aerts HJWL, Napel S, Cherezov D, Cha K, Chan HP, Flores C, Garcia A, Gillies R, Goldgof D. Semi-automated pulmonary nodule interval segmentation using the NLST data. Med Phys. 2018 Mar; 45(3):1093-1107. PMID: 29363773.
    Citations:    Fields:    Translation:HumansPHPublic Health
  35. Trebeschi S, van Griethuysen JJM, Lambregts DMJ, Lahaye MJ, Parmar C, Bakers FCH, Peters NHGM, Beets-Tan RGH, Aerts HJWL. Author Correction: Deep Learning for Fully-Automated Localization and Segmentation of Rectal Cancer on Multiparametric MR. Sci Rep. 2018 02 02; 8(1):2589. PMID: 29396399.
    Citations:    Fields:    
  36. Kwan JYY, Su J, Huang SH, Ghoraie LS, Xu W, Chan B, Yip KW, Giuliani M, Bayley A, Kim J, Hope AJ, Ringash J, Cho J, McNiven A, Hansen A, Goldstein D, de Almeida JR, Aerts HJ, Waldron JN, Haibe-Kains B, O'Sullivan B, Bratman SV, Liu FF. Radiomic Biomarkers to Refine Risk Models for Distant Metastasis in HPV-related Oropharyngeal Carcinoma. Int J Radiat Oncol Biol Phys. 2018 11 15; 102(4):1107-1116. PMID: 29506884.
    Citations:    Fields:    
  37. Abbosh C, Birkbak NJ, Wilson GA, Jamal-Hanjani M, Constantin T, Salari R, Le Quesne J, Moore DA, Veeriah S, Rosenthal R, Marafioti T, Kirkizlar E, Watkins TBK, McGranahan N, Ward S, Martinson L, Riley J, Fraioli F, Al Bakir M, Grönroos E, Zambrana F, Endozo R, Bi WL, Fennessy FM, Sponer N, Johnson D, Laycock J, Shafi S, Czyzewska-Khan J, Rowan A, Chambers T, Matthews N, Turajlic S, Hiley C, Lee SM, Forster MD, Ahmad T, Falzon M, Borg E, Lawrence D, Hayward M, Kolvekar S, Panagiotopoulos N, Janes SM, Thakrar R, Ahmed A, Blackhall F, Summers Y, Hafez D, Naik A, Ganguly A, Kareht S, Shah R, Joseph L, Quinn AM, Crosbie PA, Naidu B, Middleton G, Langman G, Trotter S, Nicolson M, Remmen H, Kerr K, Chetty M, Gomersall L, Fennell DA, Nakas A, Rathinam S, Anand G, Khan S, Russell P, Ezhil V, Ismail B, Irvin-Sellers M, Prakash V, Lester JF, Kornaszewska M, Attanoos R, Adams H, Davies H, Oukrif D, Akarca AU, Hartley JA, Lowe HL, Lock S, Iles N, Bell H, Ngai Y, Elgar G, Szallasi Z, Schwarz RF, Herrero J, Stewart A, Quezada SA, Peggs KS, Van Loo P, Dive C, Lin CJ, Rabinowitz M, Aerts HJWL, Hackshaw A, Shaw JA, Zimmermann BG, Swanton C. Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution. Nature. 2018 02 08; 554(7691):264. PMID: 29258292.
    Citations: 1     Fields:    
  38. Grossmann P, Narayan V, Chang K, Rahman R, Abrey L, Reardon DA, Schwartz LH, Wen PY, Alexander BM, Huang R, Aerts HJWL. Quantitative imaging biomarkers for risk stratification of patients with recurrent glioblastoma treated with bevacizumab. Neuro Oncol. 2017 Nov 29; 19(12):1688-1697. PMID: 28499022.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  39. Coroller TP, Bi WL, Huynh E, Abedalthagafi M, Aizer AA, Greenwald NF, Parmar C, Narayan V, Wu WW, Miranda de Moura S, Gupta S, Beroukhim R, Wen PY, Al-Mefty O, Dunn IF, Santagata S, Alexander BM, Huang RY, Aerts HJWL. Radiographic prediction of meningioma grade by semantic and radiomic features. PLoS One. 2017; 12(11):e0187908. PMID: 29145421.
    Citations: 2     Fields:    Translation:Humans
  40. Aerts HJWL. Data Science in Radiology: A Path Forward. Clin Cancer Res. 2018 02 01; 24(3):532-534. PMID: 29097379.
    Citations: 1     Fields:    
  41. van Griethuysen JJM, Fedorov A, Parmar C, Hosny A, Aucoin N, Narayan V, Beets-Tan RGH, Fillion-Robin JC, Pieper S, Aerts HJWL. Computational Radiomics System to Decode the Radiographic Phenotype. Cancer Res. 2017 11 01; 77(21):e104-e107. PMID: 29092951.
    Citations: 16     Fields:    Translation:Humans
  42. Shaikh FA, Kolowitz BJ, Awan O, Aerts HJ, von Reden A, Halabi S, Mohiuddin SA, Malik S, Shrestha RB, Deible C. Technical Challenges in the Clinical Application of Radiomics. JCO Clin Cancer Inform. 2017 Nov; 1:1-8. PMID: 30657374.
    Citations:    
  43. McGranahan N, Rosenthal R, Hiley CT, Rowan AJ, Watkins TBK, Wilson GA, Birkbak NJ, Veeriah S, Van Loo P, Herrero J, Swanton C. Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution. Cell. 2017 Nov 30; 171(6):1259-1271.e11. PMID: 29107330.
    Citations: 26     Fields:    Translation:Humans
  44. Yip SSF, Parmar C, Kim J, Huynh E, Mak RH, Aerts HJWL. Impact of experimental design on PET radiomics in predicting somatic mutation status. Eur J Radiol. 2017 Dec; 97:8-15. PMID: 29153372.
    Citations: 1     Fields:    Translation:Humans
  45. Vallières M, Kay-Rivest E, Perrin LJ, Liem X, Furstoss C, Aerts HJWL, Khaouam N, Nguyen-Tan PF, Wang CS, Sultanem K, Seuntjens J, El Naqa I. Radiomics strategies for risk assessment of tumour failure in head-and-neck cancer. Sci Rep. 2017 08 31; 7(1):10117. PMID: 28860628.
    Citations: 5     Fields:    
  46. Grossmann P, Stringfield O, El-Hachem N, Bui MM, Rios Velazquez E, Parmar C, Leijenaar RT, Haibe-Kains B, Lambin P, Gillies RJ, Aerts HJ. Defining the biological basis of radiomic phenotypes in lung cancer. Elife. 2017 07 21; 6. PMID: 28731408.
    Citations: 6     Fields:    Translation:Humans
  47. Trebeschi S, van Griethuysen JJM, Lambregts DMJ, Lahaye MJ, Parmar C, Bakers FCH, Peters NHGM, Beets-Tan RGH, Aerts HJWL. Deep Learning for Fully-Automated Localization and Segmentation of Rectal Cancer on Multiparametric MR. Sci Rep. 2017 07 13; 7(1):5301. PMID: 28706185.
    Citations: 4     Fields:    Translation:Humans
  48. Velazquez ER, Hoebers F, Aerts HJWL, Rietbergen MM, Brakenhoff RH, Leemans RC, Speel EJ, Straetmans J, Kremer B, Lambin P. Corrigendum to "Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging" [Radiother Oncol 113 (2014) 324-30]. Radiother Oncol. 2017 08; 124(2):337-338. PMID: 28709696.
    Citations:    Fields:    
  49. Yip SSF, Liu Y, Parmar C, Li Q, Liu S, Qu F, Ye Z, Gillies RJ, Aerts HJWL. Associations between radiologist-defined semantic and automatically computed radiomic features in non-small cell lung cancer. Sci Rep. 2017 06 14; 7(1):3519. PMID: 28615677.
    Citations: 4     Fields:    
  50. Yip SSF, Parmar C, Blezek D, Estepar RSJ, Pieper S, Kim J, Aerts HJWL. Application of the 3D slicer chest imaging platform segmentation algorithm for large lung nodule delineation. PLoS One. 2017; 12(6):e0178944. PMID: 28594880.
    Citations: 3     Fields:    Translation:Humans
  51. Rios Velazquez E, Parmar C, Liu Y, Coroller TP, Cruz G, Stringfield O, Ye Z, Makrigiorgos M, Fennessy F, Mak RH, Gillies R, Quackenbush J, Aerts HJWL. Somatic Mutations Drive Distinct Imaging Phenotypes in Lung Cancer. Cancer Res. 2017 07 15; 77(14):3922-3930. PMID: 28566328.
    Citations: 6     Fields:    Translation:Humans
  52. Abbosh C, Birkbak NJ, Wilson GA, Jamal-Hanjani M, Constantin T, Salari R, Le Quesne J, Moore DA, Veeriah S, Rosenthal R, Marafioti T, Kirkizlar E, Watkins TBK, McGranahan N, Ward S, Martinson L, Riley J, Fraioli F, Al Bakir M, Grönroos E, Zambrana F, Endozo R, Bi WL, Fennessy FM, Sponer N, Johnson D, Laycock J, Shafi S, Czyzewska-Khan J, Rowan A, Chambers T, Matthews N, Turajlic S, Hiley C, Lee SM, Forster MD, Ahmad T, Falzon M, Borg E, Lawrence D, Hayward M, Kolvekar S, Panagiotopoulos N, Janes SM, Thakrar R, Ahmed A, Blackhall F, Summers Y, Hafez D, Naik A, Ganguly A, Kareht S, Shah R, Joseph L, Marie Quinn A, Crosbie PA, Naidu B, Middleton G, Langman G, Trotter S, Nicolson M, Remmen H, Kerr K, Chetty M, Gomersall L, Fennell DA, Nakas A, Rathinam S, Anand G, Khan S, Russell P, Ezhil V, Ismail B, Irvin-Sellers M, Prakash V, Lester JF, Kornaszewska M, Attanoos R, Adams H, Davies H, Oukrif D, Akarca AU, Hartley JA, Lowe HL, Lock S, Iles N, Bell H, Ngai Y, Elgar G, Szallasi Z, Schwarz RF, Herrero J, Stewart A, Quezada SA, Peggs KS, Van Loo P, Dive C, Lin CJ, Rabinowitz M, Aerts HJWL, Hackshaw A, Shaw JA, Zimmermann BG, Swanton C. Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution. Nature. 2017 04 26; 545(7655):446-451. PMID: 28445469.
    Citations: 71     Fields:    Translation:HumansCells
  53. Jamal-Hanjani M, Wilson GA, McGranahan N, Birkbak NJ, Watkins TBK, Veeriah S, Shafi S, Johnson DH, Mitter R, Rosenthal R, Salm M, Horswell S, Escudero M, Matthews N, Rowan A, Chambers T, Moore DA, Turajlic S, Xu H, Lee SM, Forster MD, Ahmad T, Hiley CT, Abbosh C, Falzon M, Borg E, Marafioti T, Lawrence D, Hayward M, Kolvekar S, Panagiotopoulos N, Janes SM, Thakrar R, Ahmed A, Blackhall F, Summers Y, Shah R, Joseph L, Quinn AM, Crosbie PA, Naidu B, Middleton G, Langman G, Trotter S, Nicolson M, Remmen H, Kerr K, Chetty M, Gomersall L, Fennell DA, Nakas A, Rathinam S, Anand G, Khan S, Russell P, Ezhil V, Ismail B, Irvin-Sellers M, Prakash V, Lester JF, Kornaszewska M, Attanoos R, Adams H, Davies H, Dentro S, Taniere P, O'Sullivan B, Lowe HL, Hartley JA, Iles N, Bell H, Ngai Y, Shaw JA, Herrero J, Szallasi Z, Schwarz RF, Stewart A, Quezada SA, Le Quesne J, Van Loo P, Dive C, Hackshaw A, Swanton C. Tracking the Evolution of Non-Small-Cell Lung Cancer. N Engl J Med. 2017 06 01; 376(22):2109-2121. PMID: 28445112.
    Citations: 87     Fields:    Translation:Humans
  54. Agrawal V, Coroller TP, Hou Y, Lee SW, Romano JL, Baldini EH, Chen AB, Kozono D, Swanson SJ, Wee JO, Aerts HJWL, Mak RH. Lymph node volume predicts survival but not nodal clearance in Stage IIIA-IIIB NSCLC. PLoS One. 2017; 12(4):e0174268. PMID: 28426673.
    Citations:    Fields:    Translation:Humans
  55. Aerts HJ, Grossmann P, Tan Y, Oxnard GR, Rizvi N, Schwartz LH, Zhao B. Corrigendum: Defining a Radiomic Response Phenotype: A Pilot Study using targeted therapy in NSCLC. Sci Rep. 2017 02 17; 7:41197. PMID: 28211505.
    Citations:    Fields:    
  56. Huynh E, Coroller TP, Narayan V, Agrawal V, Romano J, Franco I, Parmar C, Hou Y, Mak RH, Aerts HJ. Associations of Radiomic Data Extracted from Static and Respiratory-Gated CT Scans with Disease Recurrence in Lung Cancer Patients Treated with SBRT. PLoS One. 2017; 12(1):e0169172. PMID: 28046060.
    Citations: 10     Fields:    Translation:Humans
  57. van Loon J, Even AJG, Aerts HJWL, Öllers M, Hoebers F, van Elmpt W, Dubois L, Dingemans AC, Lalisang RI, Kempers P, Brans B, Winnepenninckx V, Speel EJ, Thunnissen E, Smits KM, Boellaard R, Vugts DJ, De Ruysscher D, Lambin P. PET imaging of zirconium-89 labelled cetuximab: A phase I trial in patients with head and neck and lung cancer. Radiother Oncol. 2017 02; 122(2):267-273. PMID: 28012793.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  58. Aerts HJ. The Potential of Radiomic-Based Phenotyping in Precision Medicine: A Review. JAMA Oncol. 2016 Dec 01; 2(12):1636-1642. PMID: 27541161.
    Citations: 27     Fields:    Translation:Humans
  59. Safikhani Z, El-Hachem N, Smirnov P, Freeman M, Goldenberg A, Birkbak NJ, Beck AH, Aerts HJ, Quackenbush J, Haibe-Kains B. Safikhani et al. reply. Nature. 2016 11 30; 540(7631):E2-E4. PMID: 27905430.
    Citations:    Fields:    
  60. Safikhani Z, El-Hachem N, Smirnov P, Freeman M, Goldenberg A, Birkbak NJ, Beck AH, Aerts HJ, Quackenbush J, Haibe-Kains B. Safikhani et al. reply. Nature. 2016 11 30; 540(7631):E11-E12. PMID: 27905423.
    Citations:    Fields:    
  61. Safikhani Z, El-Hachem N, Smirnov P, Freeman M, Goldenberg A, Birkbak NJ, Beck AH, Aerts HJ, Quackenbush J, Haibe-Kains B. Safikhani et al. reply. Nature. 2016 11 30; 540(7631):E6-E8. PMID: 27905416.
    Citations:    Fields:    
  62. Coroller TP, Agrawal V, Huynh E, Narayan V, Lee SW, Mak RH, Aerts HJWL. Radiomic-Based Pathological Response Prediction from Primary Tumors and Lymph Nodes in NSCLC. J Thorac Oncol. 2017 03; 12(3):467-476. PMID: 27903462.
    Citations: 7     Fields:    Translation:Humans
  63. Agrawal V, Coroller TP, Hou Y, Lee SW, Romano JL, Baldini EH, Chen AB, Jackman DM, Kozono D, Swanson SJ, Wee JO, Aerts HJ, Mak RH. Radiologic-pathologic correlation of response to chemoradiation in resectable locally advanced NSCLC. Lung Cancer. 2016 12; 102:1-8. PMID: 27987576.
    Citations: 2     Fields:    Translation:Humans
  64. O'Connor JP, Aboagye EO, Adams JE, Aerts HJ, Barrington SF, Beer AJ, Boellaard R, Bohndiek SE, Brady M, Brown G, Buckley DL, Chenevert TL, Clarke LP, Collette S, Cook GJ, deSouza NM, Dickson JC, Dive C, Evelhoch JL, Faivre-Finn C, Gallagher FA, Gilbert FJ, Gillies RJ, Goh V, Griffiths JR, Groves AM, Halligan S, Harris AL, Hawkes DJ, Hoekstra OS, Huang EP, Hutton BF, Jackson EF, Jayson GC, Jones A, Koh DM, Lacombe D, Lambin P, Lassau N, Leach MO, Lee TY, Leen EL, Lewis JS, Liu Y, Lythgoe MF, Manoharan P, Maxwell RJ, Miles KA, Morgan B, Morris S, Ng T, Padhani AR, Parker GJ, Partridge M, Pathak AP, Peet AC, Punwani S, Reynolds AR, Robinson SP, Shankar LK, Sharma RA, Soloviev D, Stroobants S, Sullivan DC, Taylor SA, Tofts PS, Tozer GM, van Herk M, Walker-Samuel S, Wason J, Williams KJ, Workman P, Yankeelov TE, Brindle KM, McShane LM, Jackson A, Waterton JC. Imaging biomarker roadmap for cancer studies. Nat Rev Clin Oncol. 2017 03; 14(3):169-186. PMID: 27725679.
    Citations: 59     Fields:    Translation:Humans
  65. Hou Y, Lee S, Agrawal V, Romano J, Baldini EH, Chen AB, Kozono DE, Killoran JH, Wagar M, Hacker FL, Aerts HJ, Lewis JH, Mak RH. Inter-scan and inter-observer tumour volume delineation variability on cone beam computed tomography in patients treated with stereotactic body radiation therapy for early-stage non-small cell lung cancer. J Med Imaging Radiat Oncol. 2017 Feb; 61(1):93-98. PMID: 27709803.
    Citations:    Fields:    Translation:Humans
  66. Yip SS, Kim J, Coroller TP, Parmar C, Velazquez ER, Huynh E, Mak RH, Aerts HJ. Associations Between Somatic Mutations and Metabolic Imaging Phenotypes in Non-Small Cell Lung Cancer. J Nucl Med. 2017 04; 58(4):569-576. PMID: 27688480.
    Citations: 11     Fields:    Translation:Humans
  67. Aerts HJ, Grossmann P, Tan Y, Oxnard GR, Rizvi N, Schwartz LH, Zhao B. Defining a Radiomic Response Phenotype: A Pilot Study using targeted therapy in NSCLC. Sci Rep. 2016 09 20; 6:33860. PMID: 27645803.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  68. Safikhani Z, Smirnov P, Freeman M, El-Hachem N, She A, Rene Q, Goldenberg A, Birkbak NJ, Hatzis C, Shi L, Beck AH, Aerts HJWL, Quackenbush J, Haibe-Kains B. Revisiting inconsistency in large pharmacogenomic studies. F1000Res. 2016; 5:2333. PMID: 28928933.
    Citations: 3     
  69. Grossmann P, Gutman DA, Dunn WD, Holder CA, Aerts HJ. Imaging-genomics reveals driving pathways of MRI derived volumetric tumor phenotype features in Glioblastoma. BMC Cancer. 2016 08 08; 16:611. PMID: 27502180.
    Citations: 8     Fields:    Translation:HumansCells
  70. Dunn WD, Aerts HJWL, Cooper LA, Holder CA, Hwang SN, Jaffe CC, Brat DJ, Jain R, Flanders AE, Zinn PO, Colen RR, Gutman DA. Assessing the Effects of Software Platforms on Volumetric Segmentation of Glioblastoma. J Neuroimaging Psychiatry Neurol. 2016; 1(2):64-72. PMID: 29600296.
    Citations:    
  71. Kapur T, Pieper S, Fedorov A, Fillion-Robin JC, Halle M, O'Donnell L, Lasso A, Ungi T, Pinter C, Finet J, Pujol S, Jagadeesan J, Tokuda J, Norton I, Estepar RSJ, Gering D, Aerts HJWL, Jakab M, Hata N, Ibanez L, Blezek D, Miller J, Aylward S, Grimson WEL, Fichtinger G, Wells WM, Lorensen WE, Schroeder W, Kikinis R. Increasing the impact of medical image computing using community-based open-access hackathons: The NA-MIC and 3D Slicer experience. Med Image Anal. 2016 10; 33:176-180. PMID: 27498015.
    Citations: 3     Fields:    Translation:Humans
  72. Huynh E, Coroller TP, Narayan V, Agrawal V, Hou Y, Romano J, Franco I, Mak RH, Aerts HJ. CT-based radiomic analysis of stereotactic body radiation therapy patients with lung cancer. Radiother Oncol. 2016 08; 120(2):258-66. PMID: 27296412.
    Citations: 16     Fields:    Translation:Humans
  73. Yip SS, Aerts HJ. Applications and limitations of radiomics. Phys Med Biol. 2016 07 07; 61(13):R150-66. PMID: 27269645.
    Citations: 39     Fields:    Translation:Humans
  74. Huynh E, Coroller T, Narayan V, Agrawal V, Hou Y, Romano J, Franco I, Mak R, Aerts H. SU-F-R-53: CT-Based Radiomics Analysis of Non-Small Cell Lung Cancer Patients Treated with Stereotactic Body Radiation Therapy. Med Phys. 2016 Jun; 43(6):3385. PMID: 28048830.
    Citations:    
  75. Yip S, Kim J, Coroller T, Rios Velazquez E, Parmar C, Mak R, Aerts H. MO-DE-207B-01: JACK FOWLER JUNIOR INVESTIGATOR COMPETITION WINNER: Between Somatic Mutations and PET-Based Radiomic Features in Non-Small Cell Lung Cancer. Med Phys. 2016 Jun; 43(6):3704. PMID: 28048737.
    Citations:    
  76. Grossmann P, Narayan V, Huang R, Aerts H. TU-D-207B-07: Radiomic Response Assessment for Recurrent Glioblastoma Treated with Bevacizumab in the BRAIN Trial. Med Phys. 2016 Jun; 43(6):3751-3752. PMID: 28048647.
    Citations:    
  77. Coroller T, Bi W, Abedalthagafi M, Aizer A, Wu W, Greenwald N, Beroukhim R, Al-Mefty O, Santagata S, Dunn I, Alexander B, Huang R, Aerts H. SU-D-207B-02: Early Grade Classification in Meningioma Patients Combining Radiomics and Semantics Data. Med Phys. 2016 Jun; 43(6):3348-3349. PMID: 28048264.
    Citations:    
  78. Coroller T, Yip S, Kim J, Lee S, Mak R, Aerts H. SU-D-207B-03: A PET-CT Radiomics Comparison to Predict Distant Metastasis in Lung Adenocarcinoma. Med Phys. 2016 Jun; 43(6):3349. PMID: 28047618.
    Citations:    
  79. Rios Velazquez E, Liu Y, Parmar C, Narayan V, Gillies R, Aerts H. MO-DE-207B-08: Radiomic CT Features Complement Semantic Annotations to Predict EGFR Mutations in Lung Adenocarcinomas. Med Phys. 2016 Jun; 43(6):3706. PMID: 28046857.
    Citations:    
  80. Huynh E, Coroller T, Narayan V, Agrawal V, Romano J, Franco I, Hou Y, Mak R, Aerts H. SU-F-R-52: A Comparison of the Performance of Radiomic Features From Free Breathing and 4DCT Scans in Predicting Disease Recurrence in Lung Cancer SBRT Patients. Med Phys. 2016 Jun; 43(6):3385. PMID: 28046768.
    Citations:    
  81. Coroller T, Agrawal V, Narayan V, Lee S, Mak R, Aerts H. TU-D-207B-06: Pathological Response Prediction by Radiomic Data From Primary and Lymph Nodes in NSCLC. Med Phys. 2016 Jun; 43(6):3751. PMID: 28046592.
    Citations:    
  82. Safikhani Z, El-Hachem N, Quevedo R, Smirnov P, Goldenberg A, Juul Birkbak N, Mason C, Hatzis C, Shi L, Aerts HJ, Quackenbush J, Haibe-Kains B. Assessment of pharmacogenomic agreement. F1000Res. 2016; 5:825. PMID: 27408686.
    Citations: 9     
  83. Coroller TP, Agrawal V, Narayan V, Hou Y, Grossmann P, Lee SW, Mak RH, Aerts HJ. Radiomic phenotype features predict pathological response in non-small cell lung cancer. Radiother Oncol. 2016 06; 119(3):480-6. PMID: 27085484.
    Citations: 29     Fields:    Translation:Humans
  84. Wu W, Parmar C, Grossmann P, Quackenbush J, Lambin P, Bussink J, Mak R, Aerts HJ. Exploratory Study to Identify Radiomics Classifiers for Lung Cancer Histology. Front Oncol. 2016; 6:71. PMID: 27064691.
    Citations: 23     
  85. Yip SS, Coroller TP, Sanford NN, Mamon H, Aerts HJ, Berbeco RI. Relationship between the Temporal Changes in Positron-Emission-Tomography-Imaging-Based Textural Features and Pathologic Response and Survival in Esophageal Cancer Patients. Front Oncol. 2016; 6:72. PMID: 27066454.
    Citations: 9     
  86. Yip SS, Coroller TP, Sanford NN, Huynh E, Mamon H, Aerts HJ, Berbeco RI. Use of registration-based contour propagation in texture analysis for esophageal cancer pathologic response prediction. Phys Med Biol. 2016 Jan 21; 61(2):906-22. PMID: 26738433.
    Citations: 8     Fields:    Translation:Humans
  87. Smirnov P, Safikhani Z, El-Hachem N, Wang D, She A, Olsen C, Freeman M, Selby H, Gendoo DM, Grossmann P, Beck AH, Aerts HJ, Lupien M, Goldenberg A, Haibe-Kains B. PharmacoGx: an R package for analysis of large pharmacogenomic datasets. Bioinformatics. 2016 04 15; 32(8):1244-6. PMID: 26656004.
    Citations: 16     Fields:    Translation:Humans
  88. Parmar C, Grossmann P, Rietveld D, Rietbergen MM, Lambin P, Aerts HJ. Radiomic Machine-Learning Classifiers for Prognostic Biomarkers of Head and Neck Cancer. Front Oncol. 2015; 5:272. PMID: 26697407.
    Citations: 22     
  89. Rios Velazquez E, Meier R, Dunn WD, Alexander B, Wiest R, Bauer S, Gutman DA, Reyes M, Aerts HJ. Fully automatic GBM segmentation in the TCGA-GBM dataset: Prognosis and correlation with VASARI features. Sci Rep. 2015 Nov 18; 5:16822. PMID: 26576732.
    Citations: 12     Fields:    Translation:Humans
  90. Gutman DA, Dunn WD, Grossmann P, Cooper LA, Holder CA, Ligon KL, Alexander BM, Aerts HJ. Somatic mutations associated with MRI-derived volumetric features in glioblastoma. Neuroradiology. 2015 Dec; 57(12):1227-37. PMID: 26337765.
    Citations: 17     Fields:    Translation:Humans
  91. Parmar C, Grossmann P, Bussink J, Lambin P, Aerts HJWL. Machine Learning methods for Quantitative Radiomic Biomarkers. Sci Rep. 2015 Aug 17; 5:13087. PMID: 26278466.
    Citations: 68     Fields:    Translation:Humans
  92. Leijenaar RT, Carvalho S, Hoebers FJ, Aerts HJ, van Elmpt WJ, Huang SH, Chan B, Waldron JN, O'sullivan B, Lambin P. External validation of a prognostic CT-based radiomic signature in oropharyngeal squamous cell carcinoma. Acta Oncol. 2015; 54(9):1423-9. PMID: 26264429.
    Citations: 24     Fields:    Translation:Humans
  93. Leijenaar RT, Nalbantov G, Carvalho S, van Elmpt WJ, Troost EG, Boellaard R, Aerts HJ, Gillies RJ, Lambin P. The effect of SUV discretization in quantitative FDG-PET Radiomics: the need for standardized methodology in tumor texture analysis. Sci Rep. 2015 Aug 05; 5:11075. PMID: 26242464.
    Citations: 42     Fields:    Translation:Humans
  94. El-Hachem N, Grossmann P, Blanchet-Cohen A, Bateman AR, Bouchard N, Archambault J, Aerts HJ, Haibe-Kains B. Characterization of Conserved Toxicogenomic Responses in Chemically Exposed Hepatocytes across Species and Platforms. Environ Health Perspect. 2016 Mar; 124(3):313-20. PMID: 26173225.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  95. Parmar C, Leijenaar RT, Grossmann P, Rios Velazquez E, Bussink J, Rietveld D, Rietbergen MM, Haibe-Kains B, Lambin P, Aerts HJ. Radiomic feature clusters and prognostic signatures specific for Lung and Head & Neck cancer. Sci Rep. 2015 Jun 05; 5:11044. PMID: 26251068.
    Citations: 61     Fields:    Translation:Humans
  96. Aerts H. TU-G-303-02: Robust Radiomics Methods for PET and CT Imaging. Med Phys. 2015 Jun; 42(6):3632. PMID: 26129059.
    Citations:    
  97. Velazquez ER, Narayan V, Grossmann P, Dunn W, Gutman D, Aerts H. TU-CD-BRB-04: Automated Radiomic Features Complement the Prognostic Value of VASARI in the TCGA-GBM Dataset. Med Phys. 2015 Jun; 42(6):3603. PMID: 26128892.
    Citations:    
  98. Grossmann P, Grove O, El-Hachem N, Velazquez ER, Parmar C, Leijenaar R, Haibe-Kains B, Lambin P, Gillies R, Aerts H. TU-CD-BRB-02: BEST IN PHYSICS (JOINT IMAGING-THERAPY): Identification of Molecular Phenotypes by Integrating Radiomics and Genomics. Med Phys. 2015 Jun; 42(6):3602. PMID: 26128887.
    Citations:    
  99. Rios Velazquez E, Meier R, Dunn W, Alexander B, Wiest R, Bauer S, Gutman D, Reyes M, Aerts H. TU-AB-BRA-11: Evaluation of Fully Automatic Volumetric GBM Segmentation in the TCGA-GBM Dataset: Prognosis and Correlation with VASARI Features. Med Phys. 2015 Jun; 42(6):3589. PMID: 26128818.
    Citations:    
  100. Yip S, Coroller T, Niu N, Mamon H, Aerts H, Berbeco R. TU-AB-BRA-12: Impact of Image Registration Algorithms On the Prediction of Pathological Response with Radiomic Textures. Med Phys. 2015 Jun; 42(6):3589. PMID: 26128817.
    Citations:    
  101. Hou Y, Aileen C, Kozono D, Killoran J, Wagar M, Lee S, Hacker F, Aerts H, Lewis J, Mak R. SU-E-J-266: Cone Beam Computed Tomography (CBCT) Inter-Scan and Inter-Observer Tumor Volume Variability Assessment in Patients Treated with Stereotactic Body Radiation Therapy (SBRT) for Early Stage Non-Small Cell Lung Cancer (NSCLC). Med Phys. 2015 Jun; 42(6):3328. PMID: 26127657.
    Citations:    
  102. Coroller T, Grossmann P, Hou Y, Lee S, Mak R, Aerts H. SU-E-J-246: CT-Based Volumetric Features Are Associated with Somatic Mutations in Lung Cancer. Med Phys. 2015 Jun; 42(6):3322. PMID: 26127634.
    Citations:    
  103. Coroller TP, Grossmann P, Hou Y, Rios Velazquez E, Leijenaar RT, Hermann G, Lambin P, Haibe-Kains B, Mak RH, Aerts HJ. CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma. Radiother Oncol. 2015 Mar; 114(3):345-50. PMID: 25746350.
    Citations: 77     Fields:    Translation:Humans
  104. Grove O, Berglund AE, Schabath MB, Aerts HJ, Dekker A, Wang H, Velazquez ER, Lambin P, Gu Y, Balagurunathan Y, Eikman E, Gatenby RA, Eschrich S, Gillies RJ. Quantitative computed tomographic descriptors associate tumor shape complexity and intratumor heterogeneity with prognosis in lung adenocarcinoma. PLoS One. 2015; 10(3):e0118261. PMID: 25739030.
    Citations: 32     Fields:    Translation:Humans
  105. Yip S, McCall K, Aristophanous M, Chen AB, Aerts HJ, Berbeco R. Comparison of texture features derived from static and respiratory-gated PET images in non-small cell lung cancer. PLoS One. 2014; 9(12):e115510. PMID: 25517987.
    Citations: 15     Fields:    Translation:Humans
  106. Hendrickx DM, Aerts HJ, Caiment F, Clark D, Ebbels TM, Evelo CT, Gmuender H, Hebels DG, Herwig R, Hescheler J, Jennen DG, Jetten MJ, Kanterakis S, Keun HC, Matser V, Overington JP, Pilicheva E, Sarkans U, Segura-Lepe MP, Sotiriadou I, Wittenberger T, Wittwehr C, Zanzi A, Kleinjans JC. diXa: a data infrastructure for chemical safety assessment. Bioinformatics. 2015 May 01; 31(9):1505-7. PMID: 25505093.
    Citations: 6     Fields:    Translation:HumansAnimals
  107. Yip S, Chen AB, Aerts HJ, Berbeco R. Sensitivity study of voxel-based PET image comparison to image registration algorithms. Med Phys. 2014 Nov; 41(11):111714. PMID: 25370628.
    Citations: 1     Fields:    Translation:Humans
  108. Rios Velazquez E, Hoebers F, Aerts HJ, Rietbergen MM, Brakenhoff RH, Leemans RC, Speel EJ, Straetmans J, Kremer B, Lambin P. Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging. Radiother Oncol. 2014 Dec; 113(3):324-30. PMID: 25443497.
    Citations: 7     Fields:    Translation:HumansCells
  109. Mak RH, Hermann G, Lewis JH, Aerts HJ, Baldini EH, Chen AB, Colson YL, Hacker FH, Kozono D, Wee JO, Chen YH, Catalano PJ, Wong KK, Sher DJ. Outcomes by tumor histology and KRAS mutation status after lung stereotactic body radiation therapy for early-stage non-small-cell lung cancer. Clin Lung Cancer. 2015 Jan; 16(1):24-32. PMID: 25450872.
    Citations: 11     Fields:    Translation:Humans
  110. Aerts HJ, Velazquez ER, Leijenaar RT, Parmar C, Grossmann P, Carvalho S, Bussink J, Monshouwer R, Haibe-Kains B, Rietveld D, Hoebers F, Rietbergen MM, Leemans CR, Dekker A, Quackenbush J, Gillies RJ, Lambin P. Corrigendum: Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach. Nat Commun. 2014; 5:4644. PMID: 25100327.
    Citations:    
  111. Parmar C, Rios Velazquez E, Leijenaar R, Jermoumi M, Carvalho S, Mak RH, Mitra S, Shankar BU, Kikinis R, Haibe-Kains B, Lambin P, Aerts HJ. Robust Radiomics feature quantification using semiautomatic volumetric segmentation. PLoS One. 2014; 9(7):e102107. PMID: 25025374.
    Citations: 64     Fields:    Translation:Humans
  112. Hatzis C, Bedard PL, Birkbak NJ, Beck AH, Aerts HJ, Stem DF, Stern DF, Shi L, Clarke R, Quackenbush J, Haibe-Kains B. Enhancing reproducibility in cancer drug screening: how do we move forward? Cancer Res. 2014 Aug 01; 74(15):4016-23. PMID: 25015668.
    Citations: 15     Fields:    Translation:Humans
  113. Aerts HJ, Velazquez ER, Leijenaar RT, Parmar C, Grossmann P, Carvalho S, Cavalho S, Bussink J, Monshouwer R, Haibe-Kains B, Rietveld D, Hoebers F, Rietbergen MM, Leemans CR, Dekker A, Quackenbush J, Gillies RJ, Lambin P. Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach. Nat Commun. 2014 Jun 03; 5:4006. PMID: 24892406.
    Citations: 343     Fields:    Translation:Humans
  114. Bateman AR, El-Hachem N, Beck AH, Aerts HJ, Haibe-Kains B. Importance of collection in gene set enrichment analysis of drug response in cancer cell lines. Sci Rep. 2014 Feb 13; 4:4092. PMID: 24522610.
    Citations: 5     Fields:    Translation:HumansCells
  115. Hebels DG, Jetten MJ, Aerts HJ, Herwig R, Theunissen DH, Gaj S, van Delft JH, Kleinjans JC. Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicity. Biomark Med. 2014; 8(2):185-200. PMID: 24521014.
    Citations: 3     Fields:    Translation:HumansCells
  116. Velazquez ER, Parmar C, Jermoumi M, Mak RH, van Baardwijk A, Fennessy FM, Lewis JH, De Ruysscher D, Kikinis R, Lambin P, Aerts HJ. Volumetric CT-based segmentation of NSCLC using 3D-Slicer. Sci Rep. 2013 Dec 18; 3:3529. PMID: 24346241.
    Citations: 24     Fields:    Translation:Humans
  117. Haibe-Kains B, El-Hachem N, Birkbak NJ, Jin AC, Beck AH, Aerts HJ, Quackenbush J. Inconsistency in large pharmacogenomic studies. Nature. 2013 Dec 19; 504(7480):389-93. PMID: 24284626.
    Citations: 121     Fields:    Translation:HumansCells
  118. Carvalho S, Leijenaar RT, Velazquez ER, Oberije C, Parmar C, van Elmpt W, Reymen B, Troost EG, Oellers M, Dekker A, Gillies R, Aerts HJ, Lambin P. Prognostic value of metabolic metrics extracted from baseline positron emission tomography images in non-small cell lung cancer. Acta Oncol. 2013 Oct; 52(7):1398-404. PMID: 24047338.
    Citations: 10     Fields:    Translation:Humans
  119. Leijenaar RT, Carvalho S, Velazquez ER, van Elmpt WJ, Parmar C, Hoekstra OS, Hoekstra CJ, Boellaard R, Dekker AL, Gillies RJ, Aerts HJ, Lambin P. Stability of FDG-PET Radiomics features: an integrated analysis of test-retest and inter-observer variability. Acta Oncol. 2013 Oct; 52(7):1391-7. PMID: 24047337.
    Citations: 64     Fields:    Translation:Humans
  120. Gu Y, Kumar V, Hall LO, Goldgof DB, Li CY, Korn R, Bendtsen C, Velazquez ER, Dekker A, Aerts H, Lambin P, Li X, Tian J, Gatenby RA, Gillies RJ. Automated Delineation of Lung Tumors from CT Images Using a Single Click Ensemble Segmentation Approach. Pattern Recognit. 2013 Mar 01; 46(3):692-702. PMID: 23459617.
    Citations: 30     
  121. Papillon-Cavanagh S, De Jay N, Hachem N, Olsen C, Bontempi G, Aerts HJ, Quackenbush J, Haibe-Kains B. Comparison and validation of genomic predictors for anticancer drug sensitivity. J Am Med Inform Assoc. 2013 Jul-Aug; 20(4):597-602. PMID: 23355484.
    Citations: 19     Fields:    Translation:HumansCells
  122. Lambin P, van Stiphout RG, Starmans MH, Rios-Velazquez E, Nalbantov G, Aerts HJ, Roelofs E, van Elmpt W, Boutros PC, Granone P, Valentini V, Begg AC, De Ruysscher D, Dekker A. Predicting outcomes in radiation oncology--multifactorial decision support systems. Nat Rev Clin Oncol. 2013 Jan; 10(1):27-40. PMID: 23165123.
    Citations: 78     Fields:    Translation:Humans
  123. Rios Velazquez E, Aerts HJ, Gu Y, Goldgof DB, De Ruysscher D, Dekker A, Korn R, Gillies RJ, Lambin P. A semiautomatic CT-based ensemble segmentation of lung tumors: comparison with oncologists' delineations and with the surgical specimen. Radiother Oncol. 2012 Nov; 105(2):167-73. PMID: 23157978.
    Citations: 16     Fields:    Translation:Humans
  124. Kumar V, Gu Y, Basu S, Berglund A, Eschrich SA, Schabath MB, Forster K, Aerts HJ, Dekker A, Fenstermacher D, Goldgof DB, Hall LO, Lambin P, Balagurunathan Y, Gatenby RA, Gillies RJ. Radiomics: the process and the challenges. Magn Reson Imaging. 2012 Nov; 30(9):1234-48. PMID: 22898692.
    Citations: 162     Fields:    Translation:Humans
  125. Lambin P, Rios-Velazquez E, Leijenaar R, Carvalho S, van Stiphout RG, Granton P, Zegers CM, Gillies R, Boellard R, Dekker A, Aerts HJ. Radiomics: extracting more information from medical images using advanced feature analysis. Eur J Cancer. 2012 Mar; 48(4):441-6. PMID: 22257792.
    Citations: 255     Fields:    Translation:Humans
  126. Aerts HJ, Jaspers K, Backes WH. The precision of pharmacokinetic parameters in dynamic contrast-enhanced magnetic resonance imaging: the effect of sampling frequency and duration. Phys Med Biol. 2011 Sep 07; 56(17):5665-78. PMID: 21828909.
    Citations: 6     Fields:    Translation:Humans
  127. Aerts HJ, Bussink J, Oyen WJ, van Elmpt W, Folgering AM, Emans D, Velders M, Lambin P, De Ruysscher D. Identification of residual metabolic-active areas within NSCLC tumours using a pre-radiotherapy FDG-PET-CT scan: a prospective validation. Lung Cancer. 2012 Jan; 75(1):73-6. PMID: 21782272.
    Citations: 23     Fields:    Translation:Humans
  128. Janssen MH, Aerts HJ, Buijsen J, Lambin P, Lammering G, Öllers MC. Repeated positron emission tomography-computed tomography and perfusion-computed tomography imaging in rectal cancer: fluorodeoxyglucose uptake corresponds with tumor perfusion. Int J Radiat Oncol Biol Phys. 2012 Feb 01; 82(2):849-55. PMID: 21392896.
    Citations: 5     Fields:    Translation:Humans
  129. Buckler AJ, Bresolin L, Dunnick NR, Sullivan DC. A collaborative enterprise for multi-stakeholder participation in the advancement of quantitative imaging. Radiology. 2011 Mar; 258(3):906-14. PMID: 21339352.
    Citations: 41     Fields:    Translation:Humans
  130. Buckler AJ, Bresolin L, Dunnick NR, Sullivan DC, Aerts HJ, Bendriem B, Bendtsen C, Boellaard R, Boone JM, Cole PE, Conklin JJ, Dorfman GS, Douglas PS, Eidsaunet W, Elsinger C, Frank RA, Gatsonis C, Giger ML, Gupta SN, Gustafson D, Hoekstra OS, Jackson EF, Karam L, Kelloff GJ, Kinahan PE, McLennan G, Miller CG, Mozley PD, Muller KE, Patt R, Raunig D, Rosen M, Rupani H, Schwartz LH, Siegel BA, Sorensen AG, Wahl RL, Waterton JC, Wolf W, Zahlmann G, Zimmerman B. Quantitative imaging test approval and biomarker qualification: interrelated but distinct activities. Radiology. 2011 Jun; 259(3):875-84. PMID: 21325035.
    Citations: 32     Fields:    Translation:HumansPHPublic Health
  131. Dehing-Oberije C, Aerts H, Yu S, De Ruysscher D, Menheere P, Hilvo M, van der Weide H, Rao B, Lambin P. Development and validation of a prognostic model using blood biomarker information for prediction of survival of non-small-cell lung cancer patients treated with combined chemotherapy and radiation or radiotherapy alone (NCT00181519, NCT00573040, and NCT00572325). Int J Radiat Oncol Biol Phys. 2011 Oct 01; 81(2):360-8. PMID: 20888135.
    Citations: 21     Fields:    Translation:Humans
  132. Velazquez ER, Aerts HJ, Oberije C, De Ruysscher D, Lambin P. Prediction of residual metabolic activity after treatment in NSCLC patients. Acta Oncol. 2010 Oct; 49(7):1033-9. PMID: 20831492.
    Citations: 8     Fields:    Translation:Humans
  133. Jimenez MF, van Baardwijk A, Aerts HJ, De Ruysscher D, Novoa NM, Varela G, Lambin P. Effectiveness of surgery and individualized high-dose hyperfractionated accelerated radiotherapy on survival in clinical stage I non-small cell lung cancer. A propensity score matched analysis. Radiother Oncol. 2010 Dec; 97(3):413-7. PMID: 20851487.
    Citations:    Fields:    Translation:Humans
  134. Lambin P, Petit SF, Aerts HJ, van Elmpt WJ, Oberije CJ, Starmans MH, van Stiphout RG, van Dongen GA, Muylle K, Flamen P, Dekker AL, De Ruysscher D. The ESTRO Breur Lecture 2009. From population to voxel-based radiotherapy: exploiting intra-tumour and intra-organ heterogeneity for advanced treatment of non-small cell lung cancer. Radiother Oncol. 2010 Aug; 96(2):145-52. PMID: 20647155.
    Citations: 21     Fields:    Translation:Humans
  135. Aerts HJ, Lambin P, Ruysscher DD. FDG for dose painting: a rational choice. Radiother Oncol. 2010 Nov; 97(2):163-4. PMID: 20561697.
    Citations: 6     Fields:    Translation:Humans
  136. van Loon J, Janssen MH, Ollers M, Aerts HJ, Dubois L, Hochstenbag M, Dingemans AM, Lalisang R, Brans B, Windhorst B, van Dongen GA, Kolb H, Zhang J, De Ruysscher D, Lambin P. PET imaging of hypoxia using [18F]HX4: a phase I trial. Eur J Nucl Med Mol Imaging. 2010 Aug; 37(9):1663-8. PMID: 20369236.
    Citations: 24     Fields:    Translation:HumansCTClinical Trials
  137. Janssen MH, Aerts HJ, Kierkels RG, Backes WH, Ollers MC, Buijsen J, Lambin P, Lammering G. Tumor perfusion increases during hypofractionated short-course radiotherapy in rectal cancer: sequential perfusion-CT findings. Radiother Oncol. 2010 Feb; 94(2):156-60. PMID: 20080311.
    Citations: 8     Fields:    Translation:Humans
  138. Kierkels RG, Backes WH, Janssen MH, Buijsen J, Beets-Tan RG, Lambin P, Lammering G, Oellers MC, Aerts HJ. Comparison between perfusion computed tomography and dynamic contrast-enhanced magnetic resonance imaging in rectal cancer. Int J Radiat Oncol Biol Phys. 2010 Jun 01; 77(2):400-8. PMID: 19733445.
    Citations: 10     Fields:    Translation:Humans
  139. Jaspers K, Aerts HJ, Leiner T, Oostendorp M, van Riel NA, Post MJ, Backes WH. Reliability of pharmacokinetic parameters: small vs. medium-sized contrast agents. Magn Reson Med. 2009 Sep; 62(3):779-87. PMID: 19623622.
    Citations: 6     Fields:    Translation:Animals
  140. Janssen MH, Ollers MC, Riedl RG, van den Bogaard J, Buijsen J, van Stiphout RG, Aerts HJ, Lambin P, Lammering G. Accurate prediction of pathological rectal tumor response after two weeks of preoperative radiochemotherapy using (18)F-fluorodeoxyglucose-positron emission tomography-computed tomography imaging. Int J Radiat Oncol Biol Phys. 2010 Jun 01; 77(2):392-9. PMID: 19646825.
    Citations: 29     Fields:    Translation:Humans
  141. Jutten B, Dubois L, Li Y, Aerts H, Wouters BG, Lambin P, Theys J, Lammering G. Binding of cetuximab to the EGFRvIII deletion mutant and its biological consequences in malignant glioma cells. Radiother Oncol. 2009 Sep; 92(3):393-8. PMID: 19616334.
    Citations: 10     Fields:    Translation:HumansCells
  142. Aerts HJ, van Baardwijk AA, Petit SF, Offermann C, Loon Jv, Houben R, Dingemans AM, Wanders R, Boersma L, Borger J, Bootsma G, Geraedts W, Pitz C, Simons J, Wouters BG, Oellers M, Lambin P, Bosmans G, Dekker AL, De Ruysscher D. Identification of residual metabolic-active areas within individual NSCLC tumours using a pre-radiotherapy (18)Fluorodeoxyglucose-PET-CT scan. Radiother Oncol. 2009 Jun; 91(3):386-92. PMID: 19329207.
    Citations: 41     Fields:    Translation:Humans
  143. Petit SF, Aerts HJ, van Loon JG, Offermann C, Houben R, Winkens B, Ollers MC, Lambin P, De Ruysscher D, Dekker AL. Metabolic control probability in tumour subvolumes or how to guide tumour dose redistribution in non-small cell lung cancer (NSCLC): an exploratory clinical study. Radiother Oncol. 2009 Jun; 91(3):393-8. PMID: 19328570.
    Citations: 9     Fields:    Translation:HumansPHPublic Health
  144. De Ruysscher D, Houben A, Aerts HJ, Dehing C, Wanders R, Ollers M, Dingemans AM, Hochstenbag M, Boersma L, Borger J, Dekker A, Lambin P. Increased (18)F-deoxyglucose uptake in the lung during the first weeks of radiotherapy is correlated with subsequent Radiation-Induced Lung Toxicity (RILT): a prospective pilot study. Radiother Oncol. 2009 Jun; 91(3):415-20. PMID: 19195730.
    Citations: 13     Fields:    Translation:HumansPHPublic Health
  145. Aerts HJ, Dubois L, Perk L, Vermaelen P, van Dongen GA, Wouters BG, Lambin P. Disparity between in vivo EGFR expression and 89Zr-labeled cetuximab uptake assessed with PET. J Nucl Med. 2009 Jan; 50(1):123-31. PMID: 19091906.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  146. Janssen MH, Aerts HJ, Ollers MC, Bosmans G, Lee JA, Buijsen J, De Ruysscher D, Lambin P, Lammering G, Dekker AL. Tumor delineation based on time-activity curve differences assessed with dynamic fluorodeoxyglucose positron emission tomography-computed tomography in rectal cancer patients. Int J Radiat Oncol Biol Phys. 2009 Feb 01; 73(2):456-65. PMID: 18556143.
    Citations: 9     Fields:    Translation:Humans
  147. Aerts HJ, van Riel NA, Backes WH. System identification theory in pharmacokinetic modeling of dynamic contrast-enhanced MRI: influence of contrast injection. Magn Reson Med. 2008 May; 59(5):1111-9. PMID: 18429040.
    Citations: 8     Fields:    Translation:Humans
  148. Aerts HJ, Bosmans G, van Baardwijk AA, Dekker AL, Oellers MC, Lambin P, De Ruysscher D. Stability of 18F-deoxyglucose uptake locations within tumor during radiotherapy for NSCLC: a prospective study. Int J Radiat Oncol Biol Phys. 2008 Aug 01; 71(5):1402-7. PMID: 18234432.
    Citations: 17     Fields:    Translation:Humans
  149. Aerts HJ, Dubois L, Hackeng TM, Straathof R, Chiu RK, Lieuwes NG, Jutten B, Weppler SA, Lammering G, Wouters BG, Lambin P. Development and evaluation of a cetuximab-based imaging probe to target EGFR and EGFRvIII. Radiother Oncol. 2007 Jun; 83(3):326-32. PMID: 17531336.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.