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David Evan Leaf, M.D.

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Biography
University of PennsylvaniaBA05/2004Psychology
New York University School of MedicineMD05/2008Medicine
New York Presbyterian Hospital-Columbia Campus06/2011Internal Medicine Residency
Harvard Medical SchoolMMSc05/2014Scholars in Clinical Science Program
Brigham and Women's Hospital and Massachusetts General Hospital05/2015Nephrology Fellowship
2004
Summa Cum Laude
2004
Phi Beta Kappa
2008
Andrew Alan Friedland Memorial Award
2008
Excellence in Research
2011
Excellence in Research
2013
Excellence in teaching
2014
Excellence in teaching
2015
Chair’s Research Award
2018
Carl W. Gottschalk Research Scholar Award
2018
Outstanding Reviewer Award

Overview
Dr. Leaf is an Assistant Professor of Medicine at Harvard Medical School and the Director of Clinical and Translational Research in Acute Kidney Injury in the Division of Renal Medicine at Brigham and Women’s Hospital. He conducts patient-oriented research in acute kidney injury (AKI) and critical illness. He uses epidemiologic, translational, genetic, and interventional approaches to address clinically important questions in patients with AKI. Current areas of investigation include dysregulated mineral and iron homeostasis as novel pathways and potential therapeutic targets in AKI, as well as investigation of the nephrotoxicity of novel cancer therapies.

Dr. Leaf is the principal investigator on two R01 grants. He serves on the Editorial Boards of Kidney International and Clinical Journal of the American Society of Nephrology, and is a member of the Mass General Brigham Institutional Review Board. His publications have appeared in leading medical journals including the New England Journal of Medicine, BMJ, JAMA Internal Medicine, Nature Medicine, Journal of Clinical Investigation, Journal of the American Society of Nephrology, and Kidney International. His research has been featured in national media including The New York Times, Washington Post, USA today, CNN, and NPR.

Dr. Leaf is passionate about academic nephrology, and has received research and teaching awards from NYU, Columbia, and Harvard. He enjoys spending time with his wife (Rebecca), his two children (Emma and Teddy), his cat (Winston), as well as traveling, skiing, swimming, and playing chess.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK125786 (LEAF, DAVID EVAN) Sep 1, 2020 - Jun 30, 2025
    NIH/NIDDK
    Deferoxamine for the Prevention of Acute Kidney Injury
    Role: Principal Investigator
  2. R01DK125786 (LEAF, DAVID EVAN) Sep 1, 2020 - Jun 30, 2025
    NIH
    Deferoxamine for the Prevention of Acute Kidney Injury
    Role: Principal Investigator
  3. R01HL144566 (LEAF, DAVID EVAN) Jul 1, 2019 - Jun 30, 2023
    NIH
    Precision Medicine Approach to Vitamin D3 Administration in Critical Illness
    Role: Principal Investigator
  4. Carl W. Gottschalk Research Scholar Grant (LEAF, DAVID EVAN) Jul 1, 2018 - Jun 30, 2019
    American Society of Nephrology Foundation for Kidney Research
    Hepcidin, Dysregulated Iron Homeostasis, and Anemia in Human Acute Kidney Injury
    Role: Principal Investigator
  5. K23DK106448 (LEAF, DAVID EVAN) Jul 15, 2015 - Jun 30, 2020
    NIH
    Dysregulated Mineral Metabolism and Acute Kidney Injury
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Short SAP, Gupta S, Brenner SK, Hayek SS, Srivastava A, Shaefi S, Singh H, Wu B, Bagchi A, Al-Samkari H, Dy R, Wilkinson K, Zakai NA, Leaf DE. d-dimer and Death in Critically Ill Patients With Coronavirus Disease 2019. Crit Care Med. 2021 05 01; 49(5):e500-e511. PMID: 33591017.
    Citations:    Fields:    Translation:Humans
  2. Churpek MM, Gupta S, Spicer AB, Parker WF, Fahrenbach J, Brenner SK, Leaf DE. Hospital-Level Variation in Death for Critically Ill Patients with COVID-19. Am J Respir Crit Care Med. 2021 Apr 23. PMID: 33891529.
    Citations:    Fields:    
  3. Douin DJ, Shaefi S, Brenner SK, Gupta S, Park I, Wright FL, Mathews KS, Chan L, Al-Samkari H, Orfanos S, Radbel J, Leaf DE. Tissue Plasminogen Activator in Critically Ill Adults with COVID-19. Ann Am Thorac Soc. 2021 Apr 19. PMID: 33872546.
    Citations:    Fields:    
  4. Gupta S, Leaf DE. Diphenhydramine for the prevention of cisplatin-associated acute kidney injury. Kidney Int. 2021 04; 99(4):1025-1026. PMID: 33745534.
    Citations:    Fields:    Translation:Humans
  5. Leaf DE, Hayek SS. Questioning the Futility of Cardiopulmonary Resuscitation in Patients With Severe Coronavirus Disease 2019. Crit Care Med. 2021 Mar 26. PMID: 33779583.
    Citations:    Fields:    
  6. Leaf DE, Ginde AA. Vitamin D3 to Treat COVID-19: Different Disease, Same Answer. JAMA. 2021 03 16; 325(11):1047-1048. PMID: 33595641.
    Citations: 1     Fields:    Translation:Humans
  7. Lim ZJ, Ponnapa Reddy M, Curtis JR, Afroz A, Billah B, Sheth V, Hayek SS, Leaf DE, Miles JA, Shah P, Yuriditsky E, Jones D, Shekar K, Subramaniam A. A Systematic Review of the Incidence and Outcomes of In-Hospital Cardiac Arrests in Patients With Coronavirus Disease 2019. Crit Care Med. 2021 Mar 12. PMID: 33710030.
    Citations:    Fields:    
  8. Mathews KS, Soh H, Shaefi S, Wang W, Bose S, Coca S, Gupta S, Hayek SS, Srivastava A, Brenner SK, Radbel J, Green A, Sutherland A, Leonberg-Yoo A, Shehata A, Schenck EJ, Short SAP, Hernán MA, Chan L, Leaf DE. Prone Positioning and Survival in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Respiratory Failure. Crit Care Med. 2021 02 17. PMID: 33595960.
    Citations: 1     Fields:    
  9. Shaefi S, Brenner SK, Gupta S, O'Gara BP, Krajewski ML, Charytan DM, Chaudhry S, Mirza SH, Peev V, Anderson M, Bansal A, Hayek SS, Srivastava A, Mathews KS, Johns TS, Leonberg-Yoo A, Green A, Arunthamakun J, Wille KM, Shaukat T, Singh H, Admon AJ, Semler MW, Hernán MA, Mueller AL, Wang W, Leaf DE. Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19. Intensive Care Med. 2021 02; 47(2):208-221. PMID: 33528595.
    Citations: 4     Fields:    Translation:Humans
  10. Shaefi S, Shankar P, Mueller AL, O'Gara BP, Spear K, Khabbaz KR, Bagchi A, Chu LM, Banner-Goodspeed V, Leaf DE, Talmor DS, Marcantonio ER, Subramaniam B. Intraoperative Oxygen Concentration and Neurocognition after Cardiac Surgery. Anesthesiology. 2021 02 01; 134(2):189-201. PMID: 33331902.
    Citations: 1     Fields:    Translation:Humans
  11. Al-Samkari H, Gupta S, Leaf RK, Wang W, Rosovsky RP, Brenner SK, Hayek SS, Berlin H, Kapoor R, Shaefi S, Melamed ML, Sutherland A, Radbel J, Green A, Garibaldi BT, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Goyal N, Chan L, Mathews KS, Hedayati SS, Dy R, Toth-Manikowski SM, Zhang J, Mallappallil M, Redfern RE, Bansal AD, Short SAP, Vangel MG, Admon AJ, Semler MW, Bauer KA, Hernán MA, Leaf DE. Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19. Ann Intern Med. 2021 01 26. PMID: 33493012.
    Citations:    Fields:    
  12. Molnar MZ, Kovesdy CP, Gupta S, Leaf DE. Response to "Is the outcome of SARS-CoV-2 infection in solid organ transplant recipients really similar to that of the general population?" Am J Transplant. 2021 04; 21(4):1672-1673. PMID: 33249749.
    Citations:    Fields:    Translation:Humans
  13. Hundemer GL, Srivastava A, Jacob KA, Krishnasamudram N, Ahmed S, Boerger E, Sharma S, Pokharel KK, Hirji SA, Pelletier M, Safa K, Kulvichit W, Kellum JA, Riella LV, Leaf DE. Acute kidney injury in renal transplant recipients undergoing cardiac surgery. Nephrol Dial Transplant. 2021 01 01; 36(1):185-196. PMID: 32892219.
    Citations:    Fields:    Translation:Humans
  14. Easter SR, Gupta S, Brenner SK, Leaf DE. Outcomes of Critically Ill Pregnant Women with COVID-19 in the United States. Am J Respir Crit Care Med. 2021 01 01; 203(1):122-125. PMID: 33026829.
    Citations:    Fields:    Translation:Humans
  15. Gupta S, Wang W, Hayek SS, Chan L, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Finkel D, Green A, Mallappallil M, Faugno AJ, Zhang J, Velez JCQ, Shaefi S, Parikh CR, Charytan DM, Athavale AM, Friedman AN, Redfern RE, Short SAP, Correa S, Pokharel KK, Admon AJ, Donnelly JP, Gershengorn HB, Douin DJ, Semler MW, Hernán MA, Leaf DE. Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19. JAMA Intern Med. 2021 01 01; 181(1):41-51. PMID: 33080002.
    Citations: 32     Fields:    Translation:Humans
  16. Murakami N, Mulvaney P, Danesh M, Abudayyeh A, Diab A, Abdel-Wahab N, Abdelrahim M, Khairallah P, Shirazian S, Kukla A, Owoyemi IO, Alhamad T, Husami S, Menon M, Santeusanio A, Blosser CD, Zuniga SC, Soler MJ, Moreso F, Mithani Z, Ortiz-Melo D, Jaimes EA, Gutgarts V, Lum E, Danovitch GM, Cardarelli F, Drews RE, Bassil C, Swank JL, Westphal S, Mannon RB, Shirai K, Kitchlu A, Ong S, Machado SM, Mothi SS, Ott PA, Rahma O, Hodi FS, Sise ME, Gupta S, Leaf DE, Devoe CE, Wanchoo R, Nair VV, Schmults CD, Hanna GJ, Sprangers B, Riella LV, Jhaveri KD. A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant. Kidney Int. 2020 Dec 24. PMID: 33359528.
    Citations:    Fields:    
  17. Leaf DE, Gupta S, Wang W. Tocilizumab in Covid-19. N Engl J Med. 2021 01 07; 384(1):86-87. PMID: 33356049.
    Citations:    Fields:    Translation:Humans
  18. Gupta S, Hayek SS, Wang W, Chan L, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Sutherland A, Green A, Shehata AM, Goyal N, Vijayan A, Velez JCQ, Shaefi S, Parikh CR, Arunthamakun J, Athavale AM, Friedman AN, Short SAP, Kibbelaar ZA, Abu Omar S, Admon AJ, Donnelly JP, Gershengorn HB, Hernán MA, Semler MW, Leaf DE. Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US. JAMA Intern Med. 2020 11 01; 180(11):1436-1447. PMID: 32667668.
    Citations: 125     Fields:    
  19. Lee MD, Strohbehn IA, Seethapathy HS, Rusibamayila N, Casey KS, Gupta S, Leaf DE, Frigault MJ, Sise ME. Acute Kidney Injury After the CAR-T Therapy Tisagenlecleucel. Am J Kidney Dis. 2020 Oct 22. PMID: 33098925.
    Citations:    Fields:    
  20. Li P, Gupta S, Mothi SS, Rennke HG, Leaf DE, Waikar SS, McMahon GM. Histopathologic Correlates of Kidney Function: Insights From Nephrectomy Specimens. Am J Kidney Dis. 2021 03; 77(3):336-345. PMID: 33098926.
    Citations:    Fields:    Translation:Humans
  21. Gupta S, Coca SG, Chan L, Melamed ML, Brenner SK, Hayek SS, Sutherland A, Puri S, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Schenck EJ, Goyal N, Hedayati SS, Dy R, Bansal A, Athavale A, Nguyen HB, Vijayan A, Charytan DM, Schulze CE, Joo MJ, Friedman AN, Zhang J, Sosa MA, Judd E, Velez JCQ, Mallappallil M, Redfern RE, Bansal AD, Neyra JA, Liu KD, Renaghan AD, Christov M, Molnar MZ, Sharma S, Kamal O, Boateng JO, Short SAP, Admon AJ, Sise ME, Wang W, Parikh CR, Leaf DE. AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19. J Am Soc Nephrol. 2021 01; 32(1):161-176. PMID: 33067383.
    Citations: 13     Fields:    Translation:Humans
  22. Abou Diwan E, Patel AB, Cuenca AG, Elias N, Gilligan HM, Heher E, Leaf DE, Wojciechowski D, Safa K. Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide. Case Rep Transplant. 2020; 2020:8819345. PMID: 33083084.
    Citations:    
  23. Hayek SS, Brenner SK, Azam TU, Shadid HR, Anderson E, Berlin H, Pan M, Meloche C, Feroz R, O'Hayer P, Kaakati R, Bitar A, Padalia K, Perry D, Blakely P, Gupta S, Shaefi S, Srivastava A, Charytan DM, Bansal A, Mallappallil M, Melamed ML, Shehata AM, Sunderram J, Mathews KS, Sutherland AK, Nallamothu BK, Leaf DE. In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study. BMJ. 2020 09 30; 371:m3513. PMID: 32998872.
    Citations: 10     Fields:    Translation:HumansCellsPHPublic Health
  24. Flythe JE, Assimon MM, Tugman MJ, Chang EH, Gupta S, Shah J, Sosa MA, Renaghan AD, Melamed ML, Wilson FP, Neyra JA, Rashidi A, Boyle SM, Anand S, Christov M, Thomas LF, Edmonston D, Leaf DE. Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States. Am J Kidney Dis. 2021 02; 77(2):190-203.e1. PMID: 32961244.
    Citations: 12     Fields:    Translation:Humans
  25. Molnar MZ, Bhalla A, Azhar A, Tsujita M, Talwar M, Balaraman V, Sodhi A, Kadaria D, Eason JD, Hayek SS, Coca SG, Shaefi S, Neyra JA, Gupta S, Leaf DE, Kovesdy CP. Outcomes of critically ill solid organ transplant patients with COVID-19 in the United States. Am J Transplant. 2020 11; 20(11):3061-3071. PMID: 32844546.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  26. Averdunk L, Bernhagen J, Fehnle K, Surowy H, Lüdecke HJ, Mucha S, Meybohm P, Wieczorek D, Leng L, Marx G, Leaf DE, Zarbock A, Zacharowski K, Bucala R, Stoppe C. The Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms (rs3063368, rs755622) Predict Acute Kidney Injury and Death after Cardiac Surgery. J Clin Med. 2020 Sep 11; 9(9). PMID: 32932965.
    Citations: 1     
  27. Leaf RK, Al-Samkari H, Brenner SK, Gupta S, Leaf DE. ABO phenotype and death in critically ill patients with COVID-19. Br J Haematol. 2020 08; 190(4):e204-e208. PMID: 32609874.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  28. Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JCT, Fogerty AE, Waheed A, Goodarzi K, Bendapudi PK, Bornikova L, Gupta S, Leaf DE, Kuter DJ, Rosovsky RP. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood. 2020 07 23; 136(4):489-500. PMID: 32492712.
    Citations: 155     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  29. Seethapathy H, Zhao S, Strohbehn IA, Lee M, Chute DF, Bates H, Molina GE, Zubiri L, Gupta S, Motwani S, Leaf DE, Sullivan RJ, Rahma O, Blumenthal KG, Villani AC, Reynolds KL, Sise ME. Incidence and Clinical Features of Immune-Related Acute Kidney Injury in Patients Receiving Programmed Cell Death Ligand-1 Inhibitors. Kidney Int Rep. 2020 Oct; 5(10):1700-1705. PMID: 33102962.
    Citations: 1     
  30. Eisenga MF, De Jong MA, Leaf DE, Nolte IM, De Borst MH, Bakker SJL, Gaillard CAJM. Erythropoietin, Fibroblast Growth Factor 23, and Death After Kidney Transplantation. J Clin Med. 2020 06 04; 9(6). PMID: 32512806.
    Citations:    
  31. Kim EY, Ner-Gaon H, Varon J, Cullen AM, Guo J, Choi J, Barragan-Bradford D, Higuera A, Pinilla-Vera M, Short SA, Arciniegas-Rubio A, Tamura T, Leaf DE, Baron RM, Shay T, Brenner MB. Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-? in NK cells. J Clin Invest. 2020 06 01; 130(6):3238-3252. PMID: 32154791.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  32. Hod T, Freedberg KJ, Motwani SS, Chen M, Frendl G, Leaf DE, Gupta S, Mothi SS, Richards WG, Bueno R, Waikar SS. Acute kidney injury after cytoreductive surgery and hyperthermic intraoperative cisplatin chemotherapy for malignant pleural mesothelioma. J Thorac Cardiovasc Surg. 2021 Apr; 161(4):1510-1518. PMID: 32631662.
    Citations:    Fields:    Translation:Humans
  33. Hayek SS, Leaf DE, Reiser J. Soluble Urokinase Receptor and Acute Kidney Injury. Reply. N Engl J Med. 2020 05 28; 382(22):2167-2168. PMID: 32459936.
    Citations:    Fields:    Translation:Humans
  34. Seethapathy H, Sharma S, Zhao S, Chung RT, Connor MJ, Leaf DE, Allegretti AS. Acute Kidney Injury Following Paracentesis Among Inpatients With Cirrhosis. Kidney Int Rep. 2020 Aug; 5(8):1305-1308. PMID: 32775831.
    Citations:    
  35. Gutowski ED, Tio MC, Burch EA, Leaf DE. Peritoneal dialysate tamponading a massive retroperitoneal hemorrhage. Kidney Int. 2020 04; 97(4):810. PMID: 32200870.
    Citations:    Fields:    
  36. Simic P, Kim W, Zhou W, Pierce KA, Chang W, Sykes DB, Aziz NB, Elmariah S, Ngo D, Pajevic PD, Govea N, Kestenbaum BR, de Boer IH, Cheng Z, Christov M, Chun J, Leaf DE, Waikar SS, Tager AM, Gerszten RE, Thadhani RI, Clish CB, Jüppner H, Wein MN, Rhee EP. Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. J Clin Invest. 2020 03 02; 130(3):1513-1526. PMID: 32065590.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  37. Hayek SS, Leaf DE, Samman Tahhan A, Raad M, Sharma S, Waikar SS, Sever S, Camacho A, Wang X, Dande RR, Ibrahim NE, Baron RM, Altintas MM, Wei C, Sheikh-Hamad D, Pan JS, Holliday MW, Januzzi JL, Weisbord SD, Quyyumi AA, Reiser J. Soluble Urokinase Receptor and Acute Kidney Injury. N Engl J Med. 2020 01 30; 382(5):416-426. PMID: 31995687.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  38. Gupta S, Seethapathy H, Strohbehn IA, Frigault MJ, O'Donnell EK, Jacobson CA, Motwani SS, Parikh SM, Curhan GC, Reynolds KL, Leaf DE, Sise ME. Acute Kidney Injury and Electrolyte Abnormalities After Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for Diffuse Large B-Cell Lymphoma. Am J Kidney Dis. 2020 07; 76(1):63-71. PMID: 31973908.
    Citations: 7     Fields:    Translation:Humans
  39. Cortazar FB, Kibbelaar ZA, Glezerman IG, Abudayyeh A, Mamlouk O, Motwani SS, Murakami N, Herrmann SM, Manohar S, Shirali AC, Kitchlu A, Shirazian S, Assal A, Vijayan A, Renaghan AD, Ortiz-Melo DI, Rangarajan S, Malik AB, Hogan JJ, Dinh AR, Shin DS, Marrone KA, Mithani Z, Johnson DB, Hosseini A, Uprety D, Sharma S, Gupta S, Reynolds KL, Sise ME, Leaf DE. Clinical Features and Outcomes of Immune Checkpoint Inhibitor-Associated AKI: A Multicenter Study. J Am Soc Nephrol. 2020 02; 31(2):435-446. PMID: 31896554.
    Citations: 26     Fields:    Translation:Humans
  40. Averdunk L, Fitzner C, Levkovich T, Leaf DE, Sobotta M, Vieten J, Ochi A, Moeckel G, Marx G, Stoppe C. Secretory Leukocyte Protease Inhibitor (SLPI)-A Novel Predictive Biomarker of Acute Kidney Injury after Cardiac Surgery: A Prospective Observational Study. J Clin Med. 2019 Nov 09; 8(11). PMID: 31717603.
    Citations: 3     
  41. Seethapathy H, Zhao S, Chute DF, Zubiri L, Oppong Y, Strohbehn I, Cortazar FB, Leaf DE, Mooradian MJ, Villani AC, Sullivan RJ, Reynolds K, Sise ME. The Incidence, Causes, and Risk Factors of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors. Clin J Am Soc Nephrol. 2019 12 06; 14(12):1692-1700. PMID: 31672794.
    Citations: 28     Fields:    Translation:Humans
  42. Holliday AM, Gheihman G, Cooper C, Sullivan A, Ohyama H, Leaf DE, Leaf RK. High Prevalence of Imposterism Among Female Harvard Medical and Dental Students. J Gen Intern Med. 2020 08; 35(8):2499-2501. PMID: 31654355.
    Citations:    Fields:    
  43. Sharma S, Leaf DE. Iron Chelation as a Potential Therapeutic Strategy for AKI Prevention. J Am Soc Nephrol. 2019 11; 30(11):2060-2071. PMID: 31554656.
    Citations: 2     Fields:    Translation:HumansAnimals
  44. Jacob KA, Leaf DE. Prevention of Cardiac Surgery-Associated Acute Kidney Injury: A Review of Current Strategies. Anesthesiol Clin. 2019 Dec; 37(4):729-749. PMID: 31677688.
    Citations:    Fields:    Translation:Humans
  45. Blair RA, Leaf RK, Leaf DE. A case of severe hypothyroidism due to lenalidomide. Clin Case Rep. 2019 Sep; 7(9):1747-1749. PMID: 31534740.
    Citations:    
  46. Leaf DE, Waikar SS. IDEAL-ICU in Context. Clin J Am Soc Nephrol. 2019 08 07; 14(8):1264-1267. PMID: 31315886.
    Citations:    Fields:    Translation:Humans
  47. Eisenga MF, De Jong MA, Van der Meer P, Leaf DE, Huls G, Nolte IM, Gaillard CAJM, Bakker SJL, De Borst MH. Iron deficiency, elevated erythropoietin, fibroblast growth factor 23, and mortality in the general population of the Netherlands: A cohort study. PLoS Med. 2019 06; 16(6):e1002818. PMID: 31170159.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  48. Leaf RK, Ferreri C, Rangachari D, Mier J, Witteles W, Ansstas G, Anagnostou T, Zubiri L, Piotrowska Z, Oo TH, Iberri D, Yarchoan M, Salama AKS, Johnson DB, Leavitt AD, Rahma OE, Reynolds KL, Leaf DE. Clinical and laboratory features of autoimmune hemolytic anemia associated with immune checkpoint inhibitors. Am J Hematol. 2019 05; 94(5):563-574. PMID: 30790338.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  49. Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Boerger EAS, Mc Causland FR, Eisenga MF, Singh K, Babitt JL, Kellum JA, Palevsky PM, Christov M, Waikar SS. Iron, Hepcidin, and Death in Human AKI. J Am Soc Nephrol. 2019 03; 30(3):493-504. PMID: 30737269.
    Citations: 5     Fields:    Translation:Humans
  50. Srivastava A, Palsson R, Leaf DE, Higuera A, Chen ME, Palacios P, Baron RM, Sabbisetti V, Hoofnagle AN, Vaingankar SM, Palevsky PM, Waikar SS. Uric Acid and Acute Kidney Injury in the Critically Ill. Kidney Med. 2019 Jan-Feb; 1(1):21-30. PMID: 32734180.
    Citations: 1     
  51. Christov M, Neyra JA, Gupta S, Leaf DE. Fibroblast Growth Factor 23 and Klotho in AKI. Semin Nephrol. 2019 01; 39(1):57-75. PMID: 30606408.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  52. Leaf DE. Introduction: Cross-Talk Between the Kidneys and Remote Organ Systems in AKI. Semin Nephrol. 2019 01; 39(1):1-2. PMID: 30606402.
    Citations: 2     Fields:    Translation:Humans
  53. Leaf DE, Christov M. Dysregulated Mineral Metabolism in AKI. Semin Nephrol. 2019 01; 39(1):41-56. PMID: 30606407.
    Citations: 3     Fields:    Translation:HumansAnimals
  54. Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM. De novo NAD+ biosynthetic impairment in acute kidney injury in humans. Nat Med. 2018 09; 24(9):1351-1359. PMID: 30127395.
    Citations: 45     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  55. Neyra JA, Leaf DE. Risk Prediction Models for Acute Kidney Injury in Critically Ill Patients: Opus in Progressu. Nephron. 2018; 140(2):99-104. PMID: 29852504.
    Citations: 1     Fields:    Translation:Humans
  56. Postalcioglu M, Kim HT, Obut F, Yilmam OA, Yang J, Byun BC, Kupiec-Weglinski S, Soiffer R, Ritz J, Antin JH, Alyea E, Koreth J, Cutler C, Armand P, Paik JM, Leaf DE, Ho VT, Abdi R. Impact of Thrombotic Microangiopathy on Renal Outcomes and Survival after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2018 11; 24(11):2344-2353. PMID: 29758394.
    Citations: 7     Fields:    Translation:Humans
  57. Leaf DE, Siew ED, Eisenga MF, Singh K, Mc Causland FR, Srivastava A, Ikizler TA, Ware LB, Ginde AA, Kellum JA, Palevsky PM, Wolf M, Waikar SS. Fibroblast Growth Factor 23 Associates with Death in Critically Ill Patients. Clin J Am Soc Nephrol. 2018 04 06; 13(4):531-541. PMID: 29519954.
    Citations: 13     Fields:    Translation:Humans
  58. Rabadi S, Udo I, Leaf DE, Waikar SS, Christov M. Acute blood loss stimulates fibroblast growth factor 23 production. Am J Physiol Renal Physiol. 2018 01 01; 314(1):F132-F139. PMID: 28877877.
    Citations: 21     Fields:    Translation:Animals
  59. Kota SK, Pernicone E, Leaf DE, Stillman IE, Waikar SS, Kota SB. BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI. J Am Soc Nephrol. 2017 Dec; 28(12):3473-3478. PMID: 28775000.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  60. Eisenga MF, van Londen M, Leaf DE, Nolte IM, Navis G, Bakker SJL, de Borst MH, Gaillard CAJM. C-Terminal Fibroblast Growth Factor 23, Iron Deficiency, and Mortality in Renal Transplant Recipients. J Am Soc Nephrol. 2017 Dec; 28(12):3639-3646. PMID: 28774998.
    Citations: 15     Fields:    Translation:HumansCells
  61. Freiberg MS, Chang CH, Skanderson M, Patterson OV, DuVall SL, Brandt CA, So-Armah KA, Vasan RS, Oursler KA, Gottdiener J, Gottlieb S, Leaf D, Rodriguez-Barradas M, Tracy RP, Gibert CL, Rimland D, Bedimo RJ, Brown ST, Goetz MB, Warner A, Crothers K, Tindle HA, Alcorn C, Bachmann JM, Justice AC, Butt AA. Association Between HIV Infection and the Risk of Heart Failure With Reduced Ejection Fraction and Preserved Ejection Fraction in the Antiretroviral Therapy Era: Results From the Veterans Aging Cohort Study. JAMA Cardiol. 2017 05 01; 2(5):536-546. PMID: 28384660.
    Citations: 55     Fields:    Translation:Humans
  62. Cui S, Vaingankar SM, Stenger A, Waikar SS, Leaf DE. Stability of Fibroblast Growth Factor 23 in Human Plasma. J Appl Lab Med. 2017 May 01; 1(6):729-734. PMID: 33379820.
    Citations:    Fields:    
  63. Leaf RK, O'Brien KL, Leaf DE, Drews RE. Autoimmune hemolytic anemia in a young man with acute hepatitis E infection. Am J Hematol. 2017 May; 92(5):E77-E79. PMID: 28230259.
    Citations: 4     Fields:    Translation:Humans
  64. Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR. A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury. Am J Respir Crit Care Med. 2017 Feb 15; 195(4):482-490. PMID: 27576016.
    Citations: 8     Fields:    Translation:Humans
  65. Cortazar FB, Leaf DE, Owens CT, Laliberte K, Pendergraft WF, Niles JL. Combination therapy with rituximab, low-dose cyclophosphamide, and prednisone for idiopathic membranous nephropathy: a case series. BMC Nephrol. 2017 Feb 01; 18(1):44. PMID: 28143416.
    Citations: 4     Fields:    Translation:Humans
  66. Leaf DE, Jacob KA, Srivastava A, Chen ME, Christov M, Jüppner H, Sabbisetti VS, Martin A, Wolf M, Waikar SS. Fibroblast Growth Factor 23 Levels Associate with AKI and Death in Critical Illness. J Am Soc Nephrol. 2017 Jun; 28(6):1877-1885. PMID: 28028134.
    Citations: 27     Fields:    Translation:Humans
  67. Mendu ML, Lundquist A, Aizer AA, Leaf DE, Robinson E, Steele DJ, Waikar SS. Clinical predictors of diagnostic testing utility in the initial evaluation of chronic kidney disease. Nephrology (Carlton). 2016 Oct; 21(10):851-9. PMID: 26610178.
    Citations:    Fields:    Translation:Humans
  68. Leaf DE, Waikar SS. End Points for Clinical Trials in Acute Kidney Injury. Am J Kidney Dis. 2017 Jan; 69(1):108-116. PMID: 27599630.
    Citations: 4     Fields:    Translation:Humans
  69. Leaf DE, Swinkels DW. Catalytic iron and acute kidney injury. Am J Physiol Renal Physiol. 2016 11 01; 311(5):F871-F876. PMID: 27534995.
    Citations: 10     Fields:    Translation:HumansAnimals
  70. Cortazar FB, Marrone KA, Troxell ML, Ralto KM, Hoenig MP, Brahmer JR, Le DT, Lipson EJ, Glezerman IG, Wolchok J, Cornell LD, Feldman P, Stokes MB, Zapata SA, Hodi FS, Ott PA, Yamashita M, Leaf DE. Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors. Kidney Int. 2016 09; 90(3):638-47. PMID: 27282937.
    Citations: 112     Fields:    Translation:Humans
  71. Leaf DE, Body SC, Muehlschlegel JD, McMahon GM, Lichtner P, Collard CD, Shernan SK, Fox AA, Waikar SS. Length Polymorphisms in Heme Oxygenase-1 and AKI after Cardiac Surgery. J Am Soc Nephrol. 2016 Nov; 27(11):3291-3297. PMID: 27257045.
    Citations: 19     Fields:    Translation:Humans
  72. Leaf DE, Cheng XS, Sanders JL, Mendu M, Schiff GD, Mount DB, Bazari H. An electronic alert to decrease Kayexalate ordering. Ren Fail. 2016 Nov; 38(10):1752-1754. PMID: 27183825.
    Citations: 1     Fields:    Translation:Humans
  73. Leaf DE, Christov M, Jüppner H, Siew E, Ikizler TA, Bian A, Chen G, Sabbisetti VS, Bonventre JV, Cai X, Wolf M, Waikar SS. Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery. Kidney Int. 2016 Apr; 89(4):939-48. PMID: 26924052.
    Citations: 25     Fields:    Translation:Humans
  74. Leaf DE, Srivastava A, Zeng X, McMahon GM, Croy HE, Mendu ML, Kachalia A, Waikar SS. Excessive diagnostic testing in acute kidney injury. BMC Nephrol. 2016 Jan 15; 17:9. PMID: 26772980.
    Citations: 2     Fields:    Translation:HumansCells
  75. Jacob KA, Leaf DE, Dieleman JM, van Dijk D, Nierich AP, Rosseel PM, van der Maaten JM, Hofland J, Diephuis JC, de Lange F, Boer C, Kluin J, Waikar SS. Intraoperative High-Dose Dexamethasone and Severe AKI after Cardiac Surgery. J Am Soc Nephrol. 2015 Dec; 26(12):2947-51. PMID: 25952257.
    Citations: 18     Fields:    Translation:Humans
  76. Mendu ML, Lundquist A, Aizer AA, Leaf DE, Robinson E, Steele DJ, Waikar SS. The usefulness of diagnostic testing in the initial evaluation of chronic kidney disease. JAMA Intern Med. 2015 May; 175(5):853-6. PMID: 25730699.
    Citations: 3     Fields:    Translation:Humans
  77. Leaf DE, Croy HE, Abrahams SJ, Raed A, Waikar SS. Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients. Crit Care. 2015 Mar 10; 19:80. PMID: 25887571.
    Citations: 12     Fields:    Translation:Humans
  78. Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Rawn JD, Frendl G, Waikar SS. Increased plasma catalytic iron in patients may mediate acute kidney injury and death following cardiac surgery. Kidney Int. 2015 May; 87(5):1046-54. PMID: 25565307.
    Citations: 18     Fields:    Translation:Humans
  79. Leaf DE, Raed A, Donnino MW, Ginde AA, Waikar SS. Reply: active and native vitamin D in critical illness. Am J Respir Crit Care Med. 2014 Nov 15; 190(10):1194-6. PMID: 25398113.
    Citations:    Fields:    Translation:Humans
  80. Leaf DE, Waikar SS. Rosuvastatin for sepsis-associated ARDS. N Engl J Med. 2014 09 04; 371(10):968. PMID: 25184877.
    Citations: 1     Fields:    Translation:Humans
  81. Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Waikar SS. Plasma catalytic iron, AKI, and death among critically ill patients. Clin J Am Soc Nephrol. 2014 Nov 07; 9(11):1849-56. PMID: 25189925.
    Citations: 9     Fields:    Translation:HumansCells
  82. Leaf DE, Raed A, Donnino MW, Ginde AA, Waikar SS. Randomized controlled trial of calcitriol in severe sepsis. Am J Respir Crit Care Med. 2014 Sep 01; 190(5):533-41. PMID: 25029202.
    Citations: 33     Fields:    Translation:Humans
  83. Mendu ML, Schneider LI, Aizer AA, Singh K, Leaf DE, Lee TH, Waikar SS. Implementation of a CKD checklist for primary care providers. Clin J Am Soc Nephrol. 2014 Sep 05; 9(9):1526-35. PMID: 25135764.
    Citations: 18     Fields:    Translation:Humans
  84. Lu Y, Ossmann MM, Leaf DE, Factor PH. Patient visibility and ICU mortality: a conceptual replication. HERD. 2014; 7(2):92-103. PMID: 24554358.
    Citations: 5     Fields:    Translation:Humans
  85. Esenwa CC, Leaf DE. Colpocephaly in adults. BMJ Case Rep. 2013 May 22; 2013. PMID: 23704444.
    Citations: 2     Fields:    Translation:Humans
  86. Christov M, Waikar SS, Pereira RC, Havasi A, Leaf DE, Goltzman D, Pajevic PD, Wolf M, Jüppner H. Plasma FGF23 levels increase rapidly after acute kidney injury. Kidney Int. 2013 Oct; 84(4):776-85. PMID: 23657144.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  87. Leaf DE, McMahon GM, Seifter JL. Chloride-liberal fluids and intracellular acidosis. Kidney Int. 2013 May; 83(5):971. PMID: 23633062.
    Citations:    Fields:    Translation:Humans
  88. Leaf DE, Waikar SS, Wolf M, Cremers S, Bhan I, Stern L. Dysregulated mineral metabolism in patients with acute kidney injury and risk of adverse outcomes. Clin Endocrinol (Oxf). 2013 Oct; 79(4):491-8. PMID: 23414198.
    Citations: 24     Fields:    Translation:Humans
  89. Leaf DE, Pereira RC, Bazari H, Jüppner H. Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma. J Clin Endocrinol Metab. 2013 Mar; 98(3):887-91. PMID: 23393166.
    Citations: 22     Fields:    Translation:Humans
  90. Leaf DE, Wolf M. A physiologic-based approach to the evaluation of a patient with hyperphosphatemia. Am J Kidney Dis. 2013 Feb; 61(2):330-6. PMID: 22938849.
    Citations: 1     Fields:    Translation:Humans
  91. Leaf DE, Wolf M, Waikar SS, Chase H, Christov M, Cremers S, Stern L. FGF-23 levels in patients with AKI and risk of adverse outcomes. Clin J Am Soc Nephrol. 2012 Aug; 7(8):1217-23. PMID: 22700885.
    Citations: 34     Fields:    Translation:HumansCells
  92. Leaf DE, Bukberg PR, Goldfarb DS. Laxative abuse, eating disorders, and kidney stones: a case report and review of the literature. Am J Kidney Dis. 2012 Aug; 60(2):295-8. PMID: 22560842.
    Citations: 5     Fields:    Translation:Humans
  93. Leaf DE, Korets R, Taylor EN, Tang J, Asplin JR, Goldfarb DS, Gupta M, Curhan GC. Effect of vitamin D repletion on urinary calcium excretion among kidney stone formers. Clin J Am Soc Nephrol. 2012 May; 7(5):829-34. PMID: 22422535.
    Citations: 20     Fields:    Translation:HumansCTClinical Trials
  94. Gershengorn HB, Wunsch H, Wahab R, Leaf D, Brodie D, Li G, Factor P. Impact of nonphysician staffing on outcomes in a medical ICU. Chest. 2011 Jun; 139(6):1347-1353. PMID: 21393397.
    Citations: 11     Fields:    Translation:Humans
  95. Leaf DE. Calcium kidney stones. N Engl J Med. 2010 12 16; 363(25):2470; author reply 2471. PMID: 21158674.
    Citations: 1     Fields:    Translation:Humans
  96. Leaf DE, Langer NB, Markowski M, Garratty G, Diuguid DL. A severe case of cefoxitin-induced immune hemolytic anemia. Acta Haematol. 2010; 124(4):197-9. PMID: 21042010.
    Citations:    Fields:    Translation:Humans
  97. Leaf DE, Appel GB, Radhakrishnan J. Glomerular disease: why is there a dearth of high quality clinical trials? Kidney Int. 2010 Aug; 78(4):337-42. PMID: 20520593.
    Citations: 10     Fields:    Translation:Humans
  98. Leaf DE, Homel P, Factor PH. Relationship between ICU design and mortality. Chest. 2010 May; 137(5):1022-7. PMID: 20081100.
    Citations: 4     Fields:    Translation:Humans
  99. Leaf DE, Wolf M, Stern L. Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury. Nephrol Dial Transplant. 2010 Apr; 25(4):1335-7. PMID: 20037176.
    Citations: 11     Fields:    Translation:Humans
  100. Leaf DE, Leo J, Smith PR, Yee H, Stern A, Rosenthal PB, Cahill-Gallant EB, Pillinger MH. SOMOSAT: Utility of a web-based self-assessment tool in undergraduate medical education. Med Teach. 2009 May; 31(5):e211-9. PMID: 19811126.
    Citations: 2     Fields:    Translation:Humans
  101. Leaf DE, Goldfarb DS. Interpretation and review of health-related quality of life data in CKD patients receiving treatment for anemia. Kidney Int. 2009 Jan; 75(1):15-24. PMID: 18813284.
    Citations: 43     Fields:    Translation:Humans
  102. Leaf DE, Feig JE, Vasquez C, Riva PL, Yu C, Lader JM, Kontogeorgis A, Baron EL, Peters NS, Fisher EA, Gutstein DE, Morley GE. Connexin40 imparts conduction heterogeneity to atrial tissue. Circ Res. 2008 Oct 24; 103(9):1001-8. PMID: 18599871.
    Citations: 25     Fields:    Translation:Animals
  103. Leaf DE, Goldfarb DS. Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness. J Appl Physiol (1985). 2007 Apr; 102(4):1313-22. PMID: 17023566.
    Citations: 46     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.