Harvard Catalyst Profiles

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David Evan Leaf, M.D.

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Biography
University of PennsylvaniaBA05/2004Psychology
New York University School of MedicineMD05/2008Medicine
New York Presbyterian Hospital-Columbia Campus06/2011Internal Medicine Residency
Harvard Medical SchoolMMSc05/2014Scholars in Clinical Science Program
Brigham and Women's Hospital and Massachusetts General Hospital05/2015Nephrology Fellowship
2004
Summa Cum Laude
2004
Phi Beta Kappa
2008
Andrew Alan Friedland Memorial Award
2008
Excellence in Research
2011
Excellence in Research
2013
Excellence in teaching
2014
Excellence in teaching
2015
Chair’s Research Award
2018
Carl W. Gottschalk Research Scholar Award
2018
Outstanding Reviewer Award
2019
Chair’s Research Award
2021
Best Paper Award
2022
Best Clinical/Translational Cancer Immunotherapy Paper Award

Overview
Dr. Leaf is an Associate Professor of Medicine at Harvard Medical School and the Director of Clinical and Translational Research in Acute Kidney Injury in the Division of Renal Medicine at Brigham and Women’s Hospital. He conducts patient-oriented research in acute kidney injury (AKI) and critical illness. He uses epidemiologic, translational, genetic, and interventional approaches to address clinically important questions in patients with AKI. Current areas of investigation include dysregulated mineral and iron homeostasis as novel pathways and potential therapeutic targets in AKI, as well as investigation of the nephrotoxicity of novel cancer therapies.

Dr. Leaf is the principal investigator on two R01 grants. He serves on the Editorial Boards of Kidney International and Clinical Journal of the American Society of Nephrology, and is a member of the Mass General Brigham Institutional Review Board. His publications have appeared in leading medical journals including the New England Journal of Medicine, BMJ, JAMA Internal Medicine, Nature Medicine, Journal of Clinical Investigation, Journal of the American Society of Nephrology, and Kidney International. His research has been featured in national media including The New York Times, Washington Post, USA today, CNN, and NPR.

Dr. Leaf is passionate about academic nephrology, and has received research and teaching awards from NYU, Columbia, and Harvard. He enjoys spending time with his wife (Rebecca), his two children (Emma and Teddy), his cat (Winston), as well as traveling, skiing, swimming, and playing chess.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK126685 (LEAF, DAVID EVAN) Jul 15, 2022 - May 31, 2026
    NIH
    Hepcidin-Ferroportin-Iron Axis in Cardiac Surgery-associated Acute Kidney Injury
    Role: Principal Investigator
  2. R01DK126685 (LEAF, DAVID EVAN) Jul 15, 2022 - May 31, 2026
    NIH
    Hepcidin-Ferroportin-Iron Axis in Cardiac Surgery-associated Acute Kidney Injury
    Role: Principal Investigator
  3. R01DK125786 (LEAF, DAVID EVAN) Sep 1, 2020 - Jun 30, 2025
    NIH
    Deferoxamine for the Prevention of Acute Kidney Injury
    Role: Principal Investigator
  4. R01HL144566 (LEAF, DAVID EVAN) Jul 1, 2019 - Jun 30, 2023
    NIH
    Precision Medicine Approach to Vitamin D3 Administration in Critical Illness
    Role: Principal Investigator
  5. Carl W. Gottschalk Research Scholar Grant (LEAF, DAVID EVAN) Jul 1, 2018 - Jun 30, 2019
    American Society of Nephrology Foundation for Kidney Research
    Hepcidin, Dysregulated Iron Homeostasis, and Anemia in Human Acute Kidney Injury
    Role: Principal Investigator
The clinical trials listed below are automatically derived from ClinicalTrials.gov and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
NCT Short Title Overall Status Start Completion

Featured Content

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.