Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

David Evan Leaf, M.D.

Title
Institution
Department
Address
Phone
Profile Picture

Biography
University of PennsylvaniaBA05/2004Psychology
New York University School of MedicineMD05/2008Medicine
New York Presbyterian Hospital-Columbia Campus06/2011Internal Medicine Residency
Harvard Medical SchoolMMSc05/2014Scholars in Clinical Science Program
Brigham and Women's Hospital and Massachusetts General Hospital05/2015Nephrology Fellowship
2004
Summa Cum Laude
2004
Phi Beta Kappa
2008
Andrew Alan Friedland Memorial Award
2008
Excellence in Research
2011
Excellence in Research
2013
Excellence in teaching
2014
Excellence in teaching
2015
Chair’s Research Award
2018
Carl W. Gottschalk Research Scholar Award
2018
Outstanding Reviewer Award
2019
Chair’s Research Award
2021
Best Paper Award
2022
Best Clinical/Translational Cancer Immunotherapy Paper Award

Overview
Dr. Leaf is an Associate Professor of Medicine at Harvard Medical School and the Director of Clinical and Translational Research in Acute Kidney Injury in the Division of Renal Medicine at Brigham and Women’s Hospital. He conducts patient-oriented research in acute kidney injury (AKI) and critical illness. He uses epidemiologic, translational, genetic, and interventional approaches to address clinically important questions in patients with AKI. Current areas of investigation include dysregulated mineral and iron homeostasis as novel pathways and potential therapeutic targets in AKI, as well as investigation of the nephrotoxicity of novel cancer therapies.

Dr. Leaf is the principal investigator on two R01 grants. He serves on the Editorial Boards of Kidney International and Clinical Journal of the American Society of Nephrology, and is a member of the Mass General Brigham Institutional Review Board. His publications have appeared in leading medical journals including the New England Journal of Medicine, BMJ, JAMA Internal Medicine, Nature Medicine, Journal of Clinical Investigation, Journal of the American Society of Nephrology, and Kidney International. His research has been featured in national media including The New York Times, Washington Post, USA today, CNN, and NPR.

Dr. Leaf is passionate about academic nephrology, and has received research and teaching awards from NYU, Columbia, and Harvard. He enjoys spending time with his wife (Rebecca), his two children (Emma and Teddy), his cat (Winston), as well as traveling, skiing, swimming, and playing chess.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01AG089040 (BHASIN, SHALENDER) Sep 1, 2024 - Aug 31, 2029
    NIH
    Development, Validation, and Harmonization of Methods for Collection and Measurement of NAD+ and Related Metabolites: Application to a Randomized Trial of Patients Undergoing Coronary Artery Bypass
    Role: Co-Principal Investigator
  2. R01DK126685 (LEAF, DAVID EVAN) Jul 15, 2022 - May 31, 2026
    NIH
    Hepcidin-Ferroportin-Iron Axis in Cardiac Surgery-associated Acute Kidney Injury
    Role: Principal Investigator
  3. R01DK126685 (LEAF, DAVID EVAN) Jul 15, 2022 - May 31, 2026
    NIH
    Hepcidin-Ferroportin-Iron Axis in Cardiac Surgery-associated Acute Kidney Injury
    Role: Principal Investigator
  4. R01DK125786 (LEAF, DAVID EVAN) Sep 1, 2020 - Jun 30, 2025
    NIH
    Deferoxamine for the Prevention of Acute Kidney Injury
    Role: Principal Investigator
  5. R01HL144566 (LEAF, DAVID EVAN) Jul 1, 2019 - Jun 30, 2023
    NIH
    Precision Medicine Approach to Vitamin D3 Administration in Critical Illness
    Role: Principal Investigator
The clinical trials listed below are automatically derived from ClinicalTrials.gov and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
NCT Short Title Overall Status Start Completion

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Updating...
This operation might take several minutes to complete. Please do not close your browser.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Leaf's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (429)
Explore
_
Co-Authors (145)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.