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David Evan Leaf, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K23DK106448 (LEAF, DAVID EVAN) Jul 15, 2015 - Apr 30, 2020
    NIH/NIDDK
    Dysregulated Mineral Metabolism and Acute Kidney Injury
    Role: Principal Investigator
  2. F32DK100040 (LEAF, DAVID E) Jun 30, 2013 - Jun 29, 2015
    NIH/NIDDK
    Dysregulated Mineral Metabolism in Acute Kidney Injury
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Eisenga MF, De Jong MA, Van der Meer P, Leaf DE, Huls G, Nolte IM, Gaillard CAJM, Bakker SJL, De Borst MH. Iron deficiency, elevated erythropoietin, fibroblast growth factor 23, and mortality in the general population of the Netherlands: A cohort study. PLoS Med. 2019 Jun; 16(6):e1002818. PMID: 31170159.
    Citations:    
  2. Leaf RK, Ferreri C, Rangachari D, Mier J, Witteles W, Ansstas G, Anagnostou T, Zubiri L, Piotrowska Z, Oo TH, Iberri D, Yarchoan M, Salama AKS, Johnson DB, Leavitt AD, Rahma OE, Reynolds KL, Leaf DE. Clinical and laboratory features of autoimmune hemolytic anemia associated with immune checkpoint inhibitors. Am J Hematol. 2019 May; 94(5):563-574. PMID: 30790338.
    Citations:    
  3. Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Boerger EAS, Mc Causland FR, Eisenga MF, Singh K, Babitt JL, Kellum JA, Palevsky PM, Christov M, Waikar SS. Iron, Hepcidin, and Death in Human AKI. J Am Soc Nephrol. 2019 Feb 08. PMID: 30737269.
    Citations:    
  4. Christov M, Neyra JA, Gupta S, Leaf DE. Fibroblast Growth Factor 23 and Klotho in AKI. Semin Nephrol. 2019 01; 39(1):57-75. PMID: 30606408.
    Citations:    Fields:    
  5. Leaf DE. Introduction: Cross-Talk Between the Kidneys and Remote Organ Systems in AKI. Semin Nephrol. 2019 01; 39(1):1-2. PMID: 30606402.
    Citations:    Fields:    
  6. Leaf DE, Christov M. Dysregulated Mineral Metabolism in AKI. Semin Nephrol. 2019 01; 39(1):41-56. PMID: 30606407.
    Citations:    Fields:    
  7. Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM. De novo NAD+ biosynthetic impairment in acute kidney injury in humans. Nat Med. 2018 09; 24(9):1351-1359. PMID: 30127395.
    Citations:    Fields:    
  8. Neyra JA, Leaf DE. Risk Prediction Models for Acute Kidney Injury in Critically Ill Patients: Opus in Progressu. Nephron. 2018; 140(2):99-104. PMID: 29852504.
    Citations:    Fields:    
  9. Postalcioglu M, Kim HT, Obut F, Yilmam OA, Yang J, Byun BC, Kupiec-Weglinski S, Soiffer R, Ritz J, Antin JH, Alyea E, Koreth J, Cutler C, Armand P, Paik JM, Leaf DE, Ho VT, Abdi R. Impact of Thrombotic Microangiopathy on Renal Outcomes and Survival after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2018 11; 24(11):2344-2353. PMID: 29758394.
    Citations:    Fields:    
  10. Leaf DE, Siew ED, Eisenga MF, Singh K, Mc Causland FR, Srivastava A, Ikizler TA, Ware LB, Ginde AA, Kellum JA, Palevsky PM, Wolf M, Waikar SS. Fibroblast Growth Factor 23 Associates with Death in Critically Ill Patients. Clin J Am Soc Nephrol. 2018 04 06; 13(4):531-541. PMID: 29519954.
    Citations:    Fields:    
  11. Rabadi S, Udo I, Leaf DE, Waikar SS, Christov M. Acute blood loss stimulates fibroblast growth factor 23 production. Am J Physiol Renal Physiol. 2018 01 01; 314(1):F132-F139. PMID: 28877877.
    Citations: 2     Fields:    
  12. Kota SK, Pernicone E, Leaf DE, Stillman IE, Waikar SS, Kota SB. BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI. J Am Soc Nephrol. 2017 Dec; 28(12):3473-3478. PMID: 28775000.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Eisenga MF, van Londen M, Leaf DE, Nolte IM, Navis G, Bakker SJL, de Borst MH, Gaillard CAJM. C-Terminal Fibroblast Growth Factor 23, Iron Deficiency, and Mortality in Renal Transplant Recipients. J Am Soc Nephrol. 2017 Dec; 28(12):3639-3646. PMID: 28774998.
    Citations: 1     Fields:    Translation:HumansCells
  14. Freiberg MS, Chang CH, Skanderson M, Patterson OV, DuVall SL, Brandt CA, So-Armah KA, Vasan RS, Oursler KA, Gottdiener J, Gottlieb S, Leaf D, Rodriguez-Barradas M, Tracy RP, Gibert CL, Rimland D, Bedimo RJ, Brown ST, Goetz MB, Warner A, Crothers K, Tindle HA, Alcorn C, Bachmann JM, Justice AC, Butt AA. Association Between HIV Infection and the Risk of Heart Failure With Reduced Ejection Fraction and Preserved Ejection Fraction in the Antiretroviral Therapy Era: Results From the Veterans Aging Cohort Study. JAMA Cardiol. 2017 05 01; 2(5):536-546. PMID: 28384660.
    Citations:    
  15. Leaf RK, O'Brien KL, Leaf DE, Drews RE. Autoimmune hemolytic anemia in a young man with acute hepatitis E infection. Am J Hematol. 2017 May; 92(5):E77-E79. PMID: 28230259.
    Citations:    Fields:    Translation:Humans
  16. Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR. A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury. Am J Respir Crit Care Med. 2017 Feb 15; 195(4):482-490. PMID: 27576016.
    Citations: 1     Fields:    Translation:Humans
  17. Cortazar FB, Leaf DE, Owens CT, Laliberte K, Pendergraft WF, Niles JL. Combination therapy with rituximab, low-dose cyclophosphamide, and prednisone for idiopathic membranous nephropathy: a case series. BMC Nephrol. 2017 Feb 01; 18(1):44. PMID: 28143416.
    Citations: 2     Fields:    Translation:Humans
  18. Leaf DE, Jacob KA, Srivastava A, Chen ME, Christov M, Jüppner H, Sabbisetti VS, Martin A, Wolf M, Waikar SS. Fibroblast Growth Factor 23 Levels Associate with AKI and Death in Critical Illness. J Am Soc Nephrol. 2017 Jun; 28(6):1877-1885. PMID: 28028134.
    Citations: 9     Fields:    Translation:Humans
  19. Mendu ML, Lundquist A, Aizer AA, Leaf DE, Robinson E, Steele DJ, Waikar SS. Clinical predictors of diagnostic testing utility in the initial evaluation of chronic kidney disease. Nephrology (Carlton). 2016 Oct; 21(10):851-9. PMID: 26610178.
    Citations:    Fields:    Translation:Humans
  20. Leaf DE, Waikar SS. End Points for Clinical Trials in Acute Kidney Injury. Am J Kidney Dis. 2017 Jan; 69(1):108-116. PMID: 27599630.
    Citations:    Fields:    Translation:Humans
  21. Leaf DE, Swinkels DW. Catalytic iron and acute kidney injury. Am J Physiol Renal Physiol. 2016 11 01; 311(5):F871-F876. PMID: 27534995.
    Citations: 3     Fields:    Translation:HumansAnimals
  22. Cortazar FB, Marrone KA, Troxell ML, Ralto KM, Hoenig MP, Brahmer JR, Le DT, Lipson EJ, Glezerman IG, Wolchok J, Cornell LD, Feldman P, Stokes MB, Zapata SA, Hodi FS, Ott PA, Yamashita M, Leaf DE. Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors. Kidney Int. 2016 09; 90(3):638-47. PMID: 27282937.
    Citations: 26     Fields:    Translation:Humans
  23. Leaf DE, Body SC, Muehlschlegel JD, McMahon GM, Lichtner P, Collard CD, Shernan SK, Fox AA, Waikar SS. Length Polymorphisms in Heme Oxygenase-1 and AKI after Cardiac Surgery. J Am Soc Nephrol. 2016 Nov; 27(11):3291-3297. PMID: 27257045.
    Citations: 8     Fields:    Translation:Humans
  24. Leaf DE, Cheng XS, Sanders JL, Mendu M, Schiff GD, Mount DB, Bazari H. An electronic alert to decrease Kayexalate ordering. Ren Fail. 2016 Nov; 38(10):1752-1754. PMID: 27183825.
    Citations: 1     Fields:    Translation:Humans
  25. Leaf DE, Christov M, Jüppner H, Siew E, Ikizler TA, Bian A, Chen G, Sabbisetti VS, Bonventre JV, Cai X, Wolf M, Waikar SS. Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery. Kidney Int. 2016 Apr; 89(4):939-48. PMID: 26924052.
    Citations: 12     Fields:    Translation:Humans
  26. Leaf DE, Srivastava A, Zeng X, McMahon GM, Croy HE, Mendu ML, Kachalia A, Waikar SS. Excessive diagnostic testing in acute kidney injury. BMC Nephrol. 2016 Jan 15; 17:9. PMID: 26772980.
    Citations:    Fields:    Translation:HumansCells
  27. Jacob KA, Leaf DE, Dieleman JM, van Dijk D, Nierich AP, Rosseel PM, van der Maaten JM, Hofland J, Diephuis JC, de Lange F, Boer C, Kluin J, Waikar SS. Intraoperative High-Dose Dexamethasone and Severe AKI after Cardiac Surgery. J Am Soc Nephrol. 2015 Dec; 26(12):2947-51. PMID: 25952257.
    Citations: 9     Fields:    Translation:Humans
  28. Mendu ML, Lundquist A, Aizer AA, Leaf DE, Robinson E, Steele DJ, Waikar SS. The usefulness of diagnostic testing in the initial evaluation of chronic kidney disease. JAMA Intern Med. 2015 May; 175(5):853-6. PMID: 25730699.
    Citations: 2     Fields:    Translation:Humans
  29. Leaf DE, Croy HE, Abrahams SJ, Raed A, Waikar SS. Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients. Crit Care. 2015 Mar 10; 19:80. PMID: 25887571.
    Citations: 6     Fields:    Translation:Humans
  30. Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Rawn JD, Frendl G, Waikar SS. Increased plasma catalytic iron in patients may mediate acute kidney injury and death following cardiac surgery. Kidney Int. 2015 May; 87(5):1046-54. PMID: 25565307.
    Citations: 9     Fields:    Translation:Humans
  31. Leaf DE, Raed A, Donnino MW, Ginde AA, Waikar SS. Reply: active and native vitamin D in critical illness. Am J Respir Crit Care Med. 2014 Nov 15; 190(10):1194-6. PMID: 25398113.
    Citations:    Fields:    Translation:Humans
  32. Leaf DE, Waikar SS. Rosuvastatin for sepsis-associated ARDS. N Engl J Med. 2014 09 04; 371(10):968. PMID: 25184877.
    Citations: 1     Fields:    Translation:Humans
  33. Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Waikar SS. Plasma catalytic iron, AKI, and death among critically ill patients. Clin J Am Soc Nephrol. 2014 Nov 07; 9(11):1849-56. PMID: 25189925.
    Citations: 4     Fields:    Translation:HumansCells
  34. Leaf DE, Raed A, Donnino MW, Ginde AA, Waikar SS. Randomized controlled trial of calcitriol in severe sepsis. Am J Respir Crit Care Med. 2014 Sep 01; 190(5):533-41. PMID: 25029202.
    Citations: 19     Fields:    Translation:Humans
  35. Mendu ML, Schneider LI, Aizer AA, Singh K, Leaf DE, Lee TH, Waikar SS. Implementation of a CKD checklist for primary care providers. Clin J Am Soc Nephrol. 2014 Sep 05; 9(9):1526-35. PMID: 25135764.
    Citations: 14     Fields:    Translation:Humans
  36. Lu Y, Ossmann MM, Leaf DE, Factor PH. Patient visibility and ICU mortality: a conceptual replication. HERD. 2014; 7(2):92-103. PMID: 24554358.
    Citations: 2     Fields:    Translation:Humans
  37. Esenwa CC, Leaf DE. Colpocephaly in adults. BMJ Case Rep. 2013 May 22; 2013. PMID: 23704444.
    Citations: 1     Fields:    Translation:Humans
  38. Christov M, Waikar SS, Pereira RC, Havasi A, Leaf DE, Goltzman D, Pajevic PD, Wolf M, Jüppner H. Plasma FGF23 levels increase rapidly after acute kidney injury. Kidney Int. 2013 Oct; 84(4):776-85. PMID: 23657144.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  39. Leaf DE, McMahon GM, Seifter JL. Chloride-liberal fluids and intracellular acidosis. Kidney Int. 2013 May; 83(5):971. PMID: 23633062.
    Citations:    Fields:    Translation:Humans
  40. Leaf DE, Waikar SS, Wolf M, Cremers S, Bhan I, Stern L. Dysregulated mineral metabolism in patients with acute kidney injury and risk of adverse outcomes. Clin Endocrinol (Oxf). 2013 Oct; 79(4):491-8. PMID: 23414198.
    Citations: 13     Fields:    Translation:Humans
  41. Leaf DE, Pereira RC, Bazari H, Jüppner H. Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma. J Clin Endocrinol Metab. 2013 Mar; 98(3):887-91. PMID: 23393166.
    Citations: 14     Fields:    Translation:Humans
  42. Leaf DE, Wolf M. A physiologic-based approach to the evaluation of a patient with hyperphosphatemia. Am J Kidney Dis. 2013 Feb; 61(2):330-6. PMID: 22938849.
    Citations:    Fields:    Translation:Humans
  43. Leaf DE, Wolf M, Waikar SS, Chase H, Christov M, Cremers S, Stern L. FGF-23 levels in patients with AKI and risk of adverse outcomes. Clin J Am Soc Nephrol. 2012 Aug; 7(8):1217-23. PMID: 22700885.
    Citations: 21     Fields:    Translation:HumansCells
  44. Leaf DE, Bukberg PR, Goldfarb DS. Laxative abuse, eating disorders, and kidney stones: a case report and review of the literature. Am J Kidney Dis. 2012 Aug; 60(2):295-8. PMID: 22560842.
    Citations: 5     Fields:    Translation:Humans
  45. Leaf DE, Korets R, Taylor EN, Tang J, Asplin JR, Goldfarb DS, Gupta M, Curhan GC. Effect of vitamin D repletion on urinary calcium excretion among kidney stone formers. Clin J Am Soc Nephrol. 2012 May; 7(5):829-34. PMID: 22422535.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  46. Gershengorn HB, Wunsch H, Wahab R, Leaf D, Brodie D, Li G, Factor P. Impact of nonphysician staffing on outcomes in a medical ICU. Chest. 2011 Jun; 139(6):1347-1353. PMID: 21393397.
    Citations: 9     Fields:    Translation:Humans
  47. Leaf DE. Calcium kidney stones. N Engl J Med. 2010 12 16; 363(25):2470; author reply 2471. PMID: 21158674.
    Citations: 1     Fields:    Translation:Humans
  48. Leaf DE, Langer NB, Markowski M, Garratty G, Diuguid DL. A severe case of cefoxitin-induced immune hemolytic anemia. Acta Haematol. 2010; 124(4):197-9. PMID: 21042010.
    Citations:    Fields:    Translation:Humans
  49. Leaf DE, Appel GB, Radhakrishnan J. Glomerular disease: why is there a dearth of high quality clinical trials? Kidney Int. 2010 Aug; 78(4):337-42. PMID: 20520593.
    Citations: 7     Fields:    Translation:Humans
  50. Leaf DE, Homel P, Factor PH. Relationship between ICU design and mortality. Chest. 2010 May; 137(5):1022-7. PMID: 20081100.
    Citations: 1     Fields:    Translation:Humans
  51. Leaf DE, Wolf M, Stern L. Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury. Nephrol Dial Transplant. 2010 Apr; 25(4):1335-7. PMID: 20037176.
    Citations: 10     Fields:    Translation:Humans
  52. Leaf DE, Leo J, Smith PR, Yee H, Stern A, Rosenthal PB, Cahill-Gallant EB, Pillinger MH. SOMOSAT: Utility of a web-based self-assessment tool in undergraduate medical education. Med Teach. 2009 May; 31(5):e211-9. PMID: 19811126.
    Citations: 1     Fields:    Translation:Humans
  53. Leaf DE, Goldfarb DS. Interpretation and review of health-related quality of life data in CKD patients receiving treatment for anemia. Kidney Int. 2009 Jan; 75(1):15-24. PMID: 18813284.
    Citations: 33     Fields:    Translation:Humans
  54. Leaf DE, Feig JE, Vasquez C, Riva PL, Yu C, Lader JM, Kontogeorgis A, Baron EL, Peters NS, Fisher EA, Gutstein DE, Morley GE. Connexin40 imparts conduction heterogeneity to atrial tissue. Circ Res. 2008 Oct 24; 103(9):1001-8. PMID: 18599871.
    Citations: 24     Fields:    Translation:Animals
  55. Leaf DE, Goldfarb DS. Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness. J Appl Physiol (1985). 2007 Apr; 102(4):1313-22. PMID: 17023566.
    Citations: 29     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.