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William B Mair, Ph.D.

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Overview
Aging is a universal trait that is observed across the evolutionary spectrum. From a public health perspective, aging is also the critical risk factor for a variety of human pathologies, including neurodegenerative diseases, many forms of cancer and metabolic disease. Our lab is interested in understanding the molecular pathways underpinning the aging process, with the goal of using this knowledge to develop novel therapeutic strategies to treat age-onset disorders.

In particular, we study the mechanisms by which animals can modulate the rate at which they age in response to changes in nutrition and the environment. The profound ability to slow aging when energy availability is low is seen in organisms ranging from yeast to primates and is coupled to a striking protection against a suite of age-related pathologies. By elucidating the genetic and molecular pathways that dictate this response, we aim to recapitulate the positive effects of dietary restriction on lifespan and health without the need for changes in dietary intake and its associated detrimental side effects.

http://www.hsph.harvard.edu/william-mair/

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG067106 (MAIR, WILLIAM B) Apr 15, 2020 - Mar 31, 2025
    NIH/NIA
    Reversing Loss of Metabolic Homeostasis to Ameliorate Alzheimer's Disease Pathogenicity
    Role: Principal Investigator
  2. R01AG059595 (MAIR, WILLIAM B) Jul 15, 2018 - Mar 31, 2023
    NIH/NIA
    Cell Non-autonomous Regulation of Aging via Neuronal TORC1
    Role: Principal Investigator
  3. R21AG056930 (MAIR, WILLIAM B) Mar 15, 2018 - Feb 29, 2020
    NIH/NIA
    Defining Functional Outputs of Mitochondrial Networks in Longevity
    Role: Principal Investigator
  4. R01AG051954 (MAIR, WILLIAM B) Sep 15, 2017 - Apr 30, 2021
    NIH/NIA
    Targeting RNA homeostasis to promote healthy aging
    Role: Principal Investigator
  5. R01AG054201 (BRUNET, ANNE) Sep 1, 2016 - Apr 30, 2021
    NIH/NIA
    Link between epigenetic modifiers and fat metabolism for healthy aging
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kelley CA, Triplett O, Mallick S, Burkewitz K, Mair WB, Cram EJ. FLN-1/filamin is required to anchor the actomyosin cytoskeleton and for global organization of sub-cellular organelles in a contractile tissue. Cytoskeleton (Hoboken). 2020 Sep 24. PMID: 32969593.
    Citations:    
  2. Burkewitz K, Feng G, Dutta S, Kelley CA, Steinbaugh M, Cram EJ, Mair WB. Atf-6 Regulates Lifespan through ER-Mitochondrial Calcium Homeostasis. Cell Rep. 2020 Sep 08; 32(10):108125. PMID: 32905769.
    Citations:    
  3. Perez-Matos MC, Mair WB. Predicting longevity responses to dietary restriction: A stepping stone toward precision geroscience. PLoS Genet. 2020 07; 16(7):e1008833. PMID: 32644994.
    Citations:    
  4. Smith HJ, Sharma A, Mair WB. Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy? Dev Cell. 2020 Jul 20; 54(2):196-211. PMID: 32619405.
    Citations:    
  5. Mair WB. Remote but not isolated. Transl Med Aging. 2020; 4:86-87. PMID: 32835153.
    Citations:    
  6. Liu YJ, McIntyre RL, Janssens GE, Williams EG, Lan J, van Weeghel M, Schomakers B, van der Veen H, van der Wel NN, Yao P, Mair WB, Aebersold R, MacInnes AW, Houtkooper RH. Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30. J Cell Biol. 2020 Jun 01; 219(6). PMID: 32259199.
    Citations:    
  7. Bhadra M, Howell P, Dutta S, Heintz C, Mair WB. Alternative splicing in aging and longevity. Hum Genet. 2020 Mar; 139(3):357-369. PMID: 31834493.
    Citations:    
  8. Sharma A, Smith HJ, Yao P, Mair WB. Causal roles of mitochondrial dynamics in longevity and healthy aging. . 2019 12 05; 20(12):e48395. PMID: 31667999.
    Citations:    
  9. Zhang Y, Lanjuin A, Chowdhury SR, Mistry M, Silva-García CG, Weir HJ, Lee CL, Escoubas CC, Tabakovic E, Mair WB. Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans. Elife. 2019 08 14; 8. PMID: 31411562.
    Citations:    
  10. Silva-García CG, Lanjuin A, Heintz C, Dutta S, Clark NM, Mair WB. Single-Copy Knock-In Loci for Defined Gene Expression in Caenorhabditis elegans. G3 (Bethesda). 2019 07 09; 9(7):2195-2198. PMID: 31064766.
    Citations:    
  11. Bäckhed F, Bugianesi E, Christofk H, Dikic I, Gupta R, Mair WB, O'Neill LAJ, Ralser M, Sabatini DM, Tschöp M. The next decade of metabolism. Nat Metab. 2019 Jan; 1(1):2-4. PMID: 32694817.
    Citations:    
  12. Escoubas CC, Silva-García CG, Mair WB. Deregulation of CRTCs in Aging and Age-Related Disease Risk: (Trends in Genetics, 33, 303-321, 2017). Trends Genet. 2018 04; 34(4):326. PMID: 29398010.
    Citations:    
  13. Weir HJ, Yao P, Huynh FK, Escoubas CC, Goncalves RL, Burkewitz K, Laboy R, Hirschey MD, Mair WB. Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling. Cell Metab. 2017 Dec 05; 26(6):884-896.e5. PMID: 29107506.
    Citations: 7     Fields:    Translation:AnimalsCells
  14. Heintz C, Doktor TK, Lanjuin A, Escoubas CC, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS, Mair WB. Corrigendum: Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans. Nature. 2017 07 27; 547(7664):476. PMID: 28700577.
    Citations:    Fields:    
  15. Han S, Schroeder EA, Silva-García CG, Hebestreit K, Mair WB, Brunet A. Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan. Nature. 2017 04 13; 544(7649):185-190. PMID: 28379943.
    Citations: 13     Fields:    Translation:AnimalsCells
  16. Escoubas CC, Silva-García CG, Mair WB. Deregulation of CRTCs in Aging and Age-Related Disease Risk. Trends Genet. 2017 05; 33(5):303-321. PMID: 28365140.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  17. Heintz C, Doktor TK, Lanjuin A, Escoubas C, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS, Mair WB. Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans. Nature. 2017 01 05; 541(7635):102-106. PMID: 27919065.
    Citations: 19     Fields:    Translation:AnimalsCells
  18. Weir HJ, Mair WB. SnapShot: Neuronal Regulation of Aging. Cell. 2016 Jul 28; 166(3):784-784.e1. PMID: 27471972.
    Citations: 2     Fields:    Translation:Humans
  19. Reis Rodrigues P, Kaul TK, Ho JH, Lucanic M, Burkewitz K, Mair WB, Held JM, Bohn LM, Gill MS. Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans. G3 (Bethesda). 2016 06 01; 6(6):1695-705. PMID: 27172180.
    Citations: 1     Fields:    Translation:AnimalsCells
  20. Hou L, Wang D, Chen D, Liu Y, Zhang Y, Cheng H, Xu C, Sun N, McDermott J, Mair WB, Han JD. A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metab. 2016 Mar 08; 23(3):529-40. PMID: 26959186.
    Citations: 8     Fields:    Translation:AnimalsCells
  21. Burkewitz K, Weir HJ, Mair WB. AMPK as a Pro-longevity Target. Exp Suppl. 2016; 107:227-256. PMID: 27812983.
    Citations: 3     Translation:HumansAnimalsCells
  22. Jacobi D, Liu S, Burkewitz K, Kory N, Knudsen NH, Alexander RK, Unluturk U, Li X, Kong X, Hyde AL, Gangl MR, Mair WB, Lee CH. Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness. Cell Metab. 2015 Oct 06; 22(4):709-20. PMID: 26365180.
    Citations: 31     Fields:    Translation:AnimalsCells
  23. Burkewitz K, Morantte I, Weir HJM, Yeo R, Zhang Y, Huynh FK, Ilkayeva OR, Hirschey MD, Grant AR, Mair WB. Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. Cell. 2015 Feb 26; 160(5):842-855. PMID: 25723162.
    Citations: 27     Fields:    Translation:AnimalsCells
  24. Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee BC, Brace L, Longchamp A, Treviño-Villarreal JH, Mejia P, Ozaki CK, Wang R, Gladyshev VN, Madeo F, Mair WB, Mitchell JR. Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell. 2015 Jan 15; 160(1-2):132-44. PMID: 25542313.
    Citations: 67     Fields:    Translation:AnimalsCells
  25. Hwang AB, Ryu EA, Artan M, Chang HW, Kabir MH, Nam HJ, Lee D, Yang JS, Kim S, Mair WB, Lee C, Lee SS, Lee SJ. Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):E4458-67. PMID: 25288734.
    Citations: 42     Fields:    Translation:AnimalsCells
  26. Burkewitz K, Zhang Y, Mair WB. AMPK at the nexus of energetics and aging. Cell Metab. 2014 Jul 01; 20(1):10-25. PMID: 24726383.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  27. Heintz C, Mair W. You are what you host: microbiome modulation of the aging process. Cell. 2014 Jan 30; 156(3):408-11. PMID: 24485451.
    Citations: 35     Fields:    Translation:HumansAnimals
  28. Mair W. Tipping the energy balance toward longevity. Cell Metab. 2013 Jan 08; 17(1):5-6. PMID: 23312278.
    Citations: 4     Fields:    
  29. Mair W, Steffen KK, Dillin A. SIP-ing the elixir of youth. Cell. 2011 Sep 16; 146(6):859-60. PMID: 21925309.
    Citations:    Fields:    
  30. Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature. 2011 Feb 17; 470(7334):404-8. PMID: 21331044.
    Citations: 111     Fields:    Translation:HumansAnimalsCells
  31. Mair W. Doubling the dose. PLoS Biol. 2011 Feb 08; 9(2):e1001017. PMID: 21346808.
    Citations:    Fields:    
  32. Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science. 2011 Jan 28; 331(6016):456-61. PMID: 21205641.
    Citations: 654     Fields:    Translation:HumansAnimalsCells
  33. Mair W, McLeod CJ, Wang L, Jones DL. Dietary restriction enhances germline stem cell maintenance. Aging Cell. 2010 Oct; 9(5):916-8. PMID: 20569233.
    Citations: 20     Fields:    Translation:AnimalsCells
  34. Mair W. How normal cells can win the battle for survival against cancer cells. PLoS Biol. 2010 Jul 13; 8(7):e1000423. PMID: 20644641.
    Citations:    Fields:    
  35. Mair W. Reinforcing reinforcement. PLoS Biol. 2010 Mar 23; 8(3):e1000340. PMID: 20351768.
    Citations:    Fields:    Translation:Animals
  36. Capelson M, Liang Y, Schulte R, Mair W, Wagner U, Hetzer MW. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell. 2010 Feb 05; 140(3):372-83. PMID: 20144761.
    Citations: 174     Fields:    Translation:AnimalsCells
  37. Mair W. "Induced" eyes suggest a path to retinal repair. PLoS Biol. 2009 Aug 18; 7(8):e1000175. PMID: 20076751.
    Citations:    Fields:    
  38. Mair W. Change for the better: phosphoregulation of proteins drives evolution. PLoS Biol. 2009 Jun 23; 7(6):e1000127. PMID: 20076746.
    Citations:    Fields:    
  39. Mair W, Panowski SH, Shaw RJ, Dillin A. Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. PLoS One. 2009; 4(2):e4535. PMID: 19229346.
    Citations: 37     Fields:    Translation:Animals
  40. Mair W. A new view of embryogenesis--connective fibers join the dance. PLoS Biol. 2008 Oct; 6(10):1. PMID: 20076695.
    Citations: 2     Fields:    
  41. Mair W, Dillin A. Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem. 2008; 77:727-54. PMID: 18373439.
    Citations: 216     Fields:    Translation:HumansAnimalsCells
  42. Piper M, Mair W, Partridge L. Comment by Matthew Piper, William Mair, Linda Partridge on Min, K.J., Flatt, T., Kulaots, I., Tatar, M. (2006) "Counting calories in Drosophila dietary restriction"Exp. Gerontology, doi:10.1016/j.exger.2006.10.009. Exp Gerontol. 2007 Apr; 42(4):253-5. PMID: 17317064.
    Citations: 3     Fields:    Translation:Animals
  43. Magwere T, Goodall S, Skepper J, Mair W, Brand MD, Partridge L. The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila. J Gerontol A Biol Sci Med Sci. 2006 Jan; 61(1):36-47. PMID: 16456193.
    Citations: 13     Fields:    Translation:AnimalsCells
  44. Partridge L, Piper MD, Mair W. Dietary restriction in Drosophila. Mech Ageing Dev. 2005 Sep; 126(9):938-50. PMID: 15935441.
    Citations: 86     Fields:    Translation:Animals
  45. Mair W, Piper MD, Partridge L. Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol. 2005 Jul; 3(7):e223. PMID: 16000018.
    Citations: 135     Fields:    Translation:Animals
  46. Piper MD, Mair W, Partridge L. Counting the calories: the role of specific nutrients in extension of life span by food restriction. J Gerontol A Biol Sci Med Sci. 2005 May; 60(5):549-55. PMID: 15972601.
    Citations: 25     Fields:    Translation:Animals
  47. Partridge L, Pletcher SD, Mair W. Dietary restriction, mortality trajectories, risk and damage. Mech Ageing Dev. 2005 Jan; 126(1):35-41. PMID: 15610760.
    Citations: 28     Fields:    Translation:Animals
  48. Hulbert AJ, Clancy DJ, Mair W, Braeckman BP, Gems D, Partridge L. Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. Exp Gerontol. 2004 Aug; 39(8):1137-43. PMID: 15288688.
    Citations: 26     Fields:    Translation:Animals
  49. Mair W, Sgrò CM, Johnson AP, Chapman T, Partridge L. Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity. Exp Gerontol. 2004 Jul; 39(7):1011-9. PMID: 15236760.
    Citations: 25     Fields:    Translation:Animals
  50. Mair W, Goymer P, Pletcher SD, Partridge L. Demography of dietary restriction and death in Drosophila. Science. 2003 Sep 19; 301(5640):1731-3. PMID: 14500985.
    Citations: 126     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.