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William B Mair, Ph.D.

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Overview
Aging is a universal trait that is observed across the evolutionary spectrum. From a public health perspective, aging is also the critical risk factor for a variety of human pathologies, including neurodegenerative diseases, many forms of cancer and metabolic disease. Our lab is interested in understanding the molecular pathways underpinning the aging process, with the goal of using this knowledge to develop novel therapeutic strategies to treat age-onset disorders.

In particular, we study the mechanisms by which animals can modulate the rate at which they age in response to changes in nutrition and the environment. The profound ability to slow aging when energy availability is low is seen in organisms ranging from yeast to primates and is coupled to a striking protection against a suite of age-related pathologies. By elucidating the genetic and molecular pathways that dictate this response, we aim to recapitulate the positive effects of dietary restriction on lifespan and health without the need for changes in dietary intake and its associated detrimental side effects.

http://www.hsph.harvard.edu/william-mair/

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG067106 (MAIR, WILLIAM B) Apr 15, 2020 - Mar 31, 2025
    NIH
    Reversing Loss of Metabolic Homeostasis to Ameliorate Alzheimer's Disease Pathogenicity
    Role: Principal Investigator
  2. R01AG059595 (MAIR, WILLIAM B) Jul 15, 2018 - Mar 31, 2023
    NIH
    Cell Non-autonomous Regulation of Aging via Neuronal TORC1
    Role: Principal Investigator
  3. R21AG056930 (MAIR, WILLIAM B) Mar 15, 2018 - Feb 28, 2021
    NIH
    Defining Functional Outputs of Mitochondrial Networks in Longevity
    Role: Principal Investigator
  4. R01AG051954 (MAIR, WILLIAM B) Sep 15, 2017 - Apr 30, 2021
    NIH
    Targeting RNA homeostasis to promote healthy aging
    Role: Principal Investigator
  5. R01AG054201 (BRUNET, ANNE) Sep 1, 2016 - Apr 30, 2021
    NIH
    Link between epigenetic modifiers and fat metabolism for healthy aging
    Role: Co-Principal Investigator

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.