Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

William B Mair, Ph.D.

Profile Picture

Aging is a universal trait that is observed across the evolutionary spectrum. From a public health perspective, aging is also the critical risk factor for a variety of human pathologies, including neurodegenerative diseases, many forms of cancer and metabolic disease. Our lab is interested in understanding the molecular pathways underpinning the aging process, with the goal of using this knowledge to develop novel therapeutic strategies to treat age-onset disorders.

In particular, we study the mechanisms by which animals can modulate the rate at which they age in response to changes in nutrition and the environment. The profound ability to slow aging when energy availability is low is seen in organisms ranging from yeast to primates and is coupled to a striking protection against a suite of age-related pathologies. By elucidating the genetic and molecular pathways that dictate this response, we aim to recapitulate the positive effects of dietary restriction on lifespan and health without the need for changes in dietary intake and its associated detrimental side effects.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG067106 (MAIR, WILLIAM B) Apr 15, 2020 - Mar 31, 2025
    Reversing Loss of Metabolic Homeostasis to Ameliorate Alzheimer's Disease Pathogenicity
    Role: Principal Investigator
  2. R01AG059595 (MAIR, WILLIAM B) Jul 15, 2018 - Mar 31, 2023
    Cell Non-autonomous Regulation of Aging via Neuronal TORC1
    Role: Principal Investigator
  3. R21AG056930 (MAIR, WILLIAM B) Mar 15, 2018 - Feb 28, 2021
    Defining Functional Outputs of Mitochondrial Networks in Longevity
    Role: Principal Investigator
  4. R01AG051954 (MAIR, WILLIAM B) Sep 15, 2017 - Apr 30, 2021
    Targeting RNA homeostasis to promote healthy aging
    Role: Principal Investigator
  5. R01AG054201 (BRUNET, ANNE) Sep 1, 2016 - Apr 30, 2021
    Link between epigenetic modifiers and fat metabolism for healthy aging
    Role: Co-Principal Investigator

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
This operation might take several minutes to complete. Please do not close your browser.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: SPH faculty should contact Faculty Affairs at facultyaffairshsph.harvard.edu).
Mair's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (195)
Co-Authors (13)
Similar People (60)
Same Department 
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.