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Scott Benjamin Lovitch, M.D.,Ph.D.

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Biography
Harvard University, Cambridge, MAB.A.06/1999Biochemical Sciences
Washington University School of Medicine, St. Louis, MOMD/Ph.D.05/2007Immunology
Brigham and Women's Hospital, Boston, MAResidency06/2009Pathology
Brigham and Women's Hospital, Boston, MAFellowship06/2010Hematopathology
Harvard Medical School, Boston, MAPostdoc06/2014Immunology
1997 - 1999
John Harvard Scholarship
1997
Detur Prize
1998
Phi Beta Kappa
1998
Dean's Summer Research Award
2002
Distinguished Service Teaching Award
2005
Center for Advanced Learning Award of Honor
2007
Alpha Omega Alpha Medical Honor Society
2008 - 2009
Felix J. Brown, MD Pathologist-In-Training Award Nominee
2010 - 2014
Certificate of Excellence in Tutoring
2011 - 2014
National Multiple Sclerosis Society Postdoctoral Fellowship
2014
Excellence in Tutoring Award
2015
Stanley L. Robbins Memorial Research Award (as faculty mentor)
2016
Stowell-Orbison Research Award (as faculty mentor)
2016
Gill-Simonian Distinguished Mentor Award
2016
American Society of Clinical Pathology "40 Under 40"
2016
Donald O’Hara Prize for Excellence in Teaching (Years I & II)
2016 - 2017
Morgan-Zinsser Fellowship in Medical Education
2017
Star Family Prize for Excellence in Advising Nominee
2017
Harvard College Certificate of Teaching Excellence
2017
Harvard College Certificate of Distinction in Teaching

Overview
I am Assistant Professor of Pathology at Harvard Medical School and an Associate Pathologist at Brigham and Women’s Hospital. I received my MD/PhD from Washington University in St. Louis School of Medicine in 2007, where I worked in Emil Unanue’s laboratory studying confirmation-dependent T cell responses, then trained at Brigham and Women's Hospital as a resident in pathology and fellow in hematopathology, and completed a postdoctoral fellowship in Arlene Sharpe’s laboratory studying the role of coinhibitory pathways on effector and regulatory T cells, prior to joining the faculty in 2014. My research interests include the role of the PD-1 pathway and other coinhibitory pathways in hematologic malignancy, and the development of novel immunohistochemical and molecular diagnostic assays for diagnosis and personalized therapy of hematologic malignancy. My clinical practice activities include signout on the Hematopathology and Molecular Diagnostic Pathology services. I am also active in educational leadership and curriculum development at Harvard Medical School, where I am a member of the Academy Center for Teaching and Learning, co-direct the Foundations course for first-year medical students in the Pathways curriculum and the Pathology of Human Disease course (HBTM 200) for graduate students in the Leder Program in Human Biology and Translational Medicine, and serve as core faculty in the Homeostasis I course.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Griffin GK, Weirather JL, Roemer M, Lipschitz M, Kelley A, Chen PH, Gusenleitner D, Jeter E, Gjini E, Chapuy B, Rosenthal M, Xu J, Chen BJ, Sohani A, Lovitch SB, Abramson J, Ishizuka JJ, Kim AI, Jacobson CA, LaCasce AS, Fletcher CDM, Neuberg D, Freeman GJ, Hodi FS, Wright K, Ligon AH, Jacobsen ED, Armand P, Shipp MA, Rodig SJ. Spatial Signatures Identify Immune Escape via PD-1 as a Defining Feature of T-cell/Histiocyte-rich Large B-cell Lymphoma. Blood. 2020 Sep 01. PMID: 32871584.
    Citations:    
  2. Ouseph MM, Hasserjian RP, Dal Cin P, Lovitch SB, Steensma DP, Nardi V, Weinberg OK. Genomic alterations in patients with somatic loss of the Y chromosome as the sole cytogenetic finding in bone marrow cells. Haematologica. 2020 Mar 19. PMID: 32193254.
    Citations:    
  3. Sankaran VG, Ulirsch JC, Tchaikovskii V, Ludwig LS, Wakabayashi A, Kadirvel S, Lindsley RC, Bejar R, Shi J, Lovitch SB, Bishop DF, Steensma DP. X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation. J Clin Invest. 2020 Jan 02; 130(1):552. PMID: 31895053.
    Citations:    
  4. Clement RL, Daccache J, Mohammed MT, Diallo A, Blazar BR, Kuchroo VK, Lovitch SB, Sharpe AH, Sage PT. Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses. Nat Immunol. 2019 10; 20(10):1360-1371. PMID: 31477921.
    Citations:    
  5. Taylor J, Haddadin M, Upadhyay VA, Grussie E, Mehta-Shah N, Brunner AM, Louissaint A, Lovitch SB, Dogan A, Fathi AT, Stone RM, Tallman MS, Rampal RK, Neuberg DS, Stevenson KE, Horwitz SM, Lane AA. Multicenter analysis of outcomes in blastic plasmacytoid dendritic cell neoplasm offers a pretargeted therapy benchmark. Blood. 2019 08 22; 134(8):678-687. PMID: 31243042.
    Citations:    
  6. Rodig SJ, Gusenleitner D, Jackson DG, Gjini E, Giobbie-Hurder A, Jin C, Chang H, Lovitch SB, Horak C, Weber JS, Weirather JL, Wolchok JD, Postow MA, Pavlick AC, Chesney J, Hodi FS. MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma. Sci Transl Med. 2018 07 18; 10(450). PMID: 30021886.
    Citations: 1     Fields:    
  7. Maarouf OH, Uehara M, Kasinath V, Solhjou Z, Banouni N, Bahmani B, Jiang L, Yilmam OA, Guleria I, Lovitch SB, Grogan JL, Fiorina P, Sage PT, Bromberg JS, McGrath MM, Abdi R. Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing. JCI Insight. 2018 07 12; 3(13). PMID: 29997302.
    Citations:    Fields:    
  8. Park DC, Ozkaya N, Lovitch SB. Acute leukaemia with a pure erythroid phenotype: under-recognized morphological and cytogenetic signatures associated universally with primary refractory disease and a dismal clinical outcome. Histopathology. 2017 Aug; 71(2):316-321. PMID: 28261852.
    Citations:    Fields:    Translation:Humans
  9. Hung YP, Lovitch SB, Qian X. Histiocytic sarcoma: New insights into FNA cytomorphology and molecular characteristics. Cancer Cytopathol. 2017 Aug; 125(8):604-614. PMID: 28805986.
    Citations: 1     Fields:    Translation:Humans
  10. Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016 07 12; 24(1):104-17. PMID: 27411012.
    Citations: 27     Fields:    Translation:AnimalsCells
  11. Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, Ranganathan P, Devine SM, Burrill JS, Guo L, Sacristan C, Snyder NW, Blair IA, Milone MC, Dustin ML, Riley JL, Bernlohr DA, Murphy WJ, Fife BT, Munn DH, Miller JS, Serody JS, Freeman GJ, Sharpe AH, Turka LA, Blazar BR. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016 07 01; 126(7):2642-60. PMID: 27294527.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  12. Lovitch SB, Rodig SJ. The Role of Surgical Pathology in Guiding Cancer Immunotherapy. Annu Rev Pathol. 2016 05 23; 11:313-41. PMID: 27193453.
    Citations: 1     Fields:    Translation:Humans
  13. Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH. Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. J Exp Med. 2015 Sep 21; 212(10):1603-21. PMID: 26371185.
    Citations: 28     Fields:    Translation:AnimalsCells
  14. McKee KE, Etherton MR, Lovitch SB, Gupta AS, Micalizzi DS, Tierney T, Wadleigh M, Vaitkevicus H. A Man in His 40s With Headache, Lethargy, and Altered Mental Status. JAMA Neurol. 2015 Sep; 72(9):1061-5. PMID: 26213984.
    Citations:    Fields:    Translation:HumansCells
  15. Sankaran VG, Ulirsch JC, Tchaikovskii V, Ludwig LS, Wakabayashi A, Kadirvel S, Lindsley RC, Bejar R, Shi J, Lovitch SB, Bishop DF, Steensma DP. X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation. J Clin Invest. 2015 Apr; 125(4):1665-9. PMID: 25705881.
    Citations: 10     Fields:    Translation:HumansCells
  16. Sage PT, Paterson AM, Lovitch SB, Sharpe AH. The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells. Immunity. 2014 Dec 18; 41(6):1026-39. PMID: 25526313.
    Citations: 79     Fields:    Translation:AnimalsCells
  17. Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell. 2013 Jun 06; 50(5):686-98. PMID: 23746352.
    Citations: 72     Fields:    Translation:AnimalsCells
  18. Lovitch SB, Esparza TJ, Schweitzer G, Herzog J, Unanue ER. Activation of type B T cells after protein immunization reveals novel pathways of in vivo presentation of peptides. J Immunol. 2007 Jan 01; 178(1):122-33. PMID: 17182547.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  19. Lovitch SB, Pu Z, Unanue ER. Amino-terminal flanking residues determine the conformation of a peptide-class II MHC complex. J Immunol. 2006 Mar 01; 176(5):2958-68. PMID: 16493054.
    Citations: 24     Fields:    Translation:AnimalsCells
  20. Suri A, Lovitch SB, Unanue ER. The wide diversity and complexity of peptides bound to class II MHC molecules. Curr Opin Immunol. 2006 Feb; 18(1):70-7. PMID: 16316750.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  21. Lovitch SB, Unanue ER. Conformational isomers of a peptide-class II major histocompatibility complex. Immunol Rev. 2005 Oct; 207:293-313. PMID: 16181344.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  22. Unanue E, Byersdorfer C, Carrero J, Levisetti M, Lovitch S, Pu Z, Suri A. Antigen presentation: lysoyme, autoimmune diabetes, and Listeria--what do they have in common? Immunol Res. 2005; 32(1-3):267-92. PMID: 16106079.
    Citations:    Fields:    Translation:AnimalsCells
  23. Pu Z, Lovitch SB, Bikoff EK, Unanue ER. T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM. Immunity. 2004 Apr; 20(4):467-76. PMID: 15084275.
    Citations: 34     Fields:    Translation:AnimalsCells
  24. Lovitch SB, Petzold SJ, Unanue ER. Cutting edge: H-2DM is responsible for the large differences in presentation among peptides selected by I-Ak during antigen processing. J Immunol. 2003 Sep 01; 171(5):2183-6. PMID: 12928360.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  25. Lovitch SB, Walters JJ, Gross ML, Unanue ER. APCs present A beta(k)-derived peptides that are autoantigenic to type B T cells. J Immunol. 2003 Apr 15; 170(8):4155-60. PMID: 12682247.
    Citations: 10     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.