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Scott Benjamin Lovitch, M.D.,Ph.D.

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Other Positions

Harvard University, Cambridge, MAB.A.06/1999Biochemical Sciences
Washington University School of Medicine, St. Louis, MOMD/Ph.D.05/2007Immunology
Brigham and Women's Hospital, Boston, MAResidency06/2009Pathology
Brigham and Women's Hospital, Boston, MAFellowship06/2010Hematopathology
Harvard Medical School, Boston, MAPostdoc06/2014Immunology
1997 - 1999
John Harvard Scholarship
Detur Prize
Phi Beta Kappa
Dean's Summer Research Award
Distinguished Service Teaching Award
Center for Advanced Learning Award of Honor
Alpha Omega Alpha Medical Honor Society
2008 - 2009
Felix J. Brown, MD Pathologist-In-Training Award Nominee
2010 - 2014
Certificate of Excellence in Tutoring
2011 - 2014
National Multiple Sclerosis Society Postdoctoral Fellowship
Excellence in Tutoring Award
Stanley L. Robbins Memorial Research Award (as faculty mentor)
Stowell-Orbison Research Award (as faculty mentor)
Gill-Simonian Distinguished Mentor Award
American Society of Clinical Pathology "40 Under 40"
Donald O’Hara Prize for Excellence in Teaching (Years I & II)
2016 - 2017
Morgan-Zinsser Fellowship in Medical Education
Star Family Prize for Excellence in Advising Nominee
Harvard College Certificate of Teaching Excellence
Harvard College Certificate of Distinction in Teaching

I am Assistant Professor of Pathology at Harvard Medical School and an Associate Pathologist at Brigham and Women’s Hospital. I received my MD/PhD from Washington University in St. Louis School of Medicine in 2007, where I worked in Emil Unanue’s laboratory studying confirmation-dependent T cell responses, then trained at Brigham and Women's Hospital as a resident in pathology and fellow in hematopathology, and completed a postdoctoral fellowship in Arlene Sharpe’s laboratory studying the role of coinhibitory pathways on effector and regulatory T cells, prior to joining the faculty in 2014. My research interests include the role of the PD-1 pathway and other coinhibitory pathways in hematologic malignancy, and the development of novel immunohistochemical and molecular diagnostic assays for diagnosis and personalized therapy of hematologic malignancy. My clinical practice activities include signout on the Hematopathology and Molecular Diagnostic Pathology services. I am also active in educational leadership and curriculum development at Harvard Medical School, where I am a member of the Academy Center for Teaching and Learning, co-direct the Foundations course for first-year medical students in the Pathways curriculum and the Pathology of Human Disease course (HBTM 200) for graduate students in the Leder Program in Human Biology and Translational Medicine, and serve as core faculty in the Homeostasis I course.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Togami K, Chung SS, Madan V, Booth CAG, Kenyon CM, Cabal-Hierro L, Taylor J, Kim SS, Griffin GK, Ghandi M, Li J, Li YY, Angelot-Delettre F, Biichle S, Seiler M, Buonamici S, Lovitch SB, Louissaint A, Morgan EA, Jardin F, Piccaluga PP, Weinstock DM, Hammerman PS, Yang H, Konopleva M, Pemmaraju N, Garnache-Ottou F, Abdel-Wahab O, Koeffler HP, Lane AA. Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis. Cancer Discov. 2022 02; 12(2):522-541. PMID: 34615655; PMCID: PMC8831459.
    Citations: 5     Fields:    Translation:HumansCells
  2. Zee BM, Poels KE, Yao CH, Kawabata KC, Wu G, Duy C, Jacobus WD, Senior E, Endress JE, Jambhekar A, Lovitch SB, Ma J, Dhall A, Harris IS, Blanco MA, Sykes DB, Licht JD, Weinstock DM, Melnick A, Haigis MC, Michor F, Shi Y. Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia. iScience. 2021 Jun 25; 24(6):102651. PMID: 34151238.
  3. Griffin GK, Weirather JL, Roemer MGM, Lipschitz M, Kelley A, Chen PH, Gusenleitner D, Jeter E, Pak C, Gjini E, Chapuy B, Rosenthal MH, Xu J, Chen BJ, Sohani AR, Lovitch SB, Abramson JS, Ishizuka JJ, Kim AI, Jacobson CA, LaCasce AS, Fletcher CD, Neuberg D, Freeman GJ, Hodi FS, Wright K, Ligon AH, Jacobsen ED, Armand P, Shipp MA, Rodig SJ. Spatial signatures identify immune escape via PD-1 as a defining feature of T-cell/histiocyte-rich large B-cell lymphoma. Blood. 2021 03 11; 137(10):1353-1364. PMID: 32871584; PMCID: PMC8555417.
    Citations: 7     Fields:    Translation:HumansCells
  4. Ouseph MM, Hasserjian RP, Dal Cin P, Lovitch SB, Steensma DP, Nardi V, Weinberg OK. Genomic alterations in patients with somatic loss of the Y chromosome as the sole cytogenetic finding in bone marrow cells. Haematologica. 2021 02 01; 106(2):555-564. PMID: 32193254.
    Citations: 8     Fields:    Translation:HumansCells
  5. Tsabar M, Lovitch SB, Jambhekar A, Lahav G. Connecting Timescales in Biology: Can Early Dynamical Measurements Predict Long-Term Outcomes? Trends Cancer. 2021 04; 7(4):301-308. PMID: 33451930; PMCID: PMC8796003.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Shanmugam V, Craig JW, Hilton LK, Nguyen MH, Rushton CK, Fahimdanesh K, Lovitch S, Ferland B, Scott DW, Aster JC. Notch activation is pervasive in SMZL and uncommon in DLBCL: implications for Notch signaling in B-cell tumors. Blood Adv. 2021 01 12; 5(1):71-83. PMID: 33570635.
    Citations: 4     Fields:    Translation:HumansCells
  7. Tan CL, Kuchroo JR, Sage PT, Liang D, Francisco LM, Buck J, Thaker YR, Zhang Q, McArdel SL, Juneja VR, Lee SJ, Lovitch SB, Lian C, Murphy GF, Blazar BR, Vignali DAA, Freeman GJ, Sharpe AH. PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance. J Exp Med. 2021 01 04; 218(1). PMID: 33045061.
    Citations: 40     Fields:    Translation:AnimalsCells
  8. Sankaran VG, Ulirsch JC, Tchaikovskii V, Ludwig LS, Wakabayashi A, Kadirvel S, Lindsley RC, Bejar R, Shi J, Lovitch SB, Bishop DF, Steensma DP. X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation. J Clin Invest. 2020 Jan 02; 130(1):552. PMID: 31895053; PMCID: PMC6934225.
    Citations: 1     Fields:    
  9. Clement RL, Daccache J, Mohammed MT, Diallo A, Blazar BR, Kuchroo VK, Lovitch SB, Sharpe AH, Sage PT. Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses. Nat Immunol. 2019 10; 20(10):1360-1371. PMID: 31477921; PMCID: PMC6754271.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  10. Taylor J, Haddadin M, Upadhyay VA, Grussie E, Mehta-Shah N, Brunner AM, Louissaint A, Lovitch SB, Dogan A, Fathi AT, Stone RM, Tallman MS, Rampal RK, Neuberg DS, Stevenson KE, Horwitz SM, Lane AA. Multicenter analysis of outcomes in blastic plasmacytoid dendritic cell neoplasm offers a pretargeted therapy benchmark. Blood. 2019 08 22; 134(8):678-687. PMID: 31243042; PMCID: PMC6706810.
    Citations: 14     Fields:    Translation:HumansCells
  11. Rodig SJ, Gusenleitner D, Jackson DG, Gjini E, Giobbie-Hurder A, Jin C, Chang H, Lovitch SB, Horak C, Weber JS, Weirather JL, Wolchok JD, Postow MA, Pavlick AC, Chesney J, Hodi FS. MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma. Sci Transl Med. 2018 07 18; 10(450). PMID: 30021886.
    Citations: 168     Fields:    Translation:HumansCellsCTClinical Trials
  12. Maarouf OH, Uehara M, Kasinath V, Solhjou Z, Banouni N, Bahmani B, Jiang L, Yilmam OA, Guleria I, Lovitch SB, Grogan JL, Fiorina P, Sage PT, Bromberg JS, McGrath MM, Abdi R. Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing. JCI Insight. 2018 07 12; 3(13). PMID: 29997302.
    Citations: 20     Fields:    Translation:AnimalsCells
  13. Park DC, Ozkaya N, Lovitch SB. Acute leukaemia with a pure erythroid phenotype: under-recognized morphological and cytogenetic signatures associated universally with primary refractory disease and a dismal clinical outcome. Histopathology. 2017 Aug; 71(2):316-321. PMID: 28261852.
    Citations: 1     Fields:    Translation:Humans
  14. Hung YP, Lovitch SB, Qian X. Histiocytic sarcoma: New insights into FNA cytomorphology and molecular characteristics. Cancer Cytopathol. 2017 Aug; 125(8):604-614. PMID: 28805986.
    Citations: 9     Fields:    Translation:Humans
  15. Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016 07 12; 24(1):104-17. PMID: 27411012; PMCID: PMC5330619.
    Citations: 129     Fields:    Translation:AnimalsCells
  16. Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, Ranganathan P, Devine SM, Burrill JS, Guo L, Sacristan C, Snyder NW, Blair IA, Milone MC, Dustin ML, Riley JL, Bernlohr DA, Murphy WJ, Fife BT, Munn DH, Miller JS, Serody JS, Freeman GJ, Sharpe AH, Turka LA, Blazar BR. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016 07 01; 126(7):2642-60. PMID: 27294527; PMCID: PMC4922691.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  17. Lovitch SB, Rodig SJ. The Role of Surgical Pathology in Guiding Cancer Immunotherapy. Annu Rev Pathol. 2016 05 23; 11:313-41. PMID: 27193453.
    Citations: 7     Fields:    Translation:Humans
  18. Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH. Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. J Exp Med. 2015 Sep 21; 212(10):1603-21. PMID: 26371185; PMCID: PMC4577848.
    Citations: 79     Fields:    Translation:AnimalsCells
  19. McKee KE, Etherton MR, Lovitch SB, Gupta AS, Micalizzi DS, Tierney T, Wadleigh M, Vaitkevicus H. A Man in His 40s With Headache, Lethargy, and Altered Mental Status. JAMA Neurol. 2015 Sep; 72(9):1061-5. PMID: 26213984; PMCID: PMC5761060.
    Citations:    Fields:    Translation:HumansCells
  20. Sankaran VG, Ulirsch JC, Tchaikovskii V, Ludwig LS, Wakabayashi A, Kadirvel S, Lindsley RC, Bejar R, Shi J, Lovitch SB, Bishop DF, Steensma DP. X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation. J Clin Invest. 2015 Apr; 125(4):1665-9. PMID: 25705881; PMCID: PMC4396476.
    Citations: 21     Fields:    Translation:HumansCells
  21. Sage PT, Paterson AM, Lovitch SB, Sharpe AH. The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells. Immunity. 2014 Dec 18; 41(6):1026-39. PMID: 25526313; PMCID: PMC4309019.
    Citations: 183     Fields:    Translation:AnimalsCells
  22. Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell. 2013 Jun 06; 50(5):686-98. PMID: 23746352.
    Citations: 141     Fields:    Translation:AnimalsCells
  23. Lovitch SB, Esparza TJ, Schweitzer G, Herzog J, Unanue ER. Activation of type B T cells after protein immunization reveals novel pathways of in vivo presentation of peptides. J Immunol. 2007 Jan 01; 178(1):122-33. PMID: 17182547.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  24. Lovitch SB, Pu Z, Unanue ER. Amino-terminal flanking residues determine the conformation of a peptide-class II MHC complex. J Immunol. 2006 Mar 01; 176(5):2958-68. PMID: 16493054.
    Citations: 28     Fields:    Translation:AnimalsCells
  25. Suri A, Lovitch SB, Unanue ER. The wide diversity and complexity of peptides bound to class II MHC molecules. Curr Opin Immunol. 2006 Feb; 18(1):70-7. PMID: 16316750.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  26. Lovitch SB, Unanue ER. Conformational isomers of a peptide-class II major histocompatibility complex. Immunol Rev. 2005 Oct; 207:293-313. PMID: 16181344.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  27. Unanue E, Byersdorfer C, Carrero J, Levisetti M, Lovitch S, Pu Z, Suri A. Antigen presentation: lysoyme, autoimmune diabetes, and Listeria--what do they have in common? Immunol Res. 2005; 32(1-3):267-92. PMID: 16106079.
    Citations: 1     Fields:    Translation:AnimalsCells
  28. Pu Z, Lovitch SB, Bikoff EK, Unanue ER. T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM. Immunity. 2004 Apr; 20(4):467-76. PMID: 15084275.
    Citations: 39     Fields:    Translation:AnimalsCells
  29. Lovitch SB, Petzold SJ, Unanue ER. Cutting edge: H-2DM is responsible for the large differences in presentation among peptides selected by I-Ak during antigen processing. J Immunol. 2003 Sep 01; 171(5):2183-6. PMID: 12928360.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  30. Lovitch SB, Walters JJ, Gross ML, Unanue ER. APCs present A beta(k)-derived peptides that are autoantigenic to type B T cells. J Immunol. 2003 Apr 15; 170(8):4155-60. PMID: 12682247.
    Citations: 10     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.