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Sherrie Jill Divito, M.D.,Ph.D.

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Overview
Interest(s): (1) Effects of chemotherapy, stem cell transplant conditioning and targeted anti-cancer agents on skin (2) Graft-versus-host-disease (3) Severe Drug reactions (4) Drug and device discovery, pre-clinical modeling, clinical trials

I am trained as a basic and translational immunologist, and am particularly interested in translating problems we see in the clinic to solutions with therapeutics or diagnostics via our research in the lab.

Mentoring
Available: 12/02/19, Expires: 11/03/22

We are a translational immunology/dermatology lab studying severe drug reactions and GVHD using human samples and humanized mouse models. The main goals of this lab is to elucidate the pathobiology of severe drug reactions and/or GVHD using immunofluorescent staining and microscopy, transcript analysis and cytokine analysis on patient skin samples, correlating clinical data to laboratory findings, using a humanized mouse model to study disease pathogenesis and potential treatment options, helping with patient enrollment in prospective research studies and processing patient specimens in the lab.

We have multiple opportunities available depending on the student's interests and goals. The student will be able to learn the scientific method and proper laboratory techniques, to assist or independently perform experiments (depending on student experience/level), to analyze and interpret data, to present findings at lab meeting and potentially departmental or national meetings.

We are looking for hard working, enthusiastic students who can function as part of our research team. Students should show initiative and interest in learning from other members of our lab and our department and also for self directed learning. Students should be organized and detail-oriented. It is mandatory that students follow all research ethical guidelines. This is a full time research position which may include evenings and/or weekends depending on experiments. Projects could either be for a summer (8-10 weeks for example) or for a year off experience. Lab experience not required, but desired.

I am a physician scientist with clinic on Mondays and episodic hospital coverage. I meet with every lab member individually weekly for one hour, plus as a group weekly in our lab meetings, then one on one as needed depending on the person and their experience level/needs. Medical students would be trained by me and by post-doctoral fellows in the lab and/or senior laboratory technician.  

Investigating Cutaneous Memory T cells in Patients with Delayed-Type Drug Hypersensitivity Reactions
Full Time/Year Long, 06/05/17 - 04/27/18

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. DP5OD023091 (DIVITO, SHERRIE JILL) Sep 19, 2016 - Aug 31, 2021
    NIH
    Investigating a novel cell population in delayed-onset drug hypersensitivity reactions
    Role: Principal Investigator
  2. Physician-Scientist Career Development Award (Sherrie J. Divito) Jul 1, 2016 - Sep 19, 2016
    Dermatology Foundation
    Investigating Skin T Cells in Graft-versus-Host Disease
    Role: PI
  3. (Sherrie J. Divito) May 1, 2015 - Oct 30, 2016
    National Foundation for Ectodermal Dysplasias
    Targeted Therapeutic Development for Focal Dermal Hypoplasia
    Role: PI
  4. F30DK082131 (DIVITO, SHERRIE JILL) Jul 1, 2008 - May 31, 2011
    NIH/NIDDK
    The role of tolerogenic dendritic cells in islet-cell allograft transplantation
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chang WC, Abe R, Anderson P, Anderson W, Ardern-Jones MR, Beachkofsky TM, Bellón T, Biala AK, Bouchard C, Cavalleri GL, Chapman N, Chodosh J, Choi HK, Cibotti RR, Divito SJ, Dewar K, Dehaeck U, Etminan M, Forbes D, Fuchs E, Goldman JL, Holmes JH, Hope EA, Hung SI, Hsieh CL, Iovieno A, Jagdeo J, Kim MK, Koelle DM, Lacouture ME, Le Pallec S, Lehloenya RJ, Lim R, Lowe A, McCawley J, McCawley J, Micheletti RG, Mockenhaupt M, Niemeyer K, Norcross MA, Oboh D, Olteanu C, Pasieka HB, Peter J, Pirmohamed M, Rieder M, Saeed HN, Shear NH, Shieh C, Straus S, Sukasem C, Sung C, Trubiano JA, Tsou SY, Ueta M, Volpi S, Wan C, Wang H, Wang ZQ, Weintraub J, Whale C, Wheatley LM, Whyte-Croasdaile S, Williams KB, Wright G, Yeung SN, Zhou L, Chung WH, Phillips EJ, Carleton BC. SJS/TEN 2019: From science to translation. J Dermatol Sci. 2020 Mar 07. PMID: 32192826.
    Citations:    
  2. Li DJ, Romar GA, Hsieh PC, Wells M, Foreman RK, Lian CG, Divito SJ. Histologic features of GVHD-associated angiomatosis: Insights into pathophysiology and treatment. J Am Acad Dermatol. 2020 Jan 07. PMID: 31923444.
    Citations:    
  3. Divito SJ. Implementation of Genetic Screening to Prevent Severe Cutaneous Adverse Drug Reactions Is Crucial-Rebuttal From the Devil's Antagonist-Reply. JAMA Dermatol. 2019 Dec 18. PMID: 31851296.
    Citations:    
  4. Divito SJ. Screening HLA to Prevent Severe Drug Reactions-A Devil's Advocate Perspective. JAMA Dermatol. 2019 06 01; 155(6):655-656. PMID: 30916720.
    Citations:    
  5. Divito SJ, Morelli AE. Method of Generating Tolerogenic Maturation-Resistant Dendritic Cells and Testing for Their Immune-Regulatory Functions In Vivo in the Context of Transplantation. Methods Mol Biol. 2019; 1899:181-193. PMID: 30649773.
    Citations:    Fields:    
  6. de Masson A, O'Malley JT, Elco CP, Garcia SS, Divito SJ, Lowry EL, Tawa M, Fisher DC, Devlin PM, Teague JE, Leboeuf NR, Kirsch IR, Robins H, Clark RA, Kupper TS. High-throughput sequencing of the T cell receptor ß gene identifies aggressive early-stage mycosis fungoides. Sci Transl Med. 2018 05 09; 10(440). PMID: 29743350.
    Citations:    Fields:    
  7. Stern RS, Divito SJ. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Associations, Outcomes, and Pathobiology-Thirty Years of Progress but Still Much to Be Done. J Invest Dermatol. 2017 05; 137(5):1004-1008. PMID: 28411832.
    Citations: 1     Fields:    Translation:Humans
  8. Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017 03 09; 543(7644):252-256. PMID: 28219080.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  9. Gunasekera NS, Divito JK, Kupper TS, Huang JT, Divito SJ. Cross-Sectional Study Evaluating Skin, Hair, Nail, and Bone Disease in Patients with Focal Dermal Hypoplasia. Pediatr Dermatol. 2017 Mar; 34(2):197-198. PMID: 28025844.
    Citations:    Fields:    Translation:Humans
  10. Zhuang Q, Liu Q, Divito SJ, Zeng Q, Yatim KM, Hughes AD, Rojas-Canales DM, Nakao A, Shufesky WJ, Williams AL, Humar R, Hoffman RA, Shlomchik WD, Oberbarnscheidt MH, Lakkis FG, Morelli AE. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat Commun. 2016 08 24; 7:12623. PMID: 27554168.
    Citations: 7     Fields:    Translation:AnimalsCells
  11. Liu Q, Rojas-Canales DM, Divito SJ, Shufesky WJ, Stolz DB, Erdos G, Sullivan ML, Gibson GA, Watkins SC, Larregina AT, Morelli AE. Donor dendritic cell-derived exosomes promote allograft-targeting immune response. J Clin Invest. 2016 08 01; 126(8):2805-20. PMID: 27348586.
    Citations: 31     Fields:    Translation:AnimalsCells
  12. Romar GA, Kupper TS, Divito SJ. Research Techniques Made Simple: Techniques to Assess Cell Proliferation. J Invest Dermatol. 2016 Jan; 136(1):e1-e7. PMID: 26763463.
    Citations: 2     Fields:    Translation:Humans
  13. Griffin RL, Kupper TS, Divito SJ. Humanized Mice in Dermatology Research. J Invest Dermatol. 2015 Dec; 135(12):e39-e43. PMID: 26569593.
    Citations:    Fields:    Translation:HumansAnimals
  14. Sheu JS, Divito SJ, Enamandram M, Merola JF. Dapsone Therapy for Pustular Psoriasis: Case Series and Review of the Literature. Dermatology. 2016; 232(1):97-101. PMID: 26465742.
    Citations:    Fields:    Translation:Humans
  15. Sheu J, Divito SJ, Hoffman EP, Frank NY, Merola JF. Mosaic focal dermal hypoplasia caused by a novel somatic mutation in PORCN detected in affected skin. Br J Dermatol. 2015 Aug; 173(2):568-70. PMID: 25640089.
    Citations: 2     Fields:    Translation:Humans
  16. Larregina AT, Divito SJ, Morelli AE. Clinical implications of basic science discoveries: nociceptive neurons as targets to control immunity--potential relevance for transplantation. Am J Transplant. 2015 Jun; 15(6):1472-4. PMID: 25846743.
    Citations:    Fields:    Translation:HumansAnimalsCells
  17. Song PI, Divito SJ, Kroshinsky D. Pemphigus vulgaris presenting with multiple lesion morphologies. Dermatol Online J. 2014 Dec 14; 21(3). PMID: 25780973.
    Citations:    Fields:    Translation:Humans
  18. Divito SJ, Kupper TS. Inhibiting Janus kinases to treat alopecia areata. Nat Med. 2014 Sep; 20(9):989-90. PMID: 25198048.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  19. Wall JB, Divito SJ, Talbot SG. Chlorhexidine gluconate-impregnated central-line dressings and necrosis in complicated skin disorder patients. J Crit Care. 2014 Dec; 29(6):1130.e1-4. PMID: 25035049.
    Citations: 2     Fields:    Translation:Humans
  20. Wang Z, Divito SJ, Shufesky WJ, Sumpter T, Wang H, Tkacheva OA, Wang W, Liu C, Larregina AT, Morelli AE. Dendritic cell therapies in transplantation revisited: deletion of recipient DCs deters the effect of therapeutic DCs. Am J Transplant. 2012 Jun; 12(6):1398-408. PMID: 22500950.
    Citations: 15     Fields:    Translation:AnimalsCells
  21. Morelli, A.E. and Divito, S.J. Cell-based therapies in the prevention of solid organ transplant rejection. Am J Immunol. 2012; 8(2):52-64.
  22. Potter DM, Butterfield LH, Divito SJ, Sander CA, Kirkwood JM. Pitfalls in retrospective analyses of biomarkers: a case study with metastatic melanoma patients. J Immunol Methods. 2012 Feb 28; 376(1-2):108-12. PMID: 22210094.
    Citations: 5     Fields:    Translation:Humans
  23. Montecalvo A, Larregina AT, Shufesky WJ, Stolz DB, Sullivan ML, Karlsson JM, Baty CJ, Gibson GA, Erdos G, Wang Z, Milosevic J, Tkacheva OA, Divito SJ, Jordan R, Lyons-Weiler J, Watkins SC, Morelli AE. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 2012 Jan 19; 119(3):756-66. PMID: 22031862.
    Citations: 308     Fields:    Translation:AnimalsCells
  24. Divito SJ, Morelli AE, Larregina AT. Role of neurokinin-1 receptor in the initiation and maintenance of skin chronic inflammatory diseases. Immunol Res. 2011 Aug; 50(2-3):195-201. PMID: 21717076.
    Citations:    Fields:    Translation:HumansAnimalsCells
  25. Divito SJ, Ferris LK. Advances and short comings in the early diagnosis of melanoma. Melanoma Res. 2010 Dec; 20(6):450-8. PMID: 20856147.
    Citations: 2     Fields:    Translation:HumansAnimals
  26. Divito SJ, Wang Z, Shufesky WJ, Liu Q, Tkacheva OA, Montecalvo A, Erdos G, Larregina AT, Morelli AE. Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood. 2010 Oct 14; 116(15):2694-705. PMID: 20576812.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  27. Frank GM, Divito SJ, Maker DM, Xu M, Hendricks RL. A novel p40-independent function of IL-12p35 is required for progression and maintenance of herpes stromal keratitis. Invest Ophthalmol Vis Sci. 2010 Jul; 51(7):3591-8. PMID: 20207959.
    Citations: 9     Fields:    Translation:AnimalsCells
  28. Divito SJ, Haught JM, English JC, Ferris LK. An extensive case of dermonecrotic arachnidism. J Clin Aesthet Dermatol. 2009 Sep; 2(9):40-3. PMID: 20729958.
    Citations: 1     
  29. Wang Z, Shufesky WJ, Montecalvo A, Divito SJ, Larregina AT, Morelli AE. In situ-targeting of dendritic cells with donor-derived apoptotic cells restrains indirect allorecognition and ameliorates allograft vasculopathy. PLoS One. 2009; 4(3):e4940. PMID: 19333400.
    Citations: 17     Fields:    Translation:AnimalsCells
  30. Perone MJ, Bertera S, Shufesky WJ, Divito SJ, Montecalvo A, Mathers AR, Larregina AT, Pang M, Seth N, Wucherpfennig KW, Trucco M, Baum LG, Morelli AE. Suppression of autoimmune diabetes by soluble galectin-1. J Immunol. 2009 Mar 01; 182(5):2641-53. PMID: 19234158.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  31. Divito, S.J. and Morelli, A.E. Phagocytosis of dying cells: from molecular mechanisms to human diseases. Apoptotic cells in the treatment of transplant rejection. 2009; 319-346.
  32. Divito SJ, Hendricks RL. Activated inflammatory infiltrate in HSV-1-infected corneas without herpes stromal keratitis. Invest Ophthalmol Vis Sci. 2008 Apr; 49(4):1488-95. PMID: 18385067.
    Citations: 29     Fields:    Translation:AnimalsCells
  33. Montecalvo A, Shufesky WJ, Stolz DB, Sullivan MG, Wang Z, Divito SJ, Papworth GD, Watkins SC, Robbins PD, Larregina AT, Morelli AE. Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition. J Immunol. 2008 Mar 01; 180(5):3081-90. PMID: 18292531.
    Citations: 62     Fields:    Translation:AnimalsCells
  34. Knickelbein JE, Divito S, Hendricks RL. Modulation of CD8+ CTL effector function by fibroblasts derived from the immunoprivileged cornea. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2194-202. PMID: 17460279.
    Citations: 1     Fields:    Translation:AnimalsCells
  35. Divito S, Cherpes TL, Hendricks RL. A triple entente: virus, neurons, and CD8+ T cells maintain HSV-1 latency. Immunol Res. 2006; 36(1-3):119-26. PMID: 17337772.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  36. Lazarevic V, Yankura DJ, DiVito SJ, Flynn JL. Induction of Mycobacterium tuberculosis-specific primary and secondary T-cell responses in interleukin-15-deficient mice. Infect Immun. 2005 May; 73(5):2910-22. PMID: 15845497.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.