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Sherrie Jill Divito, M.D.,Ph.D.

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Overview
Interest(s): (1) Effects of chemotherapy, stem cell transplant conditioning and targeted anti-cancer agents on skin (2) Graft-versus-host-disease (3) Severe Drug reactions (4) Drug and device discovery, pre-clinical modeling, clinical trials

I am trained as a basic and translational immunologist, and am particularly interested in translating problems we see in the clinic to solutions with therapeutics or diagnostics via our research in the lab.

Mentoring
Investigating Cutaneous Memory T cells in Patients with Delayed-Type Drug Hypersensitivity Reactions
Full Time/Year Long, 06/05/17 - 04/27/18

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. DP5OD023091 (DIVITO, SHERRIE JILL) Sep 19, 2016 - Aug 31, 2021
    NIH
    Investigating a novel cell population in delayed-onset drug hypersensitivity reactions
    Role: Principal Investigator
  2. Physician-Scientist Career Development Award (Sherrie J. Divito) Jul 1, 2016 - Sep 19, 2016
    Dermatology Foundation
    Investigating Skin T Cells in Graft-versus-Host Disease
    Role: PI
  3. (Sherrie J. Divito) May 1, 2015 - Oct 30, 2016
    National Foundation for Ectodermal Dysplasias
    Targeted Therapeutic Development for Focal Dermal Hypoplasia
    Role: PI
  4. F30DK082131 (DIVITO, SHERRIE JILL) Jul 1, 2008 - Jun 30, 2012
    NIH/NIDDK
    The role of tolerogenic dendritic cells in islet-cell allograft transplantation
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Divito SJ. Screening HLA to Prevent Severe Drug Reactions-A Devil's Advocate Perspective. JAMA Dermatol. 2019 Mar 27. PMID: 30916720.
    Citations:    
  2. Divito SJ, Morelli AE. Method of Generating Tolerogenic Maturation-Resistant Dendritic Cells and Testing for Their Immune-Regulatory Functions In Vivo in the Context of Transplantation. Methods Mol Biol. 2019; 1899:181-193. PMID: 30649773.
    Citations:    Fields:    
  3. de Masson A, O'Malley JT, Elco CP, Garcia SS, Divito SJ, Lowry EL, Tawa M, Fisher DC, Devlin PM, Teague JE, Leboeuf NR, Kirsch IR, Robins H, Clark RA, Kupper TS. High-throughput sequencing of the T cell receptor ß gene identifies aggressive early-stage mycosis fungoides. Sci Transl Med. 2018 May 09; 10(440). PMID: 29743350.
    Citations:    Fields:    
  4. Stern RS, Divito SJ. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Associations, Outcomes, and Pathobiology-Thirty Years of Progress but Still Much to Be Done. J Invest Dermatol. 2017 05; 137(5):1004-1008. PMID: 28411832.
    Citations: 1     Fields:    Translation:Humans
  5. Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017 03 09; 543(7644):252-256. PMID: 28219080.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  6. Gunasekera NS, Divito JK, Kupper TS, Huang JT, Divito SJ. Cross-Sectional Study Evaluating Skin, Hair, Nail, and Bone Disease in Patients with Focal Dermal Hypoplasia. Pediatr Dermatol. 2017 Mar; 34(2):197-198. PMID: 28025844.
    Citations:    Fields:    Translation:Humans
  7. Zhuang Q, Liu Q, Divito SJ, Zeng Q, Yatim KM, Hughes AD, Rojas-Canales DM, Nakao A, Shufesky WJ, Williams AL, Humar R, Hoffman RA, Shlomchik WD, Oberbarnscheidt MH, Lakkis FG, Morelli AE. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat Commun. 2016 08 24; 7:12623. PMID: 27554168.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Liu Q, Rojas-Canales DM, Divito SJ, Shufesky WJ, Stolz DB, Erdos G, Sullivan ML, Gibson GA, Watkins SC, Larregina AT, Morelli AE. Donor dendritic cell-derived exosomes promote allograft-targeting immune response. J Clin Invest. 2016 08 01; 126(8):2805-20. PMID: 27348586.
    Citations: 31     Fields:    Translation:AnimalsCells
  9. Romar GA, Kupper TS, Divito SJ. Research Techniques Made Simple: Techniques to Assess Cell Proliferation. J Invest Dermatol. 2016 Jan; 136(1):e1-e7. PMID: 26763463.
    Citations: 2     Fields:    Translation:Humans
  10. Griffin RL, Kupper TS, Divito SJ. Humanized Mice in Dermatology Research. J Invest Dermatol. 2015 Dec; 135(12):e39-e43. PMID: 26569593.
    Citations:    Fields:    Translation:HumansAnimals
  11. Sheu JS, Divito SJ, Enamandram M, Merola JF. Dapsone Therapy for Pustular Psoriasis: Case Series and Review of the Literature. Dermatology. 2016; 232(1):97-101. PMID: 26465742.
    Citations:    Fields:    Translation:Humans
  12. Sheu J, Divito SJ, Hoffman EP, Frank NY, Merola JF. Mosaic focal dermal hypoplasia caused by a novel somatic mutation in PORCN detected in affected skin. Br J Dermatol. 2015 Aug; 173(2):568-70. PMID: 25640089.
    Citations: 2     Fields:    Translation:Humans
  13. Larregina AT, Divito SJ, Morelli AE. Clinical implications of basic science discoveries: nociceptive neurons as targets to control immunity--potential relevance for transplantation. Am J Transplant. 2015 Jun; 15(6):1472-4. PMID: 25846743.
    Citations:    Fields:    Translation:HumansAnimalsCells
  14. Song PI, Divito SJ, Kroshinsky D. Pemphigus vulgaris presenting with multiple lesion morphologies. Dermatol Online J. 2014 Dec 14; 21(3). PMID: 25780973.
    Citations:    Fields:    Translation:Humans
  15. Divito SJ, Kupper TS. Inhibiting Janus kinases to treat alopecia areata. Nat Med. 2014 Sep; 20(9):989-90. PMID: 25198048.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  16. Wall JB, Divito SJ, Talbot SG. Chlorhexidine gluconate-impregnated central-line dressings and necrosis in complicated skin disorder patients. J Crit Care. 2014 Dec; 29(6):1130.e1-4. PMID: 25035049.
    Citations: 2     Fields:    Translation:Humans
  17. Wang Z, Divito SJ, Shufesky WJ, Sumpter T, Wang H, Tkacheva OA, Wang W, Liu C, Larregina AT, Morelli AE. Dendritic cell therapies in transplantation revisited: deletion of recipient DCs deters the effect of therapeutic DCs. Am J Transplant. 2012 Jun; 12(6):1398-408. PMID: 22500950.
    Citations: 15     Fields:    Translation:AnimalsCells
  18. Morelli, A.E. and Divito, S.J. Cell-based therapies in the prevention of solid organ transplant rejection. Am J Immunol. 2012; 8(2):52-64.
  19. Potter DM, Butterfield LH, Divito SJ, Sander CA, Kirkwood JM. Pitfalls in retrospective analyses of biomarkers: a case study with metastatic melanoma patients. J Immunol Methods. 2012 Feb 28; 376(1-2):108-12. PMID: 22210094.
    Citations: 5     Fields:    Translation:Humans
  20. Montecalvo A, Larregina AT, Shufesky WJ, Stolz DB, Sullivan ML, Karlsson JM, Baty CJ, Gibson GA, Erdos G, Wang Z, Milosevic J, Tkacheva OA, Divito SJ, Jordan R, Lyons-Weiler J, Watkins SC, Morelli AE. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 2012 Jan 19; 119(3):756-66. PMID: 22031862.
    Citations: 308     Fields:    Translation:AnimalsCells
  21. Divito SJ, Morelli AE, Larregina AT. Role of neurokinin-1 receptor in the initiation and maintenance of skin chronic inflammatory diseases. Immunol Res. 2011 Aug; 50(2-3):195-201. PMID: 21717076.
    Citations:    Fields:    Translation:HumansAnimalsCells
  22. Divito SJ, Ferris LK. Advances and short comings in the early diagnosis of melanoma. Melanoma Res. 2010 Dec; 20(6):450-8. PMID: 20856147.
    Citations: 2     Fields:    Translation:HumansAnimals
  23. Divito SJ, Wang Z, Shufesky WJ, Liu Q, Tkacheva OA, Montecalvo A, Erdos G, Larregina AT, Morelli AE. Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood. 2010 Oct 14; 116(15):2694-705. PMID: 20576812.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  24. Frank GM, Divito SJ, Maker DM, Xu M, Hendricks RL. A novel p40-independent function of IL-12p35 is required for progression and maintenance of herpes stromal keratitis. Invest Ophthalmol Vis Sci. 2010 Jul; 51(7):3591-8. PMID: 20207959.
    Citations: 9     Fields:    Translation:AnimalsCells
  25. Divito SJ, Haught JM, English JC, Ferris LK. An extensive case of dermonecrotic arachnidism. J Clin Aesthet Dermatol. 2009 Sep; 2(9):40-3. PMID: 20729958.
    Citations: 1     
  26. Wang Z, Shufesky WJ, Montecalvo A, Divito SJ, Larregina AT, Morelli AE. In situ-targeting of dendritic cells with donor-derived apoptotic cells restrains indirect allorecognition and ameliorates allograft vasculopathy. PLoS One. 2009; 4(3):e4940. PMID: 19333400.
    Citations: 17     Fields:    Translation:AnimalsCells
  27. Perone MJ, Bertera S, Shufesky WJ, Divito SJ, Montecalvo A, Mathers AR, Larregina AT, Pang M, Seth N, Wucherpfennig KW, Trucco M, Baum LG, Morelli AE. Suppression of autoimmune diabetes by soluble galectin-1. J Immunol. 2009 Mar 01; 182(5):2641-53. PMID: 19234158.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  28. Divito, S.J. and Morelli, A.E. Phagocytosis of dying cells: from molecular mechanisms to human diseases. Apoptotic cells in the treatment of transplant rejection. 2009; 319-346.
  29. Divito SJ, Hendricks RL. Activated inflammatory infiltrate in HSV-1-infected corneas without herpes stromal keratitis. Invest Ophthalmol Vis Sci. 2008 Apr; 49(4):1488-95. PMID: 18385067.
    Citations: 29     Fields:    Translation:AnimalsCells
  30. Montecalvo A, Shufesky WJ, Stolz DB, Sullivan MG, Wang Z, Divito SJ, Papworth GD, Watkins SC, Robbins PD, Larregina AT, Morelli AE. Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition. J Immunol. 2008 Mar 01; 180(5):3081-90. PMID: 18292531.
    Citations: 62     Fields:    Translation:AnimalsCells
  31. Knickelbein JE, Divito S, Hendricks RL. Modulation of CD8+ CTL effector function by fibroblasts derived from the immunoprivileged cornea. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2194-202. PMID: 17460279.
    Citations: 1     Fields:    Translation:AnimalsCells
  32. Divito S, Cherpes TL, Hendricks RL. A triple entente: virus, neurons, and CD8+ T cells maintain HSV-1 latency. Immunol Res. 2006; 36(1-3):119-26. PMID: 17337772.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  33. Lazarevic V, Yankura DJ, DiVito SJ, Flynn JL. Induction of Mycobacterium tuberculosis-specific primary and secondary T-cell responses in interleukin-15-deficient mice. Infect Immun. 2005 May; 73(5):2910-22. PMID: 15845497.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.