"alpha-Methyltyrosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)
MeSH Number(s)
D12.125.072.050.875.485.050
Concept/Terms
alpha-Methyltyrosine- alpha-Methyltyrosine
- alpha Methyltyrosine
- alpha-Methyl-para-tyrosine
- alpha Methyl para tyrosine
- alpha-MPT
- alpha MPT
- alpha-Methyl-p-tyrosine
- alpha Methyl p tyrosine
Demser- Demser
- Merck Brand of Metyrosine
- Metyrosine Merck Brand
- Merck Sharp & Dohme Brand of Metyrosine
Racemetirosine- Racemetirosine
- alpha-Methyltyrosine, (D,L)-Isomer
- alpha-Methyltyrosine, (+,-)-Isomer
- DL-Tyrosine, alpha-methyl-
- alpha-methyl- DL-Tyrosine
Metyrosine- Metyrosine
- alpha-Methyltyrosine, (L)-Isomer
- Metirosine
Below are MeSH descriptors whose meaning is more general than "alpha-Methyltyrosine".
Below are MeSH descriptors whose meaning is more specific than "alpha-Methyltyrosine".
This graph shows the total number of publications written about "alpha-Methyltyrosine" by people in Harvard Catalyst Profiles by year, and whether "alpha-Methyltyrosine" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "alpha-Methyltyrosine" by people in Profiles.
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Alpha-methyltyrosine reduces the acute cardiovascular and behavioral sequelae in a murine model of traumatic brain injury. J Trauma Acute Care Surg. 2023 10 01; 95(4):542-548.
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Dopamine-related deficit in reward learning after catecholamine depletion in unmedicated, remitted subjects with bulimia nervosa. Neuropsychopharmacology. 2012 Jul; 37(8):1945-52.
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Increased synaptic dopamine function in associative regions of the striatum in schizophrenia. Arch Gen Psychiatry. 2010 Mar; 67(3):231-9.
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Role of neuronal nitric oxide in the regulation of vasopressin expression and release in response to inhibition of catecholamine synthesis and dehydration. Neurosci Lett. 2007 Oct 22; 426(3):160-5.
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Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: cyp2d6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling. Med Sci Monit. 2005 Nov; 11(11):BR397-404.
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Monoamine depletion in unmedicated depressed subjects. Biol Psychiatry. 2002 Mar 15; 51(6):469-73.
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Prenatal cocaine exposure increases serotonergic inhibition of electrically evoked acetylcholine release from rat striatal slices at adulthood. Synapse. 2000 Apr; 36(1):1-11.
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Effects of catecholamine depletion with AMPT (alpha-methyl-para-tyrosine) in obsessive-compulsive disorder. Biol Psychiatry. 1999 Aug 15; 46(4):573-6.
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The characterization of the effect of locally applied N-methylquipazine, a 5-HT3 receptor agonist, on extracellular dopamine levels in the anterior medial prefrontal cortex in the rat: an in vivo microdialysis study. Synapse. 1996 Dec; 24(4):313-21.
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Effects of catecholamine depletion on alertness and mood in rested and sleep deprived normal volunteers. Neuropsychopharmacology. 1993 Jun; 8(4):345-56.