"Zinostatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic.
MeSH Number(s)
D02.455.326.271.244.500
D02.455.326.397.662.500.500.500
Below are MeSH descriptors whose meaning is more general than "Zinostatin".
Below are MeSH descriptors whose meaning is more specific than "Zinostatin".
This graph shows the total number of publications written about "Zinostatin" by people in Harvard Catalyst Profiles by year, and whether "Zinostatin" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2017 | 0 | 1 | 1 |
2018 | 0 | 2 | 2 |
Below are the most recent publications written about "Zinostatin" by people in Profiles.
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TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining. Nucleic Acids Res. 2018 09 28; 46(17):8926-8939.
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Persistent 3'-phosphate termini and increased cytotoxicity of radiomimetic DNA double-strand breaks in cells lacking polynucleotide kinase/phosphatase despite presence of an alternative 3'-phosphatase. DNA Repair (Amst). 2018 08; 68:12-24.
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p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM. Sci Signal. 2017 Apr 25; 10(476).
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Designed DNA probes from the neocarzinostatin family: impact of glycosyl linkage stereochemistry on bulge base binding. Bioorg Med Chem. 2009 Mar 15; 17(6):2428-32.
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Congeners of the enediyne neocarzinostatin chromophore: designed agents for bulged nucleic acid targets. Curr Top Med Chem. 2008; 8(6):436-47.
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Solution structure of a designed spirocyclic helical ligand binding at a two-base bulge site in DNA. Biochemistry. 2007 Apr 24; 46(16):4793-803.
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Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2. Nat Cell Biol. 2007 Mar; 9(3):331-8.
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Stereochemical control of small molecule binding to bulged DNA: comparison of structures of spirocyclic enantiomer-bulged DNA complexes. Biochemistry. 2004 Jan 27; 43(3):641-50.
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New complex of post-activated neocarzinostatin chromophore with DNA: bulge DNA binding from the minor groove. Biochemistry. 2003 Feb 11; 42(5):1186-98.
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Targeting DNA bulged microenvironments with synthetic agents: lessons from a natural product. Chem Biol. 2002 Aug; 9(8):925-31.