Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Zinc Fingers

"Zinc Fingers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.


This graph shows the total number of publications written about "Zinc Fingers" by people in Harvard Catalyst Profiles by year, and whether "Zinc Fingers" was a major or minor topic of these publication.
Bar chart showing 480 publications over 30 distinct years, with a maximum of 29 publications in 1991
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.