"Withanolides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ergostane derivatives of 28 carbons with oxygens at C1, C22, and C26 positions and the side chain cyclized. They are found in WITHANIA plant genus and have cytotoxic and other effects.
MeSH Number(s)
D04.808.247.222.537.888
D04.808.247.808.756.287.888
Below are MeSH descriptors whose meaning is more general than "Withanolides".
Below are MeSH descriptors whose meaning is more specific than "Withanolides".
This graph shows the total number of publications written about "Withanolides" by people in Harvard Catalyst Profiles by year, and whether "Withanolides" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
Below are the most recent publications written about "Withanolides" by people in Profiles.
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Targeting TDP-43 Pathology Alleviates Cognitive and Motor Deficits Caused by Chronic Cerebral Hypoperfusion. Neurotherapeutics. 2021 04; 18(2):1095-1112.
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Withaferin-A Treatment Alleviates TAR DNA-Binding Protein-43 Pathology and Improves Cognitive Function in a Mouse Model of FTLD. Neurotherapeutics. 2021 01; 18(1):286-296.
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Withaferin A Improves Nonalcoholic Steatohepatitis in Mice. J Pharmacol Exp Ther. 2019 11; 371(2):360-374.
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Mimetic sHDL nanoparticles: A novel drug-delivery strategy to target triple-negative breast cancer. Surgery. 2019 12; 166(6):1168-1175.
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Isolation, characterization and DFT studies of epoxy ring containing new withanolides from Withania coagulans Dunal. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jun 15; 217:113-121.
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Regiospecific Synthesis of Ring A Fused Withaferin A Isoxazoline Analogues: Induction of Premature Senescence by W-2b in Proliferating Cancer Cells. Sci Rep. 2017 10 23; 7(1):13749.
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Synthetic high-density lipoprotein nanodisks for targeted withalongolide delivery to adrenocortical carcinoma. Int J Nanomedicine. 2017; 12:6581-6594.
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A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells. Int J Mol Sci. 2017 May 19; 18(5).
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Pharmacologic inhibition of reactive gliosis blocks TNF-a-mediated neuronal apoptosis. Cell Death Dis. 2016 09 29; 7(9):e2386.
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Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice. Nat Med. 2016 09; 22(9):1023-32.