Harvard Catalyst Profiles

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Unfolded Protein Response

"Unfolded Protein Response" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.


This graph shows the total number of publications written about "Unfolded Protein Response" by people in Harvard Catalyst Profiles by year, and whether "Unfolded Protein Response" was a major or minor topic of these publication.
Bar chart showing 198 publications over 11 distinct years, with a maximum of 26 publications in 2017
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.