Harvard Catalyst Profiles

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Two-Hybrid System Techniques

"Two-Hybrid System Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.

This graph shows the total number of publications written about "Two-Hybrid System Techniques" by people in Harvard Catalyst Profiles by year, and whether "Two-Hybrid System Techniques" was a major or minor topic of these publication.
Bar chart showing 337 publications over 25 distinct years, with a maximum of 38 publications in 2004
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.