Tristetraprolin

"Tristetraprolin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A ZINC FINGER MOTIF containing transcription factor that was originally identified as one of the IMMEDIATE-EARLY PROTEINS. It shuttles between the CYTOPLASM and the CELL NUCLEUS and is involved in destabilization of mRNAs for TUMOR NECROSIS FACTOR-ALPHA.

Descriptor ID

D051816

MeSH Number(s)

D12.776.260.790

D12.776.460.762

D12.776.930.960

Concept/Terms

Tristetraprolin

Below are MeSH descriptors whose meaning is more general than "Tristetraprolin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Tristetraprolin [D12.776.260.790]
Immediate-Early Proteins [D12.776.460]
Tristetraprolin [D12.776.460.762]
Transcription Factors [D12.776.930]
Tristetraprolin [D12.776.930.960]

Below are MeSH descriptors whose meaning is related to "Tristetraprolin".

Below are MeSH descriptors whose meaning is more specific than "Tristetraprolin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tristetraprolin" by people in Harvard Catalyst Profiles by year, and whether "Tristetraprolin" was a major or minor topic of these publication.

Bar chart showing 22 publications over 13 distinct years, with a maximum of 4 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	0	1	1
2002	0	2	2
2004	0	4	4
2005	0	1	1
2006	2	0	2
2008	1	0	1
2014	1	2	3
2015	1	0	1
2016	0	1	1
2018	2	0	2
2019	0	1	1
2020	2	0	2

Below are the most recent publications written about "Tristetraprolin" by people in Profiles.

Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages. J Biol Chem. 2020 04 03; 295(14):4661-4672.

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A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells. Genome Biol. 2020 02 10; 21(1):33.

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Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies. Nat Commun. 2019 11 14; 10(1):5157.

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Low Tristetraprolin Expression Is Associated with Lethal Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2019 03; 28(3):584-590.

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Tristetraprolin Is a Prognostic Biomarker for Poor Outcomes among Patients with Low-Grade Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2018 11; 27(11):1376-1383.

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The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator of calcineurin tumor suppressing function in the skin. PLoS Genet. 2018 05; 14(5):e1007366.

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Computational Reconstruction of NF?B Pathway Interaction Mechanisms during Prostate Cancer. PLoS Comput Biol. 2016 Apr; 12(4):e1004820.

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Post-transcriptional regulation of transcript abundance by a conserved member of the tristetraprolin family in Candida albicans. Mol Microbiol. 2015 Mar; 95(6):1036-53.

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ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages. Cell Rep. 2014 Dec 24; 9(6):2330-43.

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High-resolution sequencing and modeling identifies distinct dynamic RNA regulatory strategies. Cell. 2014 Dec 18; 159(7):1698-710.

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