Trinucleotide Repeat Expansion

"Trinucleotide Repeat Expansion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.

Descriptor ID

D019680

MeSH Number(s)

G02.111.570.080.708.800.140.865

G02.111.570.080.708.800.500.850.200

G05.355.600.220.865

G05.360.080.708.800.074.865

G05.360.080.708.800.500.850.200

G05.360.340.024.189.220.865

G05.360.340.024.850.500.850.200

G05.365.590.220.865

Concept/Terms

Trinucleotide Repeat Expansion

Below are MeSH descriptors whose meaning is more general than "Trinucleotide Repeat Expansion".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Base Sequence [G02.111.570.080]
Repetitive Sequences, Nucleic Acid [G02.111.570.080.708]
Tandem Repeat Sequences [G02.111.570.080.708.800]
DNA Repeat Expansion [G02.111.570.080.708.800.140]
Trinucleotide Repeat Expansion [G02.111.570.080.708.800.140.865]
Microsatellite Repeats [G02.111.570.080.708.800.500]
Trinucleotide Repeats [G02.111.570.080.708.800.500.850]
Trinucleotide Repeat Expansion [G02.111.570.080.708.800.500.850.200]
Genetic Phenomena [G05]
Genetic Processes [G05.355]
Mutagenesis [G05.355.600]
DNA Repeat Expansion [G05.355.600.220]
Trinucleotide Repeat Expansion [G05.355.600.220.865]
Genetic Structures [G05.360]
Base Sequence [G05.360.080]
Repetitive Sequences, Nucleic Acid [G05.360.080.708]
Tandem Repeat Sequences [G05.360.080.708.800]
DNA Repeat Expansion [G05.360.080.708.800.074]
Trinucleotide Repeat Expansion [G05.360.080.708.800.074.865]
Microsatellite Repeats [G05.360.080.708.800.500]
Trinucleotide Repeats [G05.360.080.708.800.500.850]
Trinucleotide Repeat Expansion [G05.360.080.708.800.500.850.200]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
DNA Sequence, Unstable [G05.360.340.024.189]
DNA Repeat Expansion [G05.360.340.024.189.220]
Trinucleotide Repeat Expansion [G05.360.340.024.189.220.865]
Tandem Repeat Sequences [G05.360.340.024.850]
Microsatellite Repeats [G05.360.340.024.850.500]
Trinucleotide Repeats [G05.360.340.024.850.500.850]
Trinucleotide Repeat Expansion [G05.360.340.024.850.500.850.200]
Genetic Variation [G05.365]
Mutation [G05.365.590]
DNA Repeat Expansion [G05.365.590.220]
Trinucleotide Repeat Expansion [G05.365.590.220.865]

Below are MeSH descriptors whose meaning is related to "Trinucleotide Repeat Expansion".

Below are MeSH descriptors whose meaning is more specific than "Trinucleotide Repeat Expansion".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Trinucleotide Repeat Expansion" by people in Harvard Catalyst Profiles by year, and whether "Trinucleotide Repeat Expansion" was a major or minor topic of these publication.

Bar chart showing 140 publications over 27 distinct years, with a maximum of 14 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	2	2
1999	1	2	3
2000	2	0	2
2001	2	1	3
2002	1	4	5
2003	5	2	7
2004	4	1	5
2005	2	2	4
2006	2	3	5
2007	2	1	3
2008	2	1	3
2009	5	4	9
2010	2	4	6
2011	2	2	4
2012	8	6	14
2013	3	3	6
2014	2	1	3
2015	6	3	9
2016	4	0	4
2017	3	5	8
2018	1	5	6
2019	3	4	7
2020	1	5	6
2021	7	0	7
2022	1	2	3
2023	2	3	5
2024	0	1	1

Below are the most recent publications written about "Trinucleotide Repeat Expansion" by people in Profiles.

Somatic CAG Repeat Stability in a Transgenic Sheep Model of Huntington's Disease. J Huntingtons Dis. 2024; 13(1):33-40.

View in: PubMed
CAG repeat expansion in the Huntington's disease gene shapes linear and circular RNAs biogenesis. PLoS Genet. 2023 Oct; 19(10):e1010988.

View in: PubMed
Glial dysregulation in the human brain in fragile X-associated tremor/ataxia syndrome. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2300052120.

View in: PubMed
Site-specific R-loops induce CGG repeat contraction and fragile X gene reactivation. Cell. 2023 06 08; 186(12):2593-2609.e18.

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Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease. Mol Ther. 2023 06 07; 31(6):1661-1674.

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Normal range CAG repeat size variations in the HTT gene are associated with an adverse lipoprotein profile partially mediated by body mass index. Hum Mol Genet. 2023 05 05; 32(10):1741-1752.

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Inherited HTT CAG repeat length does not have a major impact on Huntington disease duration. Am J Hum Genet. 2022 07 07; 109(7):1338-1340.

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Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset. Nat Neurosci. 2022 04; 25(4):446-457.

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Genetic modifiers of Huntington disease differentially influence motor and cognitive domains. Am J Hum Genet. 2022 05 05; 109(5):885-899.

View in: PubMed
Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection. Nucleic Acids Res. 2021 04 19; 49(7):3907-3918.

View in: PubMed

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