"Tranylcypromine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)
Concept/Terms
Tranylcypromine- Tranylcypromine
- trans-2-Phenylcyclopropylamine
- trans 2 Phenylcyclopropylamine
Jatrosom- Jatrosom
- esparma Brand of Tranylcypromine Sulfate
Parnate- Parnate
- SmithKline Brand of Tranylcypromine Sulfate
- GlaxoSmithKline Brand of Tranylcypromine Sulfate
- Goldshield Brand of Tranylcypromine Sulfate
- Link Brand of Tranylcypromine Sulfate
- Allphar Brand of Tranylcypromine Sulfate
Below are MeSH descriptors whose meaning is more general than "Tranylcypromine".
Below are MeSH descriptors whose meaning is more specific than "Tranylcypromine".
This graph shows the total number of publications written about "Tranylcypromine" by people in Harvard Catalyst Profiles by year, and whether "Tranylcypromine" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
Below are the most recent publications written about "Tranylcypromine" by people in Profiles.
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Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nat Commun. 2018 01 04; 9(1):53.
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Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes. Sci Transl Med. 2014 Dec 03; 6(265):265ra169.
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Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med. 2012 Mar 11; 18(4):605-11.
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Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action. J Med Chem. 2009 Apr 09; 52(7):1885-902.
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Juvenile rats in the forced-swim test model the human response to antidepressant treatment for pediatric depression. Psychopharmacology (Berl). 2008 Apr; 197(3):433-41.
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Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry. 2007 Jul 10; 46(27):8058-65.
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STAR*D level IV methodology. Am J Psychiatry. 2007 Apr; 164(4):681; author reply 681.
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Tranylcypromine versus venlafaxine plus mirtazapine following three failed antidepressant medication trials for depression: a STAR*D report. Am J Psychiatry. 2006 Sep; 163(9):1531-41; quiz 1666.
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Effects of stress and tranylcypromine on amphetamine-induced locomotor activity and GABA(B) receptor function in rat brain. Life Sci. 2003 Jan 17; 72(9):1085-92.
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Integrating pharmacotherapy and psychotherapy in the treatment of a bipolar patient. Am J Psychiatry. 1998 May; 155(5):686-8.