Transcription Factors, TFII
"Transcription Factors, TFII" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.
MeSH Number(s)
D12.776.260.775.875
D12.776.930.930.875
Below are MeSH descriptors whose meaning is more general than "Transcription Factors, TFII".
Below are MeSH descriptors whose meaning is more specific than "Transcription Factors, TFII".
This graph shows the total number of publications written about "Transcription Factors, TFII" by people in Harvard Catalyst Profiles by year, and whether "Transcription Factors, TFII" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 0 | 1 |
| 1995 | 5 | 0 | 5 |
| 1996 | 1 | 1 | 2 |
| 1997 | 5 | 1 | 6 |
| 1998 | 5 | 2 | 7 |
| 1999 | 3 | 2 | 5 |
| 2000 | 5 | 1 | 6 |
| 2001 | 4 | 1 | 5 |
| 2002 | 3 | 3 | 6 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 0 | 2 | 2 |
| 2018 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
Below are the most recent publications written about "Transcription Factors, TFII" by people in Profiles.
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Single-molecule studies reveal branched pathways for activator-dependent assembly of RNA polymerase II pre-initiation complexes. Mol Cell. 2021 09 02; 81(17):3576-3588.e6.
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Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA binding and long-term behavioral consequences. Hum Mol Genet. 2020 06 03; 29(9):1498-1519.
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Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug. Nat Neurosci. 2019 05; 22(5):700-708.
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The neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex. Nucleic Acids Res. 2018 12 14; 46(22):11939-11951.
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The Integrated Genomic Landscape of Thymic Epithelial Tumors. Cancer Cell. 2018 02 12; 33(2):244-258.e10.
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Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers. Eur J Hum Genet. 2017 04; 25(4):432-438.
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Uniform transitions of the general RNA polymerase II transcription complex. Nat Struct Mol Biol. 2010 Oct; 17(10):1272-8.
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Williams-Beuren syndrome-associated transcription factor TFII-I regulates osteogenic marker genes. J Biol Chem. 2009 Dec 25; 284(52):36234-36239.
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Structure of the 12-subunit RNA polymerase II refined with the aid of anomalous diffraction data. J Biol Chem. 2009 May 08; 284(19):12933-9.
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A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature. 2009 Feb 26; 457(7233):1103-8.