Transcription Factor AP-2

"Transcription Factor AP-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.

Descriptor ID

D050656

MeSH Number(s)

D12.776.260.760

D12.776.930.907

Concept/Terms

Transcription Factor AP-2

Transcription Factor AP-2 gamma Protein

Transcription Factor AP-2 delta Protein

Transcription Factor AP-2 epsilon Protein

Transcription Factor AP-2 alpha Protein

Transcription Factor AP-2 beta Protein

Below are MeSH descriptors whose meaning is more general than "Transcription Factor AP-2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Transcription Factor AP-2 [D12.776.260.760]
Transcription Factors [D12.776.930]
Transcription Factor AP-2 [D12.776.930.907]

Below are MeSH descriptors whose meaning is related to "Transcription Factor AP-2".

Below are MeSH descriptors whose meaning is more specific than "Transcription Factor AP-2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transcription Factor AP-2" by people in Harvard Catalyst Profiles by year, and whether "Transcription Factor AP-2" was a major or minor topic of these publication.

Below are the most recent publications written about "Transcription Factor AP-2" by people in Profiles.

AP-2a/AP-2ß Transcription Factors Are Key Regulators of Epidermal Homeostasis. J Invest Dermatol. 2024 Jul; 144(7):1505-1521.e12.

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Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner. Proc Natl Acad Sci U S A. 2022 07 19; 119(29):e2205498119.

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Transcription factors AP-2a and AP-2ß regulate distinct segments of the distal nephron in the mammalian kidney. Nat Commun. 2022 04 25; 13(1):2226.

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Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney. Nat Commun. 2021 04 13; 12(1):2190.

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Heterodimerization of TFAP2 pioneer factors drives epigenomic remodeling during neural crest specification. Genome Res. 2020 01; 30(1):35-48.

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TFAP2A mutation in a child and mother with predominantly ocular anomalies: non-classical presentation of branchio-oculo-facial syndrome. Clin Dysmorphol. 2019 Oct; 28(4):215-218.

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Tfap2a is a novel gatekeeper of nephron differentiation during kidney development. Development. 2019 07 10; 146(13).

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The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation. Hum Mol Genet. 2019 05 15; 28(10):1726-1737.

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A novel missense mutation in TFAP2B associated with Char syndrome and central diabetes insipidus. Am J Med Genet A. 2019 07; 179(7):1299-1303.

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Char Syndrome a novel mutation and new insights: A clinical report. Eur J Med Genet. 2019 Dec; 62(12):103607.

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