 Telomerase
"Telomerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.
| Descriptor ID |
D019098
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| MeSH Number(s) |
D08.811.913.696.445.308.300.750.750 D12.776.157.725.500.921 D12.776.664.962.500.921
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| Concept/Terms |
Telomerase- Telomerase
- Telomerase Reverse Transcriptase
- Reverse Transcriptase, Telomerase
- Transcriptase, Telomerase Reverse
Telomerase Catalytic Subunit- Telomerase Catalytic Subunit
- Catalytic Subunit, Telomerase
- Subunit, Telomerase Catalytic
- Telomerase Reverse Transcriptase Catalytic Subunit
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Below are MeSH descriptors whose meaning is more general than "Telomerase".
Below are MeSH descriptors whose meaning is more specific than "Telomerase".
This graph shows the total number of publications written about "Telomerase" by people in Harvard Catalyst Profiles by year, and whether "Telomerase" was a major or minor topic of these publication.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1997 | 3 | 2 | 5 | | 1998 | 7 | 0 | 7 | | 1999 | 3 | 1 | 4 | | 2000 | 6 | 1 | 7 | | 2001 | 14 | 7 | 21 | | 2002 | 11 | 9 | 20 | | 2003 | 18 | 9 | 27 | | 2004 | 15 | 13 | 28 | | 2005 | 9 | 3 | 12 | | 2006 | 7 | 3 | 10 | | 2007 | 3 | 3 | 6 | | 2008 | 18 | 8 | 26 | | 2009 | 10 | 7 | 17 | | 2010 | 16 | 6 | 22 | | 2011 | 13 | 11 | 24 | | 2012 | 15 | 8 | 23 | | 2013 | 18 | 8 | 26 | | 2014 | 14 | 11 | 25 | | 2015 | 14 | 8 | 22 | | 2016 | 15 | 8 | 23 | | 2017 | 5 | 6 | 11 |
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Below are the most recent publications written about "Telomerase" by people in Profiles.
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Lee HT, Bose A, Lee CY, Opresko PL, Myong S. Molecular mechanisms by which oxidative DNA damage promotes telomerase activity. Nucleic Acids Res. 2017 Nov 16; 45(20):11752-11765.
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Rajagopalan D, Pandey AK, Xiuzhen MC, Lee KK, Hora S, Zhang Y, Chua BH, Kwok HS, Bhatia SS, Deng LW, Tenen DG, Kappei D, Jha S. TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter. PLoS Pathog. 2017 Oct; 13(10):e1006681.
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D Antonio M, Weghorn D, D Antonio-Chronowska A, Coulet F, Olson KM, DeBoever C, Drees F, Arias A, Alakus H, Richardson AL, Schwab RB, Farley EK, Sunyaev SR, Frazer KA. Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer. Nat Commun. 2017 09 05; 8(1):436.
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Gansner JM, Achebe MM, Gray KJ, Yefidoff-Freedman R, Labovitis E, Parnes A, Connors JM, Connell NT, Discenza MN, Handin RI, Berliner N, Shimamura A, Ginsburg ES, Smith NA. Pregnancy outcomes in inherited bone marrow failure syndromes. Blood. 2017 10 05; 130(14):1671-1674.
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Chu HP, Cifuentes-Rojas C, Kesner B, Aeby E, Lee HG, Wei C, Oh HJ, Boukhali M, Haas W, Lee JT. TERRA RNA Antagonizes ATRX and Protects Telomeres. Cell. 2017 Jun 29; 170(1):86-101.e16.
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Reddy BY, Miller DM, Tsao H. Somatic driver mutations in melanoma. Cancer. 2017 Jun 01; 123(S11):2104-2117.
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Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T, Pizer B, Michalski A, Joshi A, Wharton SB, Jacques TS, Bailey S, Williamson D, Clifford SC. Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study. Lancet Oncol. 2017 Jul; 18(7):958-971.
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Wu RA, Tam J, Collins K. DNA-binding determinants and cellular thresholds for human telomerase repeat addition processivity. EMBO J. 2017 07 03; 36(13):1908-1927.
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Wu RA, Upton HE, Vogan JM, Collins K. Telomerase Mechanism of Telomere Synthesis. Annu Rev Biochem. 2017 Jun 20; 86:439-460.
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Chiba K, Vogan JM, Wu RA, Gill MS, Zhang X, Collins K, Hockemeyer D. Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo. Mol Cell Biol. 2017 Feb 01; 37(3).
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