Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Sterol 14-Demethylase

"Sterol 14-Demethylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.


This graph shows the total number of publications written about "Sterol 14-Demethylase" by people in Harvard Catalyst Profiles by year, and whether "Sterol 14-Demethylase" was a major or minor topic of these publication.
Bar chart showing 3 publications over 3 distinct years, with a maximum of 1 publications in 2012 and 2015 and 2016
To see the data from this visualization as text, click here.
Related Networks
People
Explore
_
Similar Concepts
_
Top Journals 
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.