"Spasms, Infantile" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)
Concept/Terms
Spasms, Infantile- Spasms, Infantile
- Infantile Spasm
- Infantile Spasms
- Lightning Attacks
- Attack, Lightning
- Attacks, Lightning
- Lightning Attack
- West Syndrome
- Syndrome, West
Symptomatic Infantile Spasms- Symptomatic Infantile Spasms
- Infantile Spasm, Symptomatic
- Infantile Spasms, Symptomatic
- Spasm, Symptomatic Infantile
- Spasms, Symptomatic Infantile
- Symptomatic Infantile Spasm
- Symptomatic West Syndrome
- Syndrome, Symptomatic West
- West Syndrome, Symptomatic
Nodding Spasm- Nodding Spasm
- Nodding Spasms
- Spasm, Nodding
- Spasms, Nodding
Salaam Attacks- Salaam Attacks
- Attacks, Salaam
- Salaam Seizures
- Seizures, Salaam
Cryptogenic Infantile Spasms- Cryptogenic Infantile Spasms
- Cryptogenic Infantile Spasm
- Infantile Spasm, Cryptogenic
- Infantile Spasms, Cryptogenic
- Spasm, Cryptogenic Infantile
- Spasms, Cryptogenic Infantile
- Cryptogenic West Syndrome
- Syndrome, Cryptogenic West
- West Syndrome, Cryptogenic
Jackknife Seizures- Jackknife Seizures
- Jackknife Seizure
- Seizure, Jackknife
- Seizures, Jackknife
Below are MeSH descriptors whose meaning is more general than "Spasms, Infantile".
Below are MeSH descriptors whose meaning is more specific than "Spasms, Infantile".
This graph shows the total number of publications written about "Spasms, Infantile" by people in Harvard Catalyst Profiles by year, and whether "Spasms, Infantile" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 2 | 1 | 3 |
| 2006 | 2 | 0 | 2 |
| 2007 | 2 | 0 | 2 |
| 2008 | 4 | 0 | 4 |
| 2009 | 1 | 1 | 2 |
| 2010 | 4 | 1 | 5 |
| 2011 | 8 | 2 | 10 |
| 2012 | 6 | 2 | 8 |
| 2013 | 6 | 1 | 7 |
| 2014 | 2 | 1 | 3 |
| 2015 | 2 | 1 | 3 |
| 2016 | 5 | 1 | 6 |
| 2017 | 10 | 3 | 13 |
| 2018 | 11 | 1 | 12 |
| 2019 | 14 | 2 | 16 |
| 2020 | 8 | 1 | 9 |
| 2021 | 15 | 2 | 17 |
| 2022 | 14 | 0 | 14 |
| 2023 | 8 | 0 | 8 |
Below are the most recent publications written about "Spasms, Infantile" by people in Profiles.
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The development, content and response process validation of a caregiver-reported severity measure for CDKL5 deficiency disorder. Epilepsy Res. 2023 11; 197:107231.
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Comment: Amenable Treatable Severe Pediatric Epilepsies. Semin Pediatr Neurol. 2023 Oct; 47:101073.
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Natural History and Developmental Trajectories of Individuals With Disease-Causing Variants in STXBP1. Neurology. 2023 08 29; 101(9):e879-e891.
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Epileptic spasms in CDKL5 deficiency disorder: Delayed treatment and poor response to first-line therapies. Epilepsia. 2023 07; 64(7):1821-1832.
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Efficacy, safety, and tolerability of soticlestat as adjunctive therapy for the treatment of seizures in patients with Dup15q syndrome or CDKL5 deficiency disorder in an open-label signal-finding phase II study (ARCADE). Epilepsy Behav. 2023 05; 142:109173.
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Comparison of evoked potentials across four related developmental encephalopathies. J Neurodev Disord. 2023 03 04; 15(1):10.
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The Epilepsy Surgery Experience in Children With Infantile Epileptic Spasms Syndrome at a Tertiary Care Center in Canada. J Child Neurol. 2023 03; 38(3-4):113-120.
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Temporal trends in the cost and use of first-line treatments for infantile epileptic spasms syndrome. Epilepsia. 2023 03; 64(3):630-640.
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Infantile epileptic spasms syndrome in children with cardiofaciocutanous syndrome: Clinical presentation and associations with genotype. Am J Med Genet C Semin Med Genet. 2022 12; 190(4):501-509.
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Diagnostic yield of a multi-strategy genetic testing procedure in a nationwide cohort of 728 patients with infantile spasms in China. Seizure. 2022 Dec; 103:51-57.