Somatic Hypermutation, Immunoglobulin
"Somatic Hypermutation, Immunoglobulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A programmed mutation process whereby changes are introduced to the nucleotide sequence of immunoglobulin gene DNA during development.
MeSH Number(s)
G05.355.600.810
G12.425.742.765
G12.500.349.765
Concept/Terms
Somatic Hypermutation, Immunoglobulin- Somatic Hypermutation, Immunoglobulin
- Hypermutation, Immunoglobulin Somatic
- Hypermutations, Immunoglobulin Somatic
- Immunoglobulin Somatic Hypermutations
- Somatic Hypermutations, Immunoglobulin
- Ig Somatic Hypermutation
- Immunoglobulin Somatic Hypermutation
- Hypermutation, Somatic, Immunoglobulin
- Somatic Hypermutation, Ig
- Hypermutation, Ig Somatic
- Hypermutations, Ig Somatic
- Ig Somatic Hypermutations
- Somatic Hypermutations, Ig
Below are MeSH descriptors whose meaning is more general than "Somatic Hypermutation, Immunoglobulin".
Below are MeSH descriptors whose meaning is more specific than "Somatic Hypermutation, Immunoglobulin".
This graph shows the total number of publications written about "Somatic Hypermutation, Immunoglobulin" by people in Harvard Catalyst Profiles by year, and whether "Somatic Hypermutation, Immunoglobulin" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 2 | 4 | 6 |
| 2005 | 0 | 2 | 2 |
| 2006 | 1 | 2 | 3 |
| 2007 | 3 | 2 | 5 |
| 2008 | 1 | 1 | 2 |
| 2009 | 3 | 1 | 4 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 2 | 2 |
| 2014 | 2 | 4 | 6 |
| 2015 | 3 | 1 | 4 |
| 2016 | 1 | 3 | 4 |
| 2017 | 2 | 2 | 4 |
| 2018 | 2 | 2 | 4 |
| 2019 | 1 | 5 | 6 |
| 2020 | 0 | 3 | 3 |
| 2021 | 2 | 5 | 7 |
| 2022 | 1 | 1 | 2 |
Below are the most recent publications written about "Somatic Hypermutation, Immunoglobulin" by people in Profiles.
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SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis. Cancer Discov. 2022 07 06; 12(7):1782-1803.
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Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops. Nucleic Acids Res. 2022 05 20; 50(9):5145-5157.
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Ig Enhancers Increase RNA Polymerase II Stalling at Somatic Hypermutation Target Sequences. J Immunol. 2022 01 01; 208(1):143-154.
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Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. Leukemia. 2021 07; 35(7):2002-2016.
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Higher-order immunoglobulin repertoire restrictions in CLL: the illustrative case of stereotyped subsets 2 and 169. Blood. 2021 04 08; 137(14):1895-1904.
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Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells. J Exp Med. 2021 04 05; 218(4).
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Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL. Blood. 2021 03 11; 137(10):1365-1376.
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An in vivo method for diversifying the functions of therapeutic antibodies. Proc Natl Acad Sci U S A. 2021 03 09; 118(10).
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Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth. Immunity. 2021 02 09; 54(2):324-339.e8.
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Sex-Biased Aging Effects on Ig Somatic Hypermutation Targeting. J Immunol. 2021 01 01; 206(1):101-108.