Smad6 Protein

"Smad6 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An inhibitory Smad protein that negatively regulates the SIGNAL TRANSDUCTION PATHWAYS from BONE MORPHOGENETIC PROTEIN RECEPTORS. Smad6 inhibits PHOSPHORYLATION of SMAD2 PROTEIN and SMAD3 PROTEIN.

Descriptor ID

D051905

MeSH Number(s)

D12.644.360.024.334.200.600

D12.776.157.057.170.249.600

D12.776.476.024.417.249.600

D12.776.930.806.875

Concept/Terms

Smad6 Protein

Below are MeSH descriptors whose meaning is more general than "Smad6 Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Smad Proteins [D12.644.360.024.334]
Smad Proteins, Inhibitory [D12.644.360.024.334.200]
Smad6 Protein [D12.644.360.024.334.200.600]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Smad Proteins [D12.776.157.057.170]
Smad Proteins, Inhibitory [D12.776.157.057.170.249]
Smad6 Protein [D12.776.157.057.170.249.600]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Smad Proteins [D12.776.476.024.417]
Smad Proteins, Inhibitory [D12.776.476.024.417.249]
Smad6 Protein [D12.776.476.024.417.249.600]
Transcription Factors [D12.776.930]
Smad Proteins [D12.776.930.806]
Smad6 Protein [D12.776.930.806.875]

Below are MeSH descriptors whose meaning is related to "Smad6 Protein".

Below are MeSH descriptors whose meaning is more specific than "Smad6 Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Smad6 Protein" by people in Harvard Catalyst Profiles by year, and whether "Smad6 Protein" was a major or minor topic of these publication.

Bar chart showing 14 publications over 12 distinct years, with a maximum of 2 publications in 1997 and 2000

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	2	2
2000	0	2	2
2001	0	1	1
2002	0	1	1
2003	0	1	1
2006	1	0	1
2008	0	1	1
2010	1	0	1
2013	0	1	1
2016	1	0	1
2017	0	1	1
2020	1	0	1

Below are the most recent publications written about "Smad6 Protein" by people in Profiles.

Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts. FEBS Lett. 2021 02; 595(3):389-403.

View in: PubMed
Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6. J Nanobiotechnology. 2020 May 06; 18(1):68.

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De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis. Proc Natl Acad Sci U S A. 2017 08 29; 114(35):E7341-E7347.

View in: PubMed
Infection of Hepatocytes With HCV Increases Cell Surface Levels of Heparan Sulfate Proteoglycans, Uptake of Cholesterol and Lipoprotein, and Virus Entry by Up-regulating SMAD6 and SMAD7. Gastroenterology. 2017 01; 152(1):257-270.e7.

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Two locus inheritance of non-syndromic midline craniosynostosis via rare SMAD6 and common BMP2 alleles. Elife. 2016 Sep 08; 5.

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Keratoconus in vitro and the key players of the TGF-ß pathway. Mol Vis. 2015; 21:577-88.

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CCN5 attenuates profibrotic phenotypes of fibroblasts through the Smad6-CCN2 pathway: Potential role in epidural ?brosis. Int J Mol Med. 2015 Jul; 36(1):123-9.

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Deletion of the sequence encoding the tail domain of the bone morphogenetic protein type 2 receptor reveals a bone morphogenetic protein 7-specific gain of function. PLoS One. 2013; 8(10):e76947.

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Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells. Gene. 2013 07 25; 524(2):282-91.

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Breast milk-transforming growth factor-ß2 specifically attenuates IL-1ß-induced inflammatory responses in the immature human intestine via an SMAD6- and ERK-dependent mechanism. Neonatology. 2011; 99(3):192-201.

View in: PubMed

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