Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Simvastatin

"Simvastatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.


This graph shows the total number of publications written about "Simvastatin" by people in Harvard Catalyst Profiles by year, and whether "Simvastatin" was a major or minor topic of these publication.
Bar chart showing 186 publications over 25 distinct years, with a maximum of 18 publications in 2010
To see the data from this visualization as text, click here.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.