Silent Information Regulator Proteins, Saccharomyces cerevisiae
"Silent Information Regulator Proteins, Saccharomyces cerevisiae" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.
MeSH Number(s)
D12.776.354.750.750
D12.776.660.820
Below are MeSH descriptors whose meaning is more general than "Silent Information Regulator Proteins, Saccharomyces cerevisiae".
Below are MeSH descriptors whose meaning is more specific than "Silent Information Regulator Proteins, Saccharomyces cerevisiae".
This graph shows the total number of publications written about "Silent Information Regulator Proteins, Saccharomyces cerevisiae" by people in Harvard Catalyst Profiles by year, and whether "Silent Information Regulator Proteins, Saccharomyces cerevisiae" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1999 | 3 | 0 | 3 |
| 2000 | 2 | 0 | 2 |
| 2001 | 5 | 0 | 5 |
| 2002 | 4 | 0 | 4 |
| 2003 | 1 | 2 | 3 |
| 2004 | 1 | 2 | 3 |
| 2005 | 3 | 1 | 4 |
| 2006 | 2 | 2 | 4 |
| 2007 | 3 | 0 | 3 |
| 2008 | 2 | 1 | 3 |
| 2009 | 1 | 3 | 4 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 2 | 3 |
| 2013 | 1 | 1 | 2 |
| 2016 | 1 | 1 | 2 |
| 2017 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Silent Information Regulator Proteins, Saccharomyces cerevisiae" by people in Profiles.
-
Systematic profiling of subtelomeric silencing factors in budding yeast. G3 (Bethesda). 2023 09 30; 13(10).
-
A SIR-independent role for cohesin in subtelomeric silencing and organization. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5659-5664.
-
Evaluation of the Nucleolar Localization of the RENT Complex to Ribosomal DNA by Chromatin Immunoprecipitation Assays. Methods Mol Biol. 2017; 1505:195-213.
-
Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes. Elife. 2016 11 11; 5.
-
Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication. PLoS Genet. 2016 Nov; 12(11):e1006414.
-
Histone Deacetylases with Antagonistic Roles in Saccharomyces cerevisiae Heterochromatin Formation. Genetics. 2016 09; 204(1):177-90.
-
Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzyme. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):17827-32.
-
Solution-state conformation and stoichiometry of yeast Sir3 heterochromatin fibres. Nat Commun. 2014 Aug 28; 5:4751.
-
The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome. Mol Biol Cell. 2013 Dec; 24(24):3920-38.
-
Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase) is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination. PLoS Genet. 2013; 9(10):e1003871.