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Silent Information Regulator Proteins, Saccharomyces cerevisiae

"Silent Information Regulator Proteins, Saccharomyces cerevisiae" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.


This graph shows the total number of publications written about "Silent Information Regulator Proteins, Saccharomyces cerevisiae" by people in Harvard Catalyst Profiles by year, and whether "Silent Information Regulator Proteins, Saccharomyces cerevisiae" was a major or minor topic of these publication.
Bar chart showing 62 publications over 18 distinct years, with a maximum of 8 publications in 2003
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.