SH2 Domain-Containing Protein Tyrosine Phosphatases
"SH2 Domain-Containing Protein Tyrosine Phosphatases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subcategory of protein tyrosine phosphatases that contain SH2 type SRC HOMOLOGY DOMAINS. Many of the proteins in this class are recruited to specific cellular targets such as a cell surface receptor complexes via their SH2 domain.
MeSH Number(s)
D08.811.277.352.650.775.700
D12.644.360.800
D12.776.476.800
Concept/Terms
SH2 Domain-Containing Protein Tyrosine Phosphatases- SH2 Domain-Containing Protein Tyrosine Phosphatases
- SH2 Domain Containing Protein Tyrosine Phosphatases
- Src Homology-2 (SH2) Domain-Containing Phosphatases
- Src Homology-2 (SH2) Domain-Containing Phosphatase
- SH2 Domain-Containing Protein Tyrosine Phosphatase
- SH2 Domain Containing Protein Tyrosine Phosphatase
- SH2 Domain-Containing Protein-Tyrosine-Phosphatases
- Domain-Containing Protein-Tyrosine-Phosphatases, SH2
- Protein-Tyrosine-Phosphatases, SH2 Domain-Containing
Below are MeSH descriptors whose meaning is more general than "SH2 Domain-Containing Protein Tyrosine Phosphatases".
Below are MeSH descriptors whose meaning is more specific than "SH2 Domain-Containing Protein Tyrosine Phosphatases".
This graph shows the total number of publications written about "SH2 Domain-Containing Protein Tyrosine Phosphatases" by people in Harvard Catalyst Profiles by year, and whether "SH2 Domain-Containing Protein Tyrosine Phosphatases" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1996 | 0 | 3 | 3 |
| 1997 | 0 | 5 | 5 |
| 1998 | 0 | 4 | 4 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 5 | 5 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
Below are the most recent publications written about "SH2 Domain-Containing Protein Tyrosine Phosphatases" by people in Profiles.
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The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration. Cancer Res. 2007 May 01; 67(9):4278-86.
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ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res. 2006 Aug 01; 66(15):7473-81.
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An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival. Dev Cell. 2006 Mar; 10(3):317-27.
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Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes. J Biol Chem. 2005 Sep 02; 280(35):30984-93.
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Denervation enhances the expression of SHPS-1 in rat skeletal muscle. J Biochem. 2005 Apr; 137(4):495-502.
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Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res. 2004 Dec 15; 64(24):8816-20.
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SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. J Cell Physiol. 2004 May; 199(2):227-36.
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Merging fluorescence resonance energy transfer and expressed protein ligation to analyze protein-protein interactions. Anal Biochem. 2003 Jun 15; 317(2):226-32.
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Chemical dissection of the effects of tyrosine phosphorylation of SHP-2. Biochemistry. 2003 May 13; 42(18):5461-8.
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Regulation of the SHP-2 tyrosine phosphatase by a novel cholesterol- and cell confluence-dependent mechanism. J Biol Chem. 2003 May 16; 278(20):18360-7.