"Receptors, Neurokinin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of cell surface receptors for tachykinins with a preference for substance P. Neurokinin-1 (NK-1) receptors have been cloned and are members of the G protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells.
MeSH Number(s)
D12.776.543.750.720.600.830.500
D12.776.543.750.750.555.830.500
Concept/Terms
Receptors, Neurokinin-1- Receptors, Neurokinin-1
- Receptors, Neurokinin 1
- Substance P Receptors
- P Receptors, Substance
- Receptors, Substance P
- NK-1 Receptor
- NK 1 Receptor
- Receptor, NK-1
- Receptors, NK-1
- Receptors, NK 1
- SP-P Receptors
- SP P Receptors
- Neurokinin-1 Receptor
- Neurokinin 1 Receptor
- Receptor, Neurokinin-1
- Neurokinin-1 Receptors
- Neurokinin 1 Receptors
- Receptors, SP-P
- Receptors, SP P
- SP-P Receptor
- Receptor, SP-P
- SP P Receptor
- Substance P Receptor
- P Receptor, Substance
- Receptor, Substance P
- NK-1 Receptors
- NK 1 Receptors
Below are MeSH descriptors whose meaning is more general than "Receptors, Neurokinin-1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Neuropeptide [D12.776.543.750.720.600]
- Receptors, Tachykinin [D12.776.543.750.720.600.830]
- Receptors, Neurokinin-1 [D12.776.543.750.720.600.830.500]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Neuropeptide [D12.776.543.750.750.555]
- Receptors, Tachykinin [D12.776.543.750.750.555.830]
- Receptors, Neurokinin-1 [D12.776.543.750.750.555.830.500]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Neurokinin-1".
This graph shows the total number of publications written about "Receptors, Neurokinin-1" by people in Harvard Catalyst Profiles by year, and whether "Receptors, Neurokinin-1" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 3 | 5 |
| 1995 | 1 | 2 | 3 |
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 2 | 2 | 4 |
| 1999 | 3 | 0 | 3 |
| 2000 | 5 | 2 | 7 |
| 2001 | 3 | 2 | 5 |
| 2002 | 4 | 0 | 4 |
| 2003 | 4 | 1 | 5 |
| 2004 | 1 | 1 | 2 |
| 2005 | 2 | 0 | 2 |
| 2006 | 1 | 2 | 3 |
| 2007 | 2 | 3 | 5 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 2 | 3 |
| 2010 | 2 | 0 | 2 |
| 2011 | 7 | 2 | 9 |
| 2012 | 2 | 1 | 3 |
| 2013 | 2 | 0 | 2 |
| 2014 | 2 | 1 | 3 |
| 2015 | 2 | 4 | 6 |
| 2016 | 2 | 0 | 2 |
| 2017 | 4 | 2 | 6 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
| 2021 | 0 | 2 | 2 |
| 2022 | 0 | 1 | 1 |
Below are the most recent publications written about "Receptors, Neurokinin-1" by people in Profiles.
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Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders. Ocul Surf. 2022 07; 25:142-153.
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Tachykinins amplify the action of capsaicin on central histaminergic neurons. Peptides. 2022 04; 150:170729.
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Corneal lymphangiogenesis in dry eye disease is regulated by substance P/neurokinin-1 receptor system through controlling expression of vascular endothelial growth factor receptor 3. Ocul Surf. 2021 10; 22:72-79.
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Restoration of Regulatory T-Cell Function in Dry Eye Disease by Antagonizing Substance P/Neurokinin-1 Receptor. Am J Pathol. 2020 09; 190(9):1859-1866.
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Sensory neurons directly promote angiogenesis in response to inflammation via substance P signaling. FASEB J. 2020 05; 34(5):6229-6243.
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Neurokinin-1 Receptor Antagonism Ameliorates Dry Eye Disease by Inhibiting Antigen-Presenting Cell Maturation and T Helper 17 Cell Activation. Am J Pathol. 2020 01; 190(1):125-133.
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Crystal structure of the human NK1 tachykinin receptor. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):13264-13269.
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Association between amygdala neurokinin-1 receptor availability and anxiety-related personality traits. Transl Psychiatry. 2018 08 28; 8(1):168.
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Brain neurokinin-1 receptor availability in never-medicated patients with major depression - A pilot study. J Affect Disord. 2019 01 01; 242:188-194.
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Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P. J Neuroinflammation. 2017 Dec 13; 14(1):245.