Receptors, N-Methyl-D-Aspartate
"Receptors, N-Methyl-D-Aspartate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
MeSH Number(s)
D12.776.157.530.400.400.500.500
D12.776.543.550.425.500.200.500
D12.776.543.585.400.500.200.500
D12.776.543.750.720.200.450.400.500
Concept/Terms
Receptors, N-Methyl-D-Aspartate- Receptors, N-Methyl-D-Aspartate
- Receptors, N Methyl D Aspartate
- N-Methylaspartate Receptors
- N Methylaspartate Receptors
- Receptors, NMDA
- NMDA Receptors
- Receptors, N-Methylaspartate
- Receptors, N Methylaspartate
- N-Methyl-D-Aspartate Receptors
- N Methyl D Aspartate Receptors
- NMDA Receptor-Ionophore Complex
- NMDA Receptor Ionophore Complex
Below are MeSH descriptors whose meaning is more general than "Receptors, N-Methyl-D-Aspartate".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Membrane Transport Proteins [D12.776.157.530]
- Ion Channels [D12.776.157.530.400]
- Ligand-Gated Ion Channels [D12.776.157.530.400.400]
- Receptors, Ionotropic Glutamate [D12.776.157.530.400.400.500]
- Receptors, N-Methyl-D-Aspartate [D12.776.157.530.400.400.500.500]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Ion Channels [D12.776.543.550.425]
- Ligand-Gated Ion Channels [D12.776.543.550.425.500]
- Receptors, Ionotropic Glutamate [D12.776.543.550.425.500.200]
- Receptors, N-Methyl-D-Aspartate [D12.776.543.550.425.500.200.500]
- Membrane Transport Proteins [D12.776.543.585]
- Ion Channels [D12.776.543.585.400]
- Ligand-Gated Ion Channels [D12.776.543.585.400.500]
- Receptors, Ionotropic Glutamate [D12.776.543.585.400.500.200]
- Receptors, N-Methyl-D-Aspartate [D12.776.543.585.400.500.200.500]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Amino Acid [D12.776.543.750.720.200]
- Receptors, Glutamate [D12.776.543.750.720.200.450]
- Receptors, Ionotropic Glutamate [D12.776.543.750.720.200.450.400]
- Receptors, N-Methyl-D-Aspartate [D12.776.543.750.720.200.450.400.500]
Below are MeSH descriptors whose meaning is more specific than "Receptors, N-Methyl-D-Aspartate".
This graph shows the total number of publications written about "Receptors, N-Methyl-D-Aspartate" by people in Harvard Catalyst Profiles by year, and whether "Receptors, N-Methyl-D-Aspartate" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1993 | 5 | 10 | 15 |
1994 | 8 | 9 | 17 |
1995 | 11 | 10 | 21 |
1996 | 13 | 6 | 19 |
1997 | 9 | 2 | 11 |
1998 | 15 | 11 | 26 |
1999 | 6 | 12 | 18 |
2000 | 9 | 8 | 17 |
2001 | 4 | 10 | 14 |
2002 | 9 | 9 | 18 |
2003 | 17 | 4 | 21 |
2004 | 18 | 10 | 28 |
2005 | 10 | 11 | 21 |
2006 | 8 | 11 | 19 |
2007 | 13 | 4 | 17 |
2008 | 15 | 8 | 23 |
2009 | 15 | 13 | 28 |
2010 | 7 | 11 | 18 |
2011 | 18 | 13 | 31 |
2012 | 20 | 6 | 26 |
2013 | 13 | 8 | 21 |
2014 | 11 | 14 | 25 |
2015 | 20 | 6 | 26 |
2016 | 12 | 10 | 22 |
2017 | 15 | 7 | 22 |
2018 | 14 | 9 | 23 |
2019 | 15 | 3 | 18 |
2020 | 9 | 6 | 15 |
2021 | 5 | 7 | 12 |
2022 | 1 | 8 | 9 |
2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Receptors, N-Methyl-D-Aspartate" by people in Profiles.
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Characterizing brain dynamics during ketamine-induced dissociation and subsequent interactions with propofol using human intracranial neurophysiology. Nat Commun. 2023 Mar 29; 14(1):1748.
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High synaptic threshold for dendritic NMDA spike generation in human layer 2/3 pyramidal neurons. Cell Rep. 2022 12 13; 41(11):111787.
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Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling. Int J Mol Sci. 2022 Oct 13; 23(20).
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Evaluation of (rac)-, (R)-, and (S)-18F-OF-NB1 for Imaging GluN2B Subunit-Containing N-Methyl-d-Aspartate Receptors in Nonhuman Primates. J Nucl Med. 2022 12; 63(12):1912-1918.
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Clinical and Preclinical Evidence for M1 Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome. Neurotherapeutics. 2022 07; 19(4):1340-1352.
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Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder. Mol Psychiatry. 2022 09; 27(9):3842-3856.
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Bioactive human Alzheimer brain soluble Aß: pathophysiology and therapeutic opportunities. Mol Psychiatry. 2022 08; 27(8):3182-3191.
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Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature. 2022 04; 604(7906):509-516.
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Comparison of three novel radiotracers for GluN2B-containing NMDA receptors in non-human primates: (R)-[11C]NR2B-Me, (R)-[18F]of-Me-NB1, and (S)-[18F]of-NB1. J Cereb Blood Flow Metab. 2022 08; 42(8):1398-1409.
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Inhibition of glial D-serine release rescues synaptic damage after brain injury. Glia. 2022 06; 70(6):1133-1152.