Receptors, Leukocyte-Adhesion
"Receptors, Leukocyte-Adhesion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Family of proteins associated with the capacity of LEUKOCYTES to adhere to each other and to certain substrata, e.g., the C3bi component of complement. Members of this family are the LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; (LFA-1), the MACROPHAGE-1 ANTIGEN; (Mac-1), and the INTEGRIN ALPHAXBETA2 or p150,95 leukocyte adhesion protein. They all share a common beta-subunit which is the CD18 antigen. All three of the above antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is characterized by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells.
MeSH Number(s)
D12.776.543.750.705.408.600
Concept/Terms
Receptors, Leukocyte-Adhesion- Receptors, Leukocyte-Adhesion
- Receptors, Leukocyte Adhesion
- Leukocyte-Adhesion Receptor
- Leukocyte Adhesion Receptor
- Receptor, Leukocyte-Adhesion
- Leukocyte-Adhesion Receptor Family
- Leukocyte Adhesion Receptor Family
- Leu-CAM Receptor Family
- Family, Leu-CAM Receptor
- Leu CAM Receptor Family
- Receptor Family, Leu-CAM
- Leukocyte-Adhesion Receptors
- Leukocyte Adhesion Receptors
Below are MeSH descriptors whose meaning is more general than "Receptors, Leukocyte-Adhesion".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Leukocyte-Adhesion".
This graph shows the total number of publications written about "Receptors, Leukocyte-Adhesion" by people in Harvard Catalyst Profiles by year, and whether "Receptors, Leukocyte-Adhesion" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 1 | 2 |
| 1994 | 1 | 2 | 3 |
| 1995 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
Below are the most recent publications written about "Receptors, Leukocyte-Adhesion" by people in Profiles.
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Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J. 2002 Mar; 16(3):438-40.
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Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. Invest Ophthalmol Vis Sci. 2000 Apr; 41(5):1153-8.
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MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature. 1999 Apr 22; 398(6729):718-23.
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A new class of obesity genes encodes leukocyte adhesion receptors. Proc Natl Acad Sci U S A. 1997 Jul 08; 94(14):7526-30.
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Neutrophil adhesion receptor CD18 mediates remote but not localized acid aspiration injury. Surgery. 1995 Jan; 117(1):83-9.
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Reduction of burn injury by inhibiting CD18-mediated leukocyte adherence in rabbits. Plast Reconstr Surg. 1994 Jun; 93(7):1473-80.
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The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements. Mol Cell Biol. 1994 Apr; 14(4):2604-15.
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Remodeling of neutrophil phospholipids with 15(S)-hydroxyeicosatetraenoic acid inhibits leukotriene B4-induced neutrophil migration across endothelium. J Clin Invest. 1994 Feb; 93(2):499-508.
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C5a-induced myocardial ischemia: role for CD18-dependent PMN localization and PMN-platelet interactions. Am J Physiol. 1993 Nov; 265(5 Pt 2):H1750-61.
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Integrin dependent neutrophil adhesion following gut ischemia and reperfusion. Behring Inst Mitt. 1993 Aug; (92):210-7.