"Receptors, LDL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
Concept/Terms
Receptors, LDL- Receptors, LDL
- LDL Receptors
- LDL Receptors, Lipoprotein
- Receptors, Lipoprotein LDL
- Lipoprotein LDL Receptors
- Low Density Lipoprotein Receptors
- Receptors, Lipoprotein, LDL
- Receptors, Low Density Lipoprotein
- LDL Receptor
- Receptor, LDL
- Low Density Lipoprotein Receptor
Below are MeSH descriptors whose meaning is more general than "Receptors, LDL".
Below are MeSH descriptors whose meaning is more specific than "Receptors, LDL".
This graph shows the total number of publications written about "Receptors, LDL" by people in Harvard Catalyst Profiles by year, and whether "Receptors, LDL" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 1 | 2 |
| 1994 | 4 | 0 | 4 |
| 1995 | 3 | 0 | 3 |
| 1996 | 1 | 0 | 1 |
| 1997 | 2 | 1 | 3 |
| 1998 | 2 | 7 | 9 |
| 1999 | 6 | 2 | 8 |
| 2000 | 7 | 4 | 11 |
| 2001 | 6 | 3 | 9 |
| 2002 | 4 | 5 | 9 |
| 2003 | 9 | 8 | 17 |
| 2004 | 10 | 5 | 15 |
| 2005 | 7 | 4 | 11 |
| 2006 | 6 | 3 | 9 |
| 2007 | 8 | 2 | 10 |
| 2008 | 3 | 3 | 6 |
| 2009 | 3 | 2 | 5 |
| 2010 | 2 | 7 | 9 |
| 2011 | 6 | 5 | 11 |
| 2012 | 5 | 6 | 11 |
| 2013 | 7 | 1 | 8 |
| 2014 | 5 | 8 | 13 |
| 2015 | 8 | 13 | 21 |
| 2016 | 5 | 9 | 14 |
| 2017 | 6 | 11 | 17 |
| 2018 | 2 | 13 | 15 |
| 2019 | 6 | 14 | 20 |
| 2020 | 3 | 7 | 10 |
| 2021 | 4 | 6 | 10 |
| 2022 | 1 | 5 | 6 |
| 2023 | 0 | 3 | 3 |
Below are the most recent publications written about "Receptors, LDL" by people in Profiles.
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LDLR and PCSK9 3´UTR variants and their putative effects on microRNA molecular interactions in familial hypercholesterolemia: a computational approach. Mol Biol Rep. 2023 Nov; 50(11):9165-9177.
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Identification of pathogenic variants in the Brazilian cohort with Familial hypercholesterolemia using exon-targeted gene sequencing. Gene. 2023 Jul 30; 875:147501.
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GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy. Nat Commun. 2023 05 15; 14(1):2776.
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Mirabegron-induced brown fat activation does not exacerbate atherosclerosis in mice with a functional hepatic ApoE-LDLR pathway. Pharmacol Res. 2023 01; 187:106634.
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Beneficial Effects of Moderate Hepatic Activin A Expression on Metabolic Pathways, Inflammation, and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2023 02; 43(2):330-349.
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Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms. Circ Res. 2022 11 11; 131(11):873-889.
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Effects of PCSK9 missense variants on molecular conformation and biological activity in transfected HEK293FT cells. Gene. 2023 Jan 30; 851:146979.
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Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor. Sci Transl Med. 2022 09 14; 14(662):eabj8670.
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P2X4 deficiency reduces atherosclerosis and plaque inflammation in mice. Sci Rep. 2022 02 18; 12(1):2801.
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Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure. Circ Genom Precis Med. 2022 04; 15(2):e003501.