Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
"Receptors, Granulocyte-Macrophage Colony-Stimulating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Receptors that bind and internalize the granulocyte-macrophage stimulating factor. Their MW is believed to be 84 kD. The most mature myelomonocytic cells, specifically human neutrophils, macrophages, and eosinophils, express the highest number of affinity receptors for this growth factor.
MeSH Number(s)
D12.776.543.750.705.852.150.310
D12.776.543.750.750.400.200.420
Concept/Terms
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor- Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
- Receptors, Granulocyte Macrophage Colony Stimulating Factor
- Receptors, GM-CSF
- Receptors, GM CSF
- GM-CSF Receptors
- GM CSF Receptors
- CD116 Antigens
- CD116 Antigen
- Antigen, CD116
- Antigens, CD116
- GM-CSF Receptor
- GM CSF Receptor
- Receptor, GM-CSF
- Receptor, Granulocyte-Macrophage Colony-Stimulating Factor
- Receptor, Granulocyte Macrophage Colony Stimulating Factor
Below are MeSH descriptors whose meaning is more general than "Receptors, Granulocyte-Macrophage Colony-Stimulating Factor".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Cytokine [D12.776.543.750.705.852]
- Receptors, Colony-Stimulating Factor [D12.776.543.750.705.852.150]
- Receptors, Granulocyte-Macrophage Colony-Stimulating Factor [D12.776.543.750.705.852.150.310]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Growth Factor [D12.776.543.750.750.400]
- Receptors, Colony-Stimulating Factor [D12.776.543.750.750.400.200]
- Receptors, Granulocyte-Macrophage Colony-Stimulating Factor [D12.776.543.750.750.400.200.420]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Granulocyte-Macrophage Colony-Stimulating Factor".
This graph shows the total number of publications written about "Receptors, Granulocyte-Macrophage Colony-Stimulating Factor" by people in Harvard Catalyst Profiles by year, and whether "Receptors, Granulocyte-Macrophage Colony-Stimulating Factor" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 3 | 0 | 3 |
| 1994 | 3 | 2 | 5 |
| 1995 | 2 | 0 | 2 |
| 1996 | 4 | 0 | 4 |
| 1997 | 3 | 0 | 3 |
| 1999 | 1 | 0 | 1 |
| 2002 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 2 | 3 |
| 2017 | 3 | 3 | 6 |
| 2018 | 3 | 5 | 8 |
| 2019 | 2 | 3 | 5 |
| 2020 | 3 | 1 | 4 |
| 2021 | 2 | 5 | 7 |
Below are the most recent publications written about "Receptors, Granulocyte-Macrophage Colony-Stimulating Factor" by people in Profiles.
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Should We Open Fire on Microglia? Depletion Models as Tools to Elucidate Microglial Role in Health and Alzheimer's Disease. Int J Mol Sci. 2021 Sep 08; 22(18).
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Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave. Elife. 2021 08 23; 10.
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Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption. Elife. 2021 06 23; 10.
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CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia. Acta Neuropathol Commun. 2021 06 08; 9(1):108.
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Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Mol Neurodegener. 2021 03 22; 16(1):18.
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LY3022855, an anti-colony stimulating factor-1 receptor (CSF-1R) monoclonal antibody, in patients with advanced solid tumors refractory to standard therapy: phase 1 dose-escalation trial. Invest New Drugs. 2021 08; 39(4):1057-1071.
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Changes in the tumor microenvironment and outcome for TME-targeting therapy in glioblastoma: A pilot study. PLoS One. 2021; 16(2):e0246646.
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Reply to Green and Hume: Nonmicroglia peripheral immune effects of short-term CSF1R inhibition with PLX5622. Proc Natl Acad Sci U S A. 2021 01 26; 118(4).
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CSF1R signaling is a regulator of pathogenesis in progressive MS. Cell Death Dis. 2020 10 23; 11(10):904.
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CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23336-23338.