Receptor-CD3 Complex, Antigen, T-Cell
"Receptor-CD3 Complex, Antigen, T-Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Molecule composed of the non-covalent association of the T-cell antigen receptor (RECEPTORS, ANTIGEN, T-CELL) with the CD3 complex (ANTIGENS, CD3). This association is required for the surface expression and function of both components. The molecule consists of up to seven chains: either the alpha/beta or gamma/delta chains of the T-cell receptor, and four or five chains in the CD3 complex.
MeSH Number(s)
D12.776.543.750.705.816.824.800
D23.050.301.264.035.103.800
D23.050.301.264.894.095.800
D23.101.100.110.103.800
D23.101.100.894.095.800
Concept/Terms
Receptor-CD3 Complex, Antigen, T-Cell- Receptor-CD3 Complex, Antigen, T-Cell
- TCR-CD3 Complex
- Complex, TCR-CD3
- TCR CD3 Complex
- T-Cell Antigen Receptor-CD3 Complex
- T Cell Antigen Receptor CD3 Complex
Below are MeSH descriptors whose meaning is more general than "Receptor-CD3 Complex, Antigen, T-Cell".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Antigen [D12.776.543.750.705.816]
- Receptors, Antigen, T-Cell [D12.776.543.750.705.816.824]
- Receptor-CD3 Complex, Antigen, T-Cell [D12.776.543.750.705.816.824.800]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, CD [D23.050.301.264.035]
- Antigens, CD3 [D23.050.301.264.035.103]
- Receptor-CD3 Complex, Antigen, T-Cell [D23.050.301.264.035.103.800]
- Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
- Antigens, CD3 [D23.050.301.264.894.095]
- Receptor-CD3 Complex, Antigen, T-Cell [D23.050.301.264.894.095.800]
- Biological Markers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, CD [D23.101.100.110]
- Antigens, CD3 [D23.101.100.110.103]
- Receptor-CD3 Complex, Antigen, T-Cell [D23.101.100.110.103.800]
- Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]
- Antigens, CD3 [D23.101.100.894.095]
- Receptor-CD3 Complex, Antigen, T-Cell [D23.101.100.894.095.800]
Below are MeSH descriptors whose meaning is more specific than "Receptor-CD3 Complex, Antigen, T-Cell".
This graph shows the total number of publications written about "Receptor-CD3 Complex, Antigen, T-Cell" by people in Harvard Catalyst Profiles by year, and whether "Receptor-CD3 Complex, Antigen, T-Cell" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 3 | 3 |
| 1994 | 1 | 0 | 1 |
| 1995 | 3 | 1 | 4 |
| 1996 | 2 | 1 | 3 |
| 1997 | 1 | 1 | 2 |
| 1998 | 0 | 2 | 2 |
| 1999 | 2 | 2 | 4 |
| 2000 | 2 | 1 | 3 |
| 2001 | 1 | 1 | 2 |
| 2002 | 2 | 2 | 4 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 1 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
Below are the most recent publications written about "Receptor-CD3 Complex, Antigen, T-Cell" by people in Profiles.
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Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex. Cell Rep. 2018 01 30; 22(5):1263-1275.
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The CD4 and CD3de Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR-CD3-pMHC-CD4 Macrocomplex. J Immunol. 2016 06 01; 196(11):4713-22.
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Molecular architecture of the aß T cell receptor-CD3 complex. Proc Natl Acad Sci U S A. 2014 Dec 09; 111(49):17576-81.
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N-Octanoyl dopamine transiently inhibits T cell proliferation via G1 cell-cycle arrest and inhibition of redox-dependent transcription factors. J Leukoc Biol. 2014 Sep; 96(3):453-62.
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Nanoscale ligand spacing influences receptor triggering in T cells and NK cells. Nano Lett. 2013; 13(11):5608-14.
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CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances ROR?t recruitment to the IL17A promoter in human T lymphocytes. J Biol Chem. 2012 Nov 02; 287(45):38168-77.
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Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection. J Virol. 2012 May; 86(9):4906-20.
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Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells. J Immunol. 2011 Jul 15; 187(2):870-8.
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Response multilayered control of T cell receptor phosphorylation. Cell. 2010 Sep 03; 142(5):669-71.
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Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development. EMBO J. 2010 Apr 07; 29(7):1285-98.