Receptor, Parathyroid Hormone, Type 2
"Receptor, Parathyroid Hormone, Type 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A parathyroid hormone receptor subtype found in the BRAIN and the PANCREAS. It is a G-protein-coupled receptor with a ligand specificity that varies between homologs from different species.
MeSH Number(s)
D12.776.543.750.100.650.200
D12.776.543.750.750.600.200
Below are MeSH descriptors whose meaning is more general than "Receptor, Parathyroid Hormone, Type 2".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.100]
- Receptors, Parathyroid Hormone [D12.776.543.750.100.650]
- Receptor, Parathyroid Hormone, Type 2 [D12.776.543.750.100.650.200]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Parathyroid Hormone [D12.776.543.750.750.600]
- Receptor, Parathyroid Hormone, Type 2 [D12.776.543.750.750.600.200]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Parathyroid Hormone, Type 2".
This graph shows the total number of publications written about "Receptor, Parathyroid Hormone, Type 2" by people in Harvard Catalyst Profiles by year, and whether "Receptor, Parathyroid Hormone, Type 2" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
Below are the most recent publications written about "Receptor, Parathyroid Hormone, Type 2" by people in Profiles.
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Receptor selectivity from minimal backbone modification of a polypeptide agonist. Proc Natl Acad Sci U S A. 2018 12 04; 115(49):12383-12388.
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Breakpoint mapping by whole genome sequencing identifies PTH2R gene disruption in a patient with midline craniosynostosis and a de novo balanced chromosomal rearrangement. J Med Genet. 2015 Oct; 52(10):706-9.
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Molecular properties of the PTH/PTHrP receptor. Trends Endocrinol Metab. 2001 Jul; 12(5):210-7.
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Direct identification of two contact sites for parathyroid hormone (PTH) in the novel PTH-2 receptor using photoaffinity cross-linking. Endocrinology. 1999 Sep; 140(9):4251-61.
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A G protein-coupled receptor from zebrafish is activated by human parathyroid hormone and not by human or teleost parathyroid hormone-related peptide. Implications for the evolutionary conservation of calcium-regulating peptide hormones. J Biol Chem. 1999 Aug 13; 274(33):23035-42.
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Residues in the membrane-spanning and extracellular loop regions of the parathyroid hormone (PTH)-2 receptor determine signaling selectivity for PTH and PTH-related peptide. J Biol Chem. 1997 Nov 14; 272(46):28861-8.
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Histidine at position 5 is the specificity "switch" between two parathyroid hormone receptor subtypes. Endocrinology. 1996 Oct; 137(10):4217-24.
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Converting parathyroid hormone-related peptide (PTHrP) into a potent PTH-2 receptor agonist. J Biol Chem. 1996 Aug 16; 271(33):19888-93.
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The human PTH2 receptor: binding and signal transduction properties of the stably expressed recombinant receptor. Endocrinology. 1996 Jul; 137(7):2748-57.