RecQ Helicases

"RecQ Helicases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of structurally-related DNA helicases that play an essential role in the maintenance of genome integrity. RecQ helicases were originally discovered in E COLI and are highly conserved across both prokaryotic and eukaryotic organisms. Genetic mutations that result in loss of RecQ helicase activity gives rise to disorders that are associated with CANCER predisposition and premature aging.

Descriptor ID

D053484

MeSH Number(s)

D08.811.277.040.025.159.249

D08.811.277.040.025.800

D08.811.399.340.249

Concept/Terms

Below are MeSH descriptors whose meaning is more general than "RecQ Helicases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
Adenosine Triphosphatases [D08.811.277.040.025]
DNA Helicases [D08.811.277.040.025.159]
RecQ Helicases [D08.811.277.040.025.159.249]
RecQ Helicases [D08.811.277.040.025.800]
Isomerases [D08.811.399]
DNA Helicases [D08.811.399.340]
RecQ Helicases [D08.811.399.340.249]

Below are MeSH descriptors whose meaning is related to "RecQ Helicases".

Below are MeSH descriptors whose meaning is more specific than "RecQ Helicases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RecQ Helicases" by people in Harvard Catalyst Profiles by year, and whether "RecQ Helicases" was a major or minor topic of these publication.

Bar chart showing 41 publications over 23 distinct years, with a maximum of 4 publications in 2009 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1999	0	1	1
2000	0	2	2
2001	0	1	1
2003	0	2	2
2004	0	1	1
2005	0	1	1
2006	0	1	1
2007	1	2	3
2008	1	0	1
2009	2	2	4
2010	1	1	2
2011	0	1	1
2012	1	0	1
2014	0	2	2
2015	2	0	2
2016	2	0	2
2017	1	0	1
2018	2	2	4
2020	3	0	3
2021	0	2	2
2022	1	1	2
2023	0	1	1

Below are the most recent publications written about "RecQ Helicases" by people in Profiles.

BLM helicase protein negatively regulates stress granule formation through unwinding RNA G-quadruplex structures. Nucleic Acids Res. 2023 09 22; 51(17):9369-9384.

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Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancer. PLoS Genet. 2022 09; 18(9):e1010122.

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Bloom helicase mediates formation of large single-stranded DNA loops during DNA end processing. Nat Commun. 2022 04 26; 13(1):2248.

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Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies. Mol Cell. 2021 03 04; 81(5):1027-1042.e4.

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CARM1 regulates replication fork speed and stress response by stimulating PARP1. Mol Cell. 2021 02 18; 81(4):784-800.e8.

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The yeast Hrq1 helicase stimulates Pso2 translesion nuclease activity and thereby promotes DNA interstrand crosslink repair. J Biol Chem. 2020 07 03; 295(27):8945-8957.

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Resolution of ROS-induced G-quadruplexes and R-loops at transcriptionally active sites is dependent on BLM helicase. FEBS Lett. 2020 05; 594(9):1359-1367.

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BLM has Contrary Effects on Repeat-Mediated Deletions, based on the Distance of DNA DSBs to a Repeat and Repeat Divergence. Cell Rep. 2020 02 04; 30(5):1342-1357.e4.

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A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases. Nat Commun. 2018 10 10; 9(1):4201.

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High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR-Cas9 in yeast. Nat Biotechnol. 2018 07; 36(6):540-546.

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