Harvard Catalyst Profiles

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RNA-Induced Silencing Complex

"RNA-Induced Silencing Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).


This graph shows the total number of publications written about "RNA-Induced Silencing Complex" by people in Harvard Catalyst Profiles by year, and whether "RNA-Induced Silencing Complex" was a major or minor topic of these publication.
Bar chart showing 39 publications over 14 distinct years, with a maximum of 6 publications in 2009 and 2011
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.