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profileRNA, Small Interfering

"RNA, Small Interfering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.


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This graph shows the total number of publications written about "RNA, Small Interfering" by people in Harvard Catalyst Profiles by year, and whether "RNA, Small Interfering" was a major or minor topic of these publication.
Bar chart showing 2101 publications over 17 distinct years, with a maximum of 216 publications in 2013
To see the data from this visualization as text, click here.