Psychosine

"Psychosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An intermediate in the biosynthesis of cerebrosides. It is formed by reaction of sphingosine with UDP-galactose and then itself reacts with fatty acid-Coenzyme A to form the cerebroside.

Descriptor ID

D011609

MeSH Number(s)

D02.033.100.700.700

D02.092.063.700.700

D09.400.410.420.806

D10.390.470.806

D10.570.877.360.806

Concept/Terms

Psychosine

Below are MeSH descriptors whose meaning is more general than "Psychosine".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Alcohols [D02.033]
Amino Alcohols [D02.033.100]
Sphingosine [D02.033.100.700]
Psychosine [D02.033.100.700.700]
Amines [D02.092]
Amino Alcohols [D02.092.063]
Sphingosine [D02.092.063.700]
Psychosine [D02.092.063.700.700]
Carbohydrates [D09]
Glycoconjugates [D09.400]
Glycolipids [D09.400.410]
Glycosphingolipids [D09.400.410.420]
Psychosine [D09.400.410.420.806]
Lipids [D10]
Glycolipids [D10.390]
Glycosphingolipids [D10.390.470]
Psychosine [D10.390.470.806]
Membrane Lipids [D10.570]
Sphingolipids [D10.570.877]
Glycosphingolipids [D10.570.877.360]
Psychosine [D10.570.877.360.806]

Below are MeSH descriptors whose meaning is related to "Psychosine".

Below are MeSH descriptors whose meaning is more specific than "Psychosine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Psychosine" by people in Harvard Catalyst Profiles by year, and whether "Psychosine" was a major or minor topic of these publication.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 2001 and 2013 and 2016 and 2018 and 2019 and 2020 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	1	0	1
2013	1	0	1
2016	0	1	1
2018	1	0	1
2019	1	0	1
2020	0	1	1
2021	0	1	1

Below are the most recent publications written about "Psychosine" by people in Profiles.

Human iPSC-based neurodevelopmental models of globoid cell leukodystrophy uncover patient- and cell type-specific disease phenotypes. Stem Cell Reports. 2021 06 08; 16(6):1478-1495.

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Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors. J Med Chem. 2020 04 09; 63(7):3634-3664.

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Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target. Proc Natl Acad Sci U S A. 2019 10 01; 116(40):20097-20103.

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Inhibition of the IGF-1-PI3K-Akt-mTORC2 pathway in lipid rafts increases neuronal vulnerability in a genetic lysosomal glycosphingolipidosis. Dis Model Mech. 2019 05 23; 12(5).

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a-Synuclein interacts directly but reversibly with psychosine: implications for a-synucleinopathies. Sci Rep. 2018 08 20; 8(1):12462.

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A HILIC-MS/MS method for simultaneous quantification of the lysosomal disease markers galactosylsphingosine and glucosylsphingosine in mouse serum. Biomed Chromatogr. 2018 Jul; 32(7):e4235.

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Analysis of age-related changes in psychosine metabolism in the human brain. PLoS One. 2018; 13(2):e0193438.

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Psychosine enhances the shedding of membrane microvesicles: Implications in demyelination in Krabbe's disease. PLoS One. 2017; 12(5):e0178103.

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Patient fibroblasts-derived induced neurons demonstrate autonomous neuronal defects in adult-onset Krabbe disease. Oncotarget. 2016 11 15; 7(46):74496-74509.

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Mechanism of neuromuscular dysfunction in Krabbe disease. J Neurosci. 2015 Jan 28; 35(4):1606-16.

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