Harvard Catalyst Profiles

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Proto-Oncogene Proteins c-kit

"Proto-Oncogene Proteins c-kit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.


This graph shows the total number of publications written about "Proto-Oncogene Proteins c-kit" by people in Harvard Catalyst Profiles by year, and whether "Proto-Oncogene Proteins c-kit" was a major or minor topic of these publication.
Bar chart showing 440 publications over 30 distinct years, with a maximum of 36 publications in 2009
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.