Protein Structure, Tertiary
"Protein Structure, Tertiary" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Concept/Terms
Protein Structure, Tertiary- Protein Structure, Tertiary
- Tertiary Protein Structure
- Protein Structures, Tertiary
- Tertiary Protein Structures
- Peptide Domain
- Domain, Peptide
- Domains, Peptide
- Peptide Domains
- Protein Domains
- Domain, Protein
- Domains, Protein
- Protein Domain
Below are MeSH descriptors whose meaning is more general than "Protein Structure, Tertiary".
Below are MeSH descriptors whose meaning is more specific than "Protein Structure, Tertiary".
This graph shows the total number of publications written about "Protein Structure, Tertiary" by people in Harvard Catalyst Profiles by year, and whether "Protein Structure, Tertiary" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 3 | 6 | 9 |
| 1994 | 5 | 8 | 13 |
| 1995 | 6 | 4 | 10 |
| 1996 | 3 | 15 | 18 |
| 1997 | 1 | 21 | 22 |
| 1998 | 6 | 23 | 29 |
| 1999 | 2 | 29 | 31 |
| 2000 | 2 | 108 | 110 |
| 2001 | 2 | 178 | 180 |
| 2002 | 11 | 178 | 189 |
| 2003 | 2 | 204 | 206 |
| 2004 | 0 | 226 | 226 |
| 2005 | 6 | 213 | 219 |
| 2006 | 8 | 200 | 208 |
| 2007 | 2 | 186 | 188 |
| 2008 | 5 | 165 | 170 |
| 2009 | 4 | 138 | 142 |
| 2010 | 5 | 160 | 165 |
| 2011 | 5 | 152 | 157 |
| 2012 | 7 | 164 | 171 |
| 2013 | 6 | 136 | 142 |
| 2014 | 2 | 140 | 142 |
| 2015 | 6 | 127 | 133 |
| 2016 | 1 | 37 | 38 |
| 2017 | 0 | 10 | 10 |
| 2018 | 0 | 11 | 11 |
| 2019 | 2 | 11 | 13 |
| 2020 | 0 | 10 | 10 |
| 2021 | 2 | 4 | 6 |
Below are the most recent publications written about "Protein Structure, Tertiary" by people in Profiles.
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Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of IL-1R10 provides structural insights into TIR domain signalling. FEBS Lett. 2022 04; 596(7):886-897.
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Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE. Eur J Med Chem. 2022 Jan 05; 227:113926.
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Breakthrough Discovery in Protein Structure Prediction and the Promise of New Treatments. JAMA. 2021 Oct 12; 326(14):1369-1370.
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Antibody-Based Inhibition of Pathogenic New World Hemorrhagic Fever Mammarenaviruses by Steric Occlusion of the Human Transferrin Receptor 1 Apical Domain. J Virol. 2021 08 10; 95(17):e0186820.
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Membrane-Facilitated Receptor Access and Binding Mechanisms of Long-Acting ß2-Adrenergic Receptor Agonists. Mol Pharmacol. 2021 10; 100(4):406-427.
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Structure-based protein function prediction using graph convolutional networks. Nat Commun. 2021 05 26; 12(1):3168.
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DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature. 2021 04; 592(7856):778-783.
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Structures of radial spokes and associated complexes important for ciliary motility. Nat Struct Mol Biol. 2021 01; 28(1):29-37.
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Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Neuron. 2021 01 20; 109(2):241-256.e9.
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Cppsite 2.0: An Available Database of Experimentally Validated Cell-Penetrating Peptides Predicting their Secondary and Tertiary Structures. J Mol Biol. 2021 05 28; 433(11):166703.