"Promegestone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.
Concept/Terms
Promegestone- Promegestone
- 17,21-Dimethyl-19-nor-4,9-pregnadiene-3,20-dione
- Promestone
R-5020- R-5020
- R 5020
- RU-5020
- RU 5020
- RU5020
- R5020
Below are MeSH descriptors whose meaning is more general than "Promegestone".
Below are MeSH descriptors whose meaning is more specific than "Promegestone".
This graph shows the total number of publications written about "Promegestone" by people in Harvard Catalyst Profiles by year, and whether "Promegestone" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
1995 | 0 | 1 | 1 |
1997 | 0 | 1 | 1 |
1999 | 1 | 0 | 1 |
2009 | 0 | 1 | 1 |
2010 | 0 | 1 | 1 |
2012 | 0 | 1 | 1 |
2018 | 0 | 1 | 1 |
2021 | 0 | 1 | 1 |
Below are the most recent publications written about "Promegestone" by people in Profiles.
-
A set of accessible enhancers enables the initial response of breast cancer cells to physiological progestin concentrations. Nucleic Acids Res. 2021 12 16; 49(22):12716-12731.
-
3D organizational mapping of collagen fibers elucidates matrix remodeling in a hormone-sensitive 3D breast tissue model. Biomaterials. 2018 10; 179:96-108.
-
Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells. Oncogene. 2016 09 29; 35(39):5191-201.
-
Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin. PLoS One. 2012; 7(7):e41593.
-
Multimodal regulation of E2F1 gene expression by progestins. Mol Cell Biol. 2010 Apr; 30(8):1866-77.
-
Progestins activate the AKT pathway in leiomyoma cells and promote survival. J Clin Endocrinol Metab. 2009 May; 94(5):1768-74.
-
Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors. Mol Endocrinol. 2003 Apr; 17(4):628-42.
-
The steroid promegestone is a noncompetitive antagonist of the Torpedo nicotinic acetylcholine receptor that interacts with the lipid-protein interface. Mol Pharmacol. 1999 Feb; 55(2):269-78.
-
Heterogeneity of binding sites and bioeffects of raloxifene on the human leukemic cell line FLG 29.1. Biochem Biophys Res Commun. 1997 Nov 26; 240(3):573-9.
-
Progesterone and glucocorticoid receptor activation in meningiomas. Neurosurgery. 1995 Jul; 37(1):92-7.