"Presenilin-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.
Below are MeSH descriptors whose meaning is more general than "Presenilin-2".
Below are MeSH descriptors whose meaning is more specific than "Presenilin-2".
This graph shows the total number of publications written about "Presenilin-2" by people in Harvard Catalyst Profiles by year, and whether "Presenilin-2" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 1 | 7 | 8 |
| 1997 | 0 | 9 | 9 |
| 1998 | 0 | 6 | 6 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 11 | 11 |
| 2001 | 0 | 6 | 6 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 3 | 3 |
| 2007 | 1 | 1 | 2 |
| 2008 | 2 | 1 | 3 |
| 2010 | 0 | 2 | 2 |
| 2012 | 0 | 2 | 2 |
| 2013 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 5 | 6 |
| 2019 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
Below are the most recent publications written about "Presenilin-2" by people in Profiles.
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Human Presenilin-1 delivered by AAV9 rescues impaired ?-secretase activity, memory deficits, and neurodegeneration in Psen mutant mice. Proc Natl Acad Sci U S A. 2023 10 17; 120(42):e2306714120.
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Pathogenic variants in the Longitudinal Early-onset Alzheimer's Disease Study cohort. Alzheimers Dement. 2023 11; 19 Suppl 9:S64-S73.
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Analysis of hidradenitis suppurativa-linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages. Hum Mol Genet. 2019 04 01; 28(7):1173-1182.
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Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology. 2018 10 02; 91(14):e1295-e1306.
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Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network. Alzheimers Res Ther. 2018 07 25; 10(1):69.
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Discovery and validation of autosomal dominant Alzheimer's disease mutations. Alzheimers Res Ther. 2018 07 18; 10(1):67.
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iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling. Mol Neurodegener. 2018 06 26; 13(1):33.
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Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain. 2018 04 01; 141(4):1186-1200.
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Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study. Lancet Neurol. 2018 03; 17(3):241-250.
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CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons. Acta Neuropathol Commun. 2017 10 27; 5(1):77.