"Polyubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An oligomer formed from the repetitive linking of the C-terminal glycine of one UBIQUITIN molecule via an isopeptide bond to a lysine residue on a second ubiquitin molecule. It is structurally distinct from UBIQUITIN C, which is a single protein containing a tandemly arrayed ubiquitin peptide sequence.
Below are MeSH descriptors whose meaning is more general than "Polyubiquitin".
Below are MeSH descriptors whose meaning is more specific than "Polyubiquitin".
This graph shows the total number of publications written about "Polyubiquitin" by people in Harvard Catalyst Profiles by year, and whether "Polyubiquitin" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1995 | 0 | 2 | 2 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 2 | 1 | 3 |
| 2008 | 1 | 2 | 3 |
| 2009 | 1 | 1 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 3 | 4 |
| 2013 | 3 | 3 | 6 |
| 2014 | 1 | 1 | 2 |
| 2015 | 1 | 3 | 4 |
| 2016 | 3 | 2 | 5 |
| 2017 | 0 | 3 | 3 |
| 2018 | 2 | 1 | 3 |
| 2019 | 1 | 2 | 3 |
| 2020 | 0 | 1 | 1 |
| 2021 | 2 | 0 | 2 |
| 2022 | 0 | 1 | 1 |
Below are the most recent publications written about "Polyubiquitin" by people in Profiles.
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A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel. Nature. 2022 07; 607(7918):374-380.
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Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase. Mol Cell. 2022 02 03; 82(3):570-584.e8.
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Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2. Mol Cell. 2021 10 21; 81(20):4176-4190.e6.
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Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming. Nat Struct Mol Biol. 2020 06; 27(6):550-560.
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Ddi1 is a ubiquitin-dependent protease. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7776-7781.
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Legionella pneumophila regulates the activity of UBE2N by deamidase-mediated deubiquitination. EMBO J. 2020 02 17; 39(4):e102806.
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Polyubiquitin Chains Linked by Lysine Residue 48 (K48) Selectively Target Oxidized Proteins In Vivo. Antioxid Redox Signal. 2019 11 20; 31(15):1133-1149.
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N6-Methyladenosine Modification Controls Circular RNA Immunity. Mol Cell. 2019 10 03; 76(1):96-109.e9.
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Insights into ubiquitin chain architecture using Ub-clipping. Nature. 2019 08; 572(7770):533-537.
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Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science. 2019 08 02; 365(6452).